|
US1726514A
(en)
|
1926-11-01 |
1929-08-27 |
Firm Ferd Liebschner & Sohn |
Picker for looms
|
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4434150A
(en)
|
1981-10-19 |
1984-02-28 |
Ortho Diagnostic Systems, Inc. |
Immunological reagents employing polymeric backbone possessing reactive functional groups
|
|
ATE37983T1
(de)
|
1982-04-22 |
1988-11-15 |
Ici Plc |
Mittel mit verzoegerter freigabe.
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US4510245A
(en)
|
1982-11-18 |
1985-04-09 |
Chiron Corporation |
Adenovirus promoter system
|
|
US4486414A
(en)
|
1983-03-21 |
1984-12-04 |
Arizona Board Of Reagents |
Dolastatins A and B cell growth inhibitory substances
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
|
US6492107B1
(en)
|
1986-11-20 |
2002-12-10 |
Stuart Kauffman |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
|
|
DE3546806C2
(enExample)
|
1985-03-30 |
1991-03-28 |
Marc Genf/Geneve Ch Ballivet |
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
US4968615A
(en)
|
1985-12-18 |
1990-11-06 |
Ciba-Geigy Corporation |
Deoxyribonucleic acid segment from a virus
|
|
DE3600905A1
(de)
|
1986-01-15 |
1987-07-16 |
Ant Nachrichtentech |
Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
FR2601675B1
(fr)
|
1986-07-17 |
1988-09-23 |
Rhone Poulenc Sante |
Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2, Inc., Danville, Calif. |
Geänderte antikörper.
|
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
|
US4816444A
(en)
|
1987-07-10 |
1989-03-28 |
Arizona Board Of Regents, Arizona State University |
Cell growth inhibitory substance
|
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
|
IL89220A
(en)
|
1988-02-11 |
1994-02-27 |
Bristol Myers Squibb Co |
Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them
|
|
US5157049A
(en)
|
1988-03-07 |
1992-10-20 |
The United States Of America As Represented By The Department Of Health & Human Services |
Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
|
|
US4942184A
(en)
|
1988-03-07 |
1990-07-17 |
The United States Of America As Represented By The Department Of Health And Human Services |
Water soluble, antineoplastic derivatives of taxol
|
|
ATE120454T1
(de)
|
1988-06-14 |
1995-04-15 |
Cetus Oncology Corp |
Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus.
|
|
US5076973A
(en)
|
1988-10-24 |
1991-12-31 |
Arizona Board Of Regents |
Synthesis of dolastatin 3
|
|
ATE102631T1
(de)
|
1988-11-11 |
1994-03-15 |
Medical Res Council |
Klonierung von immunglobulin sequenzen aus den variabelen domaenen.
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US4978744A
(en)
|
1989-01-27 |
1990-12-18 |
Arizona Board Of Regents |
Synthesis of dolastatin 10
|
|
US4960790A
(en)
|
1989-03-09 |
1990-10-02 |
University Of Kansas |
Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
|
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
|
US4879278A
(en)
|
1989-05-16 |
1989-11-07 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
|
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
|
AU652539B2
(en)
|
1989-05-16 |
1994-09-01 |
Medical Research Council |
Co-expression of heteromeric receptors
|
|
US4986988A
(en)
|
1989-05-18 |
1991-01-22 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
|
|
US5413923A
(en)
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
|
WO1991005548A1
(en)
|
1989-10-10 |
1991-05-02 |
Pitman-Moore, Inc. |
Sustained release composition for macromolecular proteins
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
