JP2002536993A5 - - Google Patents
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- JP2002536993A5 JP2002536993A5 JP2000601140A JP2000601140A JP2002536993A5 JP 2002536993 A5 JP2002536993 A5 JP 2002536993A5 JP 2000601140 A JP2000601140 A JP 2000601140A JP 2000601140 A JP2000601140 A JP 2000601140A JP 2002536993 A5 JP2002536993 A5 JP 2002536993A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid sequence
- cell
- polypeptide
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000007523 nucleic acids Chemical group 0.000 description 25
- 108091028043 Nucleic acid sequence Proteins 0.000 description 18
- 229920001184 polypeptide Polymers 0.000 description 13
- 108090000765 processed proteins & peptides Proteins 0.000 description 13
- 102000004196 processed proteins & peptides Human genes 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 108010054497 oxaloacetase Proteins 0.000 description 5
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 239000004382 Amylase Substances 0.000 description 3
- 108010065511 Amylases Proteins 0.000 description 3
- 102000013142 Amylases Human genes 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241000223218 Fusarium Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 102000004316 Oxidoreductases Human genes 0.000 description 3
- 108090000854 Oxidoreductases Proteins 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 102000035195 Peptidases Human genes 0.000 description 3
- 241000223259 Trichoderma Species 0.000 description 3
- 235000019418 amylase Nutrition 0.000 description 3
- -1 annosidase Proteins 0.000 description 3
- 108010005774 beta-Galactosidase Proteins 0.000 description 3
- 102000005936 beta-Galactosidase Human genes 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 2
- 108010011619 6-Phytase Proteins 0.000 description 2
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 description 2
- 108090000915 Aminopeptidases Proteins 0.000 description 2
- 102000004400 Aminopeptidases Human genes 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 2
- 241000223651 Aureobasidium Species 0.000 description 2
- 108010006303 Carboxypeptidases Proteins 0.000 description 2
- 102000005367 Carboxypeptidases Human genes 0.000 description 2
- 102000016938 Catalase Human genes 0.000 description 2
- 108010053835 Catalase Proteins 0.000 description 2
- 108010031396 Catechol oxidase Proteins 0.000 description 2
- 102000030523 Catechol oxidase Human genes 0.000 description 2
- 108010059892 Cellulase Proteins 0.000 description 2
- 108010022172 Chitinases Proteins 0.000 description 2
- 102000012286 Chitinases Human genes 0.000 description 2
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 2
- 108010025880 Cyclomaltodextrin glucanotransferase Proteins 0.000 description 2
- 108010053770 Deoxyribonucleases Proteins 0.000 description 2
- 102000016911 Deoxyribonucleases Human genes 0.000 description 2
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 2
- 241000223198 Humicola Species 0.000 description 2
- 108010029541 Laccase Proteins 0.000 description 2
- 108090001060 Lipase Proteins 0.000 description 2
- 239000004367 Lipase Substances 0.000 description 2
- 102000004882 Lipase Human genes 0.000 description 2
- 241001344133 Magnaporthe Species 0.000 description 2
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 108010083644 Ribonucleases Proteins 0.000 description 2
- 102000006382 Ribonucleases Human genes 0.000 description 2
- 108060008539 Transglutaminase Proteins 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 108010030291 alpha-Galactosidase Proteins 0.000 description 2
- 102000005840 alpha-Galactosidase Human genes 0.000 description 2
- 108010028144 alpha-Glucosidases Proteins 0.000 description 2
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 2
- 108010047754 beta-Glucosidase Proteins 0.000 description 2
- 102000006995 beta-Glucosidase Human genes 0.000 description 2
- 108010089934 carbohydrase Proteins 0.000 description 2
- 229940106157 cellulase Drugs 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 108010005400 cutinase Proteins 0.000 description 2
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000001573 invertase Substances 0.000 description 2
- 235000011073 invertase Nutrition 0.000 description 2
- 235000019421 lipase Nutrition 0.000 description 2
- 229940072417 peroxidase Drugs 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 229940085127 phytase Drugs 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000003601 transglutaminase Human genes 0.000 description 2
- 241000228212 Aspergillus Species 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
- 102100022624 Glucoamylase Human genes 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 102000004195 Isomerases Human genes 0.000 description 1
