CN116390771A - 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 - Google Patents

与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 Download PDF

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CN116390771A
CN116390771A CN202180062762.2A CN202180062762A CN116390771A CN 116390771 A CN116390771 A CN 116390771A CN 202180062762 A CN202180062762 A CN 202180062762A CN 116390771 A CN116390771 A CN 116390771A
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group
compound
antibody
seq
dxd
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Chinese (zh)
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A·韩
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/565Complementarity determining region [CDR]

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN202180062762.2A 2020-07-13 2021-07-12 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 Pending CN116390771A (zh)

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CN202410175152.9A CN118085100A (zh) 2020-07-13 2021-07-12 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途

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US202063051172P 2020-07-13 2020-07-13
US63/051,172 2020-07-13
US202163154531P 2021-02-26 2021-02-26
US63/154,531 2021-02-26
PCT/US2021/041304 WO2022015656A1 (en) 2020-07-13 2021-07-12 Camptothecin analogs conjugated to a glutamine residue in a protein, and their use

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