|
US5861A
(en)
|
|
1848-10-17 |
|
Locking umbrella and parasol |
|
US5863A
(en)
|
|
1848-10-17 |
|
Matthias p |
|
US510A
(en)
|
|
1837-12-07 |
|
soeel |
|
US949A
(en)
|
|
1838-09-27 |
|
Improvement in roller cotton-gins for ginning long-staple and other kinds of cotton |
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
DE4239169A1
(de)
|
1992-11-21 |
1994-05-26 |
Merck Patent Gmbh |
Cyclobutan - Benzol - Derivate
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
PT821671E
(pt)
|
1995-04-20 |
2001-04-30 |
Pfizer |
Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf
|
|
ATE225343T1
(de)
|
1995-12-20 |
2002-10-15 |
Hoffmann La Roche |
Matrix-metalloprotease inhibitoren
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
US5782605A
(en)
|
1996-07-19 |
1998-07-21 |
Andritz Sprout-Bauer, Inc. |
Impeller for separating a conveyed stream of material
|
|
IL128189A0
(en)
|
1996-08-23 |
1999-11-30 |
Pfizer |
Arylsulfonylamino hydroxamic acid derivatives
|
|
US5914251A
(en)
|
1996-10-22 |
1999-06-22 |
Amgen Inc. |
Nucleic acid molecules encoding placental-derived growth factors
|
|
US5866562A
(en)
|
1996-10-25 |
1999-02-02 |
Bayer Aktiengesellschaft |
Ring-bridged bis-quinolines
|
|
EP0950059B1
(en)
|
1997-01-06 |
2004-08-04 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
ATE248812T1
(de)
|
1997-02-03 |
2003-09-15 |
Pfizer Prod Inc |
Arylsulfonylhydroxamsäurederivate
|
|
CA2279863A1
(en)
|
1997-02-07 |
1998-08-13 |
Pfizer Inc. |
N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
|
|
TR199901926T2
(xx)
|
1997-02-11 |
1999-12-21 |
Pfizer Inc. |
Arils�lfonil hidroksamik asit t�revleri
|
|
JPH10330377A
(ja)
|
1997-06-02 |
1998-12-15 |
Kyowa Hakko Kogyo Co Ltd |
ピペリジン誘導体
|
|
PT1003720E
(pt)
|
1997-08-08 |
2004-07-30 |
Pfizer Prod Inc |
Derivados de acido ariloxiarilsulfonilamino hidroxamico
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
JP3890193B2
(ja)
|
1997-12-22 |
2007-03-07 |
株式会社ルネサステクノロジ |
電力増幅システムおよび移動体通信端末装置
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
US6479487B1
(en)
|
1998-02-26 |
2002-11-12 |
Aventis Pharmaceuticals Inc. |
6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
|
|
JP4462654B2
(ja)
|
1998-03-26 |
2010-05-12 |
ソニー株式会社 |
映像素材選択装置及び映像素材選択方法
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8474101A1
(es)
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
|
PT1004578E
(pt)
|
1998-11-05 |
2004-06-30 |
Pfizer Prod Inc |
Derivados hidroxamida do acido 5-oxo-pirrolidino-2-carboxilico
|
|
US6511993B1
(en)
|
1999-06-03 |
2003-01-28 |
Kevin Neil Dack |
Metalloprotease inhibitors
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
EP1081137A1
(en)
|
1999-08-12 |
2001-03-07 |
Pfizer Products Inc. |
Selective inhibitors of aggrecanase in osteoarthritis treatment
|
|
US20070208087A1
(en)
|
2001-11-02 |
2007-09-06 |
Sanders Virginia J |
Compounds, compositions and methods for the treatment of inflammatory diseases
|
|
ATE402164T1
(de)
|
2001-04-26 |
2008-08-15 |
Eisai R&D Man Co Ltd |
Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon
|
|
EP1401840A4
(en)
|
2001-04-30 |
2007-05-16 |
Bayer Corp |
NEW 4-AMINO-5,6-SUBSTITUTED THIOPHENO 2,3 D | PYRIMIDINE
|
|
WO2003022214A2
(en)
|
2001-09-06 |
2003-03-20 |
Millennium Pharmaceuticals, Inc. |
Piperazine and homopiperazine compounds
|
|
AU2003255482A1
(en)
|
2002-10-02 |
2004-04-23 |
Merck Patent Gmbh |
Use of 4 amino-quinazolines as anti cancer agents