- 108090000769 Isomerases Proteins 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 241000235395 Mucor Species 0.000 description 1
- 241000226677 Myceliophthora Species 0.000 description 1
- 241000223251 Myrothecium Species 0.000 description 1
- 241000233892 Neocallimastix Species 0.000 description 1
- 241000221960 Neurospora Species 0.000 description 1
- 241000222480 Schizophyllum Species 0.000 description 1
- 241000228341 Talaromyces Species 0.000 description 1
- 241000228178 Thermoascus Species 0.000 description 1
- 241001494489 Thielavia Species 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000002351 pectolytic effect Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199900231 | 1999-02-22 | ||
| DKPA199900231 | 1999-02-22 | ||
| DKPA199900231 | 1999-02-22 | ||
| PCT/DK2000/000067 WO2000050576A1 (en) | 1999-02-22 | 2000-02-18 | Oxaloacetate hydrolase deficient fungal host cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010287753A Division JP2011101651A (ja) | 1999-02-22 | 2010-12-24 | オキサロ酢酸ヒドロラーゼ欠陥真菌宿主細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002536993A JP2002536993A (ja) | 2002-11-05 |
| JP2002536993A5 true JP2002536993A5 (https=) | 2007-04-12 |
| JP4741082B2 JP4741082B2 (ja) | 2011-08-03 |
Family
ID=8091215
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000601140A Expired - Fee Related JP4741082B2 (ja) | 1999-02-22 | 2000-02-18 | オキサロ酢酸ヒドロラーゼ欠陥真菌宿主細胞 |
| JP2010287753A Pending JP2011101651A (ja) | 1999-02-22 | 2010-12-24 | オキサロ酢酸ヒドロラーゼ欠陥真菌宿主細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010287753A Pending JP2011101651A (ja) | 1999-02-22 | 2010-12-24 | オキサロ酢酸ヒドロラーゼ欠陥真菌宿主細胞 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1157100B1 (https=) |
| JP (2) | JP4741082B2 (https=) |
| CN (1) | CN1195058C (https=) |
| AT (1) | ATE315638T1 (https=) |
| AU (1) | AU2658200A (https=) |
| DE (1) | DE60025467T2 (https=) |
| DK (1) | DK1157100T3 (https=) |
| WO (1) | WO2000050576A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1157100B1 (en) * | 1999-02-22 | 2006-01-11 | Novozymes A/S | Oxaloacetate hydrolase deficient fungal host cells |
| US6544765B1 (en) | 1999-02-22 | 2003-04-08 | Novozymes, A/S | Oxaloacetate hydrolase deficient fungal host cells |
| JP2006516399A (ja) * | 2003-02-05 | 2006-07-06 | デーエスエム アイピー アセッツ ベー． ヴェー． | ポリペプチドを製造するためのシュウ酸欠損Ａｓｐｅｒｇｉｌｌｕｓｎｉｇｅｒ菌株の使用 |
| JP4638418B2 (ja) | 2003-03-31 | 2011-02-23 | ノボザイムス，インコーポレイティド | アスペルギラス・ニガーの酵素−欠失変異体における生物学的物質の生成方法 |
| EP1786908B1 (en) * | 2004-08-18 | 2010-03-03 | Bayer CropScience AG | Plants with increased plastidic activity of r3 starch-phosphorylating enzyme |
| WO2008000632A1 (en) | 2006-06-29 | 2008-01-03 | Dsm Ip Assets B.V. | A method for achieving improved polypeptide expression |
| DK2406372T3 (da) | 2009-03-10 | 2017-11-27 | Dsm Ip Assets Bv | Prægastrisk esterase og derivater deraf |
| CN102741421B (zh) | 2009-03-10 | 2015-03-25 | 帝斯曼知识产权资产管理有限公司 | 用于提高多肽产率的方法 |
| EP2421986A1 (en) | 2009-04-22 | 2012-02-29 | DSM IP Assets B.V. | Process for the production of a recombinant polypeptide of interest |
| EP3293264A1 (en) | 2009-07-22 | 2018-03-14 | DSM IP Assets B.V. | Improved host cell for the production of a compound of interest |
| RU2645252C2 (ru) * | 2012-01-05 | 2018-02-19 | Глюкос Финланд Ой | Клетка нитчатых грибов с дефицитом протеаз и способы ее применения |
| JP6468561B2 (ja) | 2012-07-19 | 2019-02-13 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | ＡｇｓＥ欠損株 |
| WO2016110453A1 (en) | 2015-01-06 | 2016-07-14 | Dsm Ip Assets B.V. | A crispr-cas system for a filamentous fungal host cell |
| CN108138213A (zh) * | 2015-02-20 | 2018-06-08 | 罗尔公司 | 控制蛋白酶产生的方法 |
| US20200063166A1 (en) | 2017-03-13 | 2020-02-27 | Dsm Ip Assets B.V. | Zinc binuclear cluster transcriptional regulator-deficient strain |
| CN110791439B (zh) * | 2019-10-10 | 2022-04-19 | 天津科技大学 | 一株基因工程构建发酵生产苹果酸的重组黑曲霉菌株及应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1157100B1 (en) * | 1999-02-22 | 2006-01-11 | Novozymes A/S | Oxaloacetate hydrolase deficient fungal host cells |
-
2000
- 2000-02-18 EP EP00904859A patent/EP1157100B1/en not_active Expired - Lifetime
- 2000-02-18 AT AT00904859T patent/ATE315638T1/de not_active IP Right Cessation
- 2000-02-18 WO PCT/DK2000/000067 patent/WO2000050576A1/en not_active Ceased
- 2000-02-18 AU AU26582/00A patent/AU2658200A/en not_active Abandoned
- 2000-02-18 JP JP2000601140A patent/JP4741082B2/ja not_active Expired - Fee Related
- 2000-02-18 DK DK00904859T patent/DK1157100T3/da active
- 2000-02-18 DE DE60025467T patent/DE60025467T2/de not_active Expired - Lifetime
- 2000-02-18 CN CNB008041679A patent/CN1195058C/zh not_active Expired - Fee Related
-
2010
- 2010-12-24 JP JP2010287753A patent/JP2011101651A/ja active Pending
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