JP2020504733A5 - - Google Patents
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- JP2020504733A5 JP2020504733A5 JP2019533490A JP2019533490A JP2020504733A5 JP 2020504733 A5 JP2020504733 A5 JP 2020504733A5 JP 2019533490 A JP2019533490 A JP 2019533490A JP 2019533490 A JP2019533490 A JP 2019533490A JP 2020504733 A5 JP2020504733 A5 JP 2020504733A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- methyl
- oxy
- propan
- phosphoryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437753P | 2016-12-22 | 2016-12-22 | |
| US62/437,753 | 2016-12-22 | ||
| US201762574493P | 2017-10-19 | 2017-10-19 | |
| US62/574,493 | 2017-10-19 | ||
| PCT/US2017/067470 WO2018119013A1 (en) | 2016-12-22 | 2017-12-20 | Antiviral aliphatic ester prodrugs of tenofovir |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504733A JP2020504733A (ja) | 2020-02-13 |
| JP2020504733A5 true JP2020504733A5 (enExample) | 2021-01-28 |
| JP6938637B2 JP6938637B2 (ja) | 2021-09-22 |
Family
ID=60972454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533490A Expired - Fee Related JP6938637B2 (ja) | 2016-12-22 | 2017-12-20 | テノホビルの抗ウイルス性脂肪族エステルプロドラッグ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10519159B2 (enExample) |
| EP (1) | EP3559011B1 (enExample) |
| JP (1) | JP6938637B2 (enExample) |
| KR (1) | KR20190100250A (enExample) |
| CN (1) | CN110099912B (enExample) |
| AU (1) | AU2017379850B2 (enExample) |
| BR (1) | BR112019013017A2 (enExample) |
| CA (1) | CA3047573A1 (enExample) |
| MA (1) | MA47094A (enExample) |
| MX (1) | MX388757B (enExample) |
| RU (1) | RU2759902C2 (enExample) |
| TW (1) | TW201829412A (enExample) |
| WO (1) | WO2018119013A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017100108A1 (en) | 2015-12-10 | 2017-06-15 | Merck Sharp & Dohme Corp. | Antiviral phosphodiamide prodrugs of tenofovir |
| WO2017106069A1 (en) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Antiviral oxime phosphoramide compounds |
| WO2018039157A1 (en) * | 2016-08-25 | 2018-03-01 | Merck Sharp & Dohme Corp. | Antiviral prodrugs of tenofovir |
| FI3526323T3 (fi) | 2016-10-14 | 2023-06-06 | Prec Biosciences Inc | Hepatiitti B -viruksen genomissa oleville tunnistussekvensseille spesifisiä muokattuja meganukleaaseja |
| US10736908B2 (en) | 2016-10-26 | 2020-08-11 | Merck Sharp & Dohme Corp. | Antiviral aryl-amide phosphodiamide compounds |
| CN110035760A (zh) | 2016-12-22 | 2019-07-19 | 默沙东公司 | 抗病毒苯甲基胺磷酰二胺化合物 |
| KR102492115B1 (ko) | 2017-12-20 | 2023-01-27 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | Sting 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 2'3' 사이클릭 다이뉴클레오티드 |
| CA3084569A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| US11447512B2 (en) | 2017-12-21 | 2022-09-20 | Shenzhen Targetrx, Inc. | Antiviral nucleoside reverse transcriptase inhibitor |
| US10836769B2 (en) | 2018-02-26 | 2020-11-17 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
| US10870691B2 (en) | 2018-04-05 | 2020-12-22 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis B virus protein X |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| CN108586239B (zh) * | 2018-04-11 | 2020-12-29 | 深圳市前海博扬研究院有限公司 | 一种3-羟基丙酸甲酯的制备方法 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| TW202014193A (zh) | 2018-05-03 | 2020-04-16 | 捷克科學院有機化學與生物化學研究所 | 包含碳環核苷酸之2’3’－環二核苷酸 |
