JP2020506903A - Ｍａｇｌ阻害薬としての複素環式スピロ化合物 - Google Patents
Ｍａｇｌ阻害薬としての複素環式スピロ化合物 Download PDFInfo
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- JBCJANCIBZULAS-UHFFFAOYSA-N tert-butyl 2-[6-(difluoromethyl)pyridin-3-yl]oxy-7-azaspiro[3.5]nonane-7-carboxylate Chemical compound FC(C1=CC=C(C=N1)OC1CC2(C1)CCN(CC2)C(=O)OC(C)(C)C)F JBCJANCIBZULAS-UHFFFAOYSA-N 0.000 description 1
- NZWYWJIGXXVBKK-UHFFFAOYSA-N tert-butyl 2-benzoyl-2,8-diazaspiro[4.5]decane-8-carboxylate Chemical compound C(C1=CC=CC=C1)(=O)N1CC2(CC1)CCN(CC2)C(=O)OC(C)(C)C NZWYWJIGXXVBKK-UHFFFAOYSA-N 0.000 description 1
- QTKGBUXGQNHIIM-UHFFFAOYSA-N tert-butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC11CC(O)C1 QTKGBUXGQNHIIM-UHFFFAOYSA-N 0.000 description 1
- RPDKPGRNPFRUDO-UHFFFAOYSA-N tert-butyl 3-(4-cyanophenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical compound C(#N)C1=CC=C(C=C1)C1COC2(C1)CCN(CC2)C(=O)OC(C)(C)C RPDKPGRNPFRUDO-UHFFFAOYSA-N 0.000 description 1
- ZVOMLUSTFVABSP-UHFFFAOYSA-N tert-butyl 3-(4-methylphenyl)sulfonyloxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical compound Cc1ccc(cc1)S(=O)(=O)OC1COC2(C1)CCN(CC2)C(=O)OC(C)(C)C ZVOMLUSTFVABSP-UHFFFAOYSA-N 0.000 description 1
- UISVBUXRNGCRPP-UHFFFAOYSA-N tert-butyl 3-(benzenesulfonamido)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical compound C1(=CC=CC=C1)S(=O)(=O)NC1COC2(C1)CCN(CC2)C(=O)OC(C)(C)C UISVBUXRNGCRPP-UHFFFAOYSA-N 0.000 description 1
- HJKDIHWOTMKPEY-UHFFFAOYSA-N tert-butyl 3-(prop-2-enoxycarbonylamino)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical compound C(C=C)OC(=O)NC1COC2(C1)CCN(CC2)C(=O)OC(C)(C)C HJKDIHWOTMKPEY-UHFFFAOYSA-N 0.000 description 1
- WIUSFIJOZKCBKX-UHFFFAOYSA-N tert-butyl 3-[methyl(prop-2-enoxycarbonyl)amino]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical compound CN(C1COC2(C1)CCN(CC2)C(=O)OC(C)(C)C)C(=O)OCC=C WIUSFIJOZKCBKX-UHFFFAOYSA-N 0.000 description 1
- HCDWHGFENXBNSC-UHFFFAOYSA-N tert-butyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC11OCC(O)C1 HCDWHGFENXBNSC-UHFFFAOYSA-N 0.000 description 1
- ZAMKJLXCEODXHR-UHFFFAOYSA-N tert-butyl 3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC21OCC(=O)NC2 ZAMKJLXCEODXHR-UHFFFAOYSA-N 0.000 description 1
- SMZXTTXMFQDIRD-UHFFFAOYSA-N tert-butyl 4-(2,3-dibromopropyl)-4-hydroxypiperidine-1-carboxylate Chemical compound BrC(CC1(CCN(CC1)C(=O)OC(C)(C)C)O)CBr SMZXTTXMFQDIRD-UHFFFAOYSA-N 0.000 description 1
- TVGYHQMRPPNVGU-UHFFFAOYSA-N tert-butyl 4-(4-fluorophenyl)sulfonyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate Chemical compound FC1=CC=C(C=C1)S(=O)(=O)N1CCOC2(C1)CCN(CC2)C(=O)OC(C)(C)C TVGYHQMRPPNVGU-UHFFFAOYSA-N 0.000 description 1
- XYWCDAFPRBDRER-UHFFFAOYSA-N tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(O)(CN)CC1 XYWCDAFPRBDRER-UHFFFAOYSA-N 0.000 description 1
- CDZNZUISZACDLH-UHFFFAOYSA-N tert-butyl 4-(benzenesulfonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate Chemical compound C1(=CC=CC=C1)S(=O)(=O)N1CCOC2(C1)CCN(CC2)C(=O)OC(C)(C)C CDZNZUISZACDLH-UHFFFAOYSA-N 0.000 description 1
