JP2020504112A5 - - Google Patents
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- JP2020504112A5 JP2020504112A5 JP2019533594A JP2019533594A JP2020504112A5 JP 2020504112 A5 JP2020504112 A5 JP 2020504112A5 JP 2019533594 A JP2019533594 A JP 2019533594A JP 2019533594 A JP2019533594 A JP 2019533594A JP 2020504112 A5 JP2020504112 A5 JP 2020504112A5
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- JP
- Japan
- Prior art keywords
- seq
- fab
- variable region
- heavy chain
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- Prior art date
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022167563A JP7622017B2 (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437622P | 2016-12-21 | 2016-12-21 | |
| US62/437,622 | 2016-12-21 | ||
| US201762520854P | 2017-06-16 | 2017-06-16 | |
| US62/520,854 | 2017-06-16 | ||
| PCT/IB2017/058159 WO2018116178A1 (en) | 2016-12-21 | 2017-12-19 | Antibody drug conjugates for ablating hematopoietic stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022167563A Division JP7622017B2 (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504112A JP2020504112A (ja) | 2020-02-06 |
| JP2020504112A5 true JP2020504112A5 (https=) | 2021-02-04 |
| JP7181203B2 JP7181203B2 (ja) | 2022-11-30 |
Family
ID=60957364
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533594A Active JP7181203B2 (ja) | 2016-12-21 | 2017-12-19 | 造血幹細胞を除去するための抗体薬物結合体 |
| JP2022167563A Active JP7622017B2 (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022167563A Active JP7622017B2 (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US11357864B2 (https=) |
| EP (1) | EP3558389A1 (https=) |
| JP (2) | JP7181203B2 (https=) |
| KR (2) | KR20240093751A (https=) |
| CN (2) | CN117653740A (https=) |
| AU (1) | AU2017383458C1 (https=) |
| BR (1) | BR112019012483A2 (https=) |
| CA (1) | CA3045592A1 (https=) |
| CL (1) | CL2019001745A1 (https=) |
| CO (1) | CO2019006455A2 (https=) |
| CR (1) | CR20190296A (https=) |
| CU (1) | CU24644B1 (https=) |
| EA (1) | EA201991526A1 (https=) |
| EC (1) | ECSP19044625A (https=) |
| IL (2) | IL300567A (https=) |
| JO (1) | JOP20190155B1 (https=) |
| MA (1) | MA47231A (https=) |
| MX (1) | MX2019007582A (https=) |
| MY (1) | MY193985A (https=) |
| PE (1) | PE20191539A1 (https=) |
| PH (1) | PH12019501330A1 (https=) |
| SA (1) | SA519402188B1 (https=) |
| TW (2) | TWI852077B (https=) |
| WO (1) | WO2018116178A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102447350B1 (ko) * | 2013-02-08 | 2022-09-23 | 노파르티스 아게 | 면역접합체의 제조를 위한 항체의 변형에 사용되는 특정 부위 |
| US10464969B2 (en) * | 2016-05-05 | 2019-11-05 | Novartis Ag | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase |
| BR112018076306A2 (pt) * | 2016-06-17 | 2019-03-26 | Magenta Therapeutics, Inc. | composições e métodos para a supressão de células cd117+ |
| WO2019234694A2 (en) * | 2018-06-07 | 2019-12-12 | Magenta Therapeutics, Inc. | Therapeutic methods using antibody drug conjugates (adcs) |
| TW202014209A (zh) * | 2018-06-20 | 2020-04-16 | 瑞士商諾華公司 | 用於消融造血幹細胞之抗體藥物軛合物 |
