|
US4452773A
(en)
|
1982-04-05 |
1984-06-05 |
Canadian Patents And Development Limited |
Magnetic iron-dextran microspheres
|
|
US4690915A
(en)
|
1985-08-08 |
1987-09-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adoptive immunotherapy as a treatment modality in humans
|
|
US4795698A
(en)
|
1985-10-04 |
1989-01-03 |
Immunicon Corporation |
Magnetic-polymer particles
|
|
US5219740A
(en)
|
1987-02-13 |
1993-06-15 |
Fred Hutchinson Cancer Research Center |
Retroviral gene transfer into diploid fibroblasts for gene therapy
|
|
AU4746590A
(en)
|
1988-12-28 |
1990-08-01 |
Stefan Miltenyi |
Methods and materials for high gradient magnetic separation of biological materials
|
|
US5200084A
(en)
|
1990-09-26 |
1993-04-06 |
Immunicon Corporation |
Apparatus and methods for magnetic separation
|
|
IE913929A1
(en)
|
1990-11-13 |
1992-05-20 |
Immunex Corp |
Bifunctional selectable fusion genes
|
|
AU6953394A
(en)
|
1993-05-21 |
1994-12-20 |
Targeted Genetics Corporation |
Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene
|
|
US5827642A
(en)
|
1994-08-31 |
1998-10-27 |
Fred Hutchinson Cancer Research Center |
Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
|
|
WO1996013593A2
(en)
|
1994-10-26 |
1996-05-09 |
Procept, Inc. |
Soluble single chain t cell receptors
|
|
WO1996018105A1
(en)
|
1994-12-06 |
1996-06-13 |
The President And Fellows Of Harvard College |
Single chain t-cell receptor
|
|
DE19608753C1
(de)
|
1996-03-06 |
1997-06-26 |
Medigene Gmbh |
Transduktionssystem und seine Verwendung
|
|
WO1997034634A1
(en)
|
1996-03-20 |
1997-09-25 |
Sloan-Kettering Institute For Cancer Research |
Single chain fv constructs of anti-ganglioside gd2 antibodies
|
|
ATE533784T1
(de)
|
1997-10-02 |
2011-12-15 |
Altor Bioscience Corp |
Lösliche, einzelkettige proteine des t- zellrezeptors
|
|
WO1999060120A2
(en)
|
1998-05-19 |
1999-11-25 |
Avidex Limited |
Soluble t cell receptor
|
|
EP1109921A4
(en)
|
1998-09-04 |
2002-08-28 |
Sloan Kettering Inst Cancer |
FUSION RECEPTORS SPECIFIC TO MEMBRANE SPECIFIC PROSTATIC ANTIGEN AND USES THEREOF
|
|
US6410319B1
(en)
|
1998-10-20 |
2002-06-25 |
City Of Hope |
CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
|
|
US20020131960A1
(en)
|
2000-06-02 |
2002-09-19 |
Michel Sadelain |
Artificial antigen presenting cells and methods of use thereof
|
|
ATE338124T1
(de)
|
2000-11-07 |
2006-09-15 |
Hope City |
Cd19-spezifische umgezielte immunzellen
|
|
US7070995B2
(en)
|
2001-04-11 |
2006-07-04 |
City Of Hope |
CE7-specific redirected immune cells
|
|
US20090257994A1
(en)
|
2001-04-30 |
2009-10-15 |
City Of Hope |
Chimeric immunoreceptor useful in treating human cancers
|
|
IL160359A0
(en)
|
2001-08-31 |
2004-07-25 |
Avidex Ltd |
Soluble t cell receptor
|
|
US20030170238A1
(en)
|
2002-03-07 |
2003-09-11 |
Gruenberg Micheal L. |
Re-activated T-cells for adoptive immunotherapy
|
|
US7446190B2
(en)
|
2002-05-28 |
2008-11-04 |
Sloan-Kettering Institute For Cancer Research |
Nucleic acids encoding chimeric T cell receptors
|
|
CA2501870C
(en)
|
2002-10-09 |
2013-07-02 |
Avidex Limited |
Single chain recombinant t cell receptors
|
|
US20050129671A1
(en)
|
2003-03-11 |
2005-06-16 |
City Of Hope |
Mammalian antigen-presenting T cells and bi-specific T cells
|
|
UA83509C2
(en)
|
2003-10-15 |
