|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
CA2008368C
(en)
|
1989-01-24 |
2003-04-08 |
Jeffrey Greve |
Soluble molecule related to but distinct from icam-1
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US20070258987A1
(en)
|
2000-11-28 |
2007-11-08 |
Seattle Genetics, Inc. |
Recombinant Anti-Cd30 Antibodies and Uses Thereof
|
|
JP2005534287A
(ja)
|
2002-04-05 |
2005-11-17 |
アジェンシス， インコーポレイテッド |
癌の処置および検出において有用な９８ｐ４ｂ６との名称の核酸および対応するタンパク質
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
WO2005079490A2
(en)
|
2004-02-13 |
2005-09-01 |
Nuvelo, Inc. |
Methods of therapy and diagnosis using targeting of cells that express steap2 polypeptides
|
|
AR048098A1
(es)
|
2004-03-15 |
2006-03-29 |
Wyeth Corp |
Conjugados de caliqueamicina
|
|
KR20120064120A
(ko)
|
2004-06-01 |
2012-06-18 |
제넨테크, 인크. |
항체 약물 접합체 및 방법
|
|
EP1817341A2
(en)
|
2004-11-29 |
2007-08-15 |
Seattle Genetics, Inc. |
Engineered antibodies and immunoconjugates
|
|
US7750116B1
(en)
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
NO347649B1
(no)
|
2006-12-14 |
2024-02-12 |
Regeneron Pharma |
Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
|
|
WO2008122039A2
(en)
|
2007-04-02 |
2008-10-09 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Selenocysteine mediated hybrid antibody molecules
|
|
JP2010528285A
(ja)
|
2007-05-23 |
2010-08-19 |
ベンタナ・メデイカル・システムズ・インコーポレーテツド |
免疫組織化学およびｉｎｓｉｔｕハイブリダーゼーションのためのポリマー担体
|
|
EP2276506A4
(en)
|
2008-04-30 |
2014-05-07 |
Immunogen Inc |
EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
|
|
EP2374481B1
(en)
|
2008-07-21 |
2015-11-04 |
Polytherics Limited |
Novel reagents and method for conjugating biological molecules
|
|
JO3182B1
(ar)
|
2009-07-29 |
2018-03-08 |
Regeneron Pharma |
مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
|
|
JP5954789B2
(ja)
|
2009-08-10 |
2016-07-20 |
ユーシーエル ビジネス パブリック リミテッド カンパニー |
機能的分子の可逆的共有結合
|
|
DK2528625T3
(da)
|
2010-04-15 |
2013-10-14 |
Spirogen Sarl |
Pyrrolobenzodiazepiner og konjugater deraf
|
|
US20130244905A1
(en)
|
2010-07-06 |
2013-09-19 |
Ed Grabczyk |
Reporter for RNA Polymerase II Termination
|
|
SG10201912639SA
(en)
|
2010-08-02 |
2020-02-27 |
Regeneron Pharma |
Mice that make binding proteins comprising vl domains
|
|
KR20140037105A
(ko)
|
2011-05-27 |
2014-03-26 |
암브룩스, 인코포레이티드 |
비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
|
|
US8815226B2
(en)
|
2011-06-10 |
2014-08-26 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
CA2850103C
(en)
|
2011-10-14 |
2019-09-10 |
Spirogen Sarl |
Pyrrolobenzodiazepines
|
|
ES2945932T3
(es)
|
2011-10-14 |
2023-07-10 |
Seagen Inc |
Pirrolobenzodiazepinas y conjugados dirigidos
|
|
CA2850096C
(en)
|
2011-10-14 |
2018-07-03 |
Spirogen Sarl |
Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
|
|
WO2013068874A1
(en)
|
2011-11-11 |
2013-05-16 |
Pfizer Inc. |
Antibody-drug conjugates
|
|
CN104244718A
(zh)
|
2011-12-05 |
2014-12-24 |
伊格尼卡生物治疗公司 |