| AU2019312200B2 (en) * | 2018-07-23 | 2024-11-14 | Heidelberg Pharma Research Gmbh | Use of anti-CD137 antibody drug conjugate (ADC) in allogeneic cell therapy |
| CA3107383A1 (en) * | 2018-07-23 | 2020-01-30 | Magenta Therapeutics, Inc. | Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy |
| CN113330026A (zh) * | 2018-10-23 | 2021-08-31 | 美真达治疗公司 | Fc沉默的抗体药物缀合物(ADC)及其用途 |
| EP3873532A1 (en) * | 2018-10-31 | 2021-09-08 | Novartis AG | Dc-sign antibody drug conjugates |
| CN119684457A (zh) | 2018-11-26 | 2025-03-25 | 四十七有限责任公司 | 针对c-kit的人源化抗体 |
| WO2020121071A1 (en) * | 2018-12-12 | 2020-06-18 | Levim Biotech Llp | Acylation process for preparation of n-substituted peptide |
| JP2022535527A (ja) * | 2019-06-04 | 2022-08-09 | マジェンタ セラピューティクス インコーポレイテッド | 自己免疫疾患を治療するための方法および組成物 |
| WO2021022678A1 (zh) * | 2019-08-07 | 2021-02-11 | 烟台迈百瑞国际生物医药股份有限公司 | 一种抗体药物偶联物及其应用 |
| CN116183899B (zh) * | 2023-04-28 | 2023-06-30 | 天津市协和医药科技集团有限公司 | 一种吖啶酯标记抗体保存液的制备方法 |
| TW202513593A (zh) * | 2023-09-08 | 2025-04-01 | 大陸商信達生物製藥（蘇州）有限公司 | 半胱胺酸改造的抗體和免疫綴合物 |
| WO2025080282A1 (en) * | 2023-10-12 | 2025-04-17 | Memorial Sloan-Kettering Cancer Center | Combination therapy with clk/dyrk inhibitors and bcl2 inhibitors to treat leukemia |
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| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| WO1992019244A2 (en) | 1991-05-01 | 1992-11-12 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | A method for treating infectious respiratory diseases |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| DK0885002T3 (da) | 1996-03-04 | 2011-08-22 | Penn State Res Found | Materialer og fremgangsmåder til forøgelse af cellulær internalisering |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| DE69732306T2 (de) | 1997-01-16 | 2006-01-12 | Massachusetts Institute Of Technology, Cambridge | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| WO1998052976A1 (en) | 1997-05-21 | 1998-11-26 | Biovation Limited | Method for the production of non-immunogenic proteins |
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| KR101033196B1 (ko) | 2002-02-14 | 2011-05-09 | 이뮤노메딕스, 인코오포레이티드 | 항-ｃｄ20 항체 및 그 융합 단백질 및 이들의 이용방법 |
| WO2004002425A2 (en) | 2002-06-28 | 2004-01-08 | Bio Transplant, Inc. | Process for promoting graft acceptance by depletion of hematopoietic stem cells |
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| ES2882360T3 (es) * | 2006-11-03 | 2021-12-01 | Univ Leland Stanford Junior | Inmunoempobrecimiento selectivo de un nicho de células madre endógenas para injerto |
| US8540517B2 (en) | 2006-11-27 | 2013-09-24 | Pharos Innovations, Llc | Calculating a behavioral path based on a statistical profile |
| AU2010270979B2 (en) | 2009-06-22 | 2015-04-23 | Medimmune, Llc | Engineered Fc regions for site-specific conjugation |
| US9540443B2 (en) * | 2011-01-26 | 2017-01-10 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies |
| AR086044A1 (es) | 2011-05-12 | 2013-11-13 | Imclone Llc | Anticuerpos que se unen especificamente a un dominio extracelular de c-kit y usos de los mismos |
