JP2019528797A5 - - Google Patents
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- JP2019528797A5 JP2019528797A5 JP2019539732A JP2019539732A JP2019528797A5 JP 2019528797 A5 JP2019528797 A5 JP 2019528797A5 JP 2019539732 A JP2019539732 A JP 2019539732A JP 2019539732 A JP2019539732 A JP 2019539732A JP 2019528797 A5 JP2019528797 A5 JP 2019528797A5
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- 210000004027 cell Anatomy 0.000 claims 37
- 150000007523 nucleic acids Chemical group 0.000 claims 22
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 19
- -1 egl6 Proteins 0.000 claims 18
- 230000002538 fungal effect Effects 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 239000002157 polynucleotide Substances 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 15
- 101100378100 Mus musculus Ace3 gene Proteins 0.000 claims 10
- 230000001939 inductive effect Effects 0.000 claims 9
- 239000000758 substrate Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 6
- 108010059892 Cellulase Proteins 0.000 claims 5
- 102000035195 Peptidases Human genes 0.000 claims 5
- 108091005804 Peptidases Proteins 0.000 claims 5
- 102100026189 Beta-galactosidase Human genes 0.000 claims 4
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims 4
- 102100022624 Glucoamylase Human genes 0.000 claims 4
- 241000499912 Trichoderma reesei Species 0.000 claims 4
- 108090000637 alpha-Amylases Proteins 0.000 claims 4
- 102000004139 alpha-Amylases Human genes 0.000 claims 4
- 108010030291 alpha-Galactosidase Proteins 0.000 claims 4
- 102000005840 alpha-Galactosidase Human genes 0.000 claims 4
- 229940024171 alpha-amylase Drugs 0.000 claims 4
- 108010005774 beta-Galactosidase Proteins 0.000 claims 4
- 229940106157 cellulase Drugs 0.000 claims 4
- 235000019833 protease Nutrition 0.000 claims 4
- 239000004382 Amylase Substances 0.000 claims 3
- 108010065511 Amylases Proteins 0.000 claims 3
- 102000013142 Amylases Human genes 0.000 claims 3
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 3
- 101100272090 Hypocrea jecorina axe1 gene Proteins 0.000 claims 3
- 235000019418 amylase Nutrition 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 3
- 230000012010 growth Effects 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 230000014616 translation Effects 0.000 claims 3
- 108010011619 6-Phytase Proteins 0.000 claims 2
- 108091005508 Acid proteases Proteins 0.000 claims 2
- 102000004400 Aminopeptidases Human genes 0.000 claims 2
- 108090000915 Aminopeptidases Proteins 0.000 claims 2
- 108010005694 Aspartate 4-decarboxylase Proteins 0.000 claims 2
- 108090000145 Bacillolysin Proteins 0.000 claims 2
- 101100499346 Caenorhabditis elegans dld-1 gene Proteins 0.000 claims 2
- 102000005367 Carboxypeptidases Human genes 0.000 claims 2
- 108010006303 Carboxypeptidases Proteins 0.000 claims 2
- 108010031396 Catechol oxidase Proteins 0.000 claims 2
- 102000030523 Catechol oxidase Human genes 0.000 claims 2
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 2
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 2
- 108010001682 Dextranase Proteins 0.000 claims 2
- 101100278473 Drosophila melanogaster PolZ1 gene Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108010036781 Fumarate Hydratase Proteins 0.000 claims 2
- 102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 claims 2
- 108010015776 Glucose oxidase Proteins 0.000 claims 2
- 239000004366 Glucose oxidase Substances 0.000 claims 2
- 108010062875 Hydroxysteroid Dehydrogenases Proteins 0.000 claims 2
- 102000011145 Hydroxysteroid Dehydrogenases Human genes 0.000 claims 2
- 101100398376 Hypocrea jecorina pki1 gene Proteins 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 108010059881 Lactase Proteins 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 108090001060 Lipase Proteins 0.000 claims 2
- 102000004882 Lipase Human genes 0.000 claims 2
- 239000004367 Lipase Substances 0.000 claims 2
- 108090000856 Lyases Proteins 0.000 claims 2
- 102000004317 Lyases Human genes 0.000 claims 2
- 102100024295 Maltase-glucoamylase Human genes 0.000 claims 2
- 108010054377 Mannosidases Proteins 0.000 claims 2
- 102000001696 Mannosidases Human genes 0.000 claims 2
- 101100216047 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) gla-1 gene Proteins 0.000 claims 2
- 108091005507 Neutral proteases Proteins 0.000 claims 2