JP2571874B2
(ja)
|
1989-11-06 |
1997-01-16 |
アルカーメス コントロールド セラピューティクス，インコーポレイテッド |
タンパク質マイクロスフェア組成物
|
|
US5138036A
(en)
|
1989-11-13 |
1992-08-11 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
CA2050918A1
(en)
|
1990-01-12 |
1991-07-13 |
Raju Kucherlapati |
Generation of xenogeneic antibodies
|
|
WO1996033735A1
(en)
|
1995-04-27 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5124471A
(en)
|
1990-03-26 |
1992-06-23 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Bifunctional dtpa-type ligand
|
|
US5407683A
(en)
|
1990-06-01 |
1995-04-18 |
Research Corporation Technologies, Inc. |
Pharmaceutical solutions and emulsions containing taxol
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
EP0544809B1
(en)
|
1990-08-24 |
1998-12-16 |
Ixsys, Inc. |
Methods of synthesizing oligonucleotides with random codons
|
|
US5278324A
(en)
|
1990-08-28 |
1994-01-11 |
Virginia Tech Intellectual Properties, Inc. |
Water soluble derivatives of taxol
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
DE69133476T2
(de)
|
1990-08-29 |
2006-01-05 |
GenPharm International, Inc., Palo Alto |
Transgene Mäuse fähig zur Produktion heterologer Antikörper
|
|
IE914504A1
(en)
|
1990-12-20 |
1992-07-01 |
Ixsys |
Optimization of binding proteins
|
|
US5399363A
(en)
|
1991-01-25 |
1995-03-21 |
Eastman Kodak Company |
Surface modified anticancer nanoparticles
|
|
DE69232706T2
(de)
|
1991-05-01 |
2002-11-28 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine, Rockville |
Verfahren zur behandlung infektiöser respiratorischer erkrankungen
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
US6287792B1
(en)
|
1991-06-17 |
2001-09-11 |
The Regents Of The University Of California |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
|
|
FR2678833B1
(fr)
|
1991-07-08 |
1995-04-07 |
Rhone Poulenc Rorer Sa |
Nouvelles compositions pharmaceutiques a base de derives de la classe des taxanes.
|
|
MX9204374A
(es)
|
1991-07-25 |
1993-03-01 |
Idec Pharma Corp |
Anticuerpo recombinante y metodo para su produccion.
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
ATE408012T1
(de)
|
1991-12-02 |
2008-09-15 |
Medical Res Council |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
GB9126094D0
(en)
|
1991-12-09 |
1992-02-12 |
Immune Systems Ltd |
In vitro antibody production
|
|
CA2103887C
(en)
|
1991-12-13 |
2005-08-30 |
Gary M. Studnicka |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
GB9201755D0
(en)
|
1992-01-28 |
1992-03-11 |
British Bio Technology |
Compounds
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US5912015A
(en)
|
1992-03-12 |
1999-06-15 |
Alkermes Controlled Therapeutics, Inc. |
Modulated release from biocompatible polymers
|
|
AU3922193A
(en)
|
1992-03-23 |
1993-10-21 |
Georgetown University |
Liposome encapsulated taxol and a method of using the same
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
GB9213077D0
(en)
|
1992-06-19 |
1992-08-05 |
Erba Carlo Spa |
Polymerbound taxol derivatives
|
|
CA2086874E
(en)
|
1992-08-03 |
2000-01-04 |
Renzo Mauro Canetta |
Methods for administration of taxol
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
FR2696458B1
(fr)
|
1992-10-05 |
1994-11-10 |
Rhone Poulenc Rorer Sa |
Procédé de préparation de dérivés du taxane.
|
|
FR2697752B1
(fr)
|
1992-11-10 |
1995-04-14 |
Rhone Poulenc Rorer Sa |
Compositions antitumorales contenant des dérivés du taxane.
|
|
FR2698543B1
(fr)
|
1992-12-02 |
1994-12-30 |
Rhone Poulenc Rorer Sa |
Nouvelles compositions à base de taxoides.
