MX2022015080A - Variantes de hsd17b13 y usos de las mismas. - Google Patents

Variantes de hsd17b13 y usos de las mismas.

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Publication number
MX2022015080A
MX2022015080A MX2022015080A MX2022015080A MX2022015080A MX 2022015080 A MX2022015080 A MX 2022015080A MX 2022015080 A MX2022015080 A MX 2022015080A MX 2022015080 A MX2022015080 A MX 2022015080A MX 2022015080 A MX2022015080 A MX 2022015080A
Authority
MX
Mexico
Prior art keywords
hsd17b13
variants
methods
nucleic acids
proteins
Prior art date
Application number
MX2022015080A
Other languages
English (en)
Inventor
Noura S Abul-Husn
Alexander Li
Xiping Cheng
Yurong Xin
Frederick E Dewey
Alan Shuldiner
Evangelos Pefanis
Suzanne Hartford
Omri Gottesman
Jesper Gromada
Aris Baras
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2022015080A publication Critical patent/MX2022015080A/es

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Abstract

Se proporcionan composiciones relacionadas con las variantes de HSD17B13, con la inclusión de los ácidos nucleicos aislados y las proteínas relacionadas con las variantes de HSD17B13, y las células que comprenden esos ácidos nucleicos y proteínas. También se proporcionan métodos relacionados con las variantes de HSD17B13. Estos métodos incluyen los métodos para modificar una célula a través del uso de cualquier combinación de agentes de nucleasa, secuencias donadoras exógenas, activadores de la transcripción, represores de la transcripción, y vectores de expresión para la expresión de un gen HSD17B13 recombinante o de un ácido nucleico que codifica una proteína de HSD17B13. También se proporcionan los métodos terapéuticos y profilácticos para el tratamiento de un sujeto que tenga o que esté en riesgo de desarrollar una enfermedad crónica del hígado.
MX2022015080A 2017-01-23 2019-07-23 Variantes de hsd17b13 y usos de las mismas. MX2022015080A (es)

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