JP2019525957A5 - - Google Patents

Download PDF

Info

Publication number
JP2019525957A5
JP2019525957A5 JP2019522627A JP2019522627A JP2019525957A5 JP 2019525957 A5 JP2019525957 A5 JP 2019525957A5 JP 2019522627 A JP2019522627 A JP 2019522627A JP 2019522627 A JP2019522627 A JP 2019522627A JP 2019525957 A5 JP2019525957 A5 JP 2019525957A5
Authority
JP
Japan
Prior art keywords
immunotherapeutic agent
hdac inhibitor
agent according
cancer
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019522627A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019525957A (ja
JP7373991B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/042199 external-priority patent/WO2018013962A1/en
Publication of JP2019525957A publication Critical patent/JP2019525957A/ja
Publication of JP2019525957A5 publication Critical patent/JP2019525957A5/ja
Priority to JP2022032796A priority Critical patent/JP2022088404A/ja
Application granted granted Critical
Publication of JP7373991B2 publication Critical patent/JP7373991B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019522627A 2016-07-15 2017-07-14 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤 Active JP7373991B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022032796A JP2022088404A (ja) 2016-07-15 2022-03-03 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662362959P 2016-07-15 2016-07-15
US62/362,959 2016-07-15
PCT/US2017/042199 WO2018013962A1 (en) 2016-07-15 2017-07-14 Histone deacetylase inhibitors for use in immunotherapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022032796A Division JP2022088404A (ja) 2016-07-15 2022-03-03 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤

Publications (3)

Publication Number Publication Date
JP2019525957A JP2019525957A (ja) 2019-09-12
JP2019525957A5 true JP2019525957A5 (https=) 2020-08-06
JP7373991B2 JP7373991B2 (ja) 2023-11-06

Family

ID=60952218

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019522629A Active JP7158104B2 (ja) 2016-07-15 2017-07-14 Nk細胞ベースの療法で使用するためのhdac阻害剤
JP2019522627A Active JP7373991B2 (ja) 2016-07-15 2017-07-14 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤
JP2022032796A Pending JP2022088404A (ja) 2016-07-15 2022-03-03 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2019522629A Active JP7158104B2 (ja) 2016-07-15 2017-07-14 Nk細胞ベースの療法で使用するためのhdac阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022032796A Pending JP2022088404A (ja) 2016-07-15 2022-03-03 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤

Country Status (6)

Country Link
US (5) US12427152B2 (https=)
EP (4) EP4650005A3 (https=)
JP (3) JP7158104B2 (https=)
CN (2) CN109715173A (https=)
GB (2) GB2567362B (https=)
WO (2) WO2018013962A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7158104B2 (ja) 2016-07-15 2022-10-21 ビラクタ セラピューティクス,インク. Nk細胞ベースの療法で使用するためのhdac阻害剤
DK3551660T5 (da) 2016-12-07 2024-09-02 Agenus Inc Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf
CN111836636A (zh) * 2018-01-12 2020-10-27 维拉克塔治疗公司 用于细胞免疫疗法的表观遗传修饰剂
MX2020013621A (es) 2018-06-19 2021-03-25 Nantcell Inc Composiciones y metodos de tratamiento de vih.
CN109306341B (zh) * 2018-09-12 2022-01-28 华东师范大学 Hdac11基因干扰的嵌合抗原受体t细胞及其应用
KR102533540B1 (ko) * 2018-10-31 2023-05-17 난트퀘스트, 인크. Pd-l1 키메라 항원 수용체-발현 nk 세포에 의한 pd-l1-양성 악성종양의 제거(elimination of pd-l1-positive malignancies by pd-l1 chimeric antigen receptor-expressing nk cells)
AU2020283590A1 (en) 2019-05-31 2022-01-20 Viracta Subsidiary, Inc. Methods of treating virally associated cancers with histone deacetylase inhibitors
TWI831999B (zh) * 2019-08-28 2024-02-11 大陸商深圳微芯生物科技股份有限公司 一種西達本胺藥物組合物及其應用
EP4041750A4 (en) * 2019-10-07 2023-11-01 Viracta Subsidiary, Inc. DOSAGE FOR HDAC TREATMENT WITH REDUCED SIDE EFFECTS
EP4491235A3 (en) 2019-11-26 2025-03-26 ImmunityBio, Inc. Primary nk car constructs and methods
JP2023503933A (ja) 2019-12-05 2023-02-01 ヴィラクタ サブシディアリー,インク. Hdac阻害剤の固体状の形態
CN111358777A (zh) * 2020-02-24 2020-07-03 军事科学院军事医学研究院环境医学与作业医学研究所 一种提高外周血单个核细胞线粒体功能的方法和应用
AU2021368107A1 (en) * 2020-10-28 2023-06-22 Viracta Subsidiary, Inc. Hdac inhibitor solid state forms
CN113502265B (zh) * 2021-05-25 2024-05-28 昭泰英基生物医药(香港)有限公司 将t细胞重编程为类nk细胞的诱导剂及其应用
WO2023003972A1 (en) * 2021-07-21 2023-01-26 Viracta Subsidiary, Inc. Cancer treatment combinations
CN119923405A (zh) * 2022-06-23 2025-05-02 艾克西米恩生物技术股份有限公司 与疱疹病毒感染相关的医学病症的治疗或预防
WO2024254774A1 (zh) * 2023-06-14 2024-12-19 香港北恒生物科技有限公司 免疫细胞联合疗法