2008-07-25 |
Оси Фармасьютикалз, Инк. |
Imidazopyrazines as tyrosine kinase inhibitors
|
|
ATE475669T1
(de)
|
2004-06-29 |
2010-08-15 |
Immunocore Ltd |
Einen modifizierten t-zellen-rezeptor exprimierende zellen
|
|
TW200613306A
(en)
|
2004-07-20 |
2006-05-01 |
Osi Pharm Inc |
Imidazotriazines as protein kinase inhibitors
|
|
US8101770B2
(en)
|
2004-12-16 |
2012-01-24 |
Vertex Pharmaceuticals Incorporated |
Pyridones useful as inhibitors of kinases
|
|
DK2526933T3
(en)
|
2006-09-22 |
2015-05-18 |
Pharmacyclics Inc |
Inhibitors of Bruton's tyrosine kinase
|
|
GB0624689D0
(en)
|
2006-12-11 |
2007-01-17 |
Glaxo Group Ltd |
Novel fluorescent kinase ligands and methods employing the same
|
|
SG10202107066WA
(en)
|
2007-03-28 |
2021-07-29 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
SI2856876T1
(en)
|
2007-03-30 |
2018-04-30 |
Memorial Sloan-Kettering Cancer Center |
Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
|
|
TWI552752B
(zh)
|
2007-10-19 |
2016-10-11 |
賽基艾維洛米斯研究股份有限公司 |
雜芳基化合物及其用途
|
|
ES2660180T3
(es)
|
2007-12-07 |
2018-03-21 |
Miltenyi Biotec Gmbh |
Sistemas y métodos para procesamiento de células
|
|
US8479118B2
(en)
|
2007-12-10 |
2013-07-02 |
Microsoft Corporation |
Switching search providers within a browser search box
|
|
WO2009124119A2
(en)
|
2008-04-01 |
2009-10-08 |
The Trustes of Columbia University in the City of New York |
Phosphodiesterase inhibitors and uses thereof
|
|
US20120164718A1
(en)
|
2008-05-06 |
2012-06-28 |
Innovative Micro Technology |
Removable/disposable apparatus for MEMS particle sorting device
|
|
JP5173594B2
(ja)
|
2008-05-27 |
2013-04-03 |
キヤノン株式会社 |
管理装置、画像形成装置及びそれらの処理方法
|
|
NZ603525A
(en)
|
2008-06-27 |
2015-02-27 |
Celgene Avilomics Res Inc |
Pyrimidine based compound and uses thereof
|
|
CA2730930C
(en)
|
2008-07-16 |
2015-01-13 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
|
|
EP2331566B1
(en)
|
2008-08-26 |
2015-10-07 |
City of Hope |
Method and compositions for enhanced anti-tumor effector functioning of t cells
|
|
PL2918604T3
(pl)
|
2008-11-07 |
2018-05-30 |
Amgen Research (Munich) Gmbh |
Leczenie pediatrycznej ostrej białaczki limfoblastycznej
|
|
US8299077B2
(en)
|
2009-03-02 |
2012-10-30 |
Roche Palo Alto Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
NZ598985A
(en)
|
2009-09-04 |
2013-07-26 |
Biogen Idec Inc |
Bruton's tyrosine kinase inhibitors
|
|
EP2486049A1
(en)
|
2009-10-06 |
2012-08-15 |
The Board Of Trustees Of The UniversityOf Illinois |
Human single-chain t cell receptors
|
|
US7718662B1
(en)
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
|
TR201904484T4
(tr)
|
2009-11-03 |
2019-05-21 |
Hope City |
Transdüse T hücre seçimine yönelik kesik epiderimal büyüme faktörü reseptörü (EGFRt).
|
|
TWI500617B
(zh)
|
2010-05-31 |
2015-09-21 |
Ono Pharmaceutical Co |
Purine ketone derivatives
|
|
CA3007787C
(en)
|
2010-06-03 |
2020-03-10 |
Pharmacyclics Llc |
The use of inhibitors of bruton's tyrosine kinase (btk)
|
|
MX342164B
(es)
|
2010-06-23 |
2016-09-19 |
Hanmi Science Co Ltd |
Derivados de pirimidina fusionados novedosos para la inhibicion de la actividad de tirosina cinasa.
|
|
MX336875B
(es)
|
2010-08-10 |
2016-02-04 |
Celgene Avilomics Res Inc |
Sal de besilato de un inhibidor de tirosina cinasa de bruton (btk).
