CN110249046A - 用于过继细胞疗法的工程化细胞的产生 - Google Patents

用于过继细胞疗法的工程化细胞的产生 Download PDF

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CN110249046A
CN110249046A CN201780085444.1A CN201780085444A CN110249046A CN 110249046 A CN110249046 A CN 110249046A CN 201780085444 A CN201780085444 A CN 201780085444A CN 110249046 A CN110249046 A CN 110249046A
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cell
cells
antigen
composition
receptor
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P·博切斯
S·U·塔瑞恩
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Juno Therapeutics Inc
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Juno Therapeutics Inc
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CN201780085444.1A 2016-12-05 2017-12-05 用于过继细胞疗法的工程化细胞的产生 Pending CN110249046A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662430349P 2016-12-05 2016-12-05
US62/430,349 2016-12-05
PCT/US2017/064778 WO2018106732A1 (en) 2016-12-05 2017-12-05 Production of engineered cells for adoptive cell therapy

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CN110249046A true CN110249046A (zh) 2019-09-17

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US (1) US20190350978A1 (https=)
EP (1) EP3548611A1 (https=)
JP (2) JP2019536461A (https=)
KR (1) KR20190098747A (https=)
CN (1) CN110249046A (https=)
AU (1) AU2017370644A1 (https=)
BR (1) BR112019011207A2 (https=)
CA (1) CA3045338A1 (https=)
MA (1) MA46998A (https=)
MX (1) MX2019006438A (https=)
WO (1) WO2018106732A1 (https=)

Cited By (7)

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CN111542596A (zh) * 2017-11-01 2020-08-14 朱诺治疗学股份有限公司 产生工程化细胞的治疗性组合物的方法
CN112831525A (zh) * 2020-10-21 2021-05-25 东莞清实生物科技有限公司 一种简单高效的慢病毒冻存液及其应用
WO2021148019A1 (zh) * 2020-01-22 2021-07-29 科济生物医药（上海）有限公司 病毒载体转导细胞的方法
CN113846099A (zh) * 2021-09-23 2021-12-28 中国农业科学院兰州兽医研究所 用于敲低猪SAMHD1基因表达的siRNA、试剂盒及其应用
CN115135148A (zh) * 2020-01-21 2022-09-30 武田药品工业株式会社 冷冻保存细胞的组合物和方法
CN115380045A (zh) * 2020-02-11 2022-11-22 Hcw生物科技公司 激活调节性t细胞的方法
CN115485370A (zh) * 2020-03-20 2022-12-16 美国卫生和人力服务部 通过单细胞分析从肿瘤分离t细胞和t细胞受体以用于免疫疗法的方法

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BR112017001183A2 (pt) 2014-07-21 2017-11-28 Novartis Ag tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado
EP3365453A2 (en) 2015-10-22 2018-08-29 Juno Therapeutics GmbH Methods, kits, agents and apparatuses for transduction
CA3056591A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
BR112019019917A2 (pt) 2017-03-27 2020-04-22 Nat Univ Singapore receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais
US11649442B2 (en) 2017-09-08 2023-05-16 The Regents Of The University Of California RNA-guided endonuclease fusion polypeptides and methods of use thereof
CN119193493A (zh) 2017-12-08 2024-12-27 朱诺治疗学股份有限公司 生产工程化t细胞组合物的过程
MX2020005907A (es) 2017-12-08 2020-10-19 Juno Therapeutics Inc Formulacion de medio libre de suero para cultivar celulas y metodos de uso de la misma.
EP3749685A4 (en) 2018-02-09 2021-12-22 National University of Singapore ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY
JP7334985B2 (ja) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
TWI890660B (zh) 2018-06-13 2025-07-21 瑞士商諾華公司 Bcma 嵌合抗原受體及其用途
US12516099B2 (en) 2018-08-09 2026-01-06 Juno Therapeutics, Inc. Processes for generating engineered cells and compositions thereof
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
EP4635978A2 (en) * 2018-08-31 2025-10-22 Novartis AG Methods of making chimeric antigen receptor-expressing cells
EP3844265A2 (en) * 2018-08-31 2021-07-07 Novartis AG Methods of making chimeric antigen receptor-expressing cells
WO2020092696A1 (en) * 2018-10-31 2020-05-07 Musc Foundation For Research Development Ex vivo activation and expansion of t cells for adoptive cell transfer therapy
AU2019372673A1 (en) 2018-11-01 2021-05-27 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for T cell engineering
WO2020102701A1 (en) * 2018-11-16 2020-05-22 Rapa Therapeutics, Llc Methods for the manufacture of th1/tc1 phenotype t cells
US10918667B2 (en) * 2018-11-20 2021-02-16 Innovative Cellular Therapeutics CO., LTD. Modified cell expressing therapeutic agent and uses thereof
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
JP2022518934A (ja) * 2019-01-29 2022-03-17 ジーピービー・サイエンティフィック・インコーポレイテッド 向上した生産性および医薬的特徴を持つ細胞集団
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
EP3953455A1 (en) * 2019-04-12 2022-02-16 Novartis AG Methods of making chimeric antigen receptor-expressing cells
US11840575B2 (en) 2019-05-07 2023-12-12 Gracell Biotechnologies (Shanghai) Co., Ltd. Engineered immune cells targeting BCMA and their uses thereof
CA3142108A1 (en) * 2019-05-28 2020-12-03 Miltenyi Biotec B.V. & Co. KG Method for generation of genetically modified t cells
KR20220073738A (ko) * 2019-08-30 2022-06-03 주노 쎄러퓨티크스 인코퍼레이티드 세포 분류를 위한 기계 학습 방법
EP4065157A1 (en) 2019-11-26 2022-10-05 Novartis AG Cd19 and cd22 chimeric antigen receptors and uses thereof
AU2021213735A1 (en) * 2020-01-30 2022-09-22 Umoja Biopharma, Inc. Bispecific transduction enhancer
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