- 102000035092 Neutral proteases Human genes 0.000 claims 2
- 108010073038 Penicillin Amidase Proteins 0.000 claims 2
- 108090000284 Pepsin A Proteins 0.000 claims 2
- 102000057297 Pepsin A Human genes 0.000 claims 2
- 102000003992 Peroxidases Human genes 0.000 claims 2
- 108010059820 Polygalacturonase Proteins 0.000 claims 2
- 108090000783 Renin Proteins 0.000 claims 2
- 102100028255 Renin Human genes 0.000 claims 2
- 108010083644 Ribonucleases Proteins 0.000 claims 2
- 102000006382 Ribonucleases Human genes 0.000 claims 2
- 108060008539 Transglutaminase Proteins 0.000 claims 2
- 241000223259 Trichoderma Species 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 108010028144 alpha-Glucosidases Proteins 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 229940009098 aspartate Drugs 0.000 claims 2
- 108010019077 beta-Amylase Proteins 0.000 claims 2
- 108010051210 beta-Fructofuranosidase Proteins 0.000 claims 2
- 108010005400 cutinase Proteins 0.000 claims 2
- YERABYSOHUZTPQ-UHFFFAOYSA-P endo-1,4-beta-Xylanase Chemical compound C=1C=CC=CC=1C[N+](CC)(CC)CCCNC(C(C=1)=O)=CC(=O)C=1NCCC[N+](CC)(CC)CC1=CC=CC=C1 YERABYSOHUZTPQ-UHFFFAOYSA-P 0.000 claims 2
- 229940088598 enzyme Drugs 0.000 claims 2
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 claims 2
- 108010093305 exopolygalacturonase Proteins 0.000 claims 2
- 229940116332 glucose oxidase Drugs 0.000 claims 2
- 235000019420 glucose oxidase Nutrition 0.000 claims 2
- 108010002430 hemicellulase Proteins 0.000 claims 2
- 239000001573 invertase Substances 0.000 claims 2
- 235000011073 invertase Nutrition 0.000 claims 2
- 229940116108 lactase Drugs 0.000 claims 2
- 230000002646 lignocellulolytic effect Effects 0.000 claims 2
- 235000019421 lipase Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- HNJJXZKZRAWDPF-UHFFFAOYSA-N methapyrilene Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CS1 HNJJXZKZRAWDPF-UHFFFAOYSA-N 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 229940111202 pepsin Drugs 0.000 claims 2
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 2
- 229940085127 phytase Drugs 0.000 claims 2
- 229940108461 rennet Drugs 0.000 claims 2
- 108010058314 rennet Proteins 0.000 claims 2
- 102000055501 telomere Human genes 0.000 claims 2
- 108091035539 telomere Proteins 0.000 claims 2
- 210000003411 telomere Anatomy 0.000 claims 2
- 102000003601 transglutaminase Human genes 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims 1
- 101150073246 AGL1 gene Proteins 0.000 claims 1
- 101150063865 AGL3 gene Proteins 0.000 claims 1
- 108091005658 Basic proteases Proteins 0.000 claims 1
- 101100489917 Caenorhabditis elegans abf-1 gene Proteins 0.000 claims 1
- 101100489922 Caenorhabditis elegans abf-2 gene Proteins 0.000 claims 1
- 101100026178 Caenorhabditis elegans egl-3 gene Proteins 0.000 claims 1
- 108010053835 Catalase Proteins 0.000 claims 1
- 102000016938 Catalase Human genes 0.000 claims 1
- 108030002440 Catalase peroxidases Proteins 0.000 claims 1
- 108010022172 Chitinases Proteins 0.000 claims 1
- 102000012286 Chitinases Human genes 0.000 claims 1
- 108010035722 Chloride peroxidase Proteins 0.000 claims 1
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 claims 1
- 108090000371 Esterases Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 108700007698 Genetic Terminator Regions Proteins 0.000 claims 1
- 101100218354 Geobacillus stearothermophilus axe2 gene Proteins 0.000 claims 1
- 108010056771 Glucosidases Proteins 0.000 claims 1
- 102000004366 Glucosidases Human genes 0.000 claims 1
- 102000009127 Glutaminase Human genes 0.000 claims 1
- 108010073324 Glutaminase Proteins 0.000 claims 1
- 101100378577 Hypocrea jecorina agl2 gene Proteins 0.000 claims 1
- 101100506040 Hypocrea jecorina cel61a gene Proteins 0.000 claims 1
- 101100506045 Hypocrea jecorina egl5 gene Proteins 0.000 claims 1
- 102000004195 Isomerases Human genes 0.000 claims 1
- 108090000769 Isomerases Proteins 0.000 claims 1
- 108010014251 Muramidase Proteins 0.000 claims 1
- 102000016943 Muramidase Human genes 0.000 claims 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 1
- 101100283946 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) gtr-1 gene Proteins 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 108010064785 Phospholipases Proteins 0.000 claims 1
