JP2020505395A - 縮合ｎ−複素環式化合物およびその使用方法 - Google Patents
縮合ｎ−複素環式化合物およびその使用方法 Download PDFInfo
- Publication number
- JP2020505395A JP2020505395A JP2019540035A JP2019540035A JP2020505395A JP 2020505395 A JP2020505395 A JP 2020505395A JP 2019540035 A JP2019540035 A JP 2019540035A JP 2019540035 A JP2019540035 A JP 2019540035A JP 2020505395 A JP2020505395 A JP 2020505395A
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- Prior art keywords
- alkyl
- cancer
- compound
- compound according
- kras
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *NCCc1cc(Br)ccc1 Chemical compound *NCCc1cc(Br)ccc1 0.000 description 15
- NMGQEJHGEUYMMA-UHFFFAOYSA-N C=CC(N(C1)C1O)=O Chemical compound C=CC(N(C1)C1O)=O NMGQEJHGEUYMMA-UHFFFAOYSA-N 0.000 description 1
- FEUUDXRNZRXDIH-UHFFFAOYSA-M CC(C)(C)OC(N(C1)CC1[Zn]I)=O Chemical compound CC(C)(C)OC(N(C1)CC1[Zn]I)=O FEUUDXRNZRXDIH-UHFFFAOYSA-M 0.000 description 1
- RIRARCHMRDHZAR-UHFFFAOYSA-N CC1C(C)CCC1 Chemical compound CC1C(C)CCC1 RIRARCHMRDHZAR-UHFFFAOYSA-N 0.000 description 1
- NAAGVHARTOSQGM-UHFFFAOYSA-N CCC(CCNc1cc(O)cc2ccccc12)=C Chemical compound CCC(CCNc1cc(O)cc2ccccc12)=C NAAGVHARTOSQGM-UHFFFAOYSA-N 0.000 description 1
- PXDLJPZNLILYOC-UHFFFAOYSA-N CCC(CCNc1cc(OC)cc2ccccc12)=C Chemical compound CCC(CCNc1cc(OC)cc2ccccc12)=C PXDLJPZNLILYOC-UHFFFAOYSA-N 0.000 description 1
- DJEQZVQFEPKLOY-UHFFFAOYSA-N CCCCN(C)C Chemical compound CCCCN(C)C DJEQZVQFEPKLOY-UHFFFAOYSA-N 0.000 description 1
- LPRBDPFWDVXEIC-UHFFFAOYSA-N CCCCNc1cc(OC)cc2ccccc12 Chemical compound CCCCNc1cc(OC)cc2ccccc12 LPRBDPFWDVXEIC-UHFFFAOYSA-N 0.000 description 1
- KKHHNJYOWVBEOK-PXNMLYILSA-N CCNC(C)(/C(/C1=O)=C\C=C)N1c1cc(O)cc2ccccc12 Chemical compound CCNC(C)(/C(/C1=O)=C\C=C)N1c1cc(O)cc2ccccc12 KKHHNJYOWVBEOK-PXNMLYILSA-N 0.000 description 1
- UXDKGEFDNRTWHK-UHFFFAOYSA-N CCOC(NCCc1cc(Br)ccc1)=O Chemical compound CCOC(NCCc1cc(Br)ccc1)=O UXDKGEFDNRTWHK-UHFFFAOYSA-N 0.000 description 1
- ANKFXLFSRINMLR-UHFFFAOYSA-N COc1cc2ccccc2c(N(CCc2c3ccc(Br)c2)C3=O)c1 Chemical compound COc1cc2ccccc2c(N(CCc2c3ccc(Br)c2)C3=O)c1 ANKFXLFSRINMLR-UHFFFAOYSA-N 0.000 description 1
- NMGNNHBGVMLQJR-UHFFFAOYSA-N COc1cnc(CCCC2)c2c1 Chemical compound COc1cnc(CCCC2)c2c1 NMGNNHBGVMLQJR-UHFFFAOYSA-N 0.000 description 1
- GXXCVOZSQBZCCF-UHFFFAOYSA-N Nc1cc(O)cc(I)c1N Chemical compound Nc1cc(O)cc(I)c1N GXXCVOZSQBZCCF-UHFFFAOYSA-N 0.000 description 1
- FQPKKECSRKYXIZ-UHFFFAOYSA-N O=C1NCCc2cc(Br)ccc12 Chemical compound O=C1NCCc2cc(Br)ccc12 FQPKKECSRKYXIZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023008128A JP2023041763A (ja) | 2017-01-26 | 2023-01-23 | 縮合ｎ－複素環式化合物およびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762450953P | 2017-01-26 | 2017-01-26 | |
| US62/450,953 | 2017-01-26 | ||
| PCT/US2018/015227 WO2018140598A1 (en) | 2017-01-26 | 2018-01-25 | Fused n-heterocyclic compounds and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023008128A Division JP2023041763A (ja) | 2017-01-26 | 2023-01-23 | 縮合ｎ－複素環式化合物およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020505395A true JP2020505395A (ja) | 2020-02-20 |
| JP2020505395A5 JP2020505395A5 (enExample) | 2021-03-04 |
Family
ID=61189554
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540035A Pending JP2020505395A (ja) | 2017-01-26 | 2018-01-25 | 縮合ｎ−複素環式化合物およびその使用方法 |
