JP2014526244A5 - - Google Patents
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- JP2014526244A5 JP2014526244A5 JP2014529143A JP2014529143A JP2014526244A5 JP 2014526244 A5 JP2014526244 A5 JP 2014526244A5 JP 2014529143 A JP2014529143 A JP 2014529143A JP 2014529143 A JP2014529143 A JP 2014529143A JP 2014526244 A5 JP2014526244 A5 JP 2014526244A5
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- Prior art keywords
- cells
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- cell population
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 71
- 238000000034 method Methods 0.000 claims 36
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 210000004443 dendritic cell Anatomy 0.000 claims 10
- 102000003812 Interleukin-15 Human genes 0.000 claims 9
- 102100030703 Interleukin-22 Human genes 0.000 claims 9
- 102100021592 Interleukin-7 Human genes 0.000 claims 9
- 108010002586 Interleukin-7 Proteins 0.000 claims 9
- 210000001744 T-lymphocyte Anatomy 0.000 claims 9
- 238000012258 culturing Methods 0.000 claims 9
- 210000001519 tissue Anatomy 0.000 claims 9
- 230000000779 depleting effect Effects 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 238000002054 transplantation Methods 0.000 claims 7
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 6
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 4
- 208000024908 graft versus host disease Diseases 0.000 claims 4
- 210000001165 lymph node Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 3
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 3
- 230000001464 adherent effect Effects 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000003614 tolerogenic effect Effects 0.000 claims 3
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000004738 parenchymal cell Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 1
- 102100033467 L-selectin Human genes 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532172P | 2011-09-08 | 2011-09-08 | |
| US61/532,172 | 2011-09-08 | ||
| PCT/IL2012/050354 WO2013035099A1 (en) | 2011-09-08 | 2012-09-06 | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526244A JP2014526244A (ja) | 2014-10-06 |
| JP2014526244A5 true JP2014526244A5 (https=) | 2015-10-29 |
| JP6196620B2 JP6196620B2 (ja) | 2017-09-13 |
Family
ID=47003163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529143A Active JP6196620B2 (ja) | 2011-09-08 | 2012-09-06 | 抗第三者セントラルメモリーｔ細胞、その作製方法ならびに移植および疾患処置におけるその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20140212398A1 (https=) |
| EP (1) | EP2753351B1 (https=) |
| JP (1) | JP6196620B2 (https=) |
| KR (1) | KR102073901B1 (https=) |
| CN (1) | CN103930130B (https=) |
| AU (1) | AU2012305931B2 (https=) |
| BR (1) | BR112014005355B1 (https=) |
| CA (1) | CA2848121C (https=) |
| ES (1) | ES2640813T3 (https=) |
| MX (1) | MX351226B (https=) |
| RU (1) | RU2636503C2 (https=) |
| SG (1) | SG11201400513PA (https=) |
| WO (1) | WO2013035099A1 (https=) |
| ZA (1) | ZA201401993B (https=) |
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| EP2365823B1 (en) | 2008-10-30 | 2016-11-30 | Yeda Research And Development Company Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| EP3101122B1 (en) | 2009-08-24 | 2023-06-14 | Baylor College of Medicine | Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses |
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| AU2012305931B2 (en) | 2011-09-08 | 2017-09-07 | Yeda Research And Development Co. Ltd | Anti third party central memory T cells, methods of producing same and use of same in transplantation and disease treatment |
| CN104769104A (zh) | 2011-12-12 | 2015-07-08 | 细胞药物有限公司 | 扩大t细胞的方法 |
| GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
| PT2812431T (pt) | 2012-02-09 | 2019-10-18 | Baylor College Medicine | Pepmixes para gerar ctls multivirais com larga especifidade |
| CN104411819B (zh) * | 2012-06-11 | 2019-05-10 | 威尔逊沃夫制造公司 | 用于过继细胞疗法的改进的细胞培养方法 |
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| JP7057748B2 (ja) | 2015-07-16 | 2022-04-20 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッド | 遺伝子改変された抗第三者中枢性メモリーｔ細胞および免疫療法におけるその使用 |
| AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
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| JP7185530B2 (ja) | 2016-06-13 | 2022-12-07 | トルク セラピューティクス， インコーポレイテッド | 免疫細胞機能を促進するための方法および組成物 |
| KR20190033066A (ko) * | 2016-06-24 | 2019-03-28 | 맥마스터 유니버시티 | 입양 세포 전달 및 종양붕괴 바이러스 병용 치료 |
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| US10751368B2 (en) | 2017-01-18 | 2020-08-25 | Yeda Research And Development Co. Ltd. | Methods of transplantation and disease treatment |
| CN110392736A (zh) * | 2017-01-18 | 2019-10-29 | 耶达研究及发展有限公司 | 遗传修饰的反抑细胞及其在免疫治疗中的用途 |
| EP3572502B1 (en) * | 2017-01-20 | 2023-01-11 | Kyoto University | Method for producing cd8alpha +beta + cytotoxic t cells |
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| CN109628396B (zh) * | 2019-01-24 | 2021-03-26 | 清华大学 | 记忆性淋巴细胞群在肝癌治疗中的应用 |
| JP2022543139A (ja) * | 2019-08-06 | 2022-10-07 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッド | ハプロタイプ一致幹細胞移植における抗ウイルスセントラルメモリーｃｄ８＋ベト細胞 |
| JP2023500277A (ja) * | 2019-11-05 | 2023-01-05 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | Ｔ細胞媒介性自己免疫疾患の治療におけるベト細胞の使用 |
| EP4055145A4 (en) * | 2019-11-05 | 2023-10-25 | Yeda Research and Development Co. Ltd | USE OF VETO CELLS FOR THE TREATMENT OF SICKLE CELL DISEASE |
| JP7771053B2 (ja) * | 2020-05-13 | 2025-11-17 | Ａｇｃ株式会社 | ヒトプロフェッショナル抗原提示細胞の製造方法 |
| IL300470A (en) * | 2020-08-11 | 2023-04-01 | Yeda res & development co ltd | Veto type CAR-T cells |
| CN116083359A (zh) * | 2021-11-05 | 2023-05-09 | 瑞创生物技术有限公司 | 一种体外大规模扩增富含Tscm和Tcm的双阴性T细胞的方法 |
| US20230287448A1 (en) * | 2022-01-20 | 2023-09-14 | 3T Biosciences, Inc. | T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells |
| US12584107B2 (en) | 2022-01-20 | 2026-03-24 | 3T Biosciences, Inc. | T cell receptor (TCR) compositions and methods for optimizing antigen reactive T-cells |
| WO2023154761A2 (en) * | 2022-02-08 | 2023-08-17 | The Wistar Institute Of Anatomy And Biology | Modified primary immune cells for induction or enhancement of immunotherapy |
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| MX2019000022A (es) | 2016-06-27 | 2019-09-18 | Yeda Res & Dev | Células veto generadas a partir de linfocitos t de memoria. |
| US10751368B2 (en) | 2017-01-18 | 2020-08-25 | Yeda Research And Development Co. Ltd. | Methods of transplantation and disease treatment |
| CN110392736A (zh) | 2017-01-18 | 2019-10-29 | 耶达研究及发展有限公司 | 遗传修饰的反抑细胞及其在免疫治疗中的用途 |
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