|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
|
DE3209472C2
(de)
|
1982-03-16 |
1984-05-17 |
Degussa Ag, 6000 Frankfurt |
Verfahren zur Herstellung von 3-Oxonitrilen sowie neue 3-Oxonitrile
|
|
ES8702440A1
(es)
|
1984-10-04 |
1986-12-16 |
Monsanto Co |
Un procedimiento para la preparacion de una composicion de polipeptido inyectable sustancialmente no acuosa.
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
US5612059A
(en)
|
1988-08-30 |
1997-03-18 |
Pfizer Inc. |
Use of asymmetric membranes in delivery devices
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
PH30995A
(en)
|
1989-07-07 |
1997-12-23 |
Novartis Inc |
Sustained release formulations of water soluble peptides.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
US5585112A
(en)
|
1989-12-22 |
1996-12-17 |
Imarx Pharmaceutical Corp. |
Method of preparing gas and gaseous precursor-filled microspheres
|
|
IT1246382B
(it)
|
1990-04-17 |
1994-11-18 |
Eurand Int |
Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
TW333456B
(en)
|
1992-12-07 |
1998-06-11 |
Takeda Pharm Ind Co Ltd |
A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
US6274552B1
(en)
|
1993-03-18 |
2001-08-14 |
Cytimmune Sciences, Inc. |
Composition and method for delivery of biologically-active factors
|
|
US5523092A
(en)
|
1993-04-14 |
1996-06-04 |
Emory University |
Device for local drug delivery and methods for using the same
|
|
US5985307A
(en)
|
1993-04-14 |
1999-11-16 |
Emory University |
Device and method for non-occlusive localized drug delivery
|
|
US6087324A
(en)
|
1993-06-24 |
2000-07-11 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6004534A
(en)
|
1993-07-23 |
1999-12-21 |
Massachusetts Institute Of Technology |
Targeted polymerized liposomes for improved drug delivery
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
US5759542A
(en)
|
1994-08-05 |
1998-06-02 |
New England Deaconess Hospital Corporation |
Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
|
|
US5660854A
(en)
|
1994-11-28 |
1997-08-26 |
Haynes; Duncan H |
Drug releasing surgical implant or dressing material
|
|
US6316652B1
(en)
|
1995-06-06 |
2001-11-13 |
Kosta Steliou |
Drug mitochondrial targeting agents
|
|
WO1997001331A2
(en)
|
1995-06-27 |
1997-01-16 |
Takeda Chemical Industries, Ltd. |
Method of producing sustained-release preparation
|
|
TW448055B
(en)
|
1995-09-04 |
2001-08-01 |
Takeda Chemical Industries Ltd |
Method of production of sustained-release preparation
|
|
JP2909418B2
(ja)
|
1995-09-18 |
1999-06-23 |
株式会社資生堂 |
薬物の遅延放出型マイクロスフイア
|
|
US6039975A
(en)
|
1995-10-17 |
2000-03-21 |
Hoffman-La Roche Inc. |
Colon targeted delivery system
|
|
WO1997017329A1
(en)
|
1995-11-07 |
1997-05-15 |
Kirin Beer Kabushiki Kaisha |
Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same
|
|
US5980945A
(en)
|
1996-01-16 |
1999-11-09 |
Societe De Conseils De Recherches Et D'applications Scientifique S.A. |
Sustained release drug formulations
|
|
TW345603B
(en)
|
1996-05-29 |
1998-11-21 |
Gmundner Fertigteile Gmbh |
A noise control device for tracks
|
|
US6264970B1
(en)
|
1996-06-26 |
2001-07-24 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6419961B1
(en)
|
1996-08-29 |
2002-07-16 |
Takeda Chemical Industries, Ltd. |
Sustained release microcapsules of a bioactive substance and a biodegradable polymer