|
|
US6034065A
(en)
|
1992-12-03 |
2000-03-07 |
Arizona Board Of Regents |
Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US5380751A
(en)
|
1992-12-04 |
1995-01-10 |
Bristol-Myers Squibb Company |
6,7-modified paclitaxels
|
|
US5410024A
(en)
|
1993-01-21 |
1995-04-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
US5750106A
(en)
|
1993-01-28 |
1998-05-12 |
Novartis Ag |
Human monoclonal antibodies to cytomegalovirus
|
|
WO1994016729A1
(en)
|
1993-01-28 |
1994-08-04 |
Neorx Corporation |
Targeted nitric oxide pathway or nitric oxide synthase modulation
|
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
|
AU6132994A
(en)
|
1993-02-02 |
1994-08-29 |
Scripps Research Institute, The |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
US5433364A
(en)
|
1993-02-19 |
1995-07-18 |
Dynetics Engineering Corporation |
Card package production system with burster and carrier verification apparatus
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US5415869A
(en)
|
1993-11-12 |
1995-05-16 |
The Research Foundation Of State University Of New York |
Taxol formulation
|
|
WO1995015770A1
(en)
|
1993-12-09 |
1995-06-15 |
Neorx Corporation |
Pretargeting methods and compounds
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
IT1275043B
(it)
|
1994-07-21 |
1997-07-29 |
Agerbioss Snc Di Zanin R & C |
Metodo e relativo prodotto per la difesa delle piante dai parassiti vegetali
|
|
US5521284A
(en)
|
1994-08-01 |
1996-05-28 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides and esters
|
|
US5530097A
(en)
|
1994-08-01 |
1996-06-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory peptide amides
|
|
US5504191A
(en)
|
1994-08-01 |
1996-04-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide methyl esters
|
|
US5554725A
(en)
|
1994-09-14 |
1996-09-10 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Synthesis of dolastatin 15
|
|
US5599902A
(en)
|
1994-11-10 |
1997-02-04 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Cancer inhibitory peptides
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
EP0805678B1
(en)
|
1995-01-05 |
2003-10-29 |
THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN |
Surface-modified nanoparticles and method of making and using same
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
US5840929A
(en)
|
1995-04-14 |
1998-11-24 |
Bristol-Myers Squibb Company |
C4 methoxy ether derivatives of paclitaxel
|
|
US5705503A
(en)
|
1995-05-25 |
1998-01-06 |
Goodall; Brian Leslie |
Addition polymers of polycycloolefins containing functional substituents
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US6127977A
(en)
|
1996-11-08 |
2000-10-03 |
Cohen; Nathan |
Microstrip patch antenna with fractal structure
|
|
AU710347B2
(en)
|
1995-08-31 |
1999-09-16 |
Alkermes Controlled Therapeutics, Inc. |
Composition for sustained release of an agent
|
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
|
US6331431B1
(en)
|
1995-11-28 |
2001-12-18 |
Ixsys, Inc. |
Vacuum device and method for isolating periplasmic fraction from cells
|
|
JP2000503639A
(ja)
|
1995-12-22 |
2000-03-28 |
ブリストル―マイヤーズ スクイブ カンパニー |
分枝ヒドラゾンのリンカー類
|
|
WO1997029131A1
(en)
|
1996-02-09 |
1997-08-14 |
Basf Aktiengesellschaft |
HUMAN ANTIBODIES THAT BIND HUMAN TNF$g(a)
|
|
EP0881299A4
(en)
*
|
1996-02-15 |
2004-12-15 |
Chugai Seiyakukabushiki Kaisha |
MONOCLONAL ANTIBODIES RECOGNIZING ANTIGENS PRESENT ON THE SURFACE OF ENDOTHELIAL CELLS OF A TUMOR VESSEL
|
|
IT1282692B1
(it)
|
1996-02-27 |
1998-03-31 |
San Raffaele Centro Fond |
Citochine modificate per l'uso in terapia
|
|
ATE508733T1
(de)
|
1996-03-04 |
2011-05-15 |
Penn State Res Found |
Materialien und verfahren zur steigerung der zellulären internalisierung