Family Cites Families (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471513A (en) 1966-11-01 1969-10-07 Searle & Co 2-(2-carboxyethyl)-5-phenyl-1-pyrrole-butyric acid and congeners
BE789077A (fr) 1971-09-22 1973-01-15 Nitto Boseki Co Ltd Procede de preparation de derives de pyrimidine
JPS5327252B2 (https=) 1973-04-17 1978-08-07
US4026895A (en) 1973-09-08 1977-05-31 Eisai Co., Ltd. 1,3-Benzodioxol derivatives
GB1498903A (en) 1974-03-25 1978-01-25 Fabre Sa Pierre Aromatic keto-acids and their derivatives
FR2300551A2 (fr) 1975-02-17 1976-09-10 Fabre Sa Pierre Nouveaux
GB1484413A (en) 1974-04-18 1977-09-01 Kissei Pharmaceutical Aromatic amidocarboxylic acid derivatives
DE2456958A1 (de) 1974-12-03 1976-06-16 Basf Ag 3-(p-biphenylyl)-butyronitril und seine anwendung als arzneimittel
US4031243A (en) 1975-07-03 1977-06-21 Juste, S.A. Quimico-Farmaceutica 2-(4-Isobutyl phenyl)butyric acid, salts thereof, and pharmaceutical compositions containing the same
GB1518764A (en) 1976-03-17 1978-07-26 Soc D Etudes Prod Chimique Isobutyramides their preparation and therapeutic composititions containing them
US4176193A (en) 1977-03-17 1979-11-27 Societe D'etudes De Produits Chimiques Therapeutic isobutyramides
US4732914A (en) 1978-02-13 1988-03-22 The Upjohn Company Prostacyclin analogs
US4234599A (en) 1978-10-04 1980-11-18 Scott Eugene J Van Treatment of skin keratoses with α-hydroxy acids and related compounds
FR2508797B1 (fr) 1981-07-03 1986-03-14 Charles Chany Medicament comprenant le produit de la reaction d'un acide carboxylique en c1 a c6 sur un amino-acide basique
US4704402A (en) 1982-06-12 1987-11-03 University Of Pittsburgh Method of treating sickle cell anemia
GB2126082A (en) 1982-08-12 1984-03-21 Heinrich Schulze Pharmaceutical preparations having analgetic and cytostatic activity
US4894364A (en) 1983-10-26 1990-01-16 Greer Sheldon B Method and materials for sensitizing neoplastic tissue to radiation
US4851229A (en) 1983-12-01 1989-07-25 Alza Corporation Composition comprising a therapeutic agent and a modulating agent
US4671901A (en) 1984-01-26 1987-06-09 Oral-D Orally effective ion chelators
CA1249968A (en) 1984-04-05 1989-02-14 Kazuo Kigasawa Ointment base
US4747825A (en) 1984-06-29 1988-05-31 Ferring Laboratories, Inc. Apparatus and methodology for pulsed administration of growth promoting agents
US4613616A (en) 1984-07-20 1986-09-23 Research Corporation Polymeric iron chelators
JPS61155358A (ja) 1984-12-21 1986-07-15 Suntory Ltd ジアリール酪酸誘導体
JPS61180740A (ja) 1985-02-05 1986-08-13 Asahi Chem Ind Co Ltd 新規なフエニル酢酸又はフエニルチオ酢酸誘導体とそれを有効成分とする植物生育調節剤
US4735967A (en) 1985-05-28 1988-04-05 Neesby Torben E Method for desensitizing the gastrointestinal tract from food allergies
DE3534743A1 (de) 1985-09-28 1987-04-02 Beiersdorf Ag Hydrocortisondiester enthaltende o/w-creme
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4699926A (en) 1986-04-04 1987-10-13 Merck & Co., Inc. Compounds useful in treating sickle cell anemia
US4751244A (en) 1986-04-04 1988-06-14 Merck & Co., Inc. Compounds useful in treating sickle cell anemia
US4731381A (en) 1986-04-04 1988-03-15 Merck & Co., Inc. Method of treating a person for sickle cell anemia
US4948592A (en) 1986-05-09 1990-08-14 Alza Corporation Pulsed drug delivery
US4723958A (en) 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
US5025029A (en) 1986-10-10 1991-06-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
US4822821A (en) 1986-10-10 1989-04-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