|
|
AU722289B2
(en)
|
1996-10-01 |
2000-07-27 |
Aptalis Pharmatech, Inc. |
Taste-masked microcapsule compositions and methods of manufacture
|
|
CA2217134A1
(en)
|
1996-10-09 |
1998-04-09 |
Sumitomo Pharmaceuticals Co., Ltd. |
Sustained release formulation
|
|
EP0839525B1
(en)
|
1996-10-31 |
2004-08-04 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6131570A
(en)
|
1998-06-30 |
2000-10-17 |
Aradigm Corporation |
Temperature controlling device for aerosol drug delivery
|
|
DE69719367T2
(de)
|
1996-12-20 |
2003-10-16 |
Takeda Chemical Industries, Ltd. |
Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe
|
|
US5891474A
(en)
|
1997-01-29 |
1999-04-06 |
Poli Industria Chimica, S.P.A. |
Time-specific controlled release dosage formulations and method of preparing same
|
|
US6120751A
(en)
|
1997-03-21 |
2000-09-19 |
Imarx Pharmaceutical Corp. |
Charged lipids and uses for the same
|
|
US6060082A
(en)
|
1997-04-18 |
2000-05-09 |
Massachusetts Institute Of Technology |
Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
|
|
US20070244120A1
(en)
|
2000-08-18 |
2007-10-18 |
Jacques Dumas |
Inhibition of raf kinase using substituted heterocyclic ureas
|
|
US6350458B1
(en)
|
1998-02-10 |
2002-02-26 |
Generex Pharmaceuticals Incorporated |
Mixed micellar drug deliver system and method of preparation
|
|
US6613358B2
(en)
|
1998-03-18 |
2003-09-02 |
Theodore W. Randolph |
Sustained-release composition including amorphous polymer
|
|
US6048736A
(en)
|
1998-04-29 |
2000-04-11 |
Kosak; Kenneth M. |
Cyclodextrin polymers for carrying and releasing drugs
|
|
KR19990085365A
(ko)
|
1998-05-16 |
1999-12-06 |
허영섭 |
지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법
|
|
DK1119567T3
(da)
|
1998-10-08 |
2005-07-25 |
Astrazeneca Ab |
Quinazolinderivater
|
|
JP3519368B2
(ja)
|
1999-01-22 |
2004-04-12 |
麒麟麦酒株式会社 |
キノリン誘導体およびキナゾリン誘導体
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6271359B1
(en)
|
1999-04-14 |
2001-08-07 |
Musc Foundation For Research Development |
Tissue-specific and pathogen-specific toxic agents and ribozymes
|
|
TWI281915B
(en)
|
1999-12-24 |
2007-06-01 |
Kirin Brewery |
Quinoline and quinazoline derivatives and drugs containing the same
|
|
MXPA03001771A
(es)
|
2000-08-30 |
2003-06-04 |
Pfizer Prod Inc |
Formulaciones de liberacion sostenida para secretagogos de hormona del crecimiento.
|
|
ATE419239T1
(de)
|
2000-10-20 |
2009-01-15 |
Eisai R&D Man Co Ltd |
Verfahren zur herstellung von 4-phenoxy chinolin derivaten
|
|
AU2002255284B2
(en)
|
2001-04-27 |
2007-10-04 |
Kyowa Kirin Co., Ltd. |
Quinoline derivative having azolyl group and quinazoline derivative
|
|
EP2088141A3
(en)
|
2001-06-22 |
2009-11-18 |
Kirin Pharma Kabushiki Kaisha |
Quinoline derivatives and quinazoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same
|
|
EP2280003B1
(en)
|
2002-07-15 |
2014-04-02 |
Symphony Evolution, Inc. |
Process for preparing receptor-type kinase modulators
|
|
EP2392565B1
(en)
|
2003-09-26 |
2014-03-19 |
Exelixis, Inc. |
c-Met modulators and methods of use
|
|
MXPA06003607A
(es)
|
2003-10-16 |
2006-06-05 |
Chiron Corp |
Quinazolinas, quinoxalinas, quinolinas e isoquinolinas 2.6-disubstituidas como inhibidores de la cinasa raf para el tratamiento del cancer.
