KR102593668B1 - 유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산 - Google Patents

유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산 Download PDF

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KR102593668B1
KR102593668B1 KR1020197010929A KR20197010929A KR102593668B1 KR 102593668 B1 KR102593668 B1 KR 102593668B1 KR 1020197010929 A KR1020197010929 A KR 1020197010929A KR 20197010929 A KR20197010929 A KR 20197010929A KR 102593668 B1 KR102593668 B1 KR 102593668B1
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KR20190057088A (ko
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마이클 워드
윈 루오
펠리페 오세아스 벤데주
마리 발꼬넨
마르꾸 살로헤이모
니나 아로
띠나 빠꿀라
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다니스코 유에스 인크.
브이티티 테크니컬 리서치 센터 오브 핀란드 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01004—Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020197010929A 2016-10-04 2017-10-03 유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산 Active KR102593668B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662403787P 2016-10-04 2016-10-04
US62/403,787 2016-10-04
PCT/US2017/054983 WO2018067599A1 (en) 2016-10-04 2017-10-03 Protein production in filamentous fungal cells in the absence of inducing substrates

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KR20190057088A KR20190057088A (ko) 2019-05-27
KR102593668B1 true KR102593668B1 (ko) 2023-10-24

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US (2) US10876103B2 (https=)
EP (1) EP3523415A1 (https=)
JP (2) JP7285780B2 (https=)
KR (1) KR102593668B1 (https=)
CN (1) CN109790510B (https=)
WO (1) WO2018067599A1 (https=)

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CA3121271A1 (en) * 2018-11-28 2020-06-04 Novozymes A/S Modified filamentous fungal host cells
EP4001398A4 (en) 2019-07-16 2023-05-31 Centro Nacional de Pesquisa em Energia e Materiais MODIFIED TRICHODERMA MUSHROOM STRAIN TO PRODUCE AN ENZYME COCKTAIL
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CN114729385B (zh) * 2019-11-18 2025-03-11 花王株式会社 突变丝状菌和使用其的蛋白质的制造方法
CN113106114B (zh) * 2020-01-13 2024-04-12 中国科学院分子植物科学卓越创新中心 调控里氏木霉蛋白表达效率的因子、调控方法及应用
KR20230004495A (ko) * 2020-04-22 2023-01-06 다니스코 유에스 인크. 사상 진균 세포에서의 개선된 단백질 생산을 위한 조성물 및 방법
JP7827410B2 (ja) 2021-04-09 2026-03-10 花王株式会社 改変糸状菌、及びそれを用いたタンパク質の製造方法
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JP7285780B2 (ja) 2023-06-02
JP7605902B2 (ja) 2024-12-24
WO2018067599A1 (en) 2018-04-12
US10876103B2 (en) 2020-12-29
US20220145278A1 (en) 2022-05-12
JP2023109919A (ja) 2023-08-08
US20190309276A1 (en) 2019-10-10
JP2019528797A (ja) 2019-10-17
EP3523415A1 (en) 2019-08-14
CN109790510A (zh) 2019-05-21
CN109790510B (zh) 2024-04-12
KR20190057088A (ko) 2019-05-27

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