US4965251A (en) 1987-04-03 1990-10-23 The Board Of Regents Of The University Of Washington Pulse treatment of hemoglobinopathies with erythropoietin
US4853388A (en) 1987-05-15 1989-08-01 Pearlman Dale L Method for treating psoriasis with cytotoxic agents
US4820711A (en) 1987-05-15 1989-04-11 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
US4849426A (en) 1987-05-15 1989-07-18 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
FR2633929B2 (fr) 1987-09-25 1995-05-24 Picardie Universite Derives non toxiques de l'acide n-butyrique, presentant des actions therapeutiques retardees
US5032507A (en) 1987-11-13 1991-07-16 The Salk Institute For Biological Studies Potentiation of erythropoiesis
DE3742222A1 (de) 1987-12-12 1989-06-22 Basf Ag (2r)-aryloxy-3-n-butyroyloxy-propan-2-ole
US4880624A (en) 1988-03-18 1989-11-14 The Board Of Trustees Of The University Of Illinois Volatile attractants for diabrotica species
GB8912700D0 (en) 1989-06-02 1989-07-19 Shell Int Research Herbicidal compounds
EP0347811B1 (en) 1988-06-20 1994-03-30 Kumiai Chemical Industry Co., Ltd. Alkanoic acid derivatives and herbicidal compositions
US4958592A (en) 1988-08-22 1990-09-25 General Electric Company Resistance heater for diamond production by CVD
US4925873A (en) 1988-09-01 1990-05-15 E. R. Squibb & Sons, Inc. Method of treating skin injuries using thromboxane A2 receptor antagonists
US4997815A (en) 1988-11-01 1991-03-05 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin by treatment with activin and/or inhibin
US5137734A (en) 1989-03-22 1992-08-11 Dana Farber Cancer Institute Angiogenic monoglycerides
US5039703A (en) 1989-11-16 1991-08-13 Breuer Richard I Method for treating inflammatory bowel disorders
GB8929070D0 (en) 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
US5674898A (en) 1990-03-05 1997-10-07 Genzyme Corporation Methods and therapeutic compositions for treating cystic fibrosis
US5258367A (en) 1990-06-29 1993-11-02 University Of Florida Uteroferrin and rose proteins for stimulating hematopoietic cells
US5216004A (en) 1990-09-13 1993-06-01 Children's Hospital Medical Center Of North California Method for preventing malaria
US5100647A (en) 1990-10-02 1992-03-31 The Trustees Of The University Of Pennsylvania Method and formulations for the therapy of cystic fibrosis, Bartter's syndrome and secretory diarrheas, and for diuretic treatment
US5674912A (en) 1991-03-01 1997-10-07 Warner-Lambert Company Sunscreen-wound healing compositions and methods for preparing and using same
US5851828A (en) 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US5270458A (en) 1991-04-02 1993-12-14 The Trustees Of Princeton University Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2
US5199942A (en) 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
WO1993007866A2 (en) 1991-10-21 1993-04-29 Dvorit Samid Compositions and methods for therapy and prevention of cancer, aids, and anemia
US5635532A (en) 1991-10-21 1997-06-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia
US5605930A (en) 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
EP0583482B1 (en) 1992-02-07 1999-12-29 Kaken Pharmaceutical Co., Ltd. Remedy for wound or hemorrhoid
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
US5366996A (en) 1992-12-07 1994-11-22 Elford Howard L Method of treating hemoglobinopathies
US5403590A (en) 1992-12-21 1995-04-04 New England Deaconess Hospital Corporation Method of pulsatile drug infusion
