JP2019536461A5 - - Google Patents
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- JP2019536461A5 JP2019536461A5 JP2019530100A JP2019530100A JP2019536461A5 JP 2019536461 A5 JP2019536461 A5 JP 2019536461A5 JP 2019530100 A JP2019530100 A JP 2019530100A JP 2019530100 A JP2019530100 A JP 2019530100A JP 2019536461 A5 JP2019536461 A5 JP 2019536461A5
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- 238000000034 method Methods 0.000 claims 37
- 210000001744 T-lymphocyte Anatomy 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 17
- 238000011534 incubation Methods 0.000 claims 13
- 108010002350 Interleukin-2 Proteins 0.000 claims 7
- 102000000588 Interleukin-2 Human genes 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 7
- 102000003812 Interleukin-15 Human genes 0.000 claims 5
- 108090000172 Interleukin-15 Proteins 0.000 claims 5
- 108091008874 T cell receptors Proteins 0.000 claims 5
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 102000006306 Antigen Receptors Human genes 0.000 claims 4
- 108010083359 Antigen Receptors Proteins 0.000 claims 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 239000013603 viral vector Substances 0.000 claims 4
- 108010029697 CD40 Ligand Proteins 0.000 claims 3
- 102100032937 CD40 ligand Human genes 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 3
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 3
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 3
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 3
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 3
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 3
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 3
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 3
- 108010002586 Interleukin-7 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 3
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 230000000638 stimulation Effects 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims 2
- 229960004308 acetylcysteine Drugs 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 230000022131 cell cycle Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 230000000284 resting effect Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 102100021696 Syncytin-1 Human genes 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 230000006052 T cell proliferation Effects 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022008417A JP2022058727A (ja) | 2016-12-05 | 2022-01-24 | 養子細胞療法のための操作細胞の産生 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430349P | 2016-12-05 | 2016-12-05 | |
| US62/430,349 | 2016-12-05 | ||
| PCT/US2017/064778 WO2018106732A1 (en) | 2016-12-05 | 2017-12-05 | Production of engineered cells for adoptive cell therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022008417A Division JP2022058727A (ja) | 2016-12-05 | 2022-01-24 | 養子細胞療法のための操作細胞の産生 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019536461A JP2019536461A (ja) | 2019-12-19 |
| JP2019536461A5 true JP2019536461A5 (https=) | 2021-01-21 |
Family
ID=60935957
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530100A Pending JP2019536461A (ja) | 2016-12-05 | 2017-12-05 | 養子細胞療法のための操作細胞の産生 |
| JP2022008417A Pending JP2022058727A (ja) | 2016-12-05 | 2022-01-24 | 養子細胞療法のための操作細胞の産生 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022008417A Pending JP2022058727A (ja) | 2016-12-05 | 2022-01-24 | 養子細胞療法のための操作細胞の産生 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20190350978A1 (https=) |
| EP (1) | EP3548611A1 (https=) |
| JP (2) | JP2019536461A (https=) |
| KR (1) | KR20190098747A (https=) |
| CN (1) | CN110249046A (https=) |
| AU (1) | AU2017370644A1 (https=) |
| BR (1) | BR112019011207A2 (https=) |
| CA (1) | CA3045338A1 (https=) |
| MA (1) | MA46998A (https=) |
| MX (1) | MX2019006438A (https=) |
| WO (1) | WO2018106732A1 (https=) |
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| RU2763795C2 (ru) | 2014-04-23 | 2022-01-11 | Джуно Терапьютикс, Инк. | Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| TWI750110B (zh) | 2014-07-21 | 2021-12-21 | 瑞士商諾華公司 | 使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症 |
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| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| KR102660336B1 (ko) | 2017-03-27 | 2024-04-26 | 내셔널 유니버시티 오브 싱가포르 | 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 |
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
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| JP7433230B2 (ja) | 2017-12-08 | 2024-02-19 | ジュノー セラピューティクス インコーポレイテッド | 細胞を培養するための無血清培地配合物およびその使用の方法 |
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-
2017
- 2017-12-05 AU AU2017370644A patent/AU2017370644A1/en not_active Abandoned
- 2017-12-05 KR KR1020197019497A patent/KR20190098747A/ko not_active Ceased
- 2017-12-05 WO PCT/US2017/064778 patent/WO2018106732A1/en not_active Ceased
- 2017-12-05 US US16/465,140 patent/US20190350978A1/en not_active Abandoned
- 2017-12-05 EP EP17825665.7A patent/EP3548611A1/en not_active Withdrawn
- 2017-12-05 CN CN201780085444.1A patent/CN110249046A/zh active Pending
- 2017-12-05 BR BR112019011207A patent/BR112019011207A2/pt not_active IP Right Cessation
- 2017-12-05 MA MA046998A patent/MA46998A/fr unknown
- 2017-12-05 MX MX2019006438A patent/MX2019006438A/es unknown
- 2017-12-05 CA CA3045338A patent/CA3045338A1/en active Pending
- 2017-12-05 JP JP2019530100A patent/JP2019536461A/ja active Pending
-
2022
- 2022-01-24 JP JP2022008417A patent/JP2022058727A/ja active Pending
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