JP2020110699A - 調節性眼内レンズデバイス - Google Patents
調節性眼内レンズデバイス Download PDFInfo
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- 238000000034 method Methods 0.000 claims description 8
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- 208000002177 Cataract Diseases 0.000 description 8
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- 230000000051 modifying effect Effects 0.000 description 3
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- NOKUWSXLHXMAOM-UHFFFAOYSA-N hydroxy(phenyl)silicon Chemical class O[Si]C1=CC=CC=C1 NOKUWSXLHXMAOM-UHFFFAOYSA-N 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 208000014733 refractive error Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
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- 230000001886 ciliary effect Effects 0.000 description 1
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- 229920006037 cross link polymer Polymers 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
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- NYMPGSQKHIOWIO-UHFFFAOYSA-N hydroxy(diphenyl)silicon Chemical class C=1C=CC=CC=1[Si](O)C1=CC=CC=C1 NYMPGSQKHIOWIO-UHFFFAOYSA-N 0.000 description 1
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Abstract
Description
第2の態様によれば、流体を閉鎖容積内に収容することができる。好ましくは、流体は、シリコーン油、フッ素化シリコーン油及びポリフェニルエーテルからなる群から選択することができる。
第4の態様によれば、閉鎖容積を、光学素子、可撓性膜及び周縁部の間に画定することができる。
第2の態様によれば、ベースレンズアセンブリは、IOLの光学素子及び/又は可撓性膜を含む側に接触するように、内側表面から半径方向内向きに延びる支持フランジを更に備えることができる。
第4の態様によれば、ベースパワー光学素子は、曲率の変化に部分的に又は完全に抵抗することができ、又は触覚システムに加えられる半径方向の圧縮力に応答して曲率を変化させることができる。
第2の態様によれば、流体を閉鎖容積内に収容することができる。好ましくは、流体は、シリコーン油、フッ素化シリコーン油及びポリフェニルエーテルからなる群から選択することができる。
第5の態様によれば、触覚システムが、力伝達領域に直接接触するか、又は力伝達領域に結合され得る。
第7の態様によれば、半径方向の圧縮力が力伝達領域に加えられたとき、閉鎖容積の体積は一定のままであることができる。
第2の態様によれば、ベースレンズアセンブリは、IOLの光学素子及び/又は可撓性膜を含む側に接触するように、内側表面から半径方向内向きに延びる支持フランジをさらに備えることができる。
第4の態様によれば、ベースパワー光学素子は、曲率の変化に部分的又は完全に抵抗するか、又は触覚システムに加えられる半径方向の圧縮力に応じて曲率を変化させることができる。
第2の態様によれば、流体を閉鎖容積内に収容することができる。好ましくは、流体は、シリコーン油、フッ素化シリコーン油及びポリフェニルエーテルからなる群から選択することができる。
第5の態様によれば、閉鎖容積を、光学素子、可撓性膜及び周方向周縁部の間に画定することができる。
