|
US5190864A
(en)
|
1986-04-15 |
1993-03-02 |
Northeastern University |
Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
|
|
US4801726A
(en)
|
1986-04-15 |
1989-01-31 |
Northeastern University |
Repetitive hit-and-run immunoassay and stable support-analyte conjugates; applied to T-2 toxin
|
|
US4937188A
(en)
|
1986-04-15 |
1990-06-26 |
Northeastern University |
Enzyme activity amplification method for increasing assay sensitivity
|
|
US5412083A
(en)
|
1992-04-16 |
1995-05-02 |
Northeastern University |
Carbohydrate heterobifunctional cross-linking reagent
|
|
US5429746A
(en)
|
1994-02-22 |
1995-07-04 |
Smith Kline Beecham Corporation |
Antibody purification
|
|
WO1996025425A1
(en)
|
1995-02-16 |
1996-08-22 |
Massachusetts Health Research Institute, Inc. |
Purified tetanus toxoid and toxin
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5695760A
(en)
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
DE69922740T2
(de)
|
1998-05-11 |
2005-12-08 |
Tosoh Corp., Shinnanyo |
Methode zur Trennung von Nucleinsäuren mittels Flüssigchromatographie
|
|
US7070959B1
(en)
|
1999-06-08 |
2006-07-04 |
Regeneron Pharmaceuticals, Inc. |
Modified chimeric polypeptides with improved pharmacokinetic properties
|
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
|
US7306799B2
(en)
|
1999-06-08 |
2007-12-11 |
Regeneron Pharmaceuticals, Inc. |
Use of VEGF inhibitors for treatment of eye disorders
|
|
US7303746B2
(en)
|
1999-06-08 |
2007-12-04 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating eye disorders with modified chimeric polypeptides
|
|
AU2002213441B2
(en)
|
2000-10-12 |
2006-10-26 |
Genentech, Inc. |
Reduced-viscosity concentrated protein formulations
|
|
US20020064860A1
(en)
|
2000-11-29 |
2002-05-30 |
Schering Corporation |
Method for purifying adenoviruses
|
|
US7101982B2
(en)
|
2001-03-30 |
2006-09-05 |
Immunex Corporation |
Control of ph transitions during chromatography
|
|
US20100333219A1
(en)
*
|
2001-11-30 |
2010-12-30 |
Synageva Biopharma Corp. |
Methods of protein production using ovomucoid regulatory regions
|
|
CA2496918A1
(en)
|
2002-08-28 |
2004-03-11 |
Introgen Therapeutics Inc. |
Chromatographic methods for adenovirus purification
|
|
DK1545574T3
(da)
|
2002-09-13 |
2014-09-08 |
Biogen Idec Inc |
Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografi
|
|
SE0300612D0
(sv)
*
|
2003-03-05 |
2003-03-05 |
Amersham Biosciences Ab |
A method of preparing ligands for hydrophobic interaction chromatography
|
|
WO2004087761A1
(ja)
|
2003-03-31 |
2004-10-14 |
Kirin Beer Kabushiki Kaisha |
ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
|
|
CA2529945A1
(en)
|
2003-06-27 |
2005-01-06 |
Biogen Idec Ma Inc. |
Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
|
|
DE602004026343D1
(de)
|
2003-10-24 |
2010-05-12 |
Amgen Inc |
Verfahren zur aufreinigung von proteinen in einer durchflussfraktion aus der chromatographie mit hydrophoben wechselwirkungen
|
|
US8084032B2
(en)
|
2004-01-21 |
2011-12-27 |
Ajinomoto Co., Inc. |
Purification method which prevents denaturation of an antibody
|
|
AU2005216847B2
(en)
|
2004-02-27 |
2010-04-01 |
Cytiva Bioprocess R&D Ab |
A process for the purification of antibodies
|
|
SE0400501D0
(sv)
|
2004-02-27 |
2004-02-27 |
Amersham Biosciences Ab |