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
US9987308B2
(en)
|
2011-03-23 |
2018-06-05 |
Fred Hutchinson Cancer Research Center |
Method and compositions for cellular immunotherapy
|
|
US8398282B2
(en)
|
2011-05-12 |
2013-03-19 |
Delphi Technologies, Inc. |
Vehicle front lighting assembly and systems having a variable tint electrowetting element
|
|
WO2013026837A1
(en)
|
2011-08-23 |
2013-02-28 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
|
CN103073508B
(zh)
|
2011-10-25 |
2016-06-01 |
北京大学深圳研究生院 |
激酶抑制剂及治疗相关疾病的方法
|
|
UA111756C2
(uk)
|
2011-11-03 |
2016-06-10 |
Ф. Хоффманн-Ля Рош Аг |
Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
|
|
EP2773639B1
(en)
|
2011-11-03 |
2017-04-26 |
F. Hoffmann-La Roche AG |
Alkylated piperazine compounds as inhibitors of btk activity
|
|
CN104080797A
(zh)
|
2011-11-11 |
2014-10-01 |
弗雷德哈钦森癌症研究中心 |
针对癌症的靶向细胞周期蛋白a1的t细胞免疫疗法
|
|
US9199997B2
(en)
|
2011-11-29 |
2015-12-01 |
Ono Pharmaceutical Co., Ltd. |
Purinone derivative hydrochloride
|
|
KR20130076046A
(ko)
|
2011-12-28 |
2013-07-08 |
한미약품 주식회사 |
타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체
|
|
CN104080789B
(zh)
|
2012-01-31 |
2016-05-11 |
南京奥昭生物科技有限公司 |
作为布鲁顿酪氨酸激酶抑制剂的环状分子
|
|
CA2861491C
(en)
|
2012-02-13 |
2020-08-25 |
Seattle Children's Hospital D/B/A Seattle Children's Research Institute |
Bispecific chimeric antigen receptors and therapeutic uses thereof
|
|
WO2013126726A1
(en)
|
2012-02-22 |
2013-08-29 |
The Trustees Of The University Of Pennsylvania |
Double transgenic t cells comprising a car and a tcr and their methods of use
|
|
EP2844743B1
(en)
|
2012-05-03 |
2021-01-13 |
Fred Hutchinson Cancer Research Center |
Enhanced affinity t cell receptors and methods for making the same
|
|
US9662343B2
(en)
*
|
2012-05-14 |
2017-05-30 |
Antecip Bioventures Ii Llc |
Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
|
|
HRP20230297T1
(hr)
|
2012-07-13 |
2023-05-12 |
The Trustees Of The University Of Pennsylvania |
UPRAVLJANJE TOKSIČNOŠĆU ZA ANTI-TUMORSKO DJELOVANJE CAR-a
|
|
BR122020002986A8
(pt)
|
2012-08-20 |
2023-04-18 |
Seattle Childrens Hospital Dba Seattle Childrens Res Inst |
Método e composições para imunoterapia celular
|
|
MX370148B
(es)
|
2012-10-02 |
2019-12-03 |
Memorial Sloan Kettering Cancer Center |
Composiciones y su uso para inmunoterapia.