|
|
WO2004030671A2
(en)
|
2002-10-02 |
2004-04-15 |
Merck Patent Gmbh |
Use of 4-amino-quinazolines as anti cancer agents
|
|
WO2004089312A2
(en)
|
2003-03-31 |
2004-10-21 |
Predix Pharmaceuticals Holdings, Inc. |
New piperidinylamino-thieno[2,3-d] pyrimidine compounds
|
|
US20050222175A1
(en)
|
2004-03-31 |
2005-10-06 |
Dhanoa Dale S |
New piperidinylamino-thieno[2,3-D] pyrimidine compounds
|
|
US7612078B2
(en)
|
2003-03-31 |
2009-11-03 |
Epix Delaware, Inc. |
Piperidinylamino-thieno[2,3-D] pyrimidine compounds
|
|
WO2005020897A2
(en)
|
2003-08-22 |
2005-03-10 |
Dendreon Corporation |
Compositions and methods for the treatment of disease associated with trp-p8 expression
|
|
US20050123906A1
(en)
|
2003-11-06 |
2005-06-09 |
Rana Tariq M. |
Protein modulation
|
|
CN101031551A
(zh)
|
2004-07-06 |
2007-09-05 |
安吉永生物制药公司 |
针对癌症治疗的肝细胞生长因子/c－met活性的喹唑啉调节剂
|
|
US7553964B2
(en)
|
2005-06-03 |
2009-06-30 |
Abbott Laboratories |
Cyclobutyl amine derivatives
|
|
US20060281771A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using aminoquinoline and aminoquinazoline kinase modulators
|
|
US20060281769A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators
|
|
KR20080040032A
(ko)
|
2005-09-02 |
2008-05-07 |
티보텍 파마슈티칼즈 리미티드 |
Ｈｃｖ 저해제로서의 벤조디아제핀
|
|
US7744968B2
(en)
|
2005-09-19 |
2010-06-29 |
Merck Patent Gmbh |
Cyclobutane and spiro[3.3]heptane compounds
|
|
FR2891829A1
(fr)
|
2005-10-12 |
2007-04-13 |
Sanofi Aventis Sa |
Derives de la 4-amino-quinazoline, leur preparation et leur application en therapeutique
|
|
ES2378473T3
(es)
|
2005-12-21 |
2012-04-12 |
Abbott Laboratories |
Compuestos antivirales
|
|
CA2651898A1
(en)
|
2006-04-07 |
2007-10-18 |
Develogen Aktiengesellschaft |
Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
|
|
EP1903044A1
(en)
|
2006-09-14 |
2008-03-26 |
Novartis AG |
Adenosine Derivatives as A2A Receptor Agonists
|
|
WO2008070303A2
(en)
|
2006-10-19 |
2008-06-12 |
The University Of Chicago |
Therapeutics to inhibit mll-menin interaction for treating leukemia
|
|
EP1947103A1
(en)
|
2007-01-22 |
2008-07-23 |
4Sc Ag |
Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments
|
|
WO2008099019A1
(en)
|
2007-02-16 |
2008-08-21 |
Tibotec Pharmaceuticals Ltd. |
6-hydroxy-dibenzodiazepinones useful as hepatitis c virus inhibitors
|
|
FR2913017A1
(fr)
|
2007-02-23 |
2008-08-29 |
Cerep Sa |
Derives de piperidine et piperazine comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire
|
|
EP2150527B1
(en)
|
2007-03-19 |
2011-01-19 |
Council of Scientific & Industrial Research |
Anthranilic acid derivative as anticancer agent and a process for the preparation thereof
|
|
WO2008135232A1
(en)
|
2007-05-02 |
2008-11-13 |
Riccardo Cortese |
Use and compositions of purine derivatives for the treatment of proliferative disorders
|
|
JP2010530736A
(ja)
|
2007-05-25 |
2010-09-16 |
バーンハム インスティトゥート フォー メディカル リサーチ |
タプシガルジンにより誘導される細胞死の阻害剤
|
|
WO2009017838A2
(en)
|
2007-08-01 |
2009-02-05 |
Exelixis, Inc. |
Combinations of jak-2 inhibitors and other agents
|
|
WO2009064388A2
(en)
|
2007-11-09 |
2009-05-22 |
Liu Jun O |
Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders
|
|
AU2008345225A1
(en)
|
2007-12-21 |
2009-07-09 |
University Of Rochester |
Method for altering the lifespan of eukaryotic organisms
|
|
CA2725066A1
(en)
|
2008-05-22 |
2009-11-26 |
Allergan, Inc. |
Bicyclic compounds having activity at the cxcr4 receptor
|