Antibody purification
|
|
AU2005218642B2
(en)
*
|
2004-03-02 |
2011-04-28 |
Seagen Inc. |
Partially loaded antibodies and methods of their conjugation
|
|
SE0400886D0
(sv)
|
2004-04-02 |
2004-04-02 |
Amersham Biosciences Ab |
Process of purification
|
|
WO2006020622A1
(en)
|
2004-08-09 |
2006-02-23 |
Guild Associates, Inc. |
Procedure for the fractionation of proteins by using sequential ion exchange and hydrophobic interaction chromatography as prefractionation steps before analysis by two dimensional electrophoresis
|
|
US7795405B2
(en)
|
2004-08-09 |
2010-09-14 |
Guild Associates, Inc. |
Procedure for the fractionation of proteins by using sequential ion exchange and hydrophobic interaction chromatography as prefractionation steps before analysis by two dimensional electrophoresis
|
|
KR101243601B1
(ko)
|
2004-10-21 |
2013-03-20 |
지이 헬스케어 바이오-사이언시스 에이비 |
크로마토그래피 리간드
|
|
EP1810035A4
(en)
*
|
2004-11-10 |
2010-03-17 |
Macrogenics Inc |
GENERATION OF FC ANTIBODY REGIONS FOR EFFECTOR FUNCTION
|
|
US7303748B2
(en)
|
2005-02-02 |
2007-12-04 |
Regeneron Pharmaceuticals, Inc. |
Method of treating eye injury with local administration of a VEGF inhibitor
|
|
EP1861708A2
(en)
*
|
2005-03-08 |
2007-12-05 |
Tanox, Inc. |
Methods for determining the bivalency of protein and antibody therapeutics
|
|
US20080299671A1
(en)
|
2005-12-02 |
2008-12-04 |
Ge Healthcare Bio-Sciences Ab |
Hydrophobic Interaction Chromatography
|
|
WO2007110339A1
(en)
|
2006-03-28 |
2007-10-04 |
F. Hoffmann-La Roche Ag |
Anti-igf-1r human monoclonal antibody formulation
|
|
KR20140071452A
(ko)
|
2006-04-05 |
2014-06-11 |
애브비 바이오테크놀로지 리미티드 |
항체 정제
|
|
US7608261B2
(en)
|
2006-06-16 |
2009-10-27 |
Regeneron Pharmacuticals, Inc. |
VEGF antagonist formulations suitable for intravitreal administration
|
|
US9766217B2
(en)
|
2006-09-08 |
2017-09-19 |
Novo Nordisk A/S |
Methods of optimizing chromatographic separation of polypeptides
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
US20100015652A1
(en)
*
|
2006-12-21 |
2010-01-21 |
Brian Walter Granda |
Antibody quantitation
|
|
WO2008109721A1
(en)
|
2007-03-06 |
2008-09-12 |
Introgen Therapeutics, Inc. |
Chromatographic methods for assessing adenovirus purity
|
|
EP2144628B1
(en)
*
|
2007-05-08 |
2012-10-17 |
Genentech, Inc. |
Cysteine engineered anti-muc16 antibodies and antibody drug conjugates
|
|
US8003364B2
(en)
|
2007-05-14 |
2011-08-23 |
Bavarian Nordic A/S |
Purification of vaccinia viruses using hydrophobic interaction chromatography
|
|
WO2009058769A1
(en)
|
2007-10-30 |
2009-05-07 |
Schering Corporation |
Purification of antibodies containing hydrophobic variants
|
|
NZ587161A
(en)
|
2008-01-25 |
2012-02-24 |
Biogen Idec Inc |
Automated system and and method for monitoring chromatography column performance by calculating performance parameters based on noise reduced process values
|
|
JP5635509B2
(ja)
|
2008-08-15 |
2014-12-03 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
クロマトグラフィーカラムの性能を評価するための方法
|
|
US20100069617A1
(en)
|
2008-09-12 |
2010-03-18 |
Ge Healthcare Bio-Sciences Ab |
Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions
|
|
MX2011004201A
(es)
|
2008-10-20 |
2011-05-24 |
Abbott Lab |
Desactivacion viral durante purificacion de anticuerpos.