抗体-药物缀合物以及相关化合物、组合物和方法
|
|
CA2864872C
(en)
*
|
2012-02-24 |
2022-07-05 |
Alteogen Inc. |
Modified antibody in which motif comprising cysteine residue is bound
|
|
DK2907824T3
(en)
*
|
2012-10-11 |
2018-07-23 |
Daiichi Sankyo Co Ltd |
ANTIBODY-drug conjugate
|
|
FI2911699T4
(fi)
|
2012-10-23 |
2025-12-09 |
Synaffix Bv |
Muokattu vasta-aine, vasta-ainekonjugaatti ja menetelmä niiden valmistamiseksi
|
|
JP6744212B2
(ja)
*
|
2013-06-21 |
2020-08-19 |
イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． |
ポリペプチドの酵素的結合
|
|
KR102252925B1
(ko)
|
2013-08-26 |
2021-05-18 |
리제너론 파마슈티칼스 인코포레이티드 |
마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도
|
|
SI3466976T1
(sl)
*
|
2014-01-31 |
2021-12-31 |
Daiichi Sankyo Company, Limited |
Anti-her2 konjugat protitelesa-zdravila
|
|
JP2017114763A
(ja)
|
2014-03-26 |
2017-06-29 |
第一三共株式会社 |
抗ｃｄ９８抗体−薬物コンジュゲート
|
|
KR102399277B1
(ko)
*
|
2014-04-10 |
2022-05-18 |
다이이찌 산쿄 가부시키가이샤 |
항her3 항체-약물 콘주게이트
|
|
CA2950155C
(en)
|
2014-06-02 |
2021-11-23 |
Regeneron Pharmaceuticals, Inc. |
Biologically active molecule conjugates, reagents and methods of manufacture, and therapeutic uses
|
|
TWI710573B
(zh)
|
2015-01-26 |
2020-11-21 |
美商再生元醫藥公司 |
抗伊波拉病毒醣蛋白之人類抗體
|
|
CN108112254B
(zh)
*
|
2015-03-13 |
2022-01-28 |
西托姆克斯治疗公司 |
抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
|
|
KR101757977B1
(ko)
|
2015-06-26 |
2017-07-13 |
아주대학교산학협력단 |
바이오 잉크의 제조방법 및 3d 프린터 적용
|
|
WO2017132173A1
(en)
|
2016-01-25 |
2017-08-03 |
Regeneron Pharmaceuticals, Inc. |
Maytansinoid derivatives, conjugates thereof, and methods of use
|
|
WO2017147542A2
(en)
|
2016-02-26 |
2017-08-31 |
Regeneron Pharmaceuticals, Inc. |
Optimized transglutaminase site-specific antibody conjugation
|
|
MX2019003325A
(es)
|
2016-09-23 |
2019-08-05 |
Regeneron Pharma |
Anticuerpos anti-steap2, conjugados anticuerpo-farmaco, y moleculas de fijacion al antigeno biespecificas que se fijan a steap2 y cd3, y usos de estos.
|
|
KR20250114431A
(ko)
|
2016-11-08 |
2025-07-29 |
리제너론 파마슈티칼스 인코포레이티드 |
스테로이드 및 이의 단백질-접합체
|
|
TWI782930B
(zh)
*
|
2016-11-16 |
2022-11-11 |
美商再生元醫藥公司 |
抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
|
|
WO2018182341A1
(ko)
|
2017-03-29 |
2018-10-04 |
주식회사 레고켐 바이오사이언스 |
피롤로벤조디아제핀 이량체 전구체 및 이의 리간드-링커 접합체 화합물
|
|
WO2018213082A1
(en)
*
|
2017-05-18 |
2018-11-22 |
Regeneron Pharmaceuticals, Inc. |
Bis-octahydrophenanthrene carboxamides and protein conjugates thereof
|
|
CN118652192A
(zh)
|
2017-05-24 |
2024-09-17 |
德克萨斯州大学系统董事会 |
用于抗体药物缀合物的接头
|
|
MX2019015057A
(es)
|
2017-06-23 |
2020-08-03 |
Velosbio Inc |
Inmunoconjugados de anticuerpos receptor huérfano similar al receptor tirosina cinasa 1 (ror1).
|
|
JP7381478B2
(ja)
|
2017-10-23 |
2023-11-15 |
マブリンク ビオシオンス |
単一分子量ポリサルコシンを含むリガンド－薬物－複合体
|
|
MX2020011487A
(es)
|
2018-04-30 |
2020-12-07 |
Regeneron Pharma |
Anticuerpos y moleculas biespecificas de union al antigeno que se unen a her2 y/o aplp2, conjugados y usos de estos.