- YNYCNEGADQYBGS-UHFFFAOYSA-N tert-butyl 4-[[(2-chloroacetyl)amino]methyl]-4-hydroxypiperidine-1-carboxylate Chemical compound ClCC(=O)NCC1(CCN(CC1)C(=O)OC(C)(C)C)O YNYCNEGADQYBGS-UHFFFAOYSA-N 0.000 description 1
- HXZCJBKFNPEFAF-UHFFFAOYSA-N tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC21OCCN(CC=1C=CC=CC=1)C2 HXZCJBKFNPEFAF-UHFFFAOYSA-N 0.000 description 1
- BWHACQPKDGMQIK-UHFFFAOYSA-N tert-butyl 4-hydroxy-4-prop-2-enylpiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(O)(CC=C)CC1 BWHACQPKDGMQIK-UHFFFAOYSA-N 0.000 description 1
- 229960005333 tetrabenazine Drugs 0.000 description 1
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- VXUYXOFXAQZZMF-UHFFFAOYSA-N titanium(IV) isopropoxide Chemical compound CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C VXUYXOFXAQZZMF-UHFFFAOYSA-N 0.000 description 1
- 229940041597 tofranil Drugs 0.000 description 1
- 229960004603 tolcapone Drugs 0.000 description 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
- 229960004045 tolterodine Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005891 transamination reaction Methods 0.000 description 1
- 229940035321 transderm scop Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229960003741 tranylcypromine Drugs 0.000 description 1
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 1
- 229960003991 trazodone Drugs 0.000 description 1
- 229940111528 trexall Drugs 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 229960001032 trihexyphenidyl Drugs 0.000 description 1
- QDWJJTJNXAKQKD-UHFFFAOYSA-N trihexyphenidyl hydrochloride Chemical compound Cl.C1CCCCC1C(C=1C=CC=CC=1)(O)CCN1CCCCC1 QDWJJTJNXAKQKD-UHFFFAOYSA-N 0.000 description 1
- YDGHCKHAXOUQOS-BTJKTKAUSA-N trimipramine maleate Chemical compound [O-]C(=O)\C=C/C([O-])=O.C1CC2=CC=CC=C2[NH+](CC(C[NH+](C)C)C)C2=CC=CC=C21 YDGHCKHAXOUQOS-BTJKTKAUSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229940045137 urecholine Drugs 0.000 description 1
- 238000009489 vacuum treatment Methods 0.000 description 1
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
- 108010084171 vanutide cridificar Proteins 0.000 description 1
- JQSHBVHOMNKWFT-DTORHVGOSA-N varenicline Chemical compound C12=CC3=NC=CN=C3C=C2[C@H]2C[C@@H]1CNC2 JQSHBVHOMNKWFT-DTORHVGOSA-N 0.000 description 1
- 229960004751 varenicline Drugs 0.000 description 1
- 229960004688 venlafaxine Drugs 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- 229940094720 viagra Drugs 0.000 description 1
- 229960001255 viloxazine Drugs 0.000 description 1
- 229960000744 vinpocetine Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 229940025158 xenazine Drugs 0.000 description 1
- BPKIMPVREBSLAJ-QTBYCLKRSA-N ziconotide Chemical compound C([C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]2C(=O)N[C@@H]3C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@H](C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC2)C(N)=O)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(N1)=O)CCSC)[C@@H](C)O)C1=CC=C(O)C=C1 BPKIMPVREBSLAJ-QTBYCLKRSA-N 0.000 description 1
