JP2015517816A5 - - Google Patents
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- Publication number
- JP2015517816A5 JP2015517816A5 JP2015514483A JP2015514483A JP2015517816A5 JP 2015517816 A5 JP2015517816 A5 JP 2015517816A5 JP 2015514483 A JP2015514483 A JP 2015514483A JP 2015514483 A JP2015514483 A JP 2015514483A JP 2015517816 A5 JP2015517816 A5 JP 2015517816A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polynucleotide
- host cell
- fungal host
- intron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims 34
- 239000002157 polynucleotide Substances 0.000 claims 34
- 102000040430 polynucleotide Human genes 0.000 claims 34
- 239000002773 nucleotide Substances 0.000 claims 24
- 125000003729 nucleotide group Chemical group 0.000 claims 24
- 210000004027 cell Anatomy 0.000 claims 23
- 230000002538 fungal effect Effects 0.000 claims 16
- 210000001324 spliceosome Anatomy 0.000 claims 14
- 108020004422 Riboswitch Proteins 0.000 claims 13
- 238000000034 method Methods 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 240000006439 Aspergillus oryzae Species 0.000 claims 6
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims 6
- 108010059892 Cellulase Proteins 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- 102000004316 Oxidoreductases Human genes 0.000 claims 6
- 108090000854 Oxidoreductases Proteins 0.000 claims 6
- 229940088598 enzyme Drugs 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 241000534944 Thia Species 0.000 claims 5
- 101150026857 ctpJ gene Proteins 0.000 claims 5
- 241001494489 Thielavia Species 0.000 claims 4
- 241001149964 Tolypocladium Species 0.000 claims 4
- 241000222354 Trametes Species 0.000 claims 4
- 241000223259 Trichoderma Species 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 108010011619 6-Phytase Proteins 0.000 claims 3
- 108090000915 Aminopeptidases Proteins 0.000 claims 3
- 102000004400 Aminopeptidases Human genes 0.000 claims 3
- 239000004382 Amylase Substances 0.000 claims 3
- 108010065511 Amylases Proteins 0.000 claims 3
- 102000013142 Amylases Human genes 0.000 claims 3
- 108010006303 Carboxypeptidases Proteins 0.000 claims 3
- 102000005367 Carboxypeptidases Human genes 0.000 claims 3
- 102000016938 Catalase Human genes 0.000 claims 3
- 108010053835 Catalase Proteins 0.000 claims 3
- 108010031396 Catechol oxidase Proteins 0.000 claims 3
- 102000030523 Catechol oxidase Human genes 0.000 claims 3
- 108010008885 Cellulose 1,4-beta-Cellobiosidase Proteins 0.000 claims 3
- 108010022172 Chitinases Proteins 0.000 claims 3
- 102000012286 Chitinases Human genes 0.000 claims 3
- 108010025880 Cyclomaltodextrin glucanotransferase Proteins 0.000 claims 3
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 3
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 3
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 claims 3
- 108090000371 Esterases Proteins 0.000 claims 3
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims 3
- 102100022624 Glucoamylase Human genes 0.000 claims 3
- 102000004157 Hydrolases Human genes 0.000 claims 3
- 108090000604 Hydrolases Proteins 0.000 claims 3
- 102000004195 Isomerases Human genes 0.000 claims 3
- 108090000769 Isomerases Proteins 0.000 claims 3
- 108010029541 Laccase Proteins 0.000 claims 3
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 3
- 102000003960 Ligases Human genes 0.000 claims 3
- 108090000364 Ligases Proteins 0.000 claims 3
- 108090001060 Lipase Proteins 0.000 claims 3
- 239000004367 Lipase Substances 0.000 claims 3
- 102000004882 Lipase Human genes 0.000 claims 3
- 102000004317 Lyases Human genes 0.000 claims 3
- 108090000856 Lyases Proteins 0.000 claims 3
- 102100024295 Maltase-glucoamylase Human genes 0.000 claims 3
- 108010054377 Mannosidases Proteins 0.000 claims 3
- 102000001696 Mannosidases Human genes 0.000 claims 3
- 241000235395 Mucor Species 0.000 claims 3
- 241000226677 Myceliophthora Species 0.000 claims 3
- 241000233892 Neocallimastix Species 0.000 claims 3
- 108090000913 Nitrate Reductases Proteins 0.000 claims 3
- 108010025915 Nitrite Reductases Proteins 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 102000035195 Peptidases Human genes 0.000 claims 3
- 102000003992 Peroxidases Human genes 0.000 claims 3
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 claims 3
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 3
- 102000006382 Ribonucleases Human genes 0.000 claims 3
