JP2020505920A5 - - Google Patents

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JP2020505920A5
JP2020505920A5 JP2019539795A JP2019539795A JP2020505920A5 JP 2020505920 A5 JP2020505920 A5 JP 2020505920A5 JP 2019539795 A JP2019539795 A JP 2019539795A JP 2019539795 A JP2019539795 A JP 2019539795A JP 2020505920 A5 JP2020505920 A5 JP 2020505920A5
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seq
nucleic acid
acid molecule
hsd17b13
human subject
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JP2019539795A
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JP2020505920A (ja
JP7458785B2 (ja
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Priority claimed from PCT/US2018/014357 external-priority patent/WO2018136702A1/en
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Priority to JP2023135380A priority Critical patent/JP7750907B2/ja
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Publication of JP7458785B2 publication Critical patent/JP7458785B2/ja
Priority to JP2025117051A priority patent/JP2025160237A/ja
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JP2019539795A 2017-01-23 2018-01-19 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用 Active JP7458785B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023135380A JP7750907B2 (ja) 2017-01-23 2023-08-23 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
JP2025117051A JP2025160237A (ja) 2017-01-23 2025-07-11 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762449335P 2017-01-23 2017-01-23
US62/449,335 2017-01-23
US201762472972P 2017-03-17 2017-03-17
US62/472,972 2017-03-17
US201762581918P 2017-11-06 2017-11-06
US62/581,918 2017-11-06
PCT/US2018/014357 WO2018136702A1 (en) 2017-01-23 2018-01-19 Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof

Related Child Applications (1)

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JP2023135380A Division JP7750907B2 (ja) 2017-01-23 2023-08-23 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用

Publications (3)

Publication Number Publication Date
JP2020505920A JP2020505920A (ja) 2020-02-27
JP2020505920A5 true JP2020505920A5 (enExample) 2021-03-04
JP7458785B2 JP7458785B2 (ja) 2024-04-01

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Family Applications (6)

Application Number Title Priority Date Filing Date
JP2019539270A Active JP7094963B2 (ja) 2017-01-23 2018-01-19 Hsd17b13バリアントおよびその使用
JP2019539795A Active JP7458785B2 (ja) 2017-01-23 2018-01-19 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
JP2022067544A Active JP7425106B2 (ja) 2017-01-23 2022-04-15 Hsd17b13バリアントおよびその使用
JP2023135380A Active JP7750907B2 (ja) 2017-01-23 2023-08-23 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
JP2023217935A Active JP7755636B2 (ja) 2017-01-23 2023-12-25 Hsd17b13バリアントおよびその使用
JP2025117051A Pending JP2025160237A (ja) 2017-01-23 2025-07-11 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用

Family Applications Before (1)

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JP2019539270A Active JP7094963B2 (ja) 2017-01-23 2018-01-19 Hsd17b13バリアントおよびその使用

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2022067544A Active JP7425106B2 (ja) 2017-01-23 2022-04-15 Hsd17b13バリアントおよびその使用
JP2023135380A Active JP7750907B2 (ja) 2017-01-23 2023-08-23 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
JP2023217935A Active JP7755636B2 (ja) 2017-01-23 2023-12-25 Hsd17b13バリアントおよびその使用
JP2025117051A Pending JP2025160237A (ja) 2017-01-23 2025-07-11 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用

Country Status (13)

Country Link
US (6) US10787647B2 (enExample)
EP (2) EP3571301A1 (enExample)
JP (6) JP7094963B2 (enExample)
KR (3) KR102712656B1 (enExample)
CN (3) CN118325899A (enExample)
AU (5) AU2018210364B2 (enExample)
BR (1) BR112019014841A2 (enExample)
CA (2) CA3047429A1 (enExample)
IL (6) IL268156B2 (enExample)
MX (5) MX2019008755A (enExample)
RU (3) RU2021133626A (enExample)
SG (2) SG11201905508VA (enExample)
WO (2) WO2018136702A1 (enExample)

