JP2002533133A5 - - Google Patents
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- JP2002533133A5 JP2002533133A5 JP2000591212A JP2000591212A JP2002533133A5 JP 2002533133 A5 JP2002533133 A5 JP 2002533133A5 JP 2000591212 A JP2000591212 A JP 2000591212A JP 2000591212 A JP2000591212 A JP 2000591212A JP 2002533133 A5 JP2002533133 A5 JP 2002533133A5
- Authority
- JP
- Japan
- Prior art keywords
- mutant
- aspergillus
- toxin
- polypeptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000228212 Aspergillus Species 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- 108700012359 toxins Proteins 0.000 description 15
- 229920001184 polypeptide Polymers 0.000 description 12
- 108090000765 processed proteins & peptides Proteins 0.000 description 12
- 102000004196 processed proteins & peptides Human genes 0.000 description 12
- 239000003053 toxin Substances 0.000 description 10
- 231100000765 toxin Toxicity 0.000 description 9
- 239000005409 aflatoxin Substances 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
- 150000007523 nucleic acids Chemical group 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 229960004799 tryptophan Drugs 0.000 description 5
- 229930195730 Aflatoxin Natural products 0.000 description 4
- XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- WBLZUCOIBUDNBV-UHFFFAOYSA-N 3-nitropropanoic acid Chemical compound OC(=O)CC[N+]([O-])=O WBLZUCOIBUDNBV-UHFFFAOYSA-N 0.000 description 3
- VWDXGKUTGQJJHJ-UHFFFAOYSA-N Catenarin Natural products C1=C(O)C=C2C(=O)C3=C(O)C(C)=CC(O)=C3C(=O)C2=C1O VWDXGKUTGQJJHJ-UHFFFAOYSA-N 0.000 description 3
- CNZIQHGDUXRUJS-UHFFFAOYSA-N Cyclopiazonic acid Natural products CC(=C/1C(=O)C2C3C(Cc4cccc5[nH]cc3c45)C(C)(C)N2C1=O)O CNZIQHGDUXRUJS-UHFFFAOYSA-N 0.000 description 3
- 239000010282 Emodin Substances 0.000 description 3
- RBLJKYCRSCQLRP-UHFFFAOYSA-N Emodin-dianthron Natural products O=C1C2=CC(C)=CC(O)=C2C(=O)C2=C1CC(=O)C=C2O RBLJKYCRSCQLRP-UHFFFAOYSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- YOOXNSPYGCZLAX-UHFFFAOYSA-N Helminthosporin Natural products C1=CC(O)=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O YOOXNSPYGCZLAX-UHFFFAOYSA-N 0.000 description 3
- RNCGDQLZIATDOU-UHFFFAOYSA-N Malformin Chemical compound N1C(=O)C(C(C)CC)NC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C2CSSCC1C(=O)N2 RNCGDQLZIATDOU-UHFFFAOYSA-N 0.000 description 3
- NTGIIKCGBNGQAR-UHFFFAOYSA-N Rheoemodin Natural products C1=C(O)C=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1O NTGIIKCGBNGQAR-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- CNZIQHGDUXRUJS-DQYPLSBCSA-N alpha-cyclopiazonic acid Natural products CC(O)=C1C(=O)[C@@H]2[C@@H]3[C@@H](Cc4cccc5[nH]cc3c45)C(C)(C)N2C1=O CNZIQHGDUXRUJS-DQYPLSBCSA-N 0.000 description 3
- ZKSIPEYIAHUPNM-ZEQRLZLVSA-N butobendine Chemical compound C([C@H](CC)N(C)CCN(C)[C@@H](CC)COC(=O)C=1C=C(OC)C(OC)=C(OC)C=1)OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 ZKSIPEYIAHUPNM-ZEQRLZLVSA-N 0.000 description 3
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 description 3
- VASFLQKDXBAWEL-UHFFFAOYSA-N emodin Natural products OC1=C(OC2=C(C=CC(=C2C1=O)O)O)C1=CC=C(C=C1)O VASFLQKDXBAWEL-UHFFFAOYSA-N 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 3
- 229960004705 kojic acid Drugs 0.000 description 3
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 3
- 229930191655 malformin Natural products 0.000 description 3
- 229930183344 ochratoxin Natural products 0.000 description 3
- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 description 3
- 101100462165 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) omtA gene Proteins 0.000 description 2
- 240000006439 Aspergillus oryzae Species 0.000 description 2
- 101100215645 Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) aflP gene Proteins 0.000 description 2
- 241001136487 Eurotium Species 0.000 description 2
- 241000130738 Hemicarpenteles Species 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- 101150118680 aflR gene Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- HCUOEKSZWPGJIM-YBRHCDHNSA-N (e,2e)-2-hydroxyimino-6-methoxy-4-methyl-5-nitrohex-3-enamide Chemical compound COCC([N+]([O-])=O)\C(C)=C\C(=N/O)\C(N)=O HCUOEKSZWPGJIM-YBRHCDHNSA-N 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108010011619 6-Phytase Proteins 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 101710152845 Arabinogalactan endo-beta-1,4-galactanase Proteins 0.000 description 1
- 235000002247 Aspergillus oryzae Nutrition 0.000 description 1
- 101100162199 Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) aflC gene Proteins 0.000 description 1
- 101100162200 Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) aflD gene Proteins 0.000 description 1
- 101100162203 Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) aflG gene Proteins 0.000 description 1
- 101100029917 Bacillus subtilis (strain 168) pksL gene Proteins 0.000 description 1
- 102100032487 Beta-mannosidase Human genes 0.000 description 1
- 102000005367 Carboxypeptidases Human genes 0.000 description 1
- 108010006303 Carboxypeptidases Proteins 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 102000030523 Catechol oxidase Human genes 0.000 description 1
- 108010031396 Catechol oxidase Proteins 0.000 description 1
- 108010059892 Cellulase Proteins 0.000 description 1
- 108010022172 Chitinases Proteins 0.000 description 1
- 102000012286 Chitinases Human genes 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 108010053770 Deoxyribonucleases Proteins 0.000 description 1
- 102000016911 Deoxyribonucleases Human genes 0.000 description 1
- 101100272070 Dothistroma septosporum (strain NZE10 / CBS 128990) avnA gene Proteins 0.000 description 1
- 101710147028 Endo-beta-1,4-galactanase Proteins 0.000 description 1
- 102000005593 Endopeptidases Human genes 0.000 description 1
- 108010059378 Endopeptidases Proteins 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 102000018389 Exopeptidases Human genes 0.000 description 1
- 108010091443 Exopeptidases Proteins 0.000 description 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
- 102100022624 Glucoamylase Human genes 0.000 description 1
- 108010055629 Glucosyltransferases Proteins 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
- 102000009127 Glutaminase Human genes 0.000 description 1
- 108010073324 Glutaminase Proteins 0.000 description 1
- 108010029541 Laccase Proteins 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 1
- 108010054377 Mannosidases Proteins 0.000 description 1
- 102000001696 Mannosidases Human genes 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004020 Oxygenases Human genes 0.000 description 1
- 108090000417 Oxygenases Proteins 0.000 description 1
- 101150078289 PKSA gene Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 108010059820 Polygalacturonase Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 108010030291 alpha-Galactosidase Proteins 0.000 description 1