|
DE102008027574A1
(de)
|
2008-06-10 |
2009-12-17 |
Merck Patent Gmbh |
Neue Pyrrolidinderivate als MetAP-2 Inhibitoren
|
|
JP5555236B2
(ja)
|
2008-08-25 |
2014-07-23 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
ヘッジホッグ経路モジュレーター
|
|
TW201024307A
(en)
|
2008-09-10 |
2010-07-01 |
Kalypsys Inc |
Aminopyrimidine inhibitors of histamine receptors for the treatment of disease
|
|
EP2451813B1
(en)
|
2009-07-08 |
2014-10-01 |
Leo Pharma A/S |
Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors
|
|
WO2011014128A1
(en)
|
2009-07-30 |
2011-02-03 |
National University Of Singapore |
Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
|
|
WO2011029054A1
(en)
|
2009-09-04 |
2011-03-10 |
The Regents Of The University Of Michigan |
Compositions and methods for treatment of leukemia
|
|
SG183233A1
(en)
|
2010-02-22 |
2012-09-27 |
Merck Patent Gmbh |
Hetarylaminonaphthyridines
|
|
KR101541086B1
(ko)
|
2010-08-20 |
2015-08-03 |
허치슨 메디파르마 리미티드 |
피롤로피리미딘 화합물 및 그 용도
|
|
US9029343B2
(en)
|
2010-12-03 |
2015-05-12 |
Epizyme, Inc. |
Modulators of histone methyltransferase, and methods of use thereof
|
|
CA2819734A1
(en)
|
2010-12-03 |
2012-06-07 |
Epizyme, Inc. |
Carbocycle-substituted purine and 7-deazapurine compounds
|
|
US9145438B2
(en)
|
2010-12-03 |
2015-09-29 |
Epizyme, Inc. |
7-deazapurine modulators of histone methyltransferase, and methods of use thereof
|
|
BR112013013659B8
(pt)
|
2010-12-03 |
2024-02-27 |
Epizyme Inc |
Compostos moduladores de enzimas epigenéticas, composição farmacêutica compreendendo ditos compostos e usos da dita composição farmacêutica para tratar câncer, câncer hematológico ou leucemia
|
|
US9090624B2
(en)
|
2011-08-04 |
2015-07-28 |
Allergan, Inc. |
Aromatic bycyclic derivatives as CXCR4 receptor modulators
|
|
GB201114212D0
(en)
|
2011-08-18 |
2011-10-05 |
Ucb Pharma Sa |
Therapeutic agents
|
|
AR090037A1
(es)
|
2011-11-15 |
2014-10-15 |
Xention Ltd |
Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
|
|
CN103833759A
(zh)
|
2012-11-23 |
2014-06-04 |
华东理工大学 |
作为blk、flt3抑制剂的蝶啶酮衍生物及其应用
|
|
US20150284422A1
(en)
|
2012-08-10 |
2015-10-08 |
Epizyme, Inc. |
Inhibitors of protein methyltransferase dot1l and methods of use thereof
|
|
US20140100184A1
(en)
|
2012-08-31 |
2014-04-10 |
Baylor College Of Medicine |
Selective inhibitors of histone methyltransferase dot1l
|
|
WO2014039839A1
(en)
|
2012-09-06 |
2014-03-13 |
Epizyme, Inc. |
Method of treating leukemia
|
|
GB201217704D0
(en)
|
2012-10-03 |
2012-11-14 |
Ucb Pharma Sa |
Therapeutic agents
|
|
CA2894220A1
(en)
|
2012-12-21 |
2014-06-26 |
Epizyme, Inc. |
Dot1l inhibitors for use in the treatment of leukemia
|
|
EP2968342B1
(en)
|
2013-03-13 |
2018-10-03 |
The Regents of the University of Michigan |
Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
|
|
US20140371238A1
(en)
|
2013-03-13 |
2014-12-18 |
Flatley Discovery Lab |
Compounds and methods for the treatment of cystic fibrosis
|
|
US9212180B2
(en)
|
2013-06-12 |
2015-12-15 |
The Regents Of The University Of Michigan |
Menin-MLL inhibitors and methods of use thereof
|
|
WO2015017863A1
(en)
|
2013-08-02 |
2015-02-05 |
Memorial Sloan-Kettering Cancer Center |
Methods for the detection and treatment of leukemias that are responsive to dot1l inhibition
|
|
CA2944669A1
(en)
|
2014-04-04 |
2015-10-08 |
Syros Pharmaceuticals, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
EP3140423A1
(en)
|
2014-05-07 |