|
|
CA2545711A1
(en)
|
2003-11-13 |
2005-06-02 |
Ambit Biosciences Corporation |
Urea derivatives as kinase modulators
|
|
JP5197016B2
(ja)
|
2004-12-23 |
2013-05-15 |
デシファラ ファーマスーティカルズ， エルエルシー |
酵素モジュレータ及び治療
|
|
US7576090B2
(en)
|
2004-12-27 |
2009-08-18 |
4Sc Ag |
Benzazole analogues and uses thereof
|
|
EP1746096A1
(en)
|
2005-07-15 |
2007-01-24 |
4Sc Ag |
2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer
|
|
CA2632929A1
(en)
|
2005-12-22 |
2007-06-28 |
Astrazeneca Ab |
Quinazoline derivatives, process for their preparation and their use as anti-cancer agents
|
|
US7989461B2
(en)
|
2005-12-23 |
2011-08-02 |
Amgen Inc. |
Substituted quinazolinamine compounds for the treatment of cancer
|
|
WO2007087245A2
(en)
*
|
2006-01-24 |
2007-08-02 |
Merck & Co., Inc. |
Ret tyrosine kinase inhibition
|
|
US20070265258A1
(en)
|
2006-03-06 |
2007-11-15 |
Ruiping Liu |
Quinazoline derivatives as phosphodiesterase 10 inhibitors
|
|
JP2009532449A
(ja)
|
2006-04-05 |
2009-09-10 |
アストラゼネカ アクチボラグ |
抗癌活性のある置換キナゾリン
|
|
CN101415688A
(zh)
|
2006-04-05 |
2009-04-22 |
阿斯利康(瑞典)有限公司 |
具有b-raf抑制活性的喹唑啉酮衍生物
|
|
WO2008005310A2
(en)
|
2006-06-30 |
2008-01-10 |
Ambit Biosciences Corp. |
Detectable nucleic acid tag
|
|
MX2009004019A
(es)
|
2006-10-19 |
2009-06-19 |
Signal Pharm Llc |
Compuestos heteroarilo, composiciones de los mismos, y uso de los mismos como inhibidores de proteina cinasa.
|
|
NZ576278A
(en)
|
2006-10-19 |
2011-12-22 |
Signal Pharm Llc |
Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
|
|
HUE025197T2
(en)
|
2008-03-17 |
2016-02-29 |
Ambit Biosciences Corp |
Quinazoline derivatives as RAF kinase modulators and methods for their use
|
|
CA2730190A1
(en)
|
2008-07-14 |
2010-01-21 |
Queen's University At Kingston |
Pharmaceutical compositions comprising ret inhibitors and methods for the treatment of cancer
|
|
WO2011050069A1
(en)
*
|
2009-10-20 |
2011-04-28 |
Prometheus Laboratories Inc. |
Proximity-mediated assays for detecting oncogenic fusion proteins
|
|
JP2014005206A
(ja)
*
|
2010-10-22 |
2014-01-16 |
Astellas Pharma Inc |
アリールアミノヘテロ環カルボキサミド化合物
|
|
AU2012240240A1
(en)
|
2011-04-04 |
2013-05-09 |
Netherlands Cancer Institute |
Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
|
|
US9216172B2
(en)
*
|
2011-08-04 |
2015-12-22 |
National Cancer Center |
Method for determining effectiveness of cancer treatment by assessing the presence of a KIF5B-RET chimeric gene
|
|
WO2013028817A1
(en)
|
2011-08-23 |
2013-02-28 |
Foundation Medicine , Inc. |
Novel kif5b-ret fusion molecules and uses thereof
|
|
WO2013163428A1
(en)
*
|
2012-04-25 |
2013-10-31 |
The Regents Of The University Of Colorado |
Detection of ret fusions in cancer
|
|
TR201815994T4
(tr)
|
2012-09-25 |
2018-11-21 |
Chugai Pharmaceutical Co Ltd |
Ret inhibitörü.
|
|
HK1214831A1
(zh)
*
|
2012-11-05 |
2016-08-05 |
Foundation Medicine, Inc. |
新型融合分子及其应用
|
|
EP2981613A4
(en)
|
2013-02-22 |
2016-11-02 |
Boris C Bastian |
FUSION POLYNUCLEOTIDES AND FUSION POLYPEPTIDES RELATED TO CANCER AND IN PARTICULAR TO MELANOMA AND USES THEREOF AS THERAPEUTIC AND DIAGNOSTIC OBJECTIVES
|
|
CN105051039A
(zh)
*
|
2013-03-11 |
2015-11-11 |
伊尼塔公司 |
喹唑啉衍生物的固态形式及其作为braf抑制剂的用途
|
|
WO2016015141A1
(en)
*
|
2014-07-28 |
2016-02-04 |
Infosec Global Inc. |
System and method for cryptographic suite management
|