| EP3823629B1 (en) | 2018-07-19 | 2024-12-25 | Merck Sharp & Dohme LLC | Phosphinic amide prodrugs of tenofovir |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| HRP20240541T1 (hr) | 2018-10-31 | 2024-07-05 | Gilead Sciences, Inc. | Supstituirani spojevi 6-azabenzimidazola kao inhibitori hpk1 |
| MX2021008751A (es) | 2019-01-25 | 2021-11-12 | Univ Brown | Composiciones y metodos para tratar, prevenir o revertir la inflamacion y los trastornos asociados a la edad. |
| EP3935066A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| US12318403B2 (en) | 2019-03-07 | 2025-06-03 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′-cyclic dinucleotides and prodrugs thereof |
| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| KR102054104B1 (ko) * | 2019-04-30 | 2019-12-09 | 유니셀랩 주식회사 | 신규한 테노포비어 알라펜아미드 염 및 이의 제조방법 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| BR112021026376A2 (pt) | 2019-06-25 | 2022-05-10 | Gilead Sciences Inc | Proteínas de fusão flt3l-fc e métodos de uso |
| WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| JP7398556B2 (ja) | 2019-09-30 | 2023-12-14 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖワクチン及びｈｂｖを治療する方法 |
| WO2021113765A1 (en) | 2019-12-06 | 2021-06-10 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
| CN111018916B (zh) * | 2019-12-30 | 2022-04-29 | 天津天士力圣特制药有限公司 | 一种替诺福韦苯基烷基酯膦酰胺前体的合成方法 |
| WO2021188959A1 (en) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| HRP20251374T1 (hr) | 2020-08-07 | 2025-12-19 | Gilead Sciences, Inc. | Prolijekovi nukleotidnih analoga fosfonamida i njihova farmaceutska uporaba |
| TW202228724A (zh) * | 2020-09-23 | 2022-08-01 | 美商昂克萊亞製藥公司 | 以反轉錄酶抑制劑治療癌症之方法 |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| WO2022241134A1 (en) | 2021-05-13 | 2022-11-17 | Gilead Sciences, Inc. | COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS |
| CA3222277A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CN117377671A (zh) | 2021-06-23 | 2024-01-09 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| IL309378A (en) | 2021-06-23 | 2024-02-01 | Gilead Sciences Inc | Diacylglyercol kinase modulating compounds |
| AU2022297367B2 (en) | 2021-06-23 | 2025-04-10 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025240244A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies comprising bulevirtide and lonafarnib for use in the treatment of hepatitis d virus infection |
| US20250345389A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922695A (en) | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| US5935946A (en) | 1997-07-25 | 1999-08-10 | Gilead Sciences, Inc. | Nucleotide analog composition and synthesis method |
| CA2416757C (en) | 2000-07-21 | 2011-02-15 | Gilead Sciences, Inc. | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
| ES2389602T3 (es) | 2003-12-30 | 2012-10-29 | Gilead Sciences, Inc. | Fosfonatos de nucleósidos y análogos de los mismos para el tratamiento de infecciones por el VPH |
| JP2008538771A (ja) | 2005-04-25 | 2008-11-06 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー， アカデミー オブ サイエンシズ オブ ザ チェコ リパブリック | テロメラーゼのプロセッシビティーを向上させるための化合物の使用 |
| WO2007002912A2 (en) | 2005-06-29 | 2007-01-04 | Gilead Sciences, Inc. | Anti-proliferative compounds, compositions, and methods of use thereof |