|
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
|
US5821263A
(en)
|
1996-08-26 |
1998-10-13 |
Bristol-Myers Squibb Company |
Sulfenamide taxane derivatives
|
|
US5773464A
(en)
|
1996-09-30 |
1998-06-30 |
Bristol-Myers Squibb Company |
C-10 epoxy taxanes
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
AU4966597A
(en)
|
1996-11-19 |
1998-06-10 |
Daiichi Pharmaceutical Co., Ltd. |
Taxol derivatives
|
|
DK1500329T3
(da)
|
1996-12-03 |
2012-07-09 |
Amgen Fremont Inc |
Humane antistoffer, der specifikt binder TNF-alfa
|
|
US5977386A
(en)
|
1996-12-24 |
1999-11-02 |
Bristol-Myers Squibb Company |
6-thio-substituted paclitaxels
|
|
DE69732306T2
(de)
|
1997-01-16 |
2006-01-12 |
Massachusetts Institute Of Technology, Cambridge |
Zubereitung von partikelhaltigen arzneimitteln zur inhalation
|
|
PL336231A1
(en)
|
1997-02-13 |
2000-06-19 |
Bone Care International |
System for aimed therapeutic delivery of vitamin d compounds
|
|
EP0973540B1
(en)
|
1997-02-25 |
2005-11-02 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18
|
|
WO1998046645A2
(en)
|
1997-04-14 |
1998-10-22 |
Micromet Gesellschaft Für Biomedizinische Forschung Mbh |
Method for the production of antihuman antigen receptors and uses thereof
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
AU8691398A
(en)
|
1997-08-04 |
1999-02-22 |
Ixsys, Incorporated |
Methods for identifying ligand specific binding molecules
|
|
US7288665B1
(en)
|
1997-08-18 |
2007-10-30 |
Florida State University |
Process for selective derivatization of taxanes
|
|
JPH1192468A
(ja)
|
1997-09-17 |
1999-04-06 |
Yakult Honsha Co Ltd |
新規なタキサン誘導体
|
|
US5989463A
(en)
|
1997-09-24 |
1999-11-23 |
Alkermes Controlled Therapeutics, Inc. |
Methods for fabricating polymer-based controlled release devices
|
|
DE69729128T2
(de)
|
1997-10-08 |
2005-04-28 |
Bio Research Corporation Of Yokohama, Yokohama |
Taxoid-derivate und verfahren zu ihrer herstellung
|
|
AU9692498A
(en)
|
1997-10-10 |
1999-05-03 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Complex of biotinylated viral vector and ligand for targeted gene delivery
|
|
SE512663C2
(sv)
|
1997-10-23 |
2000-04-17 |
Biogram Ab |
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
|
|
DK1071700T3
(da)
|
1998-04-20 |
2010-06-07 |
Glycart Biotechnology Ag |
Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
|
|
ES2198922T3
(es)
|
1998-06-24 |
2004-02-01 |
Advanced Inhalation Research, Inc. |
Particulas porosas grandes emitadas por un inhalador.
|
|
US6410319B1
(en)
|
1998-10-20 |
2002-06-25 |
City Of Hope |
CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
ES2420835T3
(es)
|
1999-04-09 |
2013-08-27 |
Kyowa Hakko Kirin Co., Ltd. |
Procedimiento para controlar la actividad de las moléculas inmunofuncionales
|
|
CN1269087C
(zh)
|
1999-07-31 |
2006-08-09 |
朴奎珍 |
使用数字音频和字幕数据的学习方法和装置
|
|
US6323315B1
(en)
|
1999-09-10 |
2001-11-27 |
Basf Aktiengesellschaft |
Dolastatin peptides
|
|
WO2001090198A1
(en)
|
2000-05-24 |
2001-11-29 |
Ludwig Institute For Cancer Research |
Multicomponent conjugates which bind to target molecules and stimulate cell lysis
|
|
MXPA03000105A
(es)
|
2000-06-28 |
2004-09-13 |
Glycofi Inc |
Metodo para producir glicoproteinas modificadas.
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
US20030083263A1
(en)
|
2001-04-30 |
2003-05-01 |
Svetlana Doronina |
Pentapeptide compounds and uses related thereto
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
CA2451998A1
(en)
|
2001-08-17 |
2003-02-27 |
Eli Lilly And Company |
Anti-a.beta. antibodies
|
|
MXPA04003798A
(es)
|
2001-10-25 |
2004-07-30 |
Genentech Inc |
Composiciones de glicoproteina.