- 108010083644 Ribonucleases Proteins 0.000 claims 3
- 241000228341 Talaromyces Species 0.000 claims 3
- 241000228178 Thermoascus Species 0.000 claims 3
- 102000004357 Transferases Human genes 0.000 claims 3
- 108090000992 Transferases Proteins 0.000 claims 3
- 108060008539 Transglutaminase Proteins 0.000 claims 3
- 108010030291 alpha-Galactosidase Proteins 0.000 claims 3
- 102000005840 alpha-Galactosidase Human genes 0.000 claims 3
- 108010028144 alpha-Glucosidases Proteins 0.000 claims 3
- 235000019418 amylase Nutrition 0.000 claims 3
- 108010051210 beta-Fructofuranosidase Proteins 0.000 claims 3
- 108010005774 beta-Galactosidase Proteins 0.000 claims 3
- 102000005936 beta-Galactosidase Human genes 0.000 claims 3
- 108010047754 beta-Glucosidase Proteins 0.000 claims 3
- 102000006995 beta-Glucosidase Human genes 0.000 claims 3
- 108010089934 carbohydrase Proteins 0.000 claims 3
- 229940106157 cellulase Drugs 0.000 claims 3
- 108010005400 cutinase Proteins 0.000 claims 3
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 claims 3
- 239000001573 invertase Substances 0.000 claims 3
- 235000011073 invertase Nutrition 0.000 claims 3
- 235000019421 lipase Nutrition 0.000 claims 3
- 229940072417 peroxidase Drugs 0.000 claims 3
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 3
- 229940085127 phytase Drugs 0.000 claims 3
- 102000003601 transglutaminase Human genes 0.000 claims 3
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims 2
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 claims 2
- 241000228212 Aspergillus Species 0.000 claims 2
- 241000223651 Aureobasidium Species 0.000 claims 2
- 241000222490 Bjerkandera Species 0.000 claims 2
- 241000146399 Ceriporiopsis Species 0.000 claims 2
- 241000123346 Chrysosporium Species 0.000 claims 2
- 241000222511 Coprinus Species 0.000 claims 2
- 241000222356 Coriolus Species 0.000 claims 2
- 241001337994 Cryptococcus <scale insect> Species 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 2
- 241000223218 Fusarium Species 0.000 claims 2
- 241000223198 Humicola Species 0.000 claims 2
- 241001344133 Magnaporthe Species 0.000 claims 2
- 241000221960 Neurospora Species 0.000 claims 2
- 241000228143 Penicillium Species 0.000 claims 2
- 241000222385 Phanerochaete Species 0.000 claims 2
- 241000235379 Piromyces Species 0.000 claims 2
- 241000222350 Pleurotus Species 0.000 claims 2
- 241000222480 Schizophyllum Species 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 206010016165 failure to thrive Diseases 0.000 claims 2
- 101150095344 niaD gene Proteins 0.000 claims 2
- 241000222395 Phlebia Species 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 respectively Proteins 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12170260.9 | 2012-05-31 | ||
| EP12170260 | 2012-05-31 | ||
| PCT/EP2013/061052 WO2013178674A1 (en) | 2012-05-31 | 2013-05-29 | Improved selection in fungi |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517816A JP2015517816A (ja) | 2015-06-25 |
| JP2015517816A5 true JP2015517816A5 (https=) | 2016-07-21 |
| JP6449763B2 JP6449763B2 (ja) | 2019-01-09 |
Family
ID=48539153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514483A Active JP6449763B2 (ja) | 2012-05-31 | 2013-05-29 | 真菌における改善された選択 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9487767B2 (https=) |
| EP (2) | EP3327113B1 (https=) |
| JP (1) | JP6449763B2 (https=) |
| CN (1) | CN104395454B (https=) |
| BR (1) | BR112014029252B8 (https=) |
| DK (1) | DK3327113T3 (https=) |
| WO (1) | WO2013178674A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3113609B1 (en) | 2014-03-05 | 2019-07-31 | Novozymes A/S | Methods for improving post-harvest properties of agricultural crops |
| US20170073890A1 (en) | 2014-03-05 | 2017-03-16 | Novozymes A/S | Compositions and Methods for Functionalizing and Linking Materials |
| EP3114272A1 (en) | 2014-03-05 | 2017-01-11 | Novozymes A/S | Compositions and methods for improving properties of cellulosic textile materials with xyloglucan endotransglycosylase |
| US20160348035A1 (en) | 2014-03-05 | 2016-12-01 | Novozymes A/S | Compositions and Methods for Improving Properties of Non-Cellulosic Textile Materials with Xyloglucan Endotransglycosylase |
| BR112016020374A2 (pt) | 2014-03-05 | 2018-01-23 | Novozymes As | formulação, e, métodos para potenciar o crescimento de plantas e para formular um ou mais agentes agricolamente benéficos |
