JP2002515253A5 - - Google Patents
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- JP2002515253A5 JP2002515253A5 JP2000549743A JP2000549743A JP2002515253A5 JP 2002515253 A5 JP2002515253 A5 JP 2002515253A5 JP 2000549743 A JP2000549743 A JP 2000549743A JP 2000549743 A JP2000549743 A JP 2000549743A JP 2002515253 A5 JP2002515253 A5 JP 2002515253A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- cell
- mutant
- acid sequence
- mutant cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical group 0.000 description 31
- 238000000034 method Methods 0.000 description 20
- 108091028043 Nucleic acid sequence Proteins 0.000 description 18
- 229920001184 polypeptide Polymers 0.000 description 14
- 108090000765 processed proteins & peptides Proteins 0.000 description 14
- 102000004196 processed proteins & peptides Human genes 0.000 description 14
- 239000002773 nucleotide Substances 0.000 description 11
- 125000003729 nucleotide group Chemical group 0.000 description 11
- 108090000913 Nitrate Reductases Proteins 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 230000002538 fungal effect Effects 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- 230000004048 modification Effects 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 238000012258 culturing Methods 0.000 description 6
- 229930013292 trichothecene Natural products 0.000 description 6
- 108010031937 Aristolochene synthase Proteins 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 239000005556 hormone Substances 0.000 description 4
- 229940088597 hormone Drugs 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- LZAJKCZTKKKZNT-PMNGPLLRSA-N trichothecene Chemical compound C12([C@@]3(CC[C@H]2OC2C=C(CCC23C)C)C)CO1 LZAJKCZTKKKZNT-PMNGPLLRSA-N 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 2
- 108010011619 6-Phytase Proteins 0.000 description 2
- 108090000915 Aminopeptidases Proteins 0.000 description 2
- 102000004400 Aminopeptidases Human genes 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- 108010006303 Carboxypeptidases Proteins 0.000 description 2
- 102000005367 Carboxypeptidases Human genes 0.000 description 2
- 102000016938 Catalase Human genes 0.000 description 2
- 108010053835 Catalase Proteins 0.000 description 2
- 108010031396 Catechol oxidase Proteins 0.000 description 2
- 102000030523 Catechol oxidase Human genes 0.000 description 2
- 108010059892 Cellulase Proteins 0.000 description 2
- 108010022172 Chitinases Proteins 0.000 description 2
- 102000012286 Chitinases Human genes 0.000 description 2
- 108010025880 Cyclomaltodextrin glucanotransferase Proteins 0.000 description 2
- 108010053770 Deoxyribonucleases Proteins 0.000 description 2
- 102000016911 Deoxyribonucleases Human genes 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 2
- 241000223218 Fusarium Species 0.000 description 2
- 108010093031 Galactosidases Proteins 0.000 description 2
- 102000002464 Galactosidases Human genes 0.000 description 2
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 2
- 102100022624 Glucoamylase Human genes 0.000 description 2
- 108010029541 Laccase Proteins 0.000 description 2
- 108090001060 Lipase Proteins 0.000 description 2
- 239000004367 Lipase Substances 0.000 description 2
- 102000004882 Lipase Human genes 0.000 description 2
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 2
- 108010054377 Mannosidases Proteins 0.000 description 2
- 102000001696 Mannosidases Human genes 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 108010083644 Ribonucleases Proteins 0.000 description 2
