JP2025031794A5 - - Google Patents
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- JP2025031794A5 JP2025031794A5 JP2024223646A JP2024223646A JP2025031794A5 JP 2025031794 A5 JP2025031794 A5 JP 2025031794A5 JP 2024223646 A JP2024223646 A JP 2024223646A JP 2024223646 A JP2024223646 A JP 2024223646A JP 2025031794 A5 JP2025031794 A5 JP 2025031794A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- naive
- sample
- intracellular signaling
- beads
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 31
- 210000001744 T-lymphocyte Anatomy 0.000 claims 14
- 239000011324 bead Substances 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 230000004068 intracellular signaling Effects 0.000 claims 7
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 230000000139 costimulatory effect Effects 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 239000013603 viral vector Substances 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 2
- 229960004308 acetylcysteine Drugs 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 210000000662 T-lymphocyte subset Anatomy 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 238000002617 apheresis Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762543359P | 2017-08-09 | 2017-08-09 | |
| US62/543,359 | 2017-08-09 | ||
| JP2020506981A JP7824728B2 (ja) | 2017-08-09 | 2018-08-09 | 遺伝子操作された細胞を調製するための方法および組成物 |
| PCT/US2018/046151 WO2019032929A1 (en) | 2017-08-09 | 2018-08-09 | METHODS AND COMPOSITIONS FOR PREPARING GENETICALLY MODIFIED CELLS |
| JP2023015156A JP2023055888A (ja) | 2017-08-09 | 2023-02-03 | 遺伝子操作された細胞を調製するための方法および組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023015156A Division JP2023055888A (ja) | 2017-08-09 | 2023-02-03 | 遺伝子操作された細胞を調製するための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025031794A JP2025031794A (ja) | 2025-03-07 |
| JP2025031794A5 true JP2025031794A5 (https=) | 2025-03-28 |
Family
ID=63405422
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506981A Active JP7824728B2 (ja) | 2017-08-09 | 2018-08-09 | 遺伝子操作された細胞を調製するための方法および組成物 |
| JP2023015156A Pending JP2023055888A (ja) | 2017-08-09 | 2023-02-03 | 遺伝子操作された細胞を調製するための方法および組成物 |
| JP2024223646A Pending JP2025031794A (ja) | 2017-08-09 | 2024-12-19 | 遺伝子操作された細胞を調製するための方法および組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506981A Active JP7824728B2 (ja) | 2017-08-09 | 2018-08-09 | 遺伝子操作された細胞を調製するための方法および組成物 |
| JP2023015156A Pending JP2023055888A (ja) | 2017-08-09 | 2023-02-03 | 遺伝子操作された細胞を調製するための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20200239910A1 (https=) |
| EP (2) | EP3664835B1 (https=) |
| JP (3) | JP7824728B2 (https=) |
| KR (2) | KR20250096881A (https=) |
| CN (2) | CN111263641B (https=) |
| AU (2) | AU2018313952B2 (https=) |
| BR (1) | BR112020001601A2 (https=) |
| CA (1) | CA3070575A1 (https=) |
| ES (1) | ES2992909T3 (https=) |
| MA (1) | MA49981A (https=) |
| MX (1) | MX2020001491A (https=) |
| WO (1) | WO2019032929A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102550778B1 (ko) | 2017-05-26 | 2023-07-03 | 에이비비트로 엘엘씨 | 고-처리량 폴리뉴클레오타이드 라이브러리 시퀀싱 및 전사체 분석 |
| AU2018275894B2 (en) | 2017-06-02 | 2025-04-24 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| KR20250016455A (ko) | 2017-08-09 | 2025-02-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 유전자 조작된 세포 조성물 및 관련 조성물의 제조 방법 |