|
|
CN112533951A
(zh)
*
|
2018-05-09 |
2021-03-19 |
里珍纳龙药品有限公司 |
抗msr1抗体及其使用方法
|
|
HUE067382T2
(hu)
*
|
2018-05-18 |
2024-10-28 |
Daiichi Sankyo Co Ltd |
Anti-MUC1-exatecan antitest-hatóanyag konjugátum
|
|
TW202019487A
(zh)
|
2018-08-06 |
2020-06-01 |
日商第一三共股份有限公司 |
抗體-藥物結合物及微管蛋白抑制劑之組合
|
|
WO2020063676A1
(zh)
|
2018-09-26 |
2020-04-02 |
江苏恒瑞医药股份有限公司 |
依喜替康类似物的配体-药物偶联物及其制备方法和应用
|
|
MA53455B1
(fr)
|
2018-11-20 |
2022-11-30 |
Regeneron Pharma |
Dérivés de bis-octahydrophénanthrène carboxamide et leurs conjugués protéiques destinés à être utilisés en tant qu'agonistes de lxr
|
|
EP3976112A1
(en)
|
2019-06-03 |
2022-04-06 |
Synaffix B.V. |
Acetal-based cleavable linkers
|
|
CN110974975B
(zh)
|
2019-12-12 |
2023-10-20 |
成都百利多特生物药业有限责任公司 |
一种快速释放的抗体药物偶联物
|
|
IL295312A
(en)
|
2020-02-28 |
2022-10-01 |
Regeneron Pharma |
Bispecific antigen binding molecules that bind her2, and methods of use thereof
|
|
JP7689979B2
(ja)
|
2020-03-25 |
2025-06-09 |
江蘇恒瑞医薬股▲ふん▼有限公司 |
抗体薬物複合体を含む医薬組成物及びその使用
|
|
KR20240038138A
(ko)
|
2020-07-13 |
2024-03-22 |
리제너론 파마슈티칼스 인코포레이티드 |
단백질에서 글루타민 잔기에 접합된 캄토테신 유사체 및 그의 용도
|
|
KR20230062600A
(ko)
|
2020-09-04 |
2023-05-09 |
메르크 파텐트 게엠베하 |
항-ceacam5 항체 및 접합체 및 이의 용도
|
|
US20250276078A1
(en)
|
2020-10-12 |
2025-09-04 |
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. |
Camptothecin Derivative And Ligand-drug Conjugate Thereof
|
|
US20240216525A1
(en)
|
2021-03-30 |
2024-07-04 |
Mablink Bioscience |
Enzyme-triggered self-reacting linker having improved physicochemical and pharmacological properties
|
|
CN116897149A
(zh)
|
2021-03-30 |
2023-10-17 |
上海复旦张江生物医药股份有限公司 |
一种连接基药物偶联物的制备方法及其中间体
|
|
BR112023023276A2
(pt)
|
2021-05-07 |
2024-01-30 |
Alx Oncology Inc |
Derivados de exatecan e conjugados anticorpo-fármaco destes
|
|
CA3218527A1
(en)
|
2021-06-02 |
2022-12-08 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Antibody drug conjugate, and preparation method therefor and use thereof
|
|
CN117500528A
(zh)
|
2021-06-18 |
2024-02-02 |
北京海步医药科技有限公司 |
连接子及其缀合物
|
|
EP4460330A1
(en)
|
2022-01-06 |
2024-11-13 |
Virtuoso Binco, Inc. |
Conjugates, compositions and methods of use
|
|
CA3241734A1
(en)
|
2022-01-12 |
2023-07-20 |
Amy Han |
Camptothecin analogs conjugated to a glutamine residue in a protein, and their use
|
|
KR20240150807A
(ko)
|
2022-02-22 |
2024-10-16 |
아라리스 바이오테크 아게 |
2개 이상의 페이로드를 포함하는 펩티드 링커
|
|
JP2025519421A
(ja)
|
2022-06-09 |
2025-06-26 |
ベイジーン スイッツァランド ゲーエムベーハー |
抗体薬物複合体
|