|
|
AU2009347206C1
(en)
|
2008-10-20 |
2016-12-08 |
Abbvie Inc. |
Isolation and purification of antibodies using Protein A affinity chromatography
|
|
MX2011011772A
(es)
|
2009-05-04 |
2012-02-08 |
Abbott Biotech Ltd |
Formulaicones estables de anticuerpos humanos anti-tnf-alfa con alta concentracion de proteina.
|
|
HUE028341T2
(en)
|
2009-06-16 |
2016-12-28 |
Genzyme Corp |
Improved methods for purification of recombinant aav vectors
|
|
SG178078A1
(en)
*
|
2009-07-24 |
2012-03-29 |
Hoffmann La Roche |
Optimizing the production of antibodies
|
|
MX2012000735A
(es)
*
|
2009-07-30 |
2012-01-27 |
Hoffmann La Roche |
Separador de columna de cromatografia movible.
|
|
WO2011028961A2
(en)
*
|
2009-09-04 |
2011-03-10 |
Xoma Technology Ltd. |
Anti-botulism antibody coformulations
|
|
ES2813398T3
(es)
|
2009-10-20 |
2021-03-23 |
Abbvie Inc |
Aislamiento y purificación de anticuerpos anti-IL-13 usando cromatografía de afinidad a Proteína A
|
|
US8246833B2
(en)
|
2009-12-17 |
2012-08-21 |
Ge Healthcare Bio-Sciences Ab |
Chromatography column and maintenance method
|
|
JP2013519652A
(ja)
|
2010-02-12 |
2013-05-30 |
ディーエスエム アイピー アセッツ ビー．ブイ． |
単一ユニット抗体精製
|
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
|
SG190069A1
(en)
|
2010-11-11 |
2013-06-28 |
Abbvie Biotechnology Ltd |
IMPROVED HIGH CONCENTRATION ANTI-TNFa ANTIBODY LIQUID FORMULATIONS
|
|
CA2821711C
(en)
|
2010-12-15 |
2017-10-10 |
Baxter International Inc. |
Eluate collection using conductivity gradient
|
|
EP2500073A1
(en)
*
|
2011-03-17 |
2012-09-19 |
ChromaCon AG |
Method for identification and purification of multi-specific polypeptides
|
|
US9943594B2
(en)
|
2011-10-11 |
2018-04-17 |
Sanofi Biotechnology |
Methods for the treatment of rheumatoid arthritis
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
EP2768857B1
(en)
*
|
2011-10-19 |
2020-01-01 |
NovImmune SA |
Methods of purifying antibodies
|
|
US20140288278A1
(en)
|
2011-10-31 |
2014-09-25 |
Joseph Nti-Gyabaah |
Chromatography process for resolving heterogeneous antibody aggregates
|
|
AU2012339722B2
(en)
|
2011-11-14 |
2017-09-14 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and/or Activin A
|
|
EP2782932A1
(en)
|
2011-11-21 |
2014-10-01 |
F.Hoffmann-La Roche Ag |
Purification of anti-c-met antibodies
|
|
ES2690213T3
(es)
|
2011-12-15 |
2018-11-19 |
Prestige Biopharma Pte. Ltd. |
Un método de purificación de anticuerpos
|
|
WO2013158273A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Methods to modulate c-terminal lysine variant distribution
|
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
|
US9150645B2
(en)
|
2012-04-20 |
2015-10-06 |
Abbvie, Inc. |
Cell culture methods to reduce acidic species
|
|
US20140154270A1
(en)
|
2012-05-21 |
2014-06-05 |
Chen Wang |
Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
|
|
TW201348246A
(zh)
|
2012-05-21 |
2013-12-01 |
Abbvie Inc |
利用蛋白質ａ親和性層析之人類、人類化或嵌合抗體之新穎純化
|
|
US9249182B2
(en)
|
2012-05-24 |
2016-02-02 |
Abbvie, Inc. |
Purification of antibodies using hydrophobic interaction chromatography
|
|
WO2014025771A2
(en)
|
2012-08-06 |
2014-02-13 |