|
|
US20040028687A1
(en)
|
2002-01-15 |
2004-02-12 |
Waelti Ernst Rudolf |
Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues
|
|
WO2003093793A2
(en)
|
2002-05-01 |
2003-11-13 |
Trellis Bioscience, Inc. |
Binary or polynary targeting and uses thereof
|
|
WO2004001381A2
(en)
*
|
2002-06-19 |
2003-12-31 |
Raven Biotechnologies, Inc. |
Novel raag10 cell surface target and a family of antibodies recognizing that target
|
|
SI1545613T1
(sl)
|
2002-07-31 |
2011-11-30 |
Seattle Genetics Inc |
Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
|
|
EP1542723B1
(en)
|
2002-08-16 |
2011-02-23 |
ImmunoGen, Inc. |
Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs
|
|
WO2004019993A1
(en)
|
2002-08-30 |
2004-03-11 |
Ramot At Tel Aviv University Ltd. |
Self-immolative dendrimers releasing many active moieties upon a single activating event
|
|
WO2004043493A1
(en)
|
2002-11-14 |
2004-05-27 |
Syntarga B.V. |
Prodrugs built as multiple self-elimination-release spacers
|
|
US7388079B2
(en)
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
EP2289559B1
(en)
|
2003-02-20 |
2014-02-12 |
Seattle Genetics, Inc. |
Anit-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
|
|
CN102943067B
(zh)
|
2003-03-05 |
2016-06-22 |
海洋酶公司 |
可溶性透明质酸酶糖蛋白(sHASEGP)、制备它们的方法、它们的用途和包含它们的药物组合物
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
EP1660534A2
(en)
|
2003-08-22 |
2006-05-31 |
MedImmune, Inc. |
Humanization of antibodies
|
|
DK1725249T3
(en)
|
2003-11-06 |
2014-03-17 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugating to ligands.
|
|
EP2392586A1
(en)
|
2004-02-20 |
2011-12-07 |
The Trustees of The University of Pennsylvania |
Binding peptidomimetics and uses of the same
|
|
JP5064037B2
(ja)
|
2004-02-23 |
2012-10-31 |
ジェネンテック， インコーポレイテッド |
複素環式自壊的リンカーおよび結合体
|
|
SI2270010T1
(sl)
|
2004-03-01 |
2012-05-31 |
Spirogen Ltd |
hidroksi H pirolo c benzodiazepin onski derivati kot ključni intermediati za pripravo C substituiranih pirolobenzodiazepinov
|
|
US20050226882A1
(en)
|
2004-04-08 |
2005-10-13 |
Awdalla Essam T |
Method and multicomponent conjugates for treating cancer
|
|
CN104611245A
(zh)
|
2004-04-15 |
2015-05-13 |
格利科菲公司 |
在低等真核生物中产生半乳糖基化糖蛋白
|
|
RU2402548C2
(ru)
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
CN114053429A
(zh)
|
2004-06-01 |
2022-02-18 |
健泰科生物技术公司 |
抗体-药物偶联物和方法
|
|
CA2583389A1
(en)
|
2004-10-07 |
2006-04-20 |
Emory University |
Multifunctional nanoparticles conjugates and their use
|
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
|
EP1695717A1
(en)
|
2005-02-23 |
2006-08-30 |
Ludwig-Maximilians-Universität |
Transport of nano-and macromolecular structures into cytoplasm and nucleus of cells
|
|
US7964089B2
(en)
|
2005-04-15 |
2011-06-21 |
Agamatrix, Inc. |
Analyte determination method and analyte meter
|
|