- 229960002811 ziconotide Drugs 0.000 description 1
- 229910052725 zinc Chemical class 0.000 description 1
- 239000011701 zinc Chemical class 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229940061740 zyvox Drugs 0.000 description 1
- XZVHHLNLLVICFA-SNVBAGLBSA-N α-difluoromethyl-dopa Chemical compound FC(F)[C@](C(O)=O)(N)CC1=CC=C(O)C(O)=C1 XZVHHLNLLVICFA-SNVBAGLBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449242P | 2017-01-23 | 2017-01-23 | |
| US62/449,242 | 2017-01-23 | ||
| PCT/IB2018/050128 WO2018134698A1 (en) | 2017-01-23 | 2018-01-09 | Heterocyclic spiro compounds as magl inhibitors |
Publications (2)
| Publication Number | Publication Date |
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| JP2020506903A true JP2020506903A (ja) | 2020-03-05 |
| JP2020506903A5 JP2020506903A5 (enExample) | 2021-02-12 |
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| Country | Link |
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| US (2) | US20180208608A1 (enExample) |
| EP (1) | EP3571202B1 (enExample) |
| JP (1) | JP2020506903A (enExample) |
| KR (1) | KR20190097242A (enExample) |
| CN (1) | CN110198944A (enExample) |
| AU (1) | AU2018208848A1 (enExample) |
| BR (1) | BR112019014099A2 (enExample) |
| CA (1) | CA3050853A1 (enExample) |
| IL (1) | IL267781A (enExample) |
| MX (1) | MX2019008690A (enExample) |
| RU (1) | RU2726631C1 (enExample) |
| SG (1) | SG11201906427QA (enExample) |
| TW (1) | TWI665199B (enExample) |
| WO (1) | WO2018134698A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023525860A (ja) * | 2020-05-12 | 2023-06-19 | ベイジン・グレートウェイ・ファーマシューティカル・テクノロジー・カンパニー・リミテッド | Ｎｍｄａ受容体の活性を調節する化合物、その医薬組成物及び使用 |
| JP2023542512A (ja) * | 2020-09-22 | 2023-10-10 | ヤンセン ファーマシューティカ エヌ．ベー． | シクロブチルアミドモノアシルグリセロールリパーゼ調節因子 |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1249101A1 (zh) | 2015-07-31 | 2018-10-26 | 辉瑞公司 | 作为magl抑制剂的1，1，1-三氟-3-羟基丙-2-基氨基甲酸酯衍生物及1，1，1-三氟-4-羟基丁-2-基氨基甲酸酯衍生物 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023525860A (ja) * | 2020-05-12 | 2023-06-19 | ベイジン・グレートウェイ・ファーマシューティカル・テクノロジー・カンパニー・リミテッド | Ｎｍｄａ受容体の活性を調節する化合物、その医薬組成物及び使用 |
| JP7654271B2 (ja) | 2020-05-12 | 2025-04-01 | ベイジン・グレートウェイ・ファーマシューティカル・テクノロジー・カンパニー・リミテッド | Ｎｍｄａ受容体の活性を調節する化合物、その医薬組成物及び使用 |
| JP2023542512A (ja) * | 2020-09-22 | 2023-10-10 | ヤンセン ファーマシューティカ エヌ．ベー． | シクロブチルアミドモノアシルグリセロールリパーゼ調節因子 |
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| SG11201906427QA (en) | 2019-08-27 |
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| CA3050853A1 (en) | 2018-07-26 |
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| EP3571202A1 (en) | 2019-11-27 |
| US20190292203A1 (en) | 2019-09-26 |
| RU2726631C1 (ru) | 2020-07-15 |
| US10858373B2 (en) | 2020-12-08 |
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