Biogen Idec Ma Inc. |
Methods and compositions for inactivating enveloped viruses
|
|
US9650411B2
(en)
|
2012-08-07 |
2017-05-16 |
Kyowa Hakko Kirin Co., Ltd. |
Method of purifying protein
|
|
JOP20200236A1
(ar)
*
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
GB201218341D0
(en)
*
|
2012-10-12 |
2012-11-28 |
Orign Sciences Ltd |
Diagnostic method
|
|
US20150344557A1
(en)
|
2012-12-20 |
2015-12-03 |
Medlmmune, Llc |
Liquid Antibody Formulation With Improved Aggregation Properties
|
|
JO3405B1
(ar)
|
2013-01-09 |
2019-10-20 |
Regeneron Pharma |
الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها
|
|
SG10201709131UA
(en)
|
2013-03-08 |
2017-12-28 |
Genzyme Corp |
Continuous purification of therapeutic proteins
|
|
SG11201507230PA
(en)
|
2013-03-12 |
2015-10-29 |
Abbvie Inc |
Human antibodies that bind human tnf-alpha and methods of preparing the same
|
|
US10118971B2
(en)
*
|
2013-03-13 |
2018-11-06 |
Ibentrus, Inc. |
Protein in which electrical interaction is introduced within hydrophobic interaction site and preparation method therefor
|
|
US10023608B1
(en)
|
2013-03-13 |
2018-07-17 |
Amgen Inc. |
Protein purification methods to remove impurities
|
|
CA2926301A1
(en)
|
2013-03-14 |
2014-10-02 |
Abbvie Inc. |
Low acidic species compositions and methods for producing and using the same
|
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
|
DK2970378T3
(da)
|
2013-03-15 |
2021-08-23 |
Biogen Ma Inc |
Hydrofob interaktionsproteinkromatografi under saltfrie betingelser
|
|
WO2014145744A1
(en)
|
2013-03-15 |
2014-09-18 |
Alder Biopharmaceuticals, Inc. |
Antibody purification and purity monitoring
|
|
CN105209076A
(zh)
*
|
2013-03-15 |
2015-12-30 |
阿布维公司 |
抗体药物偶联物(adc)纯化
|
|
HRP20251426T1
(hr)
|
2013-05-06 |
2026-01-02 |
Scholar Rock, Inc. |
Sastavi i postupci za modulaciju faktora rasta
|
|
US10111953B2
(en)
|
2013-05-30 |
2018-10-30 |
Regeneron Pharmaceuticals, Inc. |
Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
|
|
TWI682780B
(zh)
|
2013-05-30 |
2020-01-21 |
美商再生元醫藥公司 |
醫藥組成物用於製造治療與ｐｃｓｋ９功能獲得性突變有關之體染色體顯性高膽固醇血症的藥物之用途
|
|
TWI755763B
(zh)
|
2013-06-04 |
2022-02-21 |
美商再生元醫藥公司 |
藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
|
|
KR101569783B1
(ko)
|
2013-06-05 |
2015-11-19 |
한화케미칼 주식회사 |
항체의 정제 방법
|
|
US9150938B2
(en)
|
2013-06-12 |
2015-10-06 |
Orochem Technologies, Inc. |
Tagatose production from deproteinized whey and purification by continuous chromatography
|
|
AR096713A1
(es)
|
2013-06-25 |
2016-01-27 |
Cadila Healthcare Ltd |
Proceso de purificación para anticuerpos monoclonales
|
|
RU2016112549A
(ru)
|
2013-09-05 |
2017-10-10 |
Дженентек, Инк. |
Способ для повторного использования хроматографии
|
|
EP4331605A3
(en)
|
2013-09-13 |
2024-05-22 |
F. Hoffmann-La Roche AG |
Methods and compositions comprising purified recombinant polypeptides
|
|
ES2915378T3
(es)
|
2013-09-13 |
2022-06-22 |
Hoffmann La Roche |
Procedimientos para detectar y cuantificar una proteína de célula huésped en líneas celulares
|
|
SG11201601763SA
(en)
*
|
2013-09-20 |
2016-04-28 |
Bristol Myers Squibb Co |
Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors
|
|
US8946395B1
(en)
|
2013-10-18 |
2015-02-03 |
Abbvie Inc. |
Purification of proteins using hydrophobic interaction chromatography
|
|
US20160251441A1
(en)
|
2013-10-25 |
2016-09-01 |
Medimmune, Llc |
Antibody purification
|
|
US10115576B2
(en)
|
2013-12-12 |
2018-10-30 |
Waters Technologies Corporation |
Method and an apparatus for analyzing a complex sample
|
|
WO2015099838A2
(en)
*
|
2013-12-24 |
2015-07-02 |
Novelmed Therapeutics, Inc. |
Compositions and methods of treating ocular diseases
|
|
JO3701B1
(ar)
*
|
2014-05-23 |
2021-01-31 |
Regeneron Pharma |
مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
|
|
FR3025515B1
(fr)
|
2014-09-05 |
2016-09-09 |
Lab Francais Du Fractionnement |
Procede de purification d'un anticorps monoclonal
|
|
TW201628649A
(zh)
|
2014-10-09 |
2016-08-16 |
再生元醫藥公司 |
減少醫藥調配物中微可見顆粒之方法
|
|
JP2016088937A
(ja)
*
|
2014-10-31 |
2016-05-23 |
オーストリッチファーマ株式会社 |
エボラウイルスに対する抗体および抗体の製造方法
|
|
WO2016089886A2
(en)
|
2014-12-02 |
2016-06-09 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating dry eye disease by administering an il-6r antagonist
|
|
EP3247718B1
(en)
|
2015-01-21 |
2021-09-01 |
Outlook Therapeutics, Inc. |
Modulation of charge variants in a monoclonal antibody composition
|
|
TWI710573B
(zh)
|
2015-01-26 |
2020-11-21 |
美商再生元醫藥公司 |
抗伊波拉病毒醣蛋白之人類抗體
|
|
TWI756187B
(zh)
|
2015-10-09 |
2022-03-01 |
美商再生元醫藥公司 |
抗ｌａｇ３抗體及其用途
|
|
AU2016378573A1
(en)
|
2015-12-22 |
2018-07-19 |
Regeneron Pharmaceuticals, Inc. |
Bispecific anti-CD20/anti-CD3 antibodies to treat acute lymphoblastic leukemia
|
|
JP7126941B2
(ja)
|
2015-12-22 |
2022-08-29 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
がんを治療するための抗ｐｄ－１抗体と二重特異性抗ｃｄ２０／抗ｃｄ３抗体の組合せ
|
|
EP3184119A1
(en)
|
2015-12-23 |
2017-06-28 |
Themis Bioscience GmbH |
Chromatography based purification strategies for measles scaffold based viruses
|
|
GB201602938D0
(en)
|
2016-02-19 |
2016-04-06 |
Ucb Biopharma Sprl |
Protein purification
|
|
US10947262B2
(en)
|
2016-06-14 |
2021-03-16 |
Biogen Ma Inc. |
Hydrophobic interaction chromatography for purification of oligonucleotides
|
|
WO2018027195A1
(en)
|
2016-08-05 |
2018-02-08 |
Abbvie Biotherapeutics Inc. |
Compositions containing reduced amounts of daclizumab acidic isoforms and methods for preparing the same
|
|
US10626376B2
(en)
|
2016-11-14 |
2020-04-21 |
St. Jude Children's Research Hospital |
Method for isolating and purifying adeno-associated virus particles using salt
|
|
WO2019040671A1
(en)
|
2017-08-22 |
2019-02-28 |
Biogen Ma Inc. |
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|
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|
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|
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|
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|
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|
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|
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|
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|
|
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