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KR102712656B1 (ko) 2017-01-23 2024-10-04 리제너론 파마슈티칼스 인코포레이티드 Hsd17b13 변종 및 이것의 용도
US11479802B2 (en) 2017-04-11 2022-10-25 Regeneron Pharmaceuticals, Inc. Assays for screening activity of modulators of members of the hydroxy steroid (17-beta) dehydrogenase (HSD17B) family
AU2018348195B2 (en) 2017-10-11 2025-05-15 Regeneron Pharmaceuticals, Inc. Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation
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BR112020018758A2 (pt) * 2018-03-21 2021-01-26 Regeneron Pharmaceuticals, Inc. agente de ácido ribonucleico de fita dupla, célula, vetor, composição farmacêutica, e, métodos para inibição da expressão de 17¿-hidroxiesteroide desidrogenases tipo 13, para tratamento de um indivíduo, para prevenção de um sintoma em um indivíduo, para redução do risco de desenvolver doença hepática crônica, para inibição da progressão de esteatose, para inibição do acúmulo de gotículas de lipídios
CN112334577B (zh) 2018-04-19 2023-10-17 加利福尼亚大学董事会 用于基因编辑的组合物和方法
SG11202101698WA (en) * 2018-09-19 2021-04-29 Arrowhead Pharmaceuticals Inc Rnai agents for inhibiting expression of 17beta-hsd type 13- (hsd17b13), compositions thereof, and methods of use
UA128236C2 (uk) * 2018-12-21 2024-05-15 Айоніс Фармасутікалз, Інк. Модулятори експресії hsd17b13
US11957687B2 (en) 2019-07-02 2024-04-16 Regeneron Pharmaceuticals, Inc. Modulators of HSD17B13 and methods of use thereof
WO2021178556A1 (en) * 2020-03-04 2021-09-10 Regeneron Pharmaceuticals, Inc. Methods and compositions for sensitization of tumor cells to immune therapy
KR20240004092A (ko) * 2020-06-01 2024-01-11 암젠 인크 Hsd17b13 발현을 억제하기 위한 rnai 작제물 및 이의 사용 방법
EP4240866A4 (en) * 2020-11-06 2024-10-30 Inipharm, Inc. H17B13 SPECIFIC SUBSTRATES AND PRODUCTS AS LIVER DISEASE MARKERS AND BIOMARKERS FOR THE TREATMENT OF LIVER DISEASES
CN112626199A (zh) * 2021-01-04 2021-04-09 杭州艾迪康医学检验中心有限公司 检测慢性肝炎转化为肝硬化的风险预测位点的引物和方法
WO2022223015A1 (zh) * 2021-04-22 2022-10-27 上海拓界生物医药科技有限公司 靶向第13型17β-羟基类固醇脱氢酶的siRNA和siRNA缀合物
CN118103038A (zh) 2021-08-20 2024-05-28 英安塔制药有限公司 17β-羟基类固醇脱氢酶13型抑制剂及其使用方法
JP2024545602A (ja) * 2021-11-19 2024-12-10 ウェイブ ライフ サイエンシズ リミテッド Hsd17b13関連二本鎖オリゴヌクレオチド組成物及びそれに関連する方法
WO2024131916A1 (en) * 2022-12-22 2024-06-27 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of 17beta-hydroxysteroid dehydrogenase type 13 (hsd17b13)
WO2024173343A1 (en) 2023-02-14 2024-08-22 Regeneron Pharmaceuticals, Inc. Compounds targeting hydroxysteroid 17-beta dehydrogenase (hsd17b) and uses thereof
WO2025153088A1 (zh) * 2024-01-18 2025-07-24 北京安龙生物医药有限公司 靶向第13型17β-羟基类固醇脱氢酶的寡核苷酸及其用途
WO2025162435A1 (en) * 2024-02-02 2025-08-07 Accuredit Therapeutics (Suzhou) Co., Ltd. Compositions and methods for treatment of liver disease
CN120424925A (zh) * 2024-02-03 2025-08-05 北京福元医药股份有限公司 用于抑制HSD17B13表达的siRNA、其缀合物和药物组合物及其用途

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