- 102000006382 Ribonucleases Human genes 0.000 description 2
- 108060008539 Transglutaminase Proteins 0.000 description 2
- 108010030291 alpha-Galactosidase Proteins 0.000 description 2
- 102000005840 alpha-Galactosidase Human genes 0.000 description 2
- 108010028144 alpha-Glucosidases Proteins 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 2
- 108010005774 beta-Galactosidase Proteins 0.000 description 2
- 102000005936 beta-Galactosidase Human genes 0.000 description 2
- 108010047754 beta-Glucosidase Proteins 0.000 description 2
- 102000006995 beta-Glucosidase Human genes 0.000 description 2
- 108010089934 carbohydrase Proteins 0.000 description 2
- 229940106157 cellulase Drugs 0.000 description 2
- 108010005400 cutinase Proteins 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 2
- 239000001573 invertase Substances 0.000 description 2
- 235000011073 invertase Nutrition 0.000 description 2
- 235000019421 lipase Nutrition 0.000 description 2
- 229940072417 peroxidase Drugs 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 229940085127 phytase Drugs 0.000 description 2
- 102000003601 transglutaminase Human genes 0.000 description 2
- 150000003327 trichothecene derivatives Chemical class 0.000 description 2
- ZSDSQXJSNMTJDA-UHFFFAOYSA-N trifluralin Chemical compound CCCN(CCC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O ZSDSQXJSNMTJDA-UHFFFAOYSA-N 0.000 description 2
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 description 1
- 101710101939 Endo-1,4-beta-xylanase 5 Proteins 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000002351 pectolytic effect Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8221798A | 1998-05-20 | 1998-05-20 | |
| US09/082,217 | 1998-05-20 | ||
| PCT/US1999/011223 WO1999060137A2 (en) | 1998-05-20 | 1999-05-20 | Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009190191A Division JP2009291207A (ja) | 1998-05-20 | 2009-08-19 | トリコテセン−欠失糸状菌変異体細胞において異種ポリベプチドを生成するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002515253A JP2002515253A (ja) | 2002-05-28 |
| JP2002515253A5 true JP2002515253A5 (https=) | 2006-07-13 |
Family
ID=22169802
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000549743A Pending JP2002515253A (ja) | 1998-05-20 | 1999-05-20 | トリコテセン−欠失糸状菌変異体細胞において異種ポリベプチドを生成するための方法 |
| JP2009190191A Pending JP2009291207A (ja) | 1998-05-20 | 2009-08-19 | トリコテセン−欠失糸状菌変異体細胞において異種ポリベプチドを生成するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009190191A Pending JP2009291207A (ja) | 1998-05-20 | 2009-08-19 | トリコテセン−欠失糸状菌変異体細胞において異種ポリベプチドを生成するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6180366B1 (https=) |
| EP (1) | EP1078081B1 (https=) |
| JP (2) | JP2002515253A (https=) |
| CN (2) | CN1231579C (https=) |
| AT (1) | ATE395424T1 (https=) |
| AU (1) | AU4195099A (https=) |
| DE (1) | DE69938722D1 (https=) |
| DK (1) | DK1078081T3 (https=) |
| WO (1) | WO1999060137A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060305A (en) * | 1994-06-30 | 2000-05-09 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system |
| WO1999055396A1 (en) * | 1998-04-27 | 1999-11-04 | Surmodics, Inc. | Bioactive agent release coating |
| JP2002515253A (ja) * | 1998-05-20 | 2002-05-28 | ノボザイムス バイオテック，インコーポレイティド | トリコテセン−欠失糸状菌変異体細胞において異種ポリベプチドを生成するための方法 |
| FR2826978B1 (fr) * | 2001-07-06 | 2004-09-17 | Agronomique Inst Nat Rech | Procede de determination de la capacite de fusarium a produire des toxines trichotecenes |