- 102000005840 alpha-Galactosidase Human genes 0.000 description 1
- 108010028144 alpha-Glucosidases Proteins 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010047754 beta-Glucosidase Proteins 0.000 description 1
- 102000006995 beta-Glucosidase Human genes 0.000 description 1
- 108010055059 beta-Mannosidase Proteins 0.000 description 1
- 108010089934 carbohydrase Proteins 0.000 description 1
- 229940106157 cellulase Drugs 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 108010005400 cutinase Proteins 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 1
- 108010093305 exopolygalacturonase Proteins 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000001573 invertase Substances 0.000 description 1
- 235000011073 invertase Nutrition 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 108010087558 pectate lyase Proteins 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 229940085127 phytase Drugs 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199801726 | 1998-12-23 | ||
| DKPA199801726 | 1998-12-23 | ||
| DKPA199900745 | 1999-05-27 | ||
| DK199900745 | 1999-05-27 | ||
| PCT/DK1999/000726 WO2000039322A1 (en) | 1998-12-23 | 1999-12-22 | Methods for producing polypeptides in aspergillus mutant cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011103808A Division JP5453343B2 (ja) | 1998-12-23 | 2011-05-06 | アスペルギルス変異体細胞におけるポリペプチドの生産方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002533133A JP2002533133A (ja) | 2002-10-08 |
| JP2002533133A5 true JP2002533133A5 (https=) | 2007-02-15 |
Family
ID=26064565
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000591212A Withdrawn JP2002533133A (ja) | 1998-12-23 | 1999-12-22 | アスペルギルス変異体細胞におけるポリペプチドの生産方法 |
| JP2011103808A Expired - Lifetime JP5453343B2 (ja) | 1998-12-23 | 2011-05-06 | アスペルギルス変異体細胞におけるポリペプチドの生産方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011103808A Expired - Lifetime JP5453343B2 (ja) | 1998-12-23 | 2011-05-06 | アスペルギルス変異体細胞におけるポリペプチドの生産方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1141371B1 (https=) |
| JP (2) | JP2002533133A (https=) |
| CN (1) | CN100529096C (https=) |
| AT (1) | ATE414782T1 (https=) |
| AU (1) | AU1774000A (https=) |
| DE (1) | DE69939947D1 (https=) |
| DK (1) | DK1141371T3 (https=) |
| ES (1) | ES2317706T3 (https=) |
| WO (1) | WO2000039322A1 (https=) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| WO2004090549A1 (en) * | 2003-04-11 | 2004-10-21 | Novozymes A/S | Method of screening for secreted glycosylated polypeptides |
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| EP1739428A1 (en) * | 2005-07-01 | 2007-01-03 | Institut Pasteur | In vitro diagnostic method and kit for an aspergillus infection |
| WO2007045248A1 (en) | 2005-10-17 | 2007-04-26 | Novozymes A/S | Use of fungal mutants for expression of antibodies |
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| DK3219794T3 (da) | 2011-11-21 | 2019-12-16 | Novozymes Inc | GH61-polypeptidvarianter og polynukleotider, som koder for dem |
| CA2868308A1 (en) | 2012-04-27 | 2013-10-31 | Novozymes, Inc. | Gh61 polypeptide variants and polynucleotides encoding same |
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| EP3594335B1 (en) | 2014-09-05 | 2024-05-01 | Novozymes A/S | Carbohydrate binding module variants and polynucleotides encoding same |
