JP2020184996A5 - - Google Patents
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- JP2020184996A5 JP2020184996A5 JP2020112362A JP2020112362A JP2020184996A5 JP 2020184996 A5 JP2020184996 A5 JP 2020184996A5 JP 2020112362 A JP2020112362 A JP 2020112362A JP 2020112362 A JP2020112362 A JP 2020112362A JP 2020184996 A5 JP2020184996 A5 JP 2020184996A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- amino acid
- binding protein
- replaced
- multispecific antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000035772 mutation Effects 0.000 claims 40
- 102000025171 antigen binding proteins Human genes 0.000 claims 28
- 108091000831 antigen binding proteins Proteins 0.000 claims 28
- 150000001413 amino acids Chemical class 0.000 claims 21
- 238000006467 substitution reaction Methods 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 125000000539 amino acid group Chemical group 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 102220534532 Protein quaking_Q38K_mutation Human genes 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102220138687 rs201607115 Human genes 0.000 claims 2
- 102220044848 rs377730553 Human genes 0.000 claims 2
- 102220321637 rs377730553 Human genes 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022152359A JP2023002538A (ja) | 2015-04-24 | 2022-09-26 | 多特異性抗原結合タンパク質 |
| JP2024154277A JP2025000659A (ja) | 2015-04-24 | 2024-09-06 | 多特異性抗原結合タンパク質 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562152735P | 2015-04-24 | 2015-04-24 | |
| US62/152,735 | 2015-04-24 | ||
| US201562264291P | 2015-12-07 | 2015-12-07 | |
| US62/264,291 | 2015-12-07 | ||
| US201662310555P | 2016-03-18 | 2016-03-18 | |
| US62/310,555 | 2016-03-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555244A Division JP6952605B2 (ja) | 2015-04-24 | 2016-04-22 | 多特異性抗原結合タンパク質 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022152359A Division JP2023002538A (ja) | 2015-04-24 | 2022-09-26 | 多特異性抗原結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020184996A JP2020184996A (ja) | 2020-11-19 |
| JP2020184996A5 true JP2020184996A5 (enExample) | 2021-01-07 |
| JP7228545B2 JP7228545B2 (ja) | 2023-02-24 |
Family
ID=55911088
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555244A Active JP6952605B2 (ja) | 2015-04-24 | 2016-04-22 | 多特異性抗原結合タンパク質 |
| JP2020112362A Active JP7228545B2 (ja) | 2015-04-24 | 2020-06-30 | 多特異性抗原結合タンパク質 |
| JP2022152359A Withdrawn JP2023002538A (ja) | 2015-04-24 | 2022-09-26 | 多特異性抗原結合タンパク質 |
| JP2024154277A Pending JP2025000659A (ja) | 2015-04-24 | 2024-09-06 | 多特異性抗原結合タンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555244A Active JP6952605B2 (ja) | 2015-04-24 | 2016-04-22 | 多特異性抗原結合タンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022152359A Withdrawn JP2023002538A (ja) | 2015-04-24 | 2022-09-26 | 多特異性抗原結合タンパク質 |
| JP2024154277A Pending JP2025000659A (ja) | 2015-04-24 | 2024-09-06 | 多特異性抗原結合タンパク質 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US11116840B2 (enExample) |
| EP (1) | EP3286227A2 (enExample) |
| JP (4) | JP6952605B2 (enExample) |
| KR (2) | KR20240093813A (enExample) |
| CN (2) | CN116063543A (enExample) |
| AU (2) | AU2016252773B2 (enExample) |
| CA (1) | CA2980189A1 (enExample) |
| IL (2) | IL254738B (enExample) |
| MX (2) | MX2017013482A (enExample) |
| WO (1) | WO2016172485A2 (enExample) |
Families Citing this family (121)
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| US10267806B2 (en) | 2014-04-04 | 2019-04-23 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
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| US11209439B2 (en) | 2015-09-24 | 2021-12-28 | Mayo Foundation For Medical Education And Research | Identification of immunoglobulin free light chains by mass spectrometry |
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- 2016-04-22 CN CN201680037013.3A patent/CN107787332B/zh active Active
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- 2016-04-22 AU AU2016252773A patent/AU2016252773B2/en active Active
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2017
- 2017-09-27 IL IL254738A patent/IL254738B/en unknown
- 2017-10-19 MX MX2023003125A patent/MX2023003125A/es unknown
- 2017-10-20 US US15/789,670 patent/US11116840B2/en active Active
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2020
- 2020-06-30 JP JP2020112362A patent/JP7228545B2/ja active Active
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2021
- 2021-08-04 IL IL285366A patent/IL285366A/en unknown
- 2021-08-05 US US17/395,400 patent/US12053525B2/en active Active
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2022
- 2022-09-02 AU AU2022224860A patent/AU2022224860A1/en not_active Abandoned
- 2022-09-26 JP JP2022152359A patent/JP2023002538A/ja not_active Withdrawn
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2024
- 2024-06-24 US US18/752,672 patent/US20250032610A1/en active Pending
- 2024-09-06 JP JP2024154277A patent/JP2025000659A/ja active Pending
- 2024-10-14 US US18/915,061 patent/US20250177523A1/en active Pending