PL1879901T3
(pl)
|
2005-04-21 |
2010-06-30 |
Medimmune Ltd |
Pirolobenzodiazepiny
|
|
AU2006269940C1
(en)
|
2005-07-18 |
2013-11-07 |
Seagen Inc. |
Beta-glucuronide-linker drug conjugates
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
EP1800695A1
(en)
|
2005-12-21 |
2007-06-27 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Immuno-RNA-constructs
|
|
AU2007210377B2
(en)
|
2006-02-02 |
2012-08-09 |
Georg-August-Universitat Gottingen Stiftung Offentlichen Rechts (Ohne Bereich Humanmedizin) |
Water-soluble CC-1065 analogs and their conjugates
|
|
CA2690973A1
(en)
|
2006-06-23 |
2007-12-27 |
Paul M. Simon |
Targeted immune conjugates
|
|
GB0615662D0
(en)
|
2006-08-07 |
2006-09-13 |
Affitech As |
Antibody
|
|
US7718774B2
(en)
*
|
2006-11-08 |
2010-05-18 |
Macrogenics, Inc. |
TES7 and antibodies that bind thereto
|
|
US7598028B2
(en)
|
2006-11-28 |
2009-10-06 |
The Regents Of The University Of Michigan |
Compositions and methods for detecting and treating prostate disorders
|
|
KR20090114430A
(ko)
|
2007-02-02 |
2009-11-03 |
베일러 리서치 인스티튜트 |
항원-제시 세포 상에서 발현된 ｄｃｉｒ에 대한 항원 표적화에 기초한 백신
|
|
TWI422594B
(zh)
|
2007-02-02 |
2014-01-11 |
Baylor Res Inst |
經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑
|
|
JP5564266B2
(ja)
|
2007-02-16 |
2014-07-30 |
メリマック ファーマシューティカルズ インコーポレーティッド |
Ｅｒｂｂ３に対する抗体およびその使用
|
|
TW200900078A
(en)
|
2007-02-23 |
2009-01-01 |
Baylor Res Inst |
Activation of human antigen-presenting cells through CLEC-6
|
|
CA2715919C
(en)
|
2007-02-23 |
2020-04-21 |
Baylor Research Institute |
Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized ldl receptor-1 (lox-1)
|
|
EP2141997B1
(en)
|
2007-03-30 |
2012-10-31 |
Memorial Sloan-Kettering Cancer Center |
Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes
|
|
CA2687395C
(en)
|
2007-05-03 |
2017-07-11 |
Medizinische Universitat Innsbruck |
Complement factor h-derived short consensus repeat-antibody constructs
|
|
CN101990441A
(zh)
|
2007-11-28 |
2011-03-23 |
默萨那治疗学股份有限公司 |
生物相容的生物可降解的烟曲霉素类似物轭合物
|
|
JP5470817B2
(ja)
|
2008-03-10 |
2014-04-16 |
日産自動車株式会社 |
電池用電極およびこれを用いた電池、並びにその製造方法
|
|
NZ588554A
(en)
|
2008-04-29 |
2013-03-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
KR20210005318A
(ko)
|
2008-04-30 |
2021-01-13 |
이뮤노젠 아이엔씨 |
가교제 및 그 용도
|
|
WO2009134952A2
(en)
|
2008-04-30 |
2009-11-05 |
Immunogen, Inc |
Potent conjugates and hydrophilic linkers
|
|
US20090285757A1
(en)
|
2008-05-16 |
2009-11-19 |
Northeastern University |
Methods of targeting cells for diagnosis and therapy
|
|
EP4032552B1
(en)
|
2008-08-26 |
2023-10-04 |
City of Hope |
Method and compositions for enhanced anti-tumor effector functioning of t cells
|
|
US20100152725A1
(en)
|
2008-12-12 |
2010-06-17 |
Angiodynamics, Inc. |
Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
|
|
SG172259A1
