|
US4722848A
(en)
|
1982-12-08 |
1988-02-02 |
Health Research, Incorporated |
Method for immunizing animals with synthetically modified vaccinia virus
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5849589A
(en)
|
1996-03-11 |
1998-12-15 |
Duke University |
Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
|
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
ES2590912T3
(es)
|
1997-12-08 |
2016-11-24 |
Merck Patent Gmbh |
Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6864235B1
(en)
|
1999-04-01 |
2005-03-08 |
Eva A. Turley |
Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
|
|
US20020055488A1
(en)
|
2000-09-21 |
2002-05-09 |
Wessels Michael R. |
Prevention and treatment of streptococcal and staphylococcal infection
|
|
US8192744B2
(en)
|
2002-08-26 |
2012-06-05 |
Ibcc Holding As |
Drug for treating states related to the inhibition of angiogenesis and/or endothelial cell proliferation
|
|
WO2005114186A1
(ja)
|
2004-05-20 |
2005-12-01 |
Wako Pure Chemical Industries, Ltd. |
ヒアルロン酸バインディングプロテインを用いたヒアルロン酸の測定方法
|
|
CA2610791C
(en)
|
2005-06-08 |
2015-12-01 |
Cangene Corporation |
Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria
|
|
KR101411165B1
(ko)
|
2005-07-01 |
2014-06-25 |
메다렉스, 엘.엘.시. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
|
|
WO2007110205A2
(en)
|
2006-03-24 |
2007-10-04 |
Merck Patent Gmbh |
Engineered heterodimeric protein domains
|
|
US8163498B2
(en)
|
2006-08-08 |
2012-04-24 |
Seikagaku Corporation |
Method for determination of molecular weight of hyaluronic acid
|
|
WO2008089448A2
(en)
|
2007-01-19 |
2008-07-24 |
Cornell Presearch Foundation, Inc. |
Methods and compositions for promoting survival & proliferation of endothelial cells & stimulating angiogenesis
|
|
PT2235064E
(pt)
|
2008-01-07 |
2016-03-01 |
Amgen Inc |
Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática
|
|
SG189730A1
(en)
|
2008-04-02 |
2013-05-31 |
Macrogenics Inc |
Her2/neu-specific antibodies and methods of using same
|
|
ES2399584T3
(es)
|
2008-04-15 |
2013-04-02 |
Wako Pure Chemical Industries, Ltd. |
Nueva proteína capaz de unirse al ácido hialurónico y procedimiento para medir el ácido hialurónico usando la misma
|
|
BRPI1007005A2
(pt)
|
2009-01-29 |
2016-03-22 |
Medimmune Llc |
anticorpo isolado , ácido nucleico isolado n vetor, célula isolada , linhagem de célula isolada , composição farmacêutica, e, uso de um anticorpo anti-il-6
|
|
AU2010233994A1
(en)
|
2009-04-07 |
2011-09-22 |
Roche Glycart Ag |
Bispecific anti-ErbB-3/anti-c-Met antibodies
|
|
PE20120630A1
(es)
|
2009-08-17 |
2012-05-26 |
Roche Glycart Ag |
Inmunoconjugados dirigidos
|
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
CN110066339A
(zh)
|
2010-04-20 |
2019-07-30 |
根马布股份公司 |
含异二聚体抗体fc的蛋白及其制备方法
|
|
DK2560683T4
(da)
|
2010-04-23 |
2022-08-29 |
Hoffmann La Roche |
Fremstilling af heteromultimeriske proteiner
|
|
CA2807278A1
(en)
|
2010-08-24 |
2012-03-01 |
F. Hoffmann - La Roche Ag |
Bispecific antibodies comprising a disulfide stabilized - fv fragment
|
|
WO2012032080A1
(en)
|
2010-09-07 |
2012-03-15 |
F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H |
Stabilised human fc
|
|
SG10201508401TA
(en)
|
2010-10-11 |
2015-11-27 |
Abbvie Bahamas Ltd |
