JP7181203B2 - 造血幹細胞を除去するための抗体薬物結合体 - Google Patents

造血幹細胞を除去するための抗体薬物結合体 Download PDF

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JP7181203B2
JP7181203B2 JP2019533594A JP2019533594A JP7181203B2 JP 7181203 B2 JP7181203 B2 JP 7181203B2 JP 2019533594 A JP2019533594 A JP 2019533594A JP 2019533594 A JP2019533594 A JP 2019533594A JP 7181203 B2 JP7181203 B2 JP 7181203B2
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fab
antibody
heavy chain
light chain
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JP2020504112A (ja
JP2020504112A5 (https=
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ウェン，ベン
イー． ボイタノ，アンソニー
バーガー，マシュー
イー． セリッティ，スーザン
ピー． クーク，マイケル
フィナー，カトリン
ヒュバート ガイアースタンガー，バーナード
ジン，ユノ
トゥエン リー－ホフリッヒ，シ
シ ファム，ホンゴク
ホ シュライヤー，シゥ
ティソット，カスリン
哲郎 宇野
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ノバルティス アーゲー
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2019533594A 2016-12-21 2017-12-19 造血幹細胞を除去するための抗体薬物結合体 Active JP7181203B2 (ja)

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PCT/IB2017/058159 WO2018116178A1 (en) 2016-12-21 2017-12-19 Antibody drug conjugates for ablating hematopoietic stem cells

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EP2953976B1 (en) * 2013-02-08 2021-03-24 Novartis Ag Specific sites for modifying antibodies to make immunoconjugates
WO2017191579A1 (en) 2016-05-05 2017-11-09 Novartis Ag Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase
IL263744B2 (en) * 2016-06-17 2023-11-01 Magenta Therapeutics Inc Compositions and methods for the depletion of cd117 plus cells
JP2021526525A (ja) * 2018-06-07 2021-10-07 マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 抗体薬物コンジュゲート（ａｄｃｓ）を用いた治療方法
UY38265A (es) * 2018-06-20 2020-01-31 Novartis Ag Conjugados anticuerpo droga para ablación de células madre hematopoyéticas
CN112739339B (zh) * 2018-07-23 2024-12-27 海德堡医药研究有限责任公司 抗cd137抗体药物缀合物(adc)在同种异体细胞疗法中的用途
CA3107383A1 (en) * 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy
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