JP2020505920A5 - - Google Patents

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JP2020505920A5
JP2020505920A5 JP2019539795A JP2019539795A JP2020505920A5 JP 2020505920 A5 JP2020505920 A5 JP 2020505920A5 JP 2019539795 A JP2019539795 A JP 2019539795A JP 2019539795 A JP2019539795 A JP 2019539795A JP 2020505920 A5 JP2020505920 A5 JP 2020505920A5
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seq
nucleic acid
acid molecule
hsd17b13
human subject
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JP2019539795A
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JP7458785B2 (ja
JP2020505920A (ja
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Priority claimed from PCT/US2018/014357 external-priority patent/WO2018136702A1/en
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Priority to JP2023135380A priority Critical patent/JP7750907B2/ja
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Publication of JP7458785B2 publication Critical patent/JP7458785B2/ja
Priority to JP2025117051A priority patent/JP2025160237A/ja
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JP2019539795A 2017-01-23 2018-01-19 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用 Active JP7458785B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023135380A JP7750907B2 (ja) 2017-01-23 2023-08-23 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
JP2025117051A JP2025160237A (ja) 2017-01-23 2025-07-11 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762449335P 2017-01-23 2017-01-23
US62/449,335 2017-01-23
US201762472972P 2017-03-17 2017-03-17
US62/472,972 2017-03-17
US201762581918P 2017-11-06 2017-11-06
US62/581,918 2017-11-06
PCT/US2018/014357 WO2018136702A1 (en) 2017-01-23 2018-01-19 Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof

Related Child Applications (1)

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JP2023135380A Division JP7750907B2 (ja) 2017-01-23 2023-08-23 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用

Publications (3)

Publication Number Publication Date
JP2020505920A JP2020505920A (ja) 2020-02-27
JP2020505920A5 true JP2020505920A5 (enExample) 2021-03-04
JP7458785B2 JP7458785B2 (ja) 2024-04-01

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ID=61768397

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2019539795A Active JP7458785B2 (ja) 2017-01-23 2018-01-19 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
JP2019539270A Active JP7094963B2 (ja) 2017-01-23 2018-01-19 Hsd17b13バリアントおよびその使用
JP2022067544A Active JP7425106B2 (ja) 2017-01-23 2022-04-15 Hsd17b13バリアントおよびその使用
JP2023135380A Active JP7750907B2 (ja) 2017-01-23 2023-08-23 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
JP2023217935A Active JP7755636B2 (ja) 2017-01-23 2023-12-25 Hsd17b13バリアントおよびその使用
JP2025117051A Pending JP2025160237A (ja) 2017-01-23 2025-07-11 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2019539270A Active JP7094963B2 (ja) 2017-01-23 2018-01-19 Hsd17b13バリアントおよびその使用
JP2022067544A Active JP7425106B2 (ja) 2017-01-23 2022-04-15 Hsd17b13バリアントおよびその使用
JP2023135380A Active JP7750907B2 (ja) 2017-01-23 2023-08-23 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
JP2023217935A Active JP7755636B2 (ja) 2017-01-23 2023-12-25 Hsd17b13バリアントおよびその使用
JP2025117051A Pending JP2025160237A (ja) 2017-01-23 2025-07-11 ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用

Country Status (13)

Country Link
US (6) US10787647B2 (enExample)
EP (2) EP3571301A1 (enExample)
JP (6) JP7458785B2 (enExample)
KR (5) KR102712656B1 (enExample)
CN (3) CN110199032A (enExample)
AU (5) AU2018209950B2 (enExample)
BR (1) BR112019014841A2 (enExample)
CA (2) CA3049980A1 (enExample)
IL (6) IL268156B2 (enExample)
MX (7) MX2019008675A (enExample)
RU (2) RU2760851C2 (enExample)
SG (2) SG11201905508VA (enExample)
WO (2) WO2018136702A1 (enExample)

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CA3059348A1 (en) 2017-04-11 2018-10-18 Regeneron Pharmaceuticals, Inc. Assays for screening activity of modulators of members of the hydroxysteroid (17-beta) dehydrogenase (hsd17b) family
AU2018348195B2 (en) 2017-10-11 2025-05-15 Regeneron Pharmaceuticals, Inc. Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation
MY207352A (en) * 2018-03-21 2025-02-21 Regeneron Pharma 17-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
US20210000906A1 (en) * 2018-03-21 2021-01-07 Ionis Pharmaceuticals, Inc. Modulation of hsd17b13 expression
AU2019255789B2 (en) 2018-04-19 2025-11-20 The Regents Of The University Of California Compositions and methods for gene editing
US12534728B2 (en) * 2018-09-19 2026-01-27 Arrowhead Pharmaceuticals, Inc. RNAi agents for inhibiting expression of 17beta-HSD type 13 (HSD17B13), compositions thereof, and methods of use
SG11202106378VA (en) * 2018-12-21 2021-07-29 Ionis Pharmaceuticals Inc Modulators of hsd17b13 expression
MA56457A (fr) 2019-07-02 2022-05-11 Regeneron Pharma Modulateurs de hsd17b13 et leurs procédés d'utilisation
JP7837276B2 (ja) * 2020-03-04 2026-03-30 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 免疫療法に対する腫瘍細胞の感作のための方法及び組成物
US20230279399A1 (en) * 2020-06-01 2023-09-07 Amgen Inc. Rnai constructs for inhibiting hsd17b13 expression and methods of use thereof
US20230416802A1 (en) * 2020-11-06 2023-12-28 Inipharm, Inc. Specific substrates and products of hsd17b13 as markers of liver disease and biomarkers for liver disease treatment
CN112626199A (zh) * 2021-01-04 2021-04-09 杭州艾迪康医学检验中心有限公司 检测慢性肝炎转化为肝硬化的风险预测位点的引物和方法
EP4328310A4 (en) * 2021-04-22 2025-10-15 Tuojie Biotech Shanghai Co Ltd SIRNA TARGETING 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE
CA3229569A1 (en) 2021-08-20 2023-02-23 Enanta Pharmaceuticals, Inc. 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors and methods of use thereof
JP2024545602A (ja) * 2021-11-19 2024-12-10 ウェイブ ライフ サイエンシズ リミテッド Hsd17b13関連二本鎖オリゴヌクレオチド組成物及びそれに関連する方法
CN120457205A (zh) * 2022-12-22 2025-08-08 上海舶望制药有限公司 抑制17β-羟基类固醇脱氢酶13型(HSD17B13)表达的组合物和方法
WO2024173343A1 (en) 2023-02-14 2024-08-22 Regeneron Pharmaceuticals, Inc. Compounds targeting hydroxysteroid 17-beta dehydrogenase (hsd17b) and uses thereof
CN122580428A (zh) * 2024-01-18 2026-08-14 北京安龙生物医药有限公司 靶向第13型17β-羟基类固醇脱氢酶的寡核苷酸及其用途
WO2025162435A1 (en) * 2024-02-02 2025-08-07 Accuredit Therapeutics (Suzhou) Co., Ltd. Compositions and methods for treatment of liver disease
TW202540424A (zh) * 2024-02-03 2025-10-16 大陸商北京福元醫藥股份有限公司 用於抑制HSD17B13表達的siRNA、其綴合物和藥物組合物及其用途

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