- 102000015439 Phospholipases Human genes 0.000 claims 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 claims 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 101150099793 XYN3 gene Proteins 0.000 claims 1
- 101150075580 Xyn1 gene Proteins 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 108010047754 beta-Glucosidase Proteins 0.000 claims 1
- 102000006995 beta-Glucosidase Human genes 0.000 claims 1
- 101150100570 bglA gene Proteins 0.000 claims 1
- 101150052795 cbh-1 gene Proteins 0.000 claims 1
- 101150114858 cbh2 gene Proteins 0.000 claims 1
- 101150089280 cip2 gene Proteins 0.000 claims 1
- 101150066032 egl-1 gene Proteins 0.000 claims 1
- 101150003727 egl2 gene Proteins 0.000 claims 1
- 229940059442 hemicellulase Drugs 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 229960000274 lysozyme Drugs 0.000 claims 1
- 239000004325 lysozyme Substances 0.000 claims 1
- 235000010335 lysozyme Nutrition 0.000 claims 1
- 101150026430 manA gene Proteins 0.000 claims 1
- 235000019419 proteases Nutrition 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023084937A JP7605902B2 (ja) | 2016-10-04 | 2023-05-23 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662403787P | 2016-10-04 | 2016-10-04 | |
| US62/403,787 | 2016-10-04 | ||
| PCT/US2017/054983 WO2018067599A1 (en) | 2016-10-04 | 2017-10-03 | Protein production in filamentous fungal cells in the absence of inducing substrates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023084937A Division JP7605902B2 (ja) | 2016-10-04 | 2023-05-23 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528797A JP2019528797A (ja) | 2019-10-17 |
| JP2019528797A5 true JP2019528797A5 (https=) | 2020-11-12 |
| JP7285780B2 JP7285780B2 (ja) | 2023-06-02 |
Family
ID=60245185
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539732A Active JP7285780B2 (ja) | 2016-10-04 | 2017-10-03 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
| JP2023084937A Active JP7605902B2 (ja) | 2016-10-04 | 2023-05-23 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023084937A Active JP7605902B2 (ja) | 2016-10-04 | 2023-05-23 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10876103B2 (https=) |
| EP (1) | EP3523415A1 (https=) |
| JP (2) | JP7285780B2 (https=) |
| KR (1) | KR102593668B1 (https=) |
| CN (1) | CN109790510B (https=) |
| WO (1) | WO2018067599A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110760537A (zh) * | 2018-07-27 | 2020-02-07 | 中国农业科学院饲料研究所 | 用于快速筛选重组菌株的重组表达载体及应用 |
| JP7609774B2 (ja) * | 2018-11-28 | 2025-01-07 | ノボザイムス アクティーゼルスカブ | 修飾された糸状菌宿主細胞 |
| WO2021007630A1 (pt) * | 2019-07-16 | 2021-01-21 | Centro Nacional De Pesquisa Em Energia E Materiais | Linhagem de fungo trichoderma modificada para a produção de coquetel enzimático |
| FI4055177T3 (fi) * | 2019-11-08 | 2024-10-31 | Danisco Us Inc | Parantuneen proteiinituottavuuden fenotyyppejä käsittäviä sienikantoja ja menetelmiä niitä varten |
| CN114729385B (zh) * | 2019-11-18 | 2025-03-11 | 花王株式会社 | 突变丝状菌和使用其的蛋白质的制造方法 |
| CN113106114B (zh) * | 2020-01-13 | 2024-04-12 | 中国科学院分子植物科学卓越创新中心 | 调控里氏木霉蛋白表达效率的因子、调控方法及应用 |
| EP4139332A1 (en) | 2020-04-22 | 2023-03-01 | Danisco US Inc. | Compositions and methods for enhanced protein production in filamentous fungal cells |
| JP7827410B2 (ja) * | 2021-04-09 | 2026-03-10 | 花王株式会社 | 改変糸状菌、及びそれを用いたタンパク質の製造方法 |
| CN116813728B (zh) * | 2023-07-07 | 2024-08-09 | 山东大学 | 一种真菌木质纤维素降解酶合成调控蛋白突变体及其应用 |
| CN118389304A (zh) * | 2023-12-28 | 2024-07-26 | 福州道福生物科技有限公司 | 一种生产索马甜ⅰ蛋白的重组里氏木霉菌株及其构建方法与应用 |
| WO2025165968A1 (en) | 2024-01-31 | 2025-08-07 | Danisco Us Inc. | Conditional regulation of protein function in filamentous fungal cells |
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2017
- 2017-10-03 EP EP17794124.2A patent/EP3523415A1/en active Pending
- 2017-10-03 JP JP2019539732A patent/JP7285780B2/ja active Active
- 2017-10-03 WO PCT/US2017/054983 patent/WO2018067599A1/en not_active Ceased
- 2017-10-03 KR KR1020197010929A patent/KR102593668B1/ko active Active
- 2017-10-03 CN CN201780059992.7A patent/CN109790510B/zh active Active
- 2017-10-03 US US16/336,500 patent/US10876103B2/en active Active
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2020
- 2020-11-13 US US17/097,044 patent/US20220145278A1/en not_active Abandoned
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2023
- 2023-05-23 JP JP2023084937A patent/JP7605902B2/ja active Active
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