|
|
RU2658485C2
(ru)
|
2012-10-24 |
2018-06-21 |
Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез |
Химерные антигенные рецепторы м971
|
|
KR101668574B1
(ko)
|
2012-11-02 |
2016-10-24 |
화이자 인코포레이티드 |
브루톤 티로신 키나제 억제제
|
|
TW201427664A
(zh)
|
2012-11-02 |
2014-07-16 |
Pharmacyclics Inc |
Tec家族激酶抑制劑佐劑療法
|
|
EA201590855A1
(ru)
|
2012-11-15 |
2015-11-30 |
Фармасайкликс, Инк. |
Соединения пирролопиримидина как ингибиторы киназ
|
|
CN104781789B
(zh)
|
2012-12-20 |
2018-06-05 |
三菱电机株式会社 |
车载装置
|
|
DK2940014T3
(en)
|
2012-12-28 |
2018-12-10 |
Crystalgenomics Inc |
2,3-DIHYDRO-ISOINDOL-1-ON DERIVATIVE AS BTK KINase INHIBITORS AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME
|
|
EP2970985A1
(en)
|
2013-03-14 |
2016-01-20 |
Fred Hutchinson Cancer Research Center |
Compositions and methods to modify cells for therapeutic objectives
|
|
UY35468A
(es)
|
2013-03-16 |
2014-10-31 |
Novartis Ag |
Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
|
|
CN104177338B
(zh)
|
2013-05-22 |
2018-04-03 |
南京勇山生物科技有限公司 |
一类布鲁顿激酶抑制剂
|
|
TWI648272B
(zh)
|
2013-06-25 |
2019-01-21 |
美商必治妥美雅史谷比公司 |
經取代之四氫咔唑及咔唑甲醯胺化合物
|
|
US9108442B2
(en)
|
2013-08-20 |
2015-08-18 |
Ricoh Company, Ltd. |
Image forming apparatus
|
|
BR112016006978A2
(pt)
|
2013-09-30 |
2017-08-01 |
Pharmacyclics Llc |
inibidores de tirosina quinase de bruton
|
|
WO2015057992A1
(en)
|
2013-10-16 |
2015-04-23 |
Izumi Raquel |
Btk inhibitors for hematopoietic mobilization
|
|
WO2015084892A1
(en)
|
2013-12-02 |
2015-06-11 |
Cornell University |
Methods for treating b cell proliferative disorders
|
|
US9931347B2
(en)
|
2013-12-03 |
2018-04-03 |
Iomet Pharma Ltd. |
Pharmaceutical compound
|
|
CN105979948A
(zh)
|
2013-12-05 |
2016-09-28 |
安塞塔制药公司 |
Pi3k抑制剂和btk抑制剂的治疗组合
|
|
CN112353806A
(zh)
|
2014-02-21 |
2021-02-12 |
普林斯匹亚生物制药公司 |
Btk抑制剂的盐和固体形式
|
|
US20170335281A1
(en)
*
|
2014-03-15 |
2017-11-23 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor
|
|
WO2015146159A1
(en)
|
2014-03-25 |
2015-10-01 |
Ono Pharmaceutical Co., Ltd. |
Prophylactic agent and/or therapeutic agent for diffuse large b-cell lymphoma
|
|
AU2015244039B2
(en)
|
2014-04-07 |
2021-10-21 |
Novartis Ag |
Treatment of cancer using anti-CD19 chimeric antigen receptor
|
|
US10611837B2
(en)
|
2014-04-10 |
2020-04-07 |
Seattle Children's Hospital |
Transgene genetic tags and methods of use
|
|
CN105017256A
(zh)
|
2014-04-29 |
2015-11-04 |
浙江导明医药科技有限公司 |
多氟化合物作为布鲁顿酪氨酸激酶抑制剂
|
|
CN105085474B
(zh)
|
2014-05-07 |
2018-05-18 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
|
CN104829610B
(zh)
|
2014-06-20 |
2017-03-15 |
中国科学院合肥物质科学研究院 |
一种新型布鲁顿酪氨酸激酶抑制剂
|
|
JP2017528433A
(ja)
|
2014-07-21 |
2017-09-28 |
ノバルティス アーゲー |
低い免疫増強用量のmTOR阻害剤とCARの組み合わせ
|
|
TW201618783A
(zh)
*
|
2014-08-07 |
2016-06-01 |
艾森塔製藥公司 |
以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法
|
|
PL3179991T3
(pl)
|
2014-08-11 |
2022-02-14 |
Acerta Pharma B.V. |
Kombinacje terapeutyczne inhibitora btk i inhibitora bcl-2
|
|
CN105884747B
(zh)
|
2014-08-28 |
2021-01-05 |
首药控股(北京)有限公司 |
一种制备布鲁顿酪氨酸激酶(btk)激酶抑制剂的制备方法
|
|
CN105399756B