Processes for purification of proteins
|
|
RU2604490C2
(ru)
|
2010-11-05 |
2016-12-10 |
Займворкс Инк. |
ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ
|
|
LT2647707T
(lt)
|
2010-11-30 |
2018-11-12 |
Chugai Seiyaku Kabushiki Kaisha |
Citotoksiškumą indukuojantis terapinis agentas
|
|
US10689447B2
(en)
|
2011-02-04 |
2020-06-23 |
Genentech, Inc. |
Fc variants and methods for their production
|
|
LT3075745T
(lt)
|
2011-02-10 |
2018-11-26 |
Roche Glycart Ag |
Mutavę interleukino-2 polipeptidai
|
|
KR20160044598A
(ko)
|
2011-03-29 |
2016-04-25 |
로슈 글리카트 아게 |
항체 Fc 변이체
|
|
EA201892619A1
(ru)
|
2011-04-29 |
2019-04-30 |
Роше Гликарт Аг |
Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
|
|
PL2714718T3
(pl)
|
2011-05-24 |
2017-11-30 |
Symic Ip, Llc |
Syntetyczne peptydoglikany wiążące kwas hialuronowy, otrzymywanie i sposoby zastosowania
|
|
WO2013012733A1
(en)
|
2011-07-15 |
2013-01-24 |
Biogen Idec Ma Inc. |
Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
|
|
CA3101783C
(en)
|
2011-10-11 |
2023-01-31 |
Universitat Zurich Prorektorat Mnw |
Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy
|
|
EP2804586A4
(en)
|
2012-01-19 |
2016-03-16 |
Univ Johns Hopkins |
BIOMATERIALS CONTAINING HYALURONIC ACID BINDING PEPTIDES AND BIFUNCTIONAL BIOPOLYMERMOLUCKS FOR HYALURONIC ACIDIC TREATMENT AND TISSUE RENEWAL APPLICATIONS
|
|
ES2743399T3
(es)
|
2012-04-20 |
2020-02-19 |
Merus Nv |
Métodos y medios para la producción de moléculas heterodiméricas similares a Ig
|
|
WO2013163766A1
(en)
|
2012-05-04 |
2013-11-07 |
Cangene Corporation |
ANTIMICROBIAL COMPOSITIONS COMPRISING A HYALURONIC ACID BINDING PEPTIDE AND A β-LACTAM ANTIBIOTIC
|
|
KR20150038511A
(ko)
|
2012-08-02 |
2015-04-08 |
에프. 호프만-라 로슈 아게 |
불활성 면역글로불린 Ｆｃ-영역을 갖는 Ｆｃ-융합체로서의 가용성 ＦｃＲ 의 생산 방법 및 그의 용도
|
|
RU2015106812A
(ru)
|
2012-08-02 |
2016-09-27 |
Ф.Хоффманн-Ля Рош Аг |
Способ получения мономерных и мультимерных молекул и их применение
|
|
AU2013301582B2
(en)
|
2012-08-07 |
2018-09-06 |
Roche Glycart Ag |
Composition comprising two antibodies engineered to have reduced and increased effector function
|
|
JP6273205B2
(ja)
|
2012-10-05 |
2018-01-31 |
協和発酵キリン株式会社 |
ヘテロダイマータンパク質組成物
|
|
DK2927321T3
(da)
*
|
2012-11-27 |
2021-03-15 |
Univ Ajou Ind Academic Coop Found |
Ch3-domæne-variantpar der inducerer dannelse af heterodimer af tungkæde konstant region af antistof ved høj effektivitet, fremgangsmåde til fremstilling af samme, og anvendelse deraf
|
|
CA3093606A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Xencor, Inc. |
Heterodimeric proteins for induction of t cells
|
|
EA035645B1
(ru)
|
2013-03-15 |
2020-07-21 |
Дженентек, Инк. |
ПОЛИПЕПТИДЫ IL-22, ХИМЕРНЫЕ БЕЛКИ IL-22 Fc И ИХ ПРИМЕНЕНИЕ
|
|
US20140302037A1
(en)
|
2013-03-15 |
2014-10-09 |
Amgen Inc. |
BISPECIFIC-Fc MOLECULES
|
|
EP2970435B1
(en)
|
2013-03-15 |
2020-08-12 |
Eli Lilly and Company |
Methods for producing fabs and bi-specific antibodies
|
|
KR102266819B1
(ko)
|
2013-04-29 |
2021-06-18 |
에프. 호프만-라 로슈 아게 |
Fc-수용체 결합 개질된 비대칭 항체 및 이의 사용 방법
|
|
AR096891A1
(es)
|
2013-07-12 |
2016-02-03 |
Hanmi Pharm Ind Co Ltd |
Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo
|
|
UA117289C2
(uk)
|
2014-04-02 |
2018-07-10 |