| AU2003231028A1 (en) * | 2002-04-22 | 2003-11-03 | Novozymes Biotech, Inc. | Methods for increasing homologous recombination of a nucleic acid sequence |
| CN1694953B (zh) | 2002-08-30 | 2010-05-12 | 诺维信股份有限公司 | 制备哺乳动物胰蛋白酶的方法 |
| AU2003258395A1 (en) * | 2002-08-30 | 2004-03-19 | Puratos Naamloze Vennootschap | Myrothecium sp. transformation and expression system |
| CN100480391C (zh) | 2002-11-18 | 2009-04-22 | 诺维信股份有限公司 | 用于在真菌细胞中表达基因的启动子变体 |
| US20090233287A1 (en) * | 2006-04-25 | 2009-09-17 | Roelof Ary Lans Bovenberg | Production of compounds in a recombinant host |
| KR20090017608A (ko) * | 2006-05-18 | 2009-02-18 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 상부 가열수단이 상대적으로 작은 수평 토스트 장치 |
| EP2352831B1 (en) | 2008-09-30 | 2015-03-25 | Novozymes Inc. | Methods for producing polypeptides in enzyme-deficient mutants of fusarium venenatum |
| US20100316764A1 (en) * | 2009-06-10 | 2010-12-16 | Engrain, LLC | Flour supplement compositions and methods for preparing wheat flour |
| CN102695787A (zh) * | 2009-08-05 | 2012-09-26 | 诺维信公司 | 用于从木素纤维素原料产生trichodiene的丝状真菌和方法 |
| DK2513290T3 (en) | 2009-12-18 | 2016-01-25 | Novozymes Inc | Methods for Preparation of Polypeptides in Trichoderma Mutants with Protease Deficiency |
| CN108588060B (zh) * | 2017-03-07 | 2020-12-01 | 武汉康复得生物科技股份有限公司 | 一种用丝状真菌宿主细胞表达的重组草酸脱羧酶 |
| JP2021078354A (ja) | 2018-03-08 | 2021-05-27 | 有限会社アルティザイム・インターナショナル | フラビンアデニンジヌクレオチドグルコース脱水素酵素とシトクロム分子との融合タンパク質 |
| CN112522231B (zh) * | 2020-12-14 | 2023-03-14 | 广东省微生物研究所（广东省微生物分析检测中心） | 一种酰基转移酶及其编码基因和应用 |
| US20250008961A1 (en) | 2021-11-22 | 2025-01-09 | Basf Se | Paenibacillus strains producing low amounts of dab comprising compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8904762D0 (en) * | 1989-03-02 | 1989-04-12 | Glaxo Group Ltd | Biological process |
| CN101659926A (zh) * | 1994-06-30 | 2010-03-03 | 诺沃奇梅兹有限公司 | 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子 |
| US5594119A (en) * | 1994-09-20 | 1997-01-14 | Novo Nordisk A/S | Gene encoding carboxypeptidase of aspergillus niger |
| JP3628336B2 (ja) * | 1996-03-11 | 2005-03-09 | 明治製菓株式会社 | β―フルクトフラノシダーゼおよびその遺伝子、β―フルクトフラノシダーゼ遺伝子の単離法、β―フルクトフラノシダーゼの産生系、並びにβ―フルクトフラノシダーゼ変異体 |
| JP2002515253A (ja) * | 1998-05-20 | 2002-05-28 | ノボザイムス バイオテック，インコーポレイティド | トリコテセン−欠失糸状菌変異体細胞において異種ポリベプチドを生成するための方法 |
| US6383781B1 (en) * | 1998-12-23 | 2002-05-07 | Novozymes A/S | Methods for producing polypeptides in aspergillus mutant cells |
-
1999
- 1999-05-20 JP JP2000549743A patent/JP2002515253A/ja active Pending
- 1999-05-20 AT AT99925717T patent/ATE395424T1/de not_active IP Right Cessation
- 1999-05-20 CN CNB031588026A patent/CN1231579C/zh not_active Expired - Fee Related
- 1999-05-20 WO PCT/US1999/011223 patent/WO1999060137A2/en not_active Ceased
- 1999-05-20 US US09/316,080 patent/US6180366B1/en not_active Expired - Lifetime
- 1999-05-20 DK DK99925717T patent/DK1078081T3/da active
- 1999-05-20 CN CNB998081124A patent/CN1190495C/zh not_active Expired - Fee Related
- 1999-05-20 AU AU41950/99A patent/AU4195099A/en not_active Abandoned
- 1999-05-20 DE DE69938722T patent/DE69938722D1/de not_active Expired - Lifetime
- 1999-05-20 EP EP99925717A patent/EP1078081B1/en not_active Expired - Lifetime
-
2005
- 2005-03-31 US US11/095,491 patent/US7332341B2/en not_active Expired - Fee Related
-
2008
- 2008-01-31 US US12/023,417 patent/US20080213901A1/en not_active Abandoned
-
2009
- 2009-08-19 JP JP2009190191A patent/JP2009291207A/ja active Pending
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