さらに別の実施形態では、2ピース式調節性眼内レンズアセンブリが記載される。2ピース式調節性眼内レンズアセンブリは、ベースレンズアセンブリ及び本明細書に記載の調節性IOLを備えることができる。ベースアセンブリは、ベースパワー光学素子と、ベースパワー光学素子の周りに周方向に触覚システムを備えることができる。触覚システムは、調節性IOLが取り外し可能に維持される内部空間を画定することができる。
第2の態様によれば、ベースレンズアセンブリは、IOLの光学素子及び/又は可撓性膜を含む側に接触するように、内側表面から半径方向内向きに延びる支持フランジをさらに備えることができる。
第4の態様によれば、ベースパワー光学素子は、曲率の変化に部分的に又は完全に抵抗することができ、又は触覚システムに加えられる半径方向の圧縮力に応答して曲率を変化させることができる。
図面のいくつかの図を通じて、同様の参照番号は同様の部分を指す。
〔好ましい実施形態の詳細な説明〕
本発明の特定の非限定的な実施形態を、図面を参照して説明する。そのような実施形態は例示であり、本発明の範囲内の少数の実施形態の単なる例示であることを理解されたい。本発明が属する技術分野の当業者にとって明らかな様々な変更及び改変は、添付の特許請求の範囲でさらに定義される本発明の趣旨、範囲及び思想の範囲内にあるとみなされる。
図2Aは、可撓性膜102と、光学素子104と、可撓性膜102及び光学素子104を結合する周方向周縁部106とを備えるIOL100を示す。膜カプラ112が周方向周縁部106の内方側から配置され、膜102を周縁部106に結合する。膜カプラ112は、力伝達領域108の高さとほぼ同じかそれよりも小さい厚さを有することができる。同様に、光学素子カプラ114が、周方向周縁部106の内方側から配置され、光学素子104を周縁部106に結合する。好ましくは、光学素子カプラ114は、光学素子104を可撓性膜102に向かって撓ませるように可撓性膜102に向かって傾斜している。
膜の中央を200ミクロン、周辺を100ミクロンとしたことを除いて、図2Aに示すIOLに類似したIOLをモデリングした。全体の直径は7mm、中心厚さは1.2mmであった。モデリングには、IOLの閉鎖容積の内側に1.49の屈折率を有する流体が含まれていた。様々な係数の材料をモデリングし、有限要素解析によって評価した。結果は、3mmのアパーチャで5Dのパワー変化を示した。初期ジオプターパワーは22.0Dであり、最終ジオプターパワーは27.2Dであった。
実施例1のIOLは、膜に光学品質のシリコーン材料を使用して構築され、閉鎖容積は、1.49の屈折率を有するシリコーン流体で満たされた。試験は、実施例1と同様の負荷設定下で、人工カプセルを用いて行った。3mmアパーチャを用いて測定されたジオプターパワー変化は5.5Dであった。パワーは23Dから28.5Dに変化し、パワー変化の範囲全体にわたって許容可能な光学品質であった。
実施例2で試験したIOLを、次に人工レンズカプセルの中に入れたベースレンズアセンブリの内部に配置した。ベースレンズアセンブリは、図3Aに示すレンズと同様の設計であった。試験は、実施例2と同様の負荷条件で行った。ベースパワーレンズは−8.5Dパワーを有し、パワー変更レンズは23.0Dのパワーを有していた。IOLとベースレンズアセンブリが一緒に組み立てられたとき、3mmのアパーチャで14.5Dの合成パワーが測定された。3mmアパーチャを用いて測定されたジオプターパワー変化は5.5Dであった。ジオプターパワーは14.5Dから21.0Dに変化し、パワー変化の範囲全体にわたって許容可能な光学品質であった。
Claims (40)
- 調節性眼内レンズ(IOL)であって、
光学素子と、
光学素子の前方に配置された可撓性膜と、
前記光学素子及び前記可撓性膜に結合された周縁部であって、高さを有する外周面及び前記外周面の高さの一部に沿って画定された力伝達領域を含む周縁部と、
前記光学素子及び前記可撓性膜を離間させる閉鎖容積と
を含み、
前記力伝達領域に加えられた半径方向の圧縮力が、調節パワーの変化を与える前記力伝達領域を半径方向に圧縮したとき、前記光学素子は軸方向に変位し、前記可撓性膜は中心軸の周りで曲率が変化し、
前記光学素子が軸方向に変位したとき、及び/又は半径方向の圧縮力が前記力伝達領域に加えられたときに、前記光学素子が屈曲に抵抗し、又は曲率の変化に抵抗するように、前記光学素子は前記膜よりも大きな剛性を有する、調節性IOL。 - 前記力伝達領域が周方向リングである、請求項1に記載の調節性IOL。
- 前記周方向リングは、前記周縁部から外向きに突出している、請求項2に記載の調節性IOL。