| CN116574185A (zh) | 2012-07-25 | 2023-08-11 | 塞尔德克斯医疗公司 | 抗kit抗体及其用途 |
| KR102447350B1 (ko) | 2013-02-08 | 2022-09-23 | 노파르티스 아게 | 면역접합체의 제조를 위한 항체의 변형에 사용되는 특정 부위 |
| NZ710929A (en) * | 2013-03-15 | 2018-02-23 | Novartis Ag | Antibody drug conjugates |
| CA2940451A1 (en) * | 2014-03-12 | 2015-09-17 | Novartis Ag | Specific sites for modifying antibodies to make immunoconjugates |
| CN106573956A (zh) * | 2014-06-13 | 2017-04-19 | 诺华股份有限公司 | 澳瑞他汀衍生物及其缀合物 |
| US10786578B2 (en) * | 2014-08-05 | 2020-09-29 | Novartis Ag | CKIT antibody drug conjugates |
| EP3215519A1 (en) * | 2014-11-06 | 2017-09-13 | Novartis AG | Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase |
| HK1249534A1 (zh) * | 2015-04-06 | 2018-11-02 | 哈佛大学校长及研究员协会 | 用於非清髓性预处理的组合物和方法 |
| EP3310813A1 (en) * | 2015-06-17 | 2018-04-25 | Novartis AG | Antibody drug conjugates |
| BR112018076306A2 (pt) | 2016-06-17 | 2019-03-26 | Magenta Therapeutics, Inc. | composições e métodos para a supressão de células cd117+ |
-
2017
- 2017-12-19 CA CA3045592A patent/CA3045592A1/en active Pending
- 2017-12-19 WO PCT/IB2017/058159 patent/WO2018116178A1/en not_active Ceased
- 2017-12-19 CN CN202311642832.9A patent/CN117653740A/zh active Pending
- 2017-12-19 KR KR1020247016376A patent/KR20240093751A/ko not_active Ceased
- 2017-12-19 JP JP2019533594A patent/JP7181203B2/ja active Active
- 2017-12-19 CU CU2019000061A patent/CU24644B1/es unknown
- 2017-12-19 MX MX2019007582A patent/MX2019007582A/es unknown
- 2017-12-19 TW TW111133640A patent/TWI852077B/zh active
- 2017-12-19 US US16/470,897 patent/US11357864B2/en active Active
- 2017-12-19 CR CR20190296A patent/CR20190296A/es unknown
- 2017-12-19 TW TW106144615A patent/TWI778994B/zh active
- 2017-12-19 BR BR112019012483A patent/BR112019012483A2/pt unknown
- 2017-12-19 JO JOJO/P/2019/0155A patent/JOP20190155B1/ar active
- 2017-12-19 PE PE2019001291A patent/PE20191539A1/es unknown
- 2017-12-19 AU AU2017383458A patent/AU2017383458C1/en active Active
- 2017-12-19 KR KR1020197020530A patent/KR20190099238A/ko not_active Ceased
- 2017-12-19 CN CN201780079504.9A patent/CN110099697B/zh active Active
- 2017-12-19 EP EP17829033.4A patent/EP3558389A1/en active Pending
- 2017-12-19 EA EA201991526A patent/EA201991526A1/ru unknown
- 2017-12-19 MA MA047231A patent/MA47231A/fr unknown
- 2017-12-19 IL IL300567A patent/IL300567A/en unknown
- 2017-12-19 MY MYPI2019003457A patent/MY193985A/en unknown
-
2019
- 2019-06-13 PH PH12019501330A patent/PH12019501330A1/en unknown
- 2019-06-18 IL IL267478A patent/IL267478B2/en unknown
- 2019-06-19 CO CONC2019/0006455A patent/CO2019006455A2/es unknown
- 2019-06-20 CL CL2019001745A patent/CL2019001745A1/es unknown
- 2019-06-20 SA SA519402188A patent/SA519402188B1/ar unknown
- 2019-06-21 EC ECSENADI201944625A patent/ECSP19044625A/es unknown
-
2022
- 2022-06-06 US US17/833,077 patent/US12171839B2/en active Active
- 2022-10-19 JP JP2022167563A patent/JP7622017B2/ja active Active
-
2024
- 2024-11-05 US US18/937,914 patent/US20250064964A1/en active Pending
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