(en)
|
2008-12-19 |
2011-07-28 |
Genentech Inc |
Heterocyclic compounds and methods of use
|
|
EP2403524A4
(en)
|
2009-03-06 |
2012-09-26 |
Agensys Inc |
CONJUGATES ANTIBODY-DRUG (ADC) BINDING PROTEINS 24P4C12
|
|
SG174367A1
(en)
|
2009-03-23 |
2011-10-28 |
Quark Pharmaceuticals Inc |
Compounds compositions and methods of treating cancer and fibrotic diseases
|
|
AU2010254013A1
(en)
|
2009-05-28 |
2011-11-24 |
Mersana Therapeutics, Inc. |
Polyal drug conjugates comprising variable rate-releasing linkers
|
|
DE102009026075A1
(de)
|
2009-06-30 |
2011-01-05 |
Röhm Gmbh |
Bohrvorrichtung
|
|
US20110076232A1
(en)
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
WO2011057216A1
(en)
|
2009-11-06 |
2011-05-12 |
The Pennsylvania State Research Foundation |
Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo
|
|
GB0919751D0
(en)
|
2009-11-11 |
2009-12-30 |
King S College Hospital Nhs Fo |
Conjugate molecule
|
|
HUE037159T2
(hu)
*
|
2009-11-24 |
2018-08-28 |
Medimmune Ltd |
Targetált kötõdõ ágensek B7-H1 ellen
|
|
PH12012501751A1
(en)
|
2010-03-04 |
2012-11-12 |
Macrogenics Inc |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
|
PT2542256T
(pt)
*
|
2010-03-04 |
2019-09-05 |
Macrogenics Inc |
Anticorpos reativos com b7-h3, fragmentos imunologicamente ativos dos mesmos e sua utilização
|
|
US20110217363A1
(en)
|
2010-03-05 |
2011-09-08 |
Bionanox |
Two-step targeted tumor therapy with prodrug encapsulated in nanocarrier
|
|
WO2011120053A1
(en)
|
2010-03-26 |
2011-09-29 |
Mersana Therapeutics, Inc. |
Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
|
|
RS52983B
(sr)
|
2010-04-15 |
2014-02-28 |
Spirogen Sárl |
Pirolobenzodiazepini i njihovi konjugati
|
|
EP2558127B1
(en)
|
2010-04-15 |
2022-01-19 |
Seagen Inc. |
Targeted pyrrolobenzodiazepine conjugates
|
|
WO2012027494A1
(en)
|
2010-08-24 |
2012-03-01 |
Regents Of The University Of Minnesota |
Bispecific targeting reagents
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
DE102010064282B4
(de)
|
2010-12-28 |
2012-09-06 |
GLOBALFOUNDRIES Dresden Module One Ltd. Liability Company & Co. KG |
Transistor mit eingebetteten sigma-förmigen sequenziell hergestellten Halbleiterlegierungen
|
|
US9371395B2
(en)
*
|
2011-04-25 |
2016-06-21 |
Daiichi Sankyo Company, Limited |
Anti B7-H3 antibody
|
|
TWI571466B
(zh)
|
2011-10-14 |
2017-02-21 |
艾伯維有限公司 |
用於治療癌症及免疫與自體免疫疾病之細胞凋亡誘發劑
|
|
JP2015501639A
(ja)
|
2011-11-23 |
2015-01-19 |
アイジェニカ バイオセラピューティクス インコーポレイテッド |
抗ｃｄ９８抗体およびその使用方法
|
|
MX2014006739A
(es)
|
2011-12-05 |
2015-06-05 |
Igenica Biotherapeutics Inc |
Conjugados de anticuerpo-farmaco y compuestos relacionados, composiciones , y metodos.
|
|
UY34542A
(es)
|
2011-12-23 |
2013-07-31 |
Mersana Therapeutics Inc |
?formulaciones farmacéuticas para conjugados de derivados de fumagilina y phf?.