| WO2008005555A1 (en) | 2006-07-07 | 2008-01-10 | Gilead Sciences, Inc. | Modulators of toll-like receptor 7 |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| TWI444384B (zh) | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
| CN103403014B (zh) | 2011-01-03 | 2016-07-06 | 河南美泰宝生物制药有限公司 | O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途 |
| US9156874B2 (en) * | 2011-01-03 | 2015-10-13 | Nanjing Molecular Research, Inc. | Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs |
| CN102887901B (zh) | 2011-07-01 | 2015-01-07 | 四川好医生攀西药业有限责任公司 | 无环核苷酸类似物及其制备方法和应用 |
| CA2845553C (en) | 2011-08-16 | 2019-05-28 | Gilead Sciences, Inc. | Tenofovir alafenamide hemifumarate |
| CN103665043B (zh) * | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| CN103435672A (zh) * | 2013-04-25 | 2013-12-11 | 刘沛 | 含有取代苄基的新型核苷磷酸酯前药的结构与合成 |
| WO2015197006A1 (zh) * | 2014-06-25 | 2015-12-30 | 四川海思科制药有限公司 | 一种取代的氨基酸硫酯类化合物、其组合物及应用 |
| KR102589658B1 (ko) | 2014-09-15 | 2023-10-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 뉴클레오타이드 유사체 |
| CN106188139B (zh) | 2015-05-29 | 2020-02-18 | 江苏天士力帝益药业有限公司 | 替诺福韦单苄酯磷酸酰胺前药、其制备方法及应用 |
| WO2017007701A1 (en) | 2015-07-07 | 2017-01-12 | Merck Sharp & Dohme Corp. | Antiviral phosphodiamide compounds |
| CA2994720C (en) | 2015-08-10 | 2020-11-03 | Merck Sharp & Dohme Corp. | Antiviral beta-amino acid ester phosphodiamide compounds |
| EP3350191B9 (en) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Nucleotide analogs |
| CN106167504A (zh) * | 2015-11-04 | 2016-11-30 | 洛阳聚慧医药科技有限公司 | 非环核苷磷酰胺d‑氨基酸酯衍生物及其盐的制备以及在抗病毒方面的应用 |
| RU2604068C1 (ru) * | 2015-12-10 | 2016-12-10 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук | N-(2-аминопурин-6-ил)глицил-(s)-глутаминовая кислота, обладающая противотуберкулёзной активностью |
| WO2017100108A1 (en) | 2015-12-10 | 2017-06-15 | Merck Sharp & Dohme Corp. | Antiviral phosphodiamide prodrugs of tenofovir |
| WO2017106069A1 (en) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Antiviral oxime phosphoramide compounds |
| WO2018039157A1 (en) * | 2016-08-25 | 2018-03-01 | Merck Sharp & Dohme Corp. | Antiviral prodrugs of tenofovir |
| US10736908B2 (en) | 2016-10-26 | 2020-08-11 | Merck Sharp & Dohme Corp. | Antiviral aryl-amide phosphodiamide compounds |
| CN110035760A (zh) | 2016-12-22 | 2019-07-19 | 默沙东公司 | 抗病毒苯甲基胺磷酰二胺化合物 |
-
2017
- 2017-12-20 EP EP17829499.7A patent/EP3559011B1/en active Active
- 2017-12-20 KR KR1020197020682A patent/KR20190100250A/ko not_active Withdrawn
- 2017-12-20 WO PCT/US2017/067470 patent/WO2018119013A1/en not_active Ceased
- 2017-12-20 TW TW106144739A patent/TW201829412A/zh unknown
- 2017-12-20 AU AU2017379850A patent/AU2017379850B2/en not_active Ceased
- 2017-12-20 RU RU2019122414A patent/RU2759902C2/ru active
- 2017-12-20 CN CN201780079454.4A patent/CN110099912B/zh not_active Expired - Fee Related
- 2017-12-20 US US15/847,971 patent/US10519159B2/en active Active
- 2017-12-20 MX MX2019007585A patent/MX388757B/es unknown
- 2017-12-20 MA MA047094A patent/MA47094A/fr unknown
- 2017-12-20 JP JP2019533490A patent/JP6938637B2/ja not_active Expired - Fee Related
- 2017-12-20 CA CA3047573A patent/CA3047573A1/en not_active Abandoned
- 2017-12-20 BR BR112019013017A patent/BR112019013017A2/pt active Search and Examination