| EP3183339A1 (en) | 2014-08-20 | 2017-06-28 | Novozymes A/S | Xyloglucan endotransglycosylase variants and polynucleotides encoding same |
| EP3227438B1 (en) | 2014-12-02 | 2024-03-27 | Novozymes A/S | Laccase variants and polynucleotides encoding same |
| PL3265563T3 (pl) | 2015-02-02 | 2021-09-13 | Meiragtx Uk Ii Limited | Regulacja ekspresji genów poprzez modulację alternatywnego splicingu za pośrednictwem aptamerów |
| CN107429220A (zh) * | 2015-03-27 | 2017-12-01 | 嘉吉公司 | 经葡糖淀粉酶修饰的酵母菌株和用于产生生物产物的方法 |
| WO2016174258A1 (en) | 2015-04-29 | 2016-11-03 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Means and methods for protein production |
| BR112018011902A2 (pt) | 2015-12-17 | 2018-12-04 | Cargill Inc | método de fermentação, levedura geneticamente modificada, construto de ácido nucleico, vetor, célula hospedeira, meio de fermentação e utilização da levedura geneticamente modificada |
| SMT202400091T1 (it) * | 2016-08-03 | 2024-05-14 | Meiragtx Uk Ii Ltd | Screening ad alta produzione basato su cellule per 5 aptameri |
| WO2018027131A1 (en) | 2016-08-05 | 2018-02-08 | Cargill, Incorporated | Leader-modified glucoamylase polypeptides and engineered yeast strains having enhanced bioproduct production |
| CN108949579B (zh) * | 2018-04-19 | 2021-10-01 | 中国科学技术大学 | 嗜热子囊菌基因表达系统 |
| JP7210577B2 (ja) * | 2018-06-15 | 2023-01-23 | キッコーマン株式会社 | セレノネインの製造方法 |
| US20210301285A1 (en) | 2018-08-02 | 2021-09-30 | Novozymes A/S | Preparation of Combinatorial Libraries of DNA Constructs |
| DK3898985T5 (da) | 2018-12-21 | 2024-08-05 | Novozymes As | Proteinekspression i tandem |
| CN110592149B (zh) * | 2019-07-16 | 2020-07-14 | 甘肃省科学院生物研究所 | 一种梨囊鞭菌发酵秸秆生产乳酸的新方法和应用 |
| EP4004211A1 (en) | 2019-07-25 | 2022-06-01 | Novozymes A/S | Filamentous fungal expression system |
| US11479779B2 (en) * | 2020-07-31 | 2022-10-25 | Zymergen Inc. | Systems and methods for high-throughput automated strain generation for non-sporulating fungi |
| CN114292761B (zh) * | 2021-12-02 | 2023-11-03 | 南京工业大学 | 一株黑曲霉基因工程菌及构建方法与应用 |
| WO2025133003A2 (en) | 2023-12-19 | 2025-06-26 | 21St.Bio A/S | Non-animal bovine beta lactoglobulin |
| CN119752977A (zh) * | 2023-12-28 | 2025-04-04 | 南京百斯杰生物工程有限公司 | 可改善目标多肽表达效果的多核苷酸构建体及其应用 |
| WO2025226596A1 (en) | 2024-04-24 | 2025-10-30 | Novozymes A/S | Methods for producing secreted polypeptides |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| FR2704860B1 (fr) | 1993-05-05 | 1995-07-13 | Pasteur Institut | Sequences de nucleotides du locus cryiiia pour le controle de l'expression de sequences d'adn dans un hote cellulaire. |
| WO1995033836A1 (en) | 1994-06-03 | 1995-12-14 | Novo Nordisk Biotech, Inc. | Phosphonyldipeptides useful in the treatment of cardiovascular diseases |
| ATE294871T1 (de) | 1994-06-30 | 2005-05-15 | Novozymes Biotech Inc | Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren |
| AU4424597A (en) | 1996-09-13 | 1998-04-02 | Novo Nordisk Biotech, Inc. | Cells having dna insertion mutations which produce altered amounts of a polypeptide |
| DK1124949T3 (da) | 1998-10-26 | 2006-11-06 | Novozymes As | Konstruktion og screening af et DNA-bibliotek af interesse i trådformede svampeceller |
| CN100482801C (zh) | 1999-03-22 | 2009-04-29 | 诺沃奇梅兹有限公司 | 用于在真菌细胞中表达基因的启动子 |
| WO2001090393A1 (en) | 2000-05-24 | 2001-11-29 | Novozymes A/S | Method for increasing gene copy number in a host cell and resulting host cell |
| JP2007259787A (ja) | 2006-03-29 | 2007-10-11 | Hakutsuru Shuzo Kk | 遺伝子発現制御ポリヌクレオチド |
| GB201107768D0 (en) | 2011-05-10 | 2011-06-22 | Univ Manchester | Riboswitches |
-
2013
- 2013-05-29 CN CN201380028411.5A patent/CN104395454B/zh active Active
- 2013-05-29 US US14/403,355 patent/US9487767B2/en active Active
- 2013-05-29 EP EP17200169.5A patent/EP3327113B1/en active Active
- 2013-05-29 BR BR112014029252A patent/BR112014029252B8/pt active Search and Examination
- 2013-05-29 JP JP2015514483A patent/JP6449763B2/ja active Active
- 2013-05-29 EP EP13726188.9A patent/EP2855659A1/en not_active Withdrawn
- 2013-05-29 DK DK17200169.5T patent/DK3327113T3/da active
- 2013-05-29 WO PCT/EP2013/061052 patent/WO2013178674A1/en not_active Ceased
-
2016
- 2016-10-18 US US15/296,433 patent/US10351861B2/en active Active
-
2018
- 2018-06-26 US US16/018,726 patent/US10351863B2/en active Active
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