| JP2023008128A Pending JP2023041763A (ja) | 2017-01-26 | 2023-01-23 | 縮合ｎ－複素環式化合物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023008128A Pending JP2023041763A (ja) | 2017-01-26 | 2023-01-23 | 縮合ｎ－複素環式化合物およびその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20200385364A1 (enExample) |
| EP (1) | EP3573966A1 (enExample) |
| JP (2) | JP2020505395A (enExample) |
| CN (1) | CN110382483A (enExample) |
| WO (1) | WO2018140598A1 (enExample) |
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| EA038635B9 (ru) | 2015-11-16 | 2021-10-26 | Араксис Фарма Ллк | 2-замещенные соединения хиназолина, содержащие замещенную гетероциклическую группу, и способы их применения |
| US10822312B2 (en) | 2016-03-30 | 2020-11-03 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
| EP3458445B1 (en) | 2016-05-18 | 2021-02-17 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| MY196830A (en) | 2016-12-22 | 2023-05-03 | Amgen Inc | Kras g12c inhibitors and methods of using the same |
| US11279689B2 (en) | 2017-01-26 | 2022-03-22 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer |
| WO2018140514A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| WO2018140512A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| EP3573967A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused hetero-hetero bicyclic compounds and methods of use thereof |
| US11358959B2 (en) | 2017-01-26 | 2022-06-14 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
| CN110831933A (zh) | 2017-05-25 | 2020-02-21 | 亚瑞克西斯制药公司 | 喹唑啉衍生物作为突变kras、hras或nras的调节剂 |
| CA3063440A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Covalent inhibitors of kras |
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| EP3710439B1 (en) | 2017-11-15 | 2023-02-15 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| US10647715B2 (en) | 2017-11-15 | 2020-05-12 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
| AU2019262599B2 (en) | 2018-05-04 | 2023-10-12 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
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Citations (9)
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| US20110046370A1 (en) * | 2009-08-20 | 2011-02-24 | Korea Institute Of Science And Technology | 1,3,6-substituted indole derivatives having inhibitory activity for protein kinase |
| CN105348271A (zh) * | 2015-12-23 | 2016-02-24 | 常州润诺生物科技有限公司 | 喹唑啉类衍生物药用用途及其制备方法 |
| CN105399734A (zh) * | 2015-12-23 | 2016-03-16 | 吉林省长源药业有限公司 | 新型egfr抑制剂及其制备方法 |
| JP2016523911A (ja) * | 2013-06-26 | 2016-08-12 | アッヴィ・インコーポレイテッド | Ｂｔｋ阻害薬としての一級カルボキサミド類 |
| CN105924840A (zh) * | 2016-06-01 | 2016-09-07 | 扬州兰都塑料科技有限公司 | 一种阻燃电力电缆 |
| JP2016530274A (ja) * | 2013-08-23 | 2016-09-29 | ニューファーマ， インコーポレイテッド | ある特定の化学的実体、組成物および方法 |
| WO2016161361A1 (en) * | 2015-04-03 | 2016-10-06 | Nantbioscience, Inc. | Compositions and methods of targeting mutant k-ras |
| JP2016532656A (ja) * | 2013-10-10 | 2016-10-20 | アラクセス ファーマ エルエルシー | Ｋｒａｓｇ１２ｃの阻害剤 |
| CN106084164A (zh) * | 2016-06-12 | 2016-11-09 | 四川大学 | 一种结构抗菌型聚氨酯用扩链剂的制备方法 |
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| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