WO1995011699A1 (en) 1993-10-29 1995-05-04 The Trustees Of Boston University Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6011000A (en) 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
AU6714396A (en) 1995-07-28 1997-02-26 Trustees Of Boston University Methods and compositions for treating cell proliferative disorders
US5763488A (en) 1995-10-30 1998-06-09 Vertex Pharmaceuticals Incorporated Methods and compositions using butyrate esters of threitol
ATE476496T1 (de) 1996-03-04 2010-08-15 Calyx Bio Ventures Inc Modifizierte schnellvermehrungsmethode ('modified-rem') zur in vitro vermehrung von t-lymphozyten
DE69713336T2 (de) 1996-03-30 2002-12-05 Science Park Raf S.P.A., Milano Verfahren zur Herstellung von aktivierten markierten tumorspezifischen T-Zellen und deren Verwendung in der Behandlung von Tumoren
US6403647B1 (en) 1996-07-26 2002-06-11 Susan P. Perrine Pulsed administration of compositions for the treatment of blood disorders
AU3889197A (en) 1996-07-26 1998-02-20 Douglas V Faller Compositions comprising an inducing agent and an anti-viral agent for the treat ment of blood, viral and cellular disorders
US5939456A (en) 1996-07-26 1999-08-17 Perrine; Susan P. Pulsed administration of compositions for the treatment of blood disorders
US6197743B1 (en) 1996-07-26 2001-03-06 The Trustees Of Boston University Compositions and methods for the treatment of viral disorders
US6043389A (en) 1997-03-11 2000-03-28 Mor Research Applications, Ltd. Hydroxy and ether-containing oxyalkylene esters and uses thereof
US6030961A (en) 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof
US5932545A (en) 1997-03-17 1999-08-03 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
US6231880B1 (en) 1997-05-30 2001-05-15 Susan P. Perrine Compositions and administration of compositions for the treatment of blood disorders
WO1999040883A2 (en) 1998-02-11 1999-08-19 Faller Douglas V Compositions and methods for the treatment of cystic fibrosis
US7541184B2 (en) 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US20030134341A1 (en) 2001-09-19 2003-07-17 Medcell Biologics, Llc. Th1 cell adoptive immunotherapy
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
US8946295B2 (en) 2002-07-25 2015-02-03 Sunny Pharmtech Inc. Histone hyperacetylating agents for promoting wound healing and preventing scar formation
AU2005277831B2 (en) 2004-07-10 2012-11-22 The Institute For Cancer Research Genetically modified human natural killer cell lines
CA2573369A1 (en) 2004-07-12 2006-02-16 Merck & Co., Inc. Inhibitors of histone deacetylase
US20060069060A1 (en) 2004-09-27 2006-03-30 Sanjeev Redkar Salts of decitabine
US7135833B2 (en) * 2004-11-30 2006-11-14 Rockwell Automation Technologies, Inc. Motor control for flux-reduced braking
FR2881746B1 (fr) 2005-02-07 2007-04-13 Centre Nat Rech Scient Epitopes t cd4+des antigenes de latence de type i et ii du virus epstein-barr aptes a etre reconnus par la majorite des individus de la population caucasienne et leurs applications
GB0509225D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of enzymatic activity
DK2439273T3 (da) 2005-05-09 2019-06-03 Ono Pharmaceutical Co Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
GB0510204D0 (en) * 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
US20080075692A1 (en) 2006-05-09 2008-03-27 Perrine Susan P Methods for treating blood disorders
US20080057086A1 (en) 2006-09-01 2008-03-06 Pharmion Corporation Colon-targeted oral formulations of cytidine analogs
GB0619753D0 (en) 2006-10-06 2006-11-15 Chroma Therapeutics Ltd Enzyme inhibitors