- 前記閉鎖容積内に収容された流体を更に含む、請求項1〜3のいずれか一項に記載の調節性IOL。
- 前記流体が、シリコーン油、フッ素化シリコーン油及びポリフェニルエーテルからなる群から選択される、請求項4に記載の調節性IOL。
- 前記力伝達領域に接触するか又は結合された触覚を更に含む、請求項1〜5のいずれか一項に記載の調節性IOL。
- 前記閉鎖容積が、前記光学素子、前記可撓性膜及び前記周縁部の間に画定される、請求項1〜6のいずれか一項に記載の調節性IOL。
- 前記閉鎖容積によって画定される体積は、前記光学素子が軸方向に変位し前記可撓性膜の曲率が変化したとき、及び/又は半径方向の圧縮力が前記力伝達領域に加えられたとき、一定のままである、請求項1〜7のいずれか一項に記載の調節性IOL。
- ベースレンズアセンブリ及び請求項1〜8のいずれか一項に記載の調節性IOLを備える2ピース式調節性眼内レンズアセンブリであって、前記ベースレンズアセンブリは、ベースパワー光学素子と、前記ベースパワー光学素子の周りの周方向の触覚システムとを含み、前記触覚システムは、前記ベースパワー光学素子に対面する内側表面であって、調節性IOLを取り外し可能に維持する内部空間を画定する内側表面を有する、2ピース式調節性眼内レンズアセンブリ。
- 前記外周面の力伝達領域のみが前記触覚システムの前記内側表面と接触している、請求項9に記載の2ピース式調節性眼内レンズアセンブリ。
- 前記ベースレンズアセンブリは、IOLの前記光学素子及び/又は前記可撓性膜を含む側に接触するように、前記内側表面から半径方向内向きに延びる支持フランジを更に含む、請求項9又は10に記載の2ピース式調節性眼内レンズアセンブリ。
- 前記触覚システムの外側表面の周りに配置された複数の離間したノッチを更に含む、請求項9〜11のいずれか一項に記載の2ピース式調節性眼内レンズアセンブリ。
- 調節性IOLであって、
光学素子と、
光学素子の前方に配置された可撓性膜と、
内方側及び外方側を有する周方向周縁部と、
前記光学素子及び前記可撓性膜を離間させる閉鎖容積と、
前記周方向周縁部の内方側から配置された光学素子カプラ及び膜カプラと、
前記周方向周縁部の外方側に配置された力伝達領域であって、前記光学素子カプラに対向する外方側の一部に沿って配置され、前記膜カプラに対向する外方側の一部に沿って配置されない力伝達領域とを含み、
前記力伝達領域に加えられた半径方向の圧縮力が、調節パワーの変化を与える前記力伝達領域を半径方向に圧縮したとき、前記力伝達領域は、自身に加えられる半径方向の圧縮力の伝達を、前記光学素子カプラを介して前記光学素子に集中させ、中心軸に沿って前記光学素子を軸方向に変位させ、
前記光学素子の軸方向変位は、前記閉鎖容積及び流体の前記膜への接着の結果として、前記可撓性膜の曲率の変化を引き起こす、調節性IOL。 - 前記力伝達領域が周方向リングである、請求項13に記載の調節性IOL。
- 前記周方向リングは、前記周方向周縁部から外向きに突出している、請求項14に記載の調節性IOL。
- 前記閉鎖容積内に収容された流体を更に含む、請求項13〜15のいずれか一項に記載の調節性IOL。
- 前記流体が、シリコーン油、フッ素化シリコーン油及びポリフェニルエーテルからなる群から選択される、請求項16に記載の調節性IOL。
- 前記光学素子は、前記光学素子が軸方向に変位したとき、及び/又は半径方向の圧縮力が前記力伝達領域に加えられたときに、屈曲に抵抗し、又は曲率の変化に抵抗するように前記膜よりも大きな剛性を有する、請求項13〜17のいずれか一項に記載の調節性IOL。
- 前記周方向周縁部の内方側と前記可撓性膜との間に画定された周方向の溝を更に含み、前記周方向の溝は閉鎖容積内に含まれる内部容積を有する、請求項13〜18のいずれか一項に記載の調節性IOL。
- 前記力伝達領域に直接接触するか又は結合された触覚を更に含む、請求項13〜19のいずれか一項に記載の調節性IOL。
- 前記閉鎖容積が、前記光学素子、前記可撓性膜及び前記周方向周縁部の間に画定される、請求項13〜20のいずれか一項に記載の調節性IOL。
- 半径方向の圧縮力が前記力伝達領域に加えられたとき、前記閉鎖容積の体積が一定のままである、請求項13〜21のいずれか一項に記載の調節性IOL。
- ベースレンズアセンブリ及び請求項13〜22のいずれか一項に記載の調節性IOLを備える2ピース式調節性眼内レンズアセンブリであって、前記ベースレンズアセンブリは、ベースパワー光学素子と、前記ベースパワー光学素子の周りの周方向の触覚システムとを含み、前記触覚システムは、調節性IOLを取り外し可能に維持する内部空間を画定する内側表面を有する、2ピース式調節性眼内レンズアセンブリ。