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| US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
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| FI973974A7 (fi) | 1995-04-20 | 1997-10-16 | Pfizer | Aryylisulfonyylihydroksaamihappojohdannaisia MMP- ja TNF-inhibiittorei na |
| DE69624081T2 (de) | 1995-12-20 | 2003-06-12 | Agouron Pharmaceuticals, Inc. | Matrix-metalloprotease Inhibitoren |
| HUP9903014A3 (en) | 1996-07-18 | 2000-08-28 | Pfizer | Phosphinate derivatives having matrix metalloprotease inhibitor effect and medicaments containing the same |
| IL128189A0 (en) | 1996-08-23 | 1999-11-30 | Pfizer | Arylsulfonylamino hydroxamic acid derivatives |
| ES2224277T3 (es) | 1997-01-06 | 2005-03-01 | Pfizer Inc. | Derivados de sulfonas ciclicas. |
| PT977733E (pt) | 1997-02-03 | 2003-12-31 | Pfizer Prod Inc | Derivados de acido arilsulfonilamino-hidroxamico |
| JP2000507975A (ja) | 1997-02-07 | 2000-06-27 | ファイザー・インク | Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用 |
| IL131123A0 (en) | 1997-02-11 | 2001-01-28 | Pfizer | Arylsulfonyl hydroxamic acid derivatives |
| GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
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| PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
| JP2004250329A (ja) * | 2002-12-26 | 2004-09-09 | Dainippon Pharmaceut Co Ltd | イサチン誘導体 |
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| TWI659021B (zh) * | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
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2018
- 2018-01-25 US US16/480,849 patent/US20200385364A1/en not_active Abandoned
- 2018-01-25 CN CN201880008592.8A patent/CN110382483A/zh active Pending
- 2018-01-25 JP JP2019540035A patent/JP2020505395A/ja active Pending
- 2018-01-25 EP EP18704371.6A patent/EP3573966A1/en not_active Withdrawn
- 2018-01-25 WO PCT/US2018/015227 patent/WO2018140598A1/en not_active Ceased
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2023
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|---|---|---|---|---|
| US20110046370A1 (en) * | 2009-08-20 | 2011-02-24 | Korea Institute Of Science And Technology | 1,3,6-substituted indole derivatives having inhibitory activity for protein kinase |
| JP2016523911A (ja) * | 2013-06-26 | 2016-08-12 | アッヴィ・インコーポレイテッド | Ｂｔｋ阻害薬としての一級カルボキサミド類 |
| JP2016530274A (ja) * | 2013-08-23 | 2016-09-29 | ニューファーマ， インコーポレイテッド | ある特定の化学的実体、組成物および方法 |
| JP2016532656A (ja) * | 2013-10-10 | 2016-10-20 | アラクセス ファーマ エルエルシー | Ｋｒａｓｇ１２ｃの阻害剤 |
| WO2016161361A1 (en) * | 2015-04-03 | 2016-10-06 | Nantbioscience, Inc. | Compositions and methods of targeting mutant k-ras |
| CN105348271A (zh) * | 2015-12-23 | 2016-02-24 | 常州润诺生物科技有限公司 | 喹唑啉类衍生物药用用途及其制备方法 |
| CN105399734A (zh) * | 2015-12-23 | 2016-03-16 | 吉林省长源药业有限公司 | 新型egfr抑制剂及其制备方法 |
| CN105924840A (zh) * | 2016-06-01 | 2016-09-07 | 扬州兰都塑料科技有限公司 | 一种阻燃电力电缆 |
| CN106084164A (zh) * | 2016-06-12 | 2016-11-09 | 四川大学 | 一种结构抗菌型聚氨酯用扩链剂的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110382483A (zh) | 2019-10-25 |
| US20230147053A1 (en) | 2023-05-11 |
| EP3573966A1 (en) | 2019-12-04 |
| US20200385364A1 (en) | 2020-12-10 |
| WO2018140598A1 (en) | 2018-08-02 |
| JP2023041763A (ja) | 2023-03-24 |
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