| US12258580B2 (en) | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| US12161670B2 (en) * | 2017-12-08 | 2024-12-10 | Juno Therapeutics, Inc. | Phenotypic markers for cell therapy and related methods |
| MX2020005907A (es) | 2017-12-08 | 2020-10-19 | Juno Therapeutics Inc | Formulacion de medio libre de suero para cultivar celulas y metodos de uso de la misma. |
| US12516099B2 (en) * | 2018-08-09 | 2026-01-06 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| AU2019372673A1 (en) | 2018-11-01 | 2021-05-27 | Gracell Biotechnologies (Shanghai) Co., Ltd. | Compositions and methods for T cell engineering |
| CA3142108A1 (en) | 2019-05-28 | 2020-12-03 | Miltenyi Biotec B.V. & Co. KG | Method for generation of genetically modified t cells |
| JP2022554348A (ja) | 2019-11-05 | 2022-12-28 | ジュノー セラピューティクス インコーポレイテッド | 治療用ｔ細胞組成物の属性を決定する方法 |
| JP2023512209A (ja) * | 2020-01-28 | 2023-03-24 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞形質導入のための方法 |
| IL295381B1 (en) * | 2020-02-12 | 2026-04-01 | Juno Therapeutics Inc | BCMA-directed chimeric T-cell antigen receptor compounds and methods and uses thereof |
| CA3158133A1 (en) | 2020-04-28 | 2021-11-04 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| KR20230024283A (ko) | 2020-05-13 | 2023-02-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | 임상 반응과 관련된 특징을 식별하는 방법 및 이의 용도 |
| KR20230152783A (ko) | 2020-07-07 | 2023-11-03 | 칸큐어 엘엘씨 | Mic 항체 및 결합제 및 이의 사용 방법 |
| US12144827B2 (en) | 2021-02-25 | 2024-11-19 | Lyell Immunopharma, Inc. | ROR1 targeting chimeric antigen receptor |
| US20250345432A1 (en) | 2022-05-25 | 2025-11-13 | Celgene Corporation | Method for predicting response to a t cell therapy |
| CN119506185A (zh) * | 2023-08-22 | 2025-02-25 | 深圳赛桥生物创新技术有限公司 | 细胞样本处理方法、装置、系统和介质 |
| WO2025097034A1 (en) * | 2023-11-03 | 2025-05-08 | Kyverna Therapeutics, Inc. | Methods for manufacture of engineered t cells from whole blood samples |
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-
2018
- 2018-08-09 EP EP18760160.4A patent/EP3664835B1/en active Active
- 2018-08-09 MX MX2020001491A patent/MX2020001491A/es unknown
- 2018-08-09 MA MA049981A patent/MA49981A/fr unknown
- 2018-08-09 JP JP2020506981A patent/JP7824728B2/ja active Active
- 2018-08-09 WO PCT/US2018/046151 patent/WO2019032929A1/en not_active Ceased
- 2018-08-09 EP EP24207574.5A patent/EP4516896A3/en active Pending
- 2018-08-09 CN CN201880065088.1A patent/CN111263641B/zh active Active
- 2018-08-09 KR KR1020257020439A patent/KR20250096881A/ko active Pending
- 2018-08-09 BR BR112020001601-2A patent/BR112020001601A2/pt unknown
- 2018-08-09 CA CA3070575A patent/CA3070575A1/en active Pending
- 2018-08-09 ES ES18760160T patent/ES2992909T3/es active Active
- 2018-08-09 KR KR1020207006719A patent/KR20200046045A/ko not_active Ceased
- 2018-08-09 US US16/637,447 patent/US20200239910A1/en not_active Abandoned
- 2018-08-09 CN CN202511529855.8A patent/CN121699876A/zh active Pending
- 2018-08-09 AU AU2018313952A patent/AU2018313952B2/en active Active
-
2023
- 2023-02-03 JP JP2023015156A patent/JP2023055888A/ja active Pending
-
2024
- 2024-03-26 US US18/617,271 patent/US20240368625A1/en active Pending
- 2024-12-19 JP JP2024223646A patent/JP2025031794A/ja active Pending
-
2025
- 2025-10-08 AU AU2025248649A patent/AU2025248649A1/en not_active Abandoned
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