- 前記外方側の力伝達領域のみが前記触覚システムの前記内側表面と接触している、請求項23に記載の2ピース式調節性眼内レンズアセンブリ。
- 前記ベースレンズアセンブリは、IOLの前記光学素子及び/又は前記可撓性膜を含む側に接触するように、前記内側表面から半径方向内向きに延びる支持フランジを更に含む、請求項23又は24に記載の2ピース式調節性眼内レンズアセンブリ。
- 前記触覚システムの外側表面の周りに配置された複数の離間したノッチを更に含む、請求項23〜25のいずれか一項に記載の2ピース式調節性眼内レンズアセンブリ。
- 調節性IOLであって、
光学素子と、
光学素子の前方に配置された可撓性膜と、
内方側及び外方側を有する周方向周縁部と、
前記光学素子と前記可撓性膜との間に空間を提供する閉鎖容積と、
前記周方向周縁部の内方側から配置された光学素子カプラ及び膜カプラと、
前記周方向周縁部の外方側に配置された力伝達領域であって、前記膜カプラに対向する外方側の一部に沿って配置され、前記光学素子カプラに対向する外方側の一部に沿って配置されない力伝達領域とを含み、
前記力伝達領域に加えられた半径方向の圧縮力が、調節パワーの変化を与える前記力伝達領域を半径方向に圧縮したとき、前記力伝達領域は、自身に加えられる半径方向の圧縮力の伝達を、前記膜カプラを介して前記可撓性膜に集中させ、中心軸の周りで前記可撓性膜の曲率を変化させ、
前記可撓性膜の曲率の変化は、前記閉鎖容積及び流体の前記光学素子への接着の結果として、前記光学素子の対応する軸方向変位を引き起こす、調節性IOL。 - 前記力伝達領域が周方向リングである、請求項27に記載の調節性IOL。
- 前記周方向リングは、前記周方向周縁部から外向きに突出している、請求項28に記載の調節性IOL。
- 前記閉鎖容積内に収容された流体を更に含む、請求項27〜29のいずれか一項に記載の調節性IOL。
- 前記流体が、シリコーン油、フッ素化シリコーン油及びポリフェニルエーテルからなる群から選択される、請求項30に記載の調節性IOL。
- 前記可撓性膜の曲率の変化に応答して、かつ/又は、半径方向の圧縮力が力伝達領域に加えられたとき、前記光学素子が中心軸に沿って軸方向に自由に変位するように、前記光学素子カプラは複数の折り畳まれた領域を含む、請求項27〜31のいずれか一項に記載の調節性IOL。
- 前記力伝達領域に直接接触するか又は結合された触覚を更に含む、請求項27〜32のいずれか一項に記載の調節性IOL。
- 前記閉鎖容積が、前記光学素子、前記可撓性膜及び前記周方向周縁部の間に画定される、請求項27〜33のいずれか一項に記載の調節性IOL。
- 半径方向の圧縮力が前記力伝達領域に加えられたとき、前記閉鎖容積が一定のままである、請求項27〜34のいずれか一項に記載の調節性IOL。
- ベースレンズアセンブリ及び請求項27〜35のいずれか一項に記載の調節性IOLを備える2ピース式調節性眼内レンズアセンブリであって、前記ベースレンズアセンブリは、ベースパワー光学素子と、前記ベースパワー光学素子の周りの周方向の触覚システムとを含み、前記触覚システムは、調節性IOLを取り外し可能に維持する内部空間を画定する内側表面を有する、2ピース式調節性眼内レンズアセンブリ。
- 前記外方側の力伝達領域のみが前記触覚システムの内側表面と接触している、請求項36に記載の2ピース式調節性眼内レンズアセンブリ。
- 前記ベースレンズアセンブリは、IOLの前記光学素子及び/又は前記可撓性膜を含む側に接触するように、前記内側表面から半径方向内向きに延びる支持フランジを更に含む、請求項36又は37に記載の2ピース式調節性眼内レンズアセンブリ。
- 前記触覚システムの外側表面の周りに配置された複数の離間したノッチを更に含む、請求項36〜38のいずれか一項に記載の2ピース式調節性眼内レンズアセンブリ。
- 調節性眼内レンズ(IOL)であって、
光学素子と、
光学素子の前方に配置された可撓性膜と、
前記光学素子及び前記可撓性膜に結合された力伝達領域と、
前記光学素子及び前記可撓性膜を離間させる閉鎖容積と
を含み、
前記力伝達領域に加えられた半径方向の圧縮力が、調節パワーの変化を与える前記力伝達領域を半径方向に圧縮したとき、前記光学素子は軸方向に変位し、前記可撓性膜は中心軸の周りで曲率が変化し、
前記光学素子が軸方向に変位したとき、及び/又は半径方向の圧縮力が前記力伝達領域に加えられたときに、前記光学素子が屈曲に抵抗し、又は曲率の変化に抵抗するように、前記光学素子は前記膜よりも大きな剛性を有する、調節性IOL。
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