CN110382483A - 稠合的n-杂环化合物及其使用方法 - Google Patents
稠合的n-杂环化合物及其使用方法 Download PDFInfo
- Publication number
- CN110382483A CN110382483A CN201880008592.8A CN201880008592A CN110382483A CN 110382483 A CN110382483 A CN 110382483A CN 201880008592 A CN201880008592 A CN 201880008592A CN 110382483 A CN110382483 A CN 110382483A
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- Prior art keywords
- alkyl
- compound
- amido
- heterocycle
- amino
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762450953P | 2017-01-26 | 2017-01-26 | |
| US62/450,953 | 2017-01-26 | ||
| PCT/US2018/015227 WO2018140598A1 (en) | 2017-01-26 | 2018-01-25 | Fused n-heterocyclic compounds and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110382483A true CN110382483A (zh) | 2019-10-25 |
Family
ID=61189554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880008592.8A Pending CN110382483A (zh) | 2017-01-26 | 2018-01-25 | 稠合的n-杂环化合物及其使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20200385364A1 (enExample) |
| EP (1) | EP3573966A1 (enExample) |
| JP (2) | JP2020505395A (enExample) |
| CN (1) | CN110382483A (enExample) |
| WO (1) | WO2018140598A1 (enExample) |
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| EA038635B9 (ru) | 2015-11-16 | 2021-10-26 | Араксис Фарма Ллк | 2-замещенные соединения хиназолина, содержащие замещенную гетероциклическую группу, и способы их применения |
| US10822312B2 (en) | 2016-03-30 | 2020-11-03 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
| EP3458445B1 (en) | 2016-05-18 | 2021-02-17 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| MY196830A (en) | 2016-12-22 | 2023-05-03 | Amgen Inc | Kras g12c inhibitors and methods of using the same |
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| EP3710439B1 (en) | 2017-11-15 | 2023-02-15 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| US10647715B2 (en) | 2017-11-15 | 2020-05-12 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
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| CN105399734A (zh) * | 2015-12-23 | 2016-03-16 | 吉林省长源药业有限公司 | 新型egfr抑制剂及其制备方法 |
| CN105924840A (zh) * | 2016-06-01 | 2016-09-07 | 扬州兰都塑料科技有限公司 | 一种阻燃电力电缆 |
| CN106084164A (zh) * | 2016-06-12 | 2016-11-09 | 四川大学 | 一种结构抗菌型聚氨酯用扩链剂的制备方法 |
-
2018
- 2018-01-25 US US16/480,849 patent/US20200385364A1/en not_active Abandoned
- 2018-01-25 CN CN201880008592.8A patent/CN110382483A/zh active Pending
- 2018-01-25 JP JP2019540035A patent/JP2020505395A/ja active Pending
- 2018-01-25 EP EP18704371.6A patent/EP3573966A1/en not_active Withdrawn
- 2018-01-25 WO PCT/US2018/015227 patent/WO2018140598A1/en not_active Ceased
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2022
- 2022-06-13 US US17/839,232 patent/US20230147053A1/en active Pending
-
2023
- 2023-01-23 JP JP2023008128A patent/JP2023041763A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986001207A1 (fr) * | 1984-08-06 | 1986-02-27 | Mitsui Petrochemical Industries, Ltd. | Derives de pyridopyrimidine et leur procede de preparation |
| JP2004250329A (ja) * | 2002-12-26 | 2004-09-09 | Dainippon Pharmaceut Co Ltd | イサチン誘導体 |
| WO2005087746A1 (en) * | 2004-03-12 | 2005-09-22 | Glaxo Group Limited | Benzazepine derivatives for the treatment of neurological and psychiatric disorders |
| US20110046370A1 (en) * | 2009-08-20 | 2011-02-24 | Korea Institute Of Science And Technology | 1,3,6-substituted indole derivatives having inhibitory activity for protein kinase |
| WO2015054572A1 (en) * | 2013-10-10 | 2015-04-16 | Araxes Pharma Llc | Inhibitors of kras g12c |
Also Published As
| Publication number | Publication date |
|---|---|
| US20230147053A1 (en) | 2023-05-11 |
| EP3573966A1 (en) | 2019-12-04 |
| JP2020505395A (ja) | 2020-02-20 |
| US20200385364A1 (en) | 2020-12-10 |
| WO2018140598A1 (en) | 2018-08-02 |
| JP2023041763A (ja) | 2023-03-24 |
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