CN105481788A (zh) 2006-10-28 2016-04-13 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
WO2008053131A1 (en) 2006-10-30 2008-05-08 Chroma Therapeutics Ltd. Hydroxamates as inhibitors of histone deacetylase
US20100324034A1 (en) 2007-02-08 2010-12-23 Hazuda Daria J Methods of Using SAHA for Treating HIV Infection
US20090131367A1 (en) 2007-11-19 2009-05-21 The Regents Of The University Of Colorado Combinations of HDAC Inhibitors and Proteasome Inhibitors
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
US20110086869A1 (en) 2009-09-24 2011-04-14 The Trustees Of Boston University Methods for treating viral disorders
US8491927B2 (en) 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
WO2011072086A1 (en) 2009-12-08 2011-06-16 Hemaquest Pharmaceuticals, Inc. Methods and low dose regimens for treating red blood cell disorders
WO2011113013A2 (en) 2010-03-11 2011-09-15 Hemaquest Pharmaceuticals, Inc. Methods and compositions for treating viral or virally-induced conditions
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
KR20140004174A (ko) 2011-01-18 2014-01-10 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암 치료를 위한 조성물 및 방법
DK2683371T3 (da) 2011-03-09 2021-01-18 Cereno Scient Ab Forbindelser og fremgangsmåder til forbedring af forringet endogen fibrinolyse ved anvendelse af histondeacetylasehæmmere
MX358254B (es) 2011-09-02 2018-08-10 Syndax Pharmaceuticals Inc Métodos para el tratamiento de cáncer de mama.
JP6330118B2 (ja) 2011-09-13 2018-05-30 ファーマサイクリックス エルエルシー ベンダムスチンと組み合わせたヒストンデアセチラーゼ阻害剤の製剤とその使用
WO2013044225A1 (en) 2011-09-22 2013-03-28 The Trustees Of The University Of Pennsylvania A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
US9943536B2 (en) 2011-10-03 2018-04-17 Universite Libre De Bruxelles Reactivation of HIV-1 gene expression to treat persistent HIV infection
CN102675153A (zh) * 2011-10-18 2012-09-19 华东理工大学 异羟肟酸的二元羧酸单酯衍生物的抗肿瘤作用和制备方法
CN102516124B (zh) * 2011-11-11 2015-02-25 华东理工大学 具有抗肿瘤作用的二元羧酸双(异羟肟酸)酯及制备方法
CN102391359B (zh) 2011-11-17 2014-07-16 南京优科生物医药研究有限公司 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途
MX373124B (es) 2011-12-08 2020-04-14 Fund Sales Metodos y composiciones para tratar canceres resistentes a antiprogestina.
US20150031739A1 (en) 2012-01-27 2015-01-29 Aarhus Universitet Panobinostat for use in the treatment of hiv-1
US20150099012A1 (en) 2012-03-02 2015-04-09 Erasmus University Medical Center Rotterdam Methods for activating retrovirus in latent infected cells, and compounds for use therein
WO2013149026A2 (en) 2012-03-30 2013-10-03 The Johns Hopkins University Use of n-(4-((3-(2-amino-4-pyrimidinyl) -2-pyridinyl)oxy)phenyl)-4-(4-methyl -2-thienyl)-1-phthalazinamine in combination with histone deacetylase inhibitors for treatment of cancer
AU2013267209B2 (en) 2012-06-01 2017-02-02 Baruch S. Blumberg Institute Modulation of hepatitis B virus cccDNA transcription
CN102793693A (zh) 2012-09-07 2012-11-28 天津医科大学 伏立诺他在制备治疗自身免疫及炎症性疾病药物方面的应用
WO2014074952A1 (en) 2012-11-09 2014-05-15 Massachusetts Institute Of Technology Methods and compositions for localized delivery of agents to hiv-infected cells and tissues
SG11201506766PA (en) 2013-03-15 2015-09-29 Dana Farber Cancer Inst Inc Therapeutic peptides
CN103232474A (zh) 2013-04-16 2013-08-07 中国药科大学 组蛋白去乙酰化酶抑制剂
WO2015010096A1 (en) 2013-07-18 2015-01-22 Baylor College Of Medicine Method of enhancing potency of immune cells
AU2014364593A1 (en) 2013-12-17 2016-07-07 Genentech, Inc. Methods of treating cancer using PD-1 axis binding antagonists and an anti-CD20 antibody