|
|
CA2873097A1
(en)
|
2012-05-11 |
2013-11-14 |
Todd M. Hansen |
Pyridazine and pyridine derivatives as nampt inhibitors
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
JP6423340B2
(ja)
|
2012-05-15 |
2018-11-14 |
シアトル ジェネティクス，インコーポレイティド |
自己安定化リンカー結合体
|
|
WO2014008375A1
(en)
|
2012-07-05 |
2014-01-09 |
Mersana Therapeutics, Inc. |
Terminally modified polymers and conjugates thereof
|
|
DK3342785T3
(da)
*
|
2012-10-11 |
2020-03-23 |
Daiichi Sankyo Co Ltd |
Linker til antistof-lægemiddelkonjugat
|
|
EP2928503B1
(en)
|
2012-12-10 |
2019-02-20 |
Mersana Therapeutics, Inc. |
Conjugates of auristatin compounds
|
|
JP6334553B2
(ja)
|
2012-12-10 |
2018-05-30 |
メルサナ セラピューティクス，インコーポレイティド |
タンパク質−高分子−薬剤コンジュゲート
|
|
WO2014093640A1
(en)
|
2012-12-12 |
2014-06-19 |
Mersana Therapeutics,Inc. |
Hydroxy-polmer-drug-protein conjugates
|
|
US20140199319A1
(en)
|
2012-12-14 |
2014-07-17 |
Abbvie, Inc. |
Methods for increasing the efficiency of hybridoma generation
|
|
NZ630601A
(en)
|
2012-12-21 |
2017-05-26 |
Biolliance C V |
Hydrophilic self-immolative linkers and conjugates thereof
|
|
JP6136279B2
(ja)
|
2013-01-15 |
2017-05-31 |
株式会社ジェイテクト |
転がり軸受装置
|
|
KR102685501B1
(ko)
|
2013-02-20 |
2024-07-17 |
노파르티스 아게 |
인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료
|
|
JP2016519070A
(ja)
|
2013-03-15 |
2016-06-30 |
アッヴィ・インコーポレイテッド |
抗体薬物複合体（ａｄｃ）の精製
|
|
TWI503850B
(zh)
|
2013-03-22 |
2015-10-11 |
Polytronics Technology Corp |
過電流保護元件
|
|
TWI510996B
(zh)
|
2013-10-03 |
2015-12-01 |
Acer Inc |
控制觸控面板的方法以及使用該方法的可攜式電腦
|
|
PE20211798A1
(es)
|
2014-03-21 |
2021-09-13 |
Abbvie Inc |
Anticuerpos y conjugados de anticuerpo y farmaco anti-egfr
|
|
JP2017114763A
(ja)
|
2014-03-26 |
2017-06-29 |
第一三共株式会社 |
抗ｃｄ９８抗体−薬物コンジュゲート
|
|
US20190209704A1
(en)
|
2014-10-20 |
2019-07-11 |
Igenica Biotherapeutics, Inc. |
Novel antibody-drug conjugates and related compounds, compositions and methods of use
|
|
MX2017007629A
(es)
*
|
2014-12-09 |
2018-05-17 |
Abbvie Inc |
Compuestos inhibidores de bcl-xl que tienen una baja permeabilidad en las celulas y conjugados de anticuerpo-farmaco que los incluyen.
|
|
EP3230283A1
(en)
|
2014-12-09 |
2017-10-18 |
AbbVie Inc. |
Bcl-xl inhibitory compounds and antibody drug conjugates including the same
|
|
CA2969908A1
(en)
*
|
2014-12-09 |
2016-06-16 |
Abbvie Inc. |
Antibody drug conjugates with cell permeable bcl-xl inhibitors
|
|
CA3027178A1
(en)
|
2016-06-08 |
2017-12-14 |
Abbvie Inc. |
Anti-egfr antibody drug conjugates
|
|
EP3468615A1
(en)
|
2016-06-08 |
2019-04-17 |
AbbVie Inc. |
Anti-egfr antibody drug conjugates
|
|
BR112018075630A2
(pt)
|
2016-06-08 |
2019-03-19 |
Abbvie Inc. |
anticorpos anti-cd98 e conjugados de fármaco de anticorpo
|
|
WO2017214322A1
(en)
|
2016-06-08 |
2017-12-14 |
Abbvie Inc. |
Anti-b7-h3 antibodies and antibody drug conjugates
|
|
JP2019521973A
(ja)
|
2016-06-08 |
2019-08-08 |
アッヴィ・インコーポレイテッド |
抗ｂｈ７−ｈ３抗体及び抗体薬物コンジュゲート
|
|
WO2017214458A2
(en)
|
2016-06-08 |
2017-12-14 |
Abbvie Inc. |
Anti-cd98 antibodies and antibody drug conjugates
|
|
AU2017277534A1
(en)
|
2016-06-08 |
2019-01-03 |
Abbvie Inc. |
Anti-EGFR antibody drug conjugates
|
|
US20200121803A1
(en)
|
2016-06-08 |
2020-04-23 |
Abbvie Inc. |
Anti-cd98 antibodies and antibody drug conjugates
|
|
US9816280B1
(en)
|
2016-11-02 |
2017-11-14 |
Matthew Reitnauer |
Portable floor
|