SG11201408536WA - METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF - Google Patents

METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF

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Publication number
SG11201408536WA
SG11201408536WA SG11201408536WA SG11201408536WA SG11201408536WA SG 11201408536W A SG11201408536W A SG 11201408536WA SG 11201408536W A SG11201408536W A SG 11201408536WA SG 11201408536W A SG11201408536W A SG 11201408536WA SG 11201408536W A SG11201408536W A SG 11201408536WA
Authority
SG
Singapore
Prior art keywords
international
penzberg
pct
fusion
denotes
Prior art date
Application number
SG11201408536WA
Inventor
Petra Rueger
Tilman Schlothauer
Stefan Seeber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201408536WA publication Critical patent/SG11201408536WA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70535Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70535Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau „ (10) International Publication Number (43) International Publication Date ^ ^ WO 2014/020056 A1 6 February 2014 (06.02.2014) WIPO I PCT (51) International Patent Classification: C12N15/79 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/EP2013/066065 31 July 2013 (31.07.2013) English English (30) Priority Data: 12179025.7 2 August 2012 (02.08.2012) (71) Applicant (for all designated States except US): F. HOFF­ MANN-LA ROCHE AG [CH/CH]; Grenzacher Strasse 124, CH-4070 Basel (CH). (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; 340 Kingsland Street, Nutley, New Jersey 07110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. I |i (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (72) Inventors: RUEGER, Petra; Auf der Leiten 4, 82377 Penzberg (DE). SCHLOTHAUER, Tilman; Sommer- strasse 3a, 82377 Penzberg (DE). SEEBER, Stefan; Bre- unetsrieder Weg 22, 82377 Penzberg (DE). (74) Agents: SKOLAUT, Alexander et al.; Roche Diagnostics GmbH, Patent Department (LPP 6164), P.O.Box 11 52, 82372 Penzberg (DE). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) V© © o CJ o o CJ o & (54) Title: METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF (57) Abstract: Herein is a fusion polypeptide with the formula R1-FC-R2, wherein R1 denotes a first Fc-receptor, R2 denotes a second Fc-receptor, and FC denotes heavy chain Fc-region polypeptide, wherein a R1 or R2 or both are present, wherein FC does not substantially bind to R1 and/or R2 and uses thereof.
SG11201408536WA 2012-08-02 2013-07-31 METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF SG11201408536WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12179025 2012-08-02
PCT/EP2013/066065 WO2014020056A1 (en) 2012-08-02 2013-07-31 METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF

Publications (1)

Publication Number Publication Date
SG11201408536WA true SG11201408536WA (en) 2015-01-29

Family

ID=48986096

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201408536WA SG11201408536WA (en) 2012-08-02 2013-07-31 METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF

Country Status (17)

Country Link
US (2) US10011644B2 (en)
EP (1) EP2880170B1 (en)
JP (1) JP6307077B2 (en)
KR (1) KR20150038511A (en)
CN (1) CN104508132B (en)
BR (1) BR112015002263A2 (en)
CA (1) CA2876096A1 (en)
DK (1) DK2880170T3 (en)
ES (1) ES2602030T3 (en)
HK (1) HK1208881A1 (en)
HU (1) HUE029634T2 (en)
MX (1) MX2015000681A (en)
PL (1) PL2880170T3 (en)
RU (1) RU2630659C2 (en)
SG (1) SG11201408536WA (en)
SI (1) SI2880170T1 (en)
WO (1) WO2014020056A1 (en)

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CN107206257A (en) * 2014-10-27 2017-09-26 英伊布里克斯有限合伙公司 Serpin fusion polypeptide and its application method
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
CN107849149A (en) 2015-03-13 2018-03-27 马里兰大学巴尔的摩分校 The biology sensor of universal antibody mediation
US20180284130A1 (en) * 2015-10-02 2018-10-04 The Macfarlane Burnet Institute For Medical Research And Publichealth Ltd Binding assays and method for probing antibody function with fc binding multimers
CN109071613A (en) 2016-05-11 2018-12-21 通用电气医疗集团生物工艺研发股份公司 Isolation medium
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
CN109311949B (en) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 Method for storing separation matrices
WO2017194593A1 (en) 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Method of cleaning and/or sanitizing a separation matrix
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
CA3026778A1 (en) * 2016-06-07 2017-12-14 Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinschaft Chimeric antigen receptor and car-t cells that bind bcma
BR112019002394B1 (en) 2016-08-10 2021-12-21 Ajou University Industry-Academic Cooperation Foundation HETERODIMERIC PROTEIN FLUTED WITH CF AND ITS USE
EP3784699A4 (en) 2018-04-25 2022-04-13 Prometheus Biosciences, Inc. Optimized anti-tl1a antibodies
SG11202104136YA (en) 2018-10-23 2021-05-28 Dragonfly Therapeutics Inc Heterodimeric fc-fused proteins
SG11202103568PA (en) * 2018-10-23 2021-05-28 Magenta Therapeutics Inc Fc silenced antibody drug conjugates (adcs) and uses thereof
KR20220103721A (en) 2019-10-24 2022-07-22 프로메테우스 바이오사이언시즈, 인크. Humanized Antibodies to TNF-Like Ligand 1A (TL1A) and Uses Thereof
GB2595299B (en) 2020-05-21 2022-08-03 Mabsolve Ltd Modified immunoglobulin FC regions

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Also Published As

Publication number Publication date
US10093714B1 (en) 2018-10-09
RU2630659C2 (en) 2017-09-11
HK1208881A1 (en) 2016-03-18
EP2880170A1 (en) 2015-06-10
WO2014020056A1 (en) 2014-02-06
EP2880170B1 (en) 2016-08-24
DK2880170T3 (en) 2016-10-24
MX2015000681A (en) 2015-04-10
US20150140683A1 (en) 2015-05-21
CN104508132B (en) 2017-09-15
HUE029634T2 (en) 2017-03-28
CN104508132A (en) 2015-04-08
PL2880170T3 (en) 2017-02-28
KR20150038511A (en) 2015-04-08
RU2015104625A (en) 2016-09-20
US20180265564A1 (en) 2018-09-20
BR112015002263A2 (en) 2017-12-12
SI2880170T1 (en) 2016-12-30
ES2602030T3 (en) 2017-02-17
CA2876096A1 (en) 2014-02-06
JP6307077B2 (en) 2018-04-04
US10011644B2 (en) 2018-07-03
JP2015526429A (en) 2015-09-10

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