| MX383142B (es) | 2014-12-19 | 2025-03-13 | Novozymes As | Composiciones que comprenden polipéptidos que tienen actividad xilanasa y polipéptidos que tienen actividad arabinofuranosidasa. |
| DK3739045T3 (da) | 2015-02-24 | 2024-10-21 | Novozymes As | Cellobiohydrolasevarianter og polynukleotider, som koder for dem |
| CN116676293A (zh) | 2015-05-27 | 2023-09-01 | 国投生物科技投资有限公司 | 具有纤维二糖水解酶活性的多肽以及对其进行编码的多核苷酸 |
| CN108350044B (zh) | 2015-09-22 | 2022-05-24 | 诺维信公司 | 具有纤维二糖水解酶活性的多肽以及对其进行编码的多核苷酸 |
| JP6950873B2 (ja) * | 2017-06-07 | 2021-10-13 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | セルラーゼ及びキシラナーゼを生産するための変異株アスペルギルス・アクレアツス並びにその調製方法 |
| AU2018319349B2 (en) | 2017-08-25 | 2024-02-29 | Novozymes A/S | Enzyme assisted crude palm oil extraction |
| EP3775222B1 (en) | 2018-03-26 | 2024-01-03 | Novozymes A/S | Fungal chaperone proteins |
| CN108823178B (zh) * | 2018-06-08 | 2021-12-10 | 中国中医科学院中药研究所 | 大黄素糖基转移酶蛋白FtUGT73BE5及其编码基因与应用 |
| CN108753748B (zh) * | 2018-06-08 | 2021-12-10 | 中国中医科学院中药研究所 | 大黄素糖基转移酶蛋白FtUGT75R2及其编码基因与应用 |
| CN108795903B (zh) * | 2018-06-08 | 2020-12-15 | 南京林业大学 | 一种高酶活淀粉酶的表达方法 |
| CN113302293A (zh) | 2018-12-12 | 2021-08-24 | 诺维信公司 | 具有木聚糖酶活性的多肽以及编码这些多肽的多核苷酸 |
| DK3898985T5 (da) | 2018-12-21 | 2024-08-05 | Novozymes As | Proteinekspression i tandem |
| CN110218750B (zh) * | 2019-04-24 | 2023-04-11 | 郑州轻工业学院 | 杂色曲霉菌株在发酵生产曲酸中应用 |
| CN110106152B (zh) * | 2019-04-30 | 2021-08-17 | 中国农业科学院油料作物研究所 | 杂交瘤细胞株ytt-2及其产生的抗环匹阿尼酸单克隆抗体 |
| CN110108874B (zh) * | 2019-04-30 | 2022-09-20 | 中国农业科学院油料作物研究所 | 快速检测环匹阿尼酸的胶体金免疫分析试纸条、制备及其应用 |
| EP4004211A1 (en) | 2019-07-25 | 2022-06-01 | Novozymes A/S | Filamentous fungal expression system |
| CN111139189B (zh) * | 2020-01-14 | 2022-04-19 | 浙江工业大学 | 曲霉wbx-38及其在生产环匹阿尼酸中的应用 |
| CN116024096B (zh) * | 2022-07-14 | 2025-06-03 | 浙江树人学院 | 泡盛曲霉sr3-28及其在从朱砂七提取大黄素中的应用 |
| JP2025542263A (ja) | 2022-12-21 | 2025-12-25 | ノボザイムス アクティーゼルスカブ | 細胞剥離のための微生物プロテアーゼ |
| CN116064437B (zh) * | 2023-02-20 | 2025-09-23 | 武汉轻工大学 | 用于降解黄曲霉毒素的复合酶制剂、复合酶制剂溶液及其制备方法和应用 |
| WO2025133003A2 (en) | 2023-12-19 | 2025-06-26 | 21St.Bio A/S | Non-animal bovine beta lactoglobulin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI962287A7 (fi) * | 1993-12-01 | 1996-07-26 | Novo Nordisk Biotech Inc | Aspergillus foetidus ilmentämisjärjestelmä |
| FI962288L (fi) * | 1993-12-01 | 1996-07-26 | Novo Nordisk Biotech Inc | Aspergillus ilmentämisjärjestelmä |
| AU4424597A (en) * | 1996-09-13 | 1998-04-02 | Novo Nordisk Biotech, Inc. | Cells having dna insertion mutations which produce altered amounts of a polypeptide |
| DK0956338T3 (da) * | 1996-09-19 | 2006-05-08 | Novozymes As | Værtsceller og fremgangsmåder til produktion af proteiner |
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- 1999-12-22 DK DK99960956T patent/DK1141371T3/da active
- 1999-12-22 AT AT99960956T patent/ATE414782T1/de active
- 1999-12-22 WO PCT/DK1999/000726 patent/WO2000039322A1/en not_active Ceased
- 1999-12-22 ES ES99960956T patent/ES2317706T3/es not_active Expired - Lifetime
- 1999-12-22 EP EP99960956A patent/EP1141371B1/en not_active Expired - Lifetime
- 1999-12-22 CN CNB99815766XA patent/CN100529096C/zh not_active Expired - Lifetime
- 1999-12-22 AU AU17740/00A patent/AU1774000A/en not_active Abandoned
- 1999-12-22 DE DE69939947T patent/DE69939947D1/de not_active Expired - Lifetime
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2011
- 2011-05-06 JP JP2011103808A patent/JP5453343B2/ja not_active Expired - Lifetime
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