2017-03-15 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
New biomarker for aml
|
|
US20170119769A1
(en)
|
2014-06-10 |
2017-05-04 |
The Trustees Of The University Of Pennsylvania |
Scaffolds for inhibitors of menin-mll interactions
|
|
AU2015301746A1
(en)
*
|
2014-08-13 |
2017-02-16 |
Celgene Corporation |
Combination therapy for treating cancer
|
|
WO2016025649A1
(en)
|
2014-08-13 |
2016-02-18 |
Celgene Avilomics Research, Inc. |
Combinations of an erk inhibitor and a dot1l inhibitor and related methods
|
|
WO2016040330A1
(en)
*
|
2014-09-09 |
2016-03-17 |
The Regents Of The University Of Michigan |
Thienopyrimidine and thienopyridine compounds and methods of use thereof
|
|
US10526341B2
(en)
|
2014-11-19 |
2020-01-07 |
Memorial Sloan-Kettering Cancer Center |
Thienopyrimidines and uses thereof
|
|
US10588907B2
(en)
|
2015-06-04 |
2020-03-17 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with MLL proteins
|
|
AR104020A1
(es)
|
2015-06-04 |
2017-06-21 |
Kura Oncology Inc |
Métodos y composiciones para inhibir la interacción de menina con proteínas mill
|
|
AU2016324920B2
(en)
|
2015-09-14 |
2022-03-03 |
Brunangelo Falini |
Dactinomycin compositions and methods for the treatment of acute myeloid leukemia
|
|
RU2018126774A
(ru)
|
2015-12-22 |
2020-01-23 |
Витэ Фармасьютикалз, Инк. |
Ингибиторы менин-mll взаимодействия
|
|
ES3044036T3
(en)
|
2016-01-26 |
2025-11-26 |
Memorial Sloan Kettering Cancer Center |
Targeting chromatin regulators for inhibiting leukemogenic gene expression in npm1
|
|
BR112018068703B1
(pt)
*
|
2016-03-16 |
2024-02-06 |
Kura Oncology, Inc. |
Inibidores substituídos de menin-mll e métodos de uso
|
|
KR102419524B1
(ko)
|
2016-03-16 |
2022-07-08 |
쿠라 온콜로지, 인크. |
메닌-mll의 가교된 이환식 억제제 및 사용 방법
|
|
MX384087B
(es)
|
2016-05-02 |
2025-03-14 |
Univ Michigan Regents |
Piperidinas como inhibidores de menina.
|
|
WO2017207387A1
(en)
|
2016-05-31 |
2017-12-07 |
Bayer Pharma Aktiengesellschaft |
Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction
|
|
PT3468966T
(pt)
|
2016-06-10 |
2020-11-10 |
Vitae Pharmaceuticals Llc |
Inibidores da interação menina-mll
|
|
TW201805000A
(zh)
|
2016-06-20 |
2018-02-16 |
庫拉腫瘤技術股份有限公司 |
利用erk抑制劑之鱗狀細胞癌之治療
|
|
CA2937896A1
(en)
|
2016-08-02 |
2018-02-02 |
Universite De Montreal |
Use of mubritinib for the treatment of poor prognosis acute myeloid leukemia
|
|
WO2018024602A1
(en)
|
2016-08-04 |
2018-02-08 |
Bayer Aktiengesellschaft |
2,7-diazaspiro[4.4]nonanes
|
|
TWI738864B
(zh)
|
2016-09-14 |
2021-09-11 |
比利時商健生藥品公司 |
Ｍｅｎｉｎ-ｍｌｌ相互作用之螺二環抑制劑
|
|
TWI753016B
(zh)
|
2016-09-14 |
2022-01-21 |
比利時商健生藥品公司 |
Menin-mll相互作用之稠合二環抑制劑
|
|
AR109658A1
(es)
|
2016-09-16 |
2019-01-09 |
Vitae Pharmaceuticals Inc |
Inhibidores de la interacción de menina-mll
|
|
CN108778276A
(zh)
|
2016-11-02 |
2018-11-09 |
安罗格制药有限责任公司 |
用于治疗flt3突变型增殖性疾患相关突变的克莱拉尼
|
|
WO2018106820A1
(en)
|
2016-12-07 |
2018-06-14 |
Kura Oncology, Inc. |
Methods of promoting beta cell proliferation
|
|
WO2018106818A1
(en)
|
2016-12-07 |
2018-06-14 |
Kura Oncology, Inc. |
Methods of promoting beta cell proliferation
|
|
JP7193460B2
(ja)
|
2016-12-23 |
2022-12-20 |
プレキシコン インコーポレーテッド |
Ｃｄｋ８調節およびその適応症のための化合物および方法
|
|
CN117298275A
(zh)
|
2017-03-24 |
2023-12-29 |
库拉肿瘤学公司 |
治疗血液系统恶性肿瘤和尤因肉瘤的方法
|
|
WO2018226976A1
(en)
|
2017-06-08 |
2018-12-13 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
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