CN116390771A - 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 - Google Patents
与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 Download PDFInfo
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- CN116390771A CN116390771A CN202180062762.2A CN202180062762A CN116390771A CN 116390771 A CN116390771 A CN 116390771A CN 202180062762 A CN202180062762 A CN 202180062762A CN 116390771 A CN116390771 A CN 116390771A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410175152.9A CN118085100A (zh) | 2020-07-13 | 2021-07-12 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063051172P | 2020-07-13 | 2020-07-13 | |
| US63/051,172 | 2020-07-13 | ||
| US202163154531P | 2021-02-26 | 2021-02-26 | |
| US63/154,531 | 2021-02-26 | ||
| PCT/US2021/041304 WO2022015656A1 (en) | 2020-07-13 | 2021-07-12 | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410175152.9A Division CN118085100A (zh) | 2020-07-13 | 2021-07-12 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116390771A true CN116390771A (zh) | 2023-07-04 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180062762.2A Pending CN116390771A (zh) | 2020-07-13 | 2021-07-12 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
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| WO2025103474A1 (zh) * | 2023-11-17 | 2025-05-22 | 成都康弘生物科技有限公司 | 双毒素抗体药物偶联物及其用途 |
| WO2026032411A1 (en) * | 2024-08-09 | 2026-02-12 | Beone Guangzhou Biologics Manufacturing Co., Ltd. | Self-stabilizing linker conjugates |
Also Published As
| Publication number | Publication date |
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| KR20230038738A (ko) | 2023-03-21 |
| KR20240038138A (ko) | 2024-03-22 |
| JP2023534437A (ja) | 2023-08-09 |
| US20240252661A1 (en) | 2024-08-01 |
| IL309173A (en) | 2024-02-01 |
| EP4406608A3 (en) | 2024-10-30 |
| CL2023000098A1 (es) | 2023-06-30 |
| WO2022015656A9 (en) | 2022-09-22 |
| CN118085100A (zh) | 2024-05-28 |
| CA3183184A1 (en) | 2022-01-20 |
| WO2022015656A1 (en) | 2022-01-20 |
| AU2024200822A1 (en) | 2024-02-29 |
| CO2023001402A2 (es) | 2023-02-16 |
| MX2024003180A (es) | 2024-03-25 |
| MA71650A (fr) | 2025-05-30 |
| EP4406608A2 (en) | 2024-07-31 |
| JP2024059609A (ja) | 2024-05-01 |
| US20220072141A1 (en) | 2022-03-10 |
| MX2023000544A (es) | 2023-02-13 |
| IL299153A (en) | 2023-02-01 |
| US12605459B2 (en) | 2026-04-21 |
| JP7776485B2 (ja) | 2025-11-26 |
| AU2021308190A1 (en) | 2023-02-02 |
| AU2024200822B2 (en) | 2026-02-19 |
| BR112023000489A2 (pt) | 2023-03-28 |
| EP4178625A1 (en) | 2023-05-17 |
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