JP7181203B2 - 造血幹細胞を除去するための抗体薬物結合体 - Google Patents

造血幹細胞を除去するための抗体薬物結合体 Download PDF

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JP7181203B2
JP7181203B2 JP2019533594A JP2019533594A JP7181203B2 JP 7181203 B2 JP7181203 B2 JP 7181203B2 JP 2019533594 A JP2019533594 A JP 2019533594A JP 2019533594 A JP2019533594 A JP 2019533594A JP 7181203 B2 JP7181203 B2 JP 7181203B2
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seq
fab
antibody
heavy chain
light chain
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JP2020504112A5 (https=
JP2020504112A (ja
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ウェン，ベン
イー． ボイタノ，アンソニー
バーガー，マシュー
イー． セリッティ，スーザン
ピー． クーク，マイケル
フィナー，カトリン
ヒュバート ガイアースタンガー，バーナード
ジン，ユノ
トゥエン リー－ホフリッヒ，シ
シ ファム，ホンゴク
ホ シュライヤー，シゥ
ティソット，カスリン
哲郎 宇野
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ノバルティス アーゲー
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2019533594A 2016-12-21 2017-12-19 造血幹細胞を除去するための抗体薬物結合体 Active JP7181203B2 (ja)

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US201662437622P 2016-12-21 2016-12-21
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US201762520854P 2017-06-16 2017-06-16
US62/520,854 2017-06-16
PCT/IB2017/058159 WO2018116178A1 (en) 2016-12-21 2017-12-19 Antibody drug conjugates for ablating hematopoietic stem cells

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KR102447350B1 (ko) * 2013-02-08 2022-09-23 노파르티스 아게 면역접합체의 제조를 위한 항체의 변형에 사용되는 특정 부위
US10464969B2 (en) * 2016-05-05 2019-11-05 Novartis Ag Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
BR112018076306A2 (pt) * 2016-06-17 2019-03-26 Magenta Therapeutics, Inc. composições e métodos para a supressão de células cd117+
WO2019234694A2 (en) * 2018-06-07 2019-12-12 Magenta Therapeutics, Inc. Therapeutic methods using antibody drug conjugates (adcs)
TW202014209A (zh) * 2018-06-20 2020-04-16 瑞士商諾華公司 用於消融造血幹細胞之抗體藥物軛合物
AU2019312200B2 (en) * 2018-07-23 2024-11-14 Heidelberg Pharma Research Gmbh Use of anti-CD137 antibody drug conjugate (ADC) in allogeneic cell therapy
CA3107383A1 (en) * 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy
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