CN110191705A - 治疗癌症的方法 - Google Patents

治疗癌症的方法 Download PDF

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Publication number
CN110191705A
CN110191705A CN201780078431.1A CN201780078431A CN110191705A CN 110191705 A CN110191705 A CN 110191705A CN 201780078431 A CN201780078431 A CN 201780078431A CN 110191705 A CN110191705 A CN 110191705A
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CN
China
Prior art keywords
ret
subject
cancer
fusion
genetic alteration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201780078431.1A
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English (en)
Chinese (zh)
Inventor
林毅仁
普拉蒂克·S·穆尔塔尼
理查德·兰丁
鲁巴尔·A·帕特尔
珍妮弗·赖特·奥利弗
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Ignyta Inc
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Ignyta Inc
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Publication of CN110191705A publication Critical patent/CN110191705A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201780078431.1A 2016-12-01 2017-11-29 治疗癌症的方法 Pending CN110191705A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662428947P 2016-12-01 2016-12-01
US62/428,947 2016-12-01
PCT/US2017/063779 WO2018102455A1 (en) 2016-12-01 2017-11-29 Methods for the treatment of cancer

Publications (1)

Publication Number Publication Date
CN110191705A true CN110191705A (zh) 2019-08-30

Family

ID=62241840

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780078431.1A Pending CN110191705A (zh) 2016-12-01 2017-11-29 治疗癌症的方法

Country Status (6)

Country Link
US (1) US10799503B2 (enExample)
EP (1) EP3548007A4 (enExample)
JP (1) JP7105774B2 (enExample)
CN (1) CN110191705A (enExample)
TW (1) TW201821078A (enExample)
WO (1) WO2018102455A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116669765A (zh) * 2020-12-29 2023-08-29 上海岸阔医药科技有限公司 预防或治疗egfr功能异常相关的副作用的方法

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CA3003721C (en) 2015-11-02 2024-02-06 Blueprint Medicines Corporation Inhibitors of ret to treat cancer
CA3087972C (en) 2018-01-18 2023-01-10 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CN111971286B (zh) 2018-01-18 2023-04-14 阿雷生物药品公司 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物
CA3096043A1 (en) 2018-04-03 2019-10-10 Blueprint Medicines Corporation Ret inhibitor for use in treating cancer having a ret alteration
JP2023527412A (ja) 2020-05-29 2023-06-28 ブループリント メディシンズ コーポレイション プラルセチニブの固体形態

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CN105051039A (zh) * 2013-03-11 2015-11-11 伊尼塔公司 喹唑啉衍生物的固态形式及其作为braf抑制剂的用途
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Publication number Priority date Publication date Assignee Title
CN116669765A (zh) * 2020-12-29 2023-08-29 上海岸阔医药科技有限公司 预防或治疗egfr功能异常相关的副作用的方法

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JP2019536790A (ja) 2019-12-19
TW201821078A (zh) 2018-06-16
US20200069688A1 (en) 2020-03-05
EP3548007A4 (en) 2020-08-12
JP7105774B2 (ja) 2022-07-25
US10799503B2 (en) 2020-10-13
EP3548007A1 (en) 2019-10-09
WO2018102455A1 (en) 2018-06-07

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