JP2022522694A5 - - Google Patents
Info
- Publication number
- JP2022522694A5 JP2022522694A5 JP2021549973A JP2021549973A JP2022522694A5 JP 2022522694 A5 JP2022522694 A5 JP 2022522694A5 JP 2021549973 A JP2021549973 A JP 2021549973A JP 2021549973 A JP2021549973 A JP 2021549973A JP 2022522694 A5 JP2022522694 A5 JP 2022522694A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- cycloalkyl
- heteroaryl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2019/019854 | 2019-02-27 | ||
| PCT/US2019/019854 WO2019168999A1 (en) | 2018-02-28 | 2019-02-27 | Compounds with ferroptosis inducing activity and methods of their use |
| US16/287,805 | 2019-02-27 | ||
| US16/287,805 US11098040B2 (en) | 2018-02-28 | 2019-02-27 | Compounds and methods of use |
| US201962893092P | 2019-08-28 | 2019-08-28 | |
| US62/893,092 | 2019-08-28 | ||
| PCT/US2020/020150 WO2020176757A1 (en) | 2019-02-27 | 2020-02-27 | Compounds with ferroptosis inducing activity and methods of their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022522694A JP2022522694A (ja) | 2022-04-20 |
| JP2022522694A5 true JP2022522694A5 (enExample) | 2023-03-03 |
| JP7704680B2 JP7704680B2 (ja) | 2025-07-08 |
Family
ID=72238937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021549973A Active JP7704680B2 (ja) | 2019-02-27 | 2020-02-27 | フェロトーシス誘導活性を有する化合物およびそれらの使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP3931183B1 (enExample) |
| JP (1) | JP7704680B2 (enExample) |
| KR (1) | KR20220012221A (enExample) |
| CN (1) | CN114008024A (enExample) |
| AU (1) | AU2020228056A1 (enExample) |
| BR (1) | BR112021016833A2 (enExample) |
| CA (1) | CA3131385A1 (enExample) |
| EA (1) | EA202192122A1 (enExample) |
| ES (1) | ES3013815T3 (enExample) |
| IL (1) | IL285730A (enExample) |
| MX (1) | MX2021010173A (enExample) |
| SG (1) | SG11202109035QA (enExample) |
| TW (1) | TW202045480A (enExample) |
| WO (1) | WO2020176757A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| US11098040B2 (en) | 2018-02-28 | 2021-08-24 | Ferro Therapeutics, Inc. | Compounds and methods of use |
| US11040964B2 (en) | 2019-02-27 | 2021-06-22 | Ferro Therapeutics, Inc. | Compounds and methods of use |
| WO2022042657A1 (en) * | 2020-08-26 | 2022-03-03 | Ferro Therapeutics, Inc. | Compounds and methods of use |
| KR102759930B1 (ko) * | 2022-01-17 | 2025-01-23 | 포항공과대학교 산학협력단 | Marh6(marchf6) 조절제를 포함하는, 페로토시스 조절용 조성물 및 방법 |
| JP2025522339A (ja) * | 2022-06-01 | 2025-07-15 | クダ セラピューティクス インコーポレイテッド | イミダゾピリジン及びオキサゾロピリジン誘導体及びその類似体、その調製方法、ＨＩＦ－１／２ａ経路阻害の方法、並びに、フェロトーシスの誘導 |
| WO2024015637A1 (en) * | 2022-07-15 | 2024-01-18 | Ferro Therapeutics, Inc. | Glutathione peroxidase 4 (gpx4) inhibitors for the treatment of cancer |
| CN114984019B (zh) * | 2022-07-15 | 2023-08-22 | 山东中医药大学 | 一种铁死亡抑制剂化合物及在肝损伤修复领域的应用 |
| CN117209521A (zh) * | 2022-11-04 | 2023-12-12 | 台州道致科技股份有限公司 | 丙炔酰氯制备方法 |
| CN116983310B (zh) * | 2023-08-29 | 2024-04-30 | 南方医科大学南方医院 | 一种治疗肝癌的药物组合物及其应用 |
| CN118047698B (zh) * | 2024-01-30 | 2026-05-12 | 山东科巢生物制药有限公司 | 一种n-[(1r)-2-[1,1'-联苯]-4-基-1-(羟基甲基)乙基]氨基甲酸叔丁酯的制备方法 |
| CN118994147B (zh) * | 2024-07-18 | 2026-01-02 | 中国海洋大学 | 一种基于疏水标签的gpx4蛋白降解剂及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2427608C (en) * | 2000-11-08 | 2010-05-04 | Lilly Icos Llc | Condensed pyradizindione derivatives as pde inhibitors |
| EP3076962A4 (en) * | 2013-12-02 | 2017-10-18 | The Trustees of Columbia University in the City of New York | Modulating ferroptosis and treating excitotoxic disorders |
| WO2017035354A1 (en) * | 2015-08-26 | 2017-03-02 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| US20190008961A1 (en) * | 2016-01-07 | 2019-01-10 | The Broad Institute, Inc. | Compounds and methods for increasing tumor infiltration by immune cells |
| WO2018118711A1 (en) * | 2016-12-19 | 2018-06-28 | The Trustees Of Columbia University In The City Of New York | Small molecule ferroptosis inducers |
| US11098040B2 (en) * | 2018-02-28 | 2021-08-24 | Ferro Therapeutics, Inc. | Compounds and methods of use |
| JP2023509359A (ja) * | 2019-12-17 | 2023-03-08 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | 鉄依存性細胞分解の誘導物質との併用抗癌療法 |
| CN113336748B (zh) * | 2021-04-12 | 2022-03-25 | 北京大学 | 一种gpx4蛋白降解剂及其制备方法和应用、一种抗肿瘤细胞药物 |
-
2020
- 2020-02-27 ES ES20712811T patent/ES3013815T3/es active Active
- 2020-02-27 SG SG11202109035QA patent/SG11202109035QA/en unknown
- 2020-02-27 WO PCT/US2020/020150 patent/WO2020176757A1/en not_active Ceased
- 2020-02-27 TW TW109106570A patent/TW202045480A/zh unknown
- 2020-02-27 KR KR1020217030619A patent/KR20220012221A/ko not_active Withdrawn
- 2020-02-27 EP EP20712811.7A patent/EP3931183B1/en active Active
- 2020-02-27 CA CA3131385A patent/CA3131385A1/en active Pending
- 2020-02-27 EA EA202192122A patent/EA202192122A1/ru unknown
- 2020-02-27 BR BR112021016833A patent/BR112021016833A2/pt not_active Application Discontinuation
- 2020-02-27 JP JP2021549973A patent/JP7704680B2/ja active Active
- 2020-02-27 CN CN202080028989.0A patent/CN114008024A/zh active Pending
- 2020-02-27 AU AU2020228056A patent/AU2020228056A1/en not_active Abandoned
- 2020-02-27 MX MX2021010173A patent/MX2021010173A/es unknown
-
2021
- 2021-08-19 IL IL285730A patent/IL285730A/en unknown
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