Ф. Хоффманн-Ля Рош Аг |
Мультиспецифічне антитіло
|
|
ES2955736T3
(es)
|
2014-05-06 |
2023-12-05 |
Hoffmann La Roche |
Producción de proteínas heteromultiméricas usando células de mamífero
|
|
KR101721295B1
(ko)
|
2014-06-11 |
2017-04-10 |
주식회사 엘지화학 |
염화비닐계 수지의 제조방법
|
|
US10519234B2
(en)
|
2014-06-27 |
2019-12-31 |
Innate Pharma |
NKp46 binding proteins
|
|
EP3215524B1
(en)
|
2014-11-06 |
2021-01-13 |
F.Hoffmann-La Roche Ag |
Fc-region variants with modified fcrn- and protein a-binding properties
|
|
SI3215528T1
(sl)
|
2014-11-06 |
2019-11-29 |
Hoffmann La Roche |
Variante regije Fc s spremenjeno vezavo FcRn in postopki uporabe
|
|
CN104628870A
(zh)
*
|
2015-02-04 |
2015-05-20 |
中国药科大学 |
一种人IL12Rβ1-CHR蛋白及其Fc融合蛋白
|
|
JP6898303B2
(ja)
|
2015-08-07 |
2021-07-07 |
エーエルエックス オンコロジー インコーポレイテッド |
Ｓｉｒｐ−アルファドメインまたはそのバリアントを有する構築物
|
|
CA3001185A1
(en)
|
2015-10-06 |
2017-04-13 |
Regents Of The University Of Minnesota |
Nk engaging compounds and methods
|
|
KR101851380B1
(ko)
|
2015-10-12 |
2018-04-23 |
아주대학교산학협력단 |
효모접합을 이용한 항체 ch3 도메인 이종이중체 돌연변이쌍 제조 방법 및 이에 의하여 제조된 ch3 돌연변이체 쌍
|
|
WO2018007314A1
(en)
|
2016-07-04 |
2018-01-11 |
F. Hoffmann-La Roche Ag |
Novel antibody format
|
|
WO2018030806A1
(ko)
|
2016-08-10 |
2018-02-15 |
아주대학교산학협력단 |
항체 중쇄불변부위 이종이중체에 융합된 사이토카인 및 이를 포함하는 약제학적 조성물
|
|
ES3000558T3
(en)
|
2016-08-10 |
2025-02-28 |
Univ Ajou Ind Academic Coop Found |
Heterodimeric fc-fused cytokine and pharmaceutical composition comprising the same
|
|
KR101928981B1
(ko)
|
2016-09-02 |
2018-12-13 |
고려대학교 산학협력단 |
항체 중쇄불변부위 이종이중체 (heterodimeric Fc)에 융합된 IL-21 (heterodimeric Fc-fused IL-21) 및 이를 포함하는 약제학적 조성물
|
|
CN110214148A
(zh)
|
2016-10-14 |
2019-09-06 |
Xencor股份有限公司 |
含有IL-15/IL-15Rα Fc融合蛋白和PD-1抗体片段的双特异性异源二聚体融合蛋白
|
|
ES2955074T3
(es)
|
2017-02-20 |
2023-11-28 |
Dragonfly Therapeutics Inc |
Proteínas que se unen a HER2, NKG2D Y CD16
|
|
AU2018241624B2
(en)
|
2017-03-27 |
2024-01-25 |
F. Hoffmann-La Roche Ag |
Improved antigen binding receptors
|
|
CA3062519A1
(en)
|
2017-05-11 |
2018-11-15 |
Emd Millipore Corporation |
Method of maintaining narrow residence time distributions in continuous flow systems using solid material packet interfaces
|
|
MX2019013517A
(es)
|
2017-05-24 |
2020-08-17 |
Pandion Operations Inc |
Inmunotolerancia dirigida.
|
|
US11426706B2
(en)
|
2017-06-21 |
2022-08-30 |
Cephalon, Inc. |
Cation exchange chromatography wash buffer
|
|
JP2019014449A
(ja)
|
2017-07-10 |
2019-01-31 |
トヨタ自動車株式会社 |
車両用動力伝達装置
|
|
CN113004417A
(zh)
|
2017-09-07 |
2021-06-22 |
蜻蜓疗法股份有限公司 |
结合nkg2d、cd16和肿瘤相关抗原的蛋白质
|
|
CN111132997A
(zh)
|
2017-09-21 |
2020-05-08 |
默克专利有限公司 |
包含fgf-18部分的融合蛋白
|
|
MY202919A
(en)
|
2017-09-22 |
2024-05-29 |
Wuxi Biologics Ireland Ltd |
Novel bispecific polypeptide complexes
|
|
CN111246885B
(zh)
|
2017-10-20 |
2024-06-11 |
豪夫迈·罗氏有限公司 |
从单特异性抗体生成多特异性抗体的方法
|
|
BR112021000392A2
(pt)
|
2018-07-11 |
2021-04-06 |
Momenta Pharmaceuticals, Inc. |
Composições e métodos relacionados a construtos do domínio de ligação fc-antígeno manipulados
|
|
SG11202103192RA
(en)
|
2018-10-03 |
2021-04-29 |
Xencor Inc |
Il-12 heterodimeric fc-fusion proteins
|
|
AU2019366956B2
(en)
|
2018-10-23 |
2025-10-30 |
Dragonfly Therapeutics, Inc. |
Heterodimeric Fc-fused proteins
|