(zh)
|
2014-09-05 |
2019-06-25 |
广东东阳光药业有限公司 |
Btk抑制剂及其用途
|
|
CN105153154A
(zh)
|
2014-09-26 |
2015-12-16 |
广东东阳光药业有限公司 |
Btk抑制剂及其用途
|
|
CN105837576B
(zh)
|
2015-01-14 |
2019-03-26 |
湖北生物医药产业技术研究院有限公司 |
Btk抑制剂
|
|
US9278919B1
(en)
|
2015-03-13 |
2016-03-08 |
Yong Xu |
Synthesis of N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide
|
|
ES2876974T3
(es)
|
2015-04-07 |
2021-11-15 |
Novartis Ag |
Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina
|
|
JP6961490B2
(ja)
|
2015-04-08 |
2021-11-05 |
ノバルティス アーゲー |
Cd20療法、cd22療法、およびcd19キメラ抗原受容体(car)発現細胞との併用療法
|
|
CN104844573A
(zh)
|
2015-04-17 |
2015-08-19 |
中国药科大学 |
嘧啶类btk抑制剂、其制备方法及医药用途
|
|
GB201513540D0
(en)
|
2015-07-31 |
2015-09-16 |
King S College London |
Therapeutic agents
|
|
EP3747472B1
(en)
|
2015-09-15 |
2024-04-03 |
Acerta Pharma B.V. |
Therapeutic combinations of a cd19 inhibitor and a btk inhibitor
|
|
TWI755547B
(zh)
|
2016-01-21 |
2022-02-21 |
美商輝瑞股份有限公司 |
靶向表皮生長因子受體變異體iii之嵌合型抗原受體
|
|
CN105732638B
(zh)
|
2016-01-22 |
2018-01-30 |
成都倍特药业有限公司 |
一种具有螺环或桥环结构的布鲁顿酪氨酸激酶抑制剂及其制备方法
|
|
WO2017210617A2
(en)
|
2016-06-02 |
2017-12-07 |
Porter, David, L. |
Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
|
|
CA3024725A1
(en)
|
2016-06-06 |
2017-12-14 |
Juno Therapeutics, Inc. |
Methods for the treatment of b cell malignancies using adoptive cell therapy
|
|
DK3523326T3
(da)
|
2016-10-04 |
2020-08-03 |
Prec Biosciences Inc |
Samstimulerende domæner til anvendelse i genetisk modificerede celler
|
|
JP2019532997A
(ja)
|
2016-11-03 |
2019-11-14 |
ジュノー セラピューティクス インコーポレイテッド |
T細胞療法とbtk阻害剤との併用療法
|
|
BR112019017767A2
(pt)
|
2017-02-27 |
2020-04-07 |
Juno Therapeutics Inc |
composições, artigos de fabricação e métodos relacionados à dosagem em terapia celular
|
|
US11629340B2
(en)
|
2017-03-03 |
2023-04-18 |
Obsidian Therapeutics, Inc. |
DHFR tunable protein regulation
|
|
EP3621988A1
(en)
|
2017-05-09 |
2020-03-18 |
Bellicum Pharmaceuticals, Inc. |
Methods to augment or alter signal transduction
|
|
IL315340A
(en)
|
2017-09-01 |
2024-10-01 |
Lonza Walkersville Inc |
End-to-end cell therapy automation
|
|
PT3703750T
(pt)
|
2017-11-01 |
2025-01-17 |
Memorial Sloan Kettering Cancer Center |
Recetores de antigénio quimérico específicos para o antigénio de maturação das células b e polinucleótidos codificantes
|
|
MA51210A
(fr)
|
2017-12-01 |
2020-10-07 |
Juno Therapeutics Inc |
Procédés de dosage et de modulation de cellules génétiquement modifiées
|
|
KR20210044736A
(ko)
|
2018-05-03 |
2021-04-23 |
주노 쎄러퓨티크스 인코퍼레이티드 |
키메라 항원 수용체(car) t세포 요법과 키나제 억제제의 조합요법
|
|
EP3801769A1
(en)
|
2018-05-25 |
2021-04-14 |
Novartis AG |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
US20210223248A1
(en)
|
2018-06-01 |
2021-07-22 |
Fred Hutchinson Cancer Research Center |
Biomarkers, uses thereof for selecting immunotherapy intervention, and immunotherapy methods
|
|
CN113692285A
(zh)
|
2018-11-30 |
2021-11-23 |
朱诺治疗学股份有限公司 |
在过继细胞疗法中给药和治疗b细胞恶性肿瘤的方法
|
|
IL292665B2
(en)
|
2019-11-06 |
2026-02-01 |
Kite Pharma Inc |
Chimeric antigen receptor T cell therapy
|