ES2872998T3 (es) 2013-12-19 2021-11-03 Puretein Bioscience Llc Procedimientos de tratamiento de animales
HUE045065T2 (hu) * 2014-01-31 2019-12-30 Novartis Ag TIM-3 antitest molekulák és felhasználásaik
US20150320754A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
CN104083763A (zh) 2014-07-16 2014-10-08 中国人民解放军军事医学科学院野战输血研究所 组蛋白去乙酰化酶抑制剂在制备潜伏病毒激活剂中的应用
RU2555474C1 (ru) 2014-09-09 2015-07-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО РостГМУ Минздрава России) Способ лечения эпштейна-барр вирусной инфекции у детей с вич-инфекцией
US10813952B2 (en) * 2014-11-14 2020-10-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services NK cells with an increased antibody-dependent cellular toxicity (ADCC) against tumors
TWI595006B (zh) * 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗pd-1抗體類和使用彼等之方法
JP6797803B2 (ja) * 2014-12-31 2020-12-09 セルジーン コーポレイション ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法
US20180044418A1 (en) 2015-03-20 2018-02-15 Merck Sharp & Dohme Corp. Combination of a pd-1 antagonist and vorinostat for treating cancer
US20170021002A1 (en) * 2015-05-18 2017-01-26 Batu Biologics, Inc. Augmentation of cancer and cancer endothelial vaccine immunogenicity by histone deacetylase inhibitors
AU2016274989A1 (en) * 2015-06-12 2017-11-02 Immunomedics, Inc. Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
US20180185345A1 (en) 2015-06-19 2018-07-05 Trustees Of Boston University Methods and compositions for treating herpesvirus induced conditions
EP3322731B1 (en) * 2015-07-14 2021-01-13 Bristol-Myers Squibb Company Method of treating cancer using immune checkpoint inhibitor; antibody that binds to programmed death-1 receptor (pd-1) or programmed death ligand 1 (pd-l1)
CN105055386A (zh) 2015-08-12 2015-11-18 天津医科大学总医院 伏立诺他用于制备免疫调节药物的应用
BR112018003238A2 (en) 2015-09-02 2018-09-25 Syndax Pharmaceuticals, Inc. patient selection for combination therapy
WO2017053823A1 (en) 2015-09-25 2017-03-30 Pharmacyclics Llc Treatment using hdac inhibitors and immunotherapy
ITUB20155193A1 (it) 2015-11-03 2017-05-03 Italfarmaco Spa Sospensioni orali di Givinostat fisicamente e chimicamente stabili
KR20180123214A (ko) * 2015-12-09 2018-11-15 난트 홀딩스 아이피, 엘엘씨 Her2 양성 전이성 유방암의 치료를 위한 조성물 및 방법
US20190183870A1 (en) 2016-01-05 2019-06-20 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Combination of histone deacetylase inhibitor and immunotherapy
CN105647946B (zh) 2016-03-18 2019-09-20 江苏普瑞康生物医药科技有限公司 一种基于FcγRⅢa的嵌合基因及其用途
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) * 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
LT3458053T (lt) 2016-05-20 2022-02-25 Biohaven Pharmaceutical Holding Company Ltd. Riluzolo, rilizolo provaistų arba riluzolo analogų panaudojimas kartu su imunoterapijomis vėžio formų gydymui
CN116376812A (zh) 2016-05-25 2023-07-04 国家医疗保健研究所 治疗癌症的方法和组合物
EP4101447A1 (en) * 2016-06-30 2022-12-14 Nant Holdings IP, LLC Nant cancer vaccine
JP7158104B2 (ja) 2016-07-15 2022-10-21 ビラクタ セラピューティクス,インク. Nk細胞ベースの療法で使用するためのhdac阻害剤
CA3042238C (en) * 2016-10-28 2021-08-10 Nant Holdings Ip, Llc Avatar dendritic cells: the neoantigen natural killer t-cell chemo immuno radiation composition inducing immunogenic cell death
WO2018104562A1 (en) * 2016-12-09 2018-06-14 Onkimmune Limited Engineered natural killer cells and uses thereof
EP3688144A4 (en) * 2017-09-29 2021-10-20 NantCell, Inc. CD1D AND TCR-NKT CELLS
CN111132696B (zh) 2017-10-13 2023-05-16 江苏恒瑞医药股份有限公司 Pd-1抗体和表观遗传调节剂联合在制备治疗肿瘤的药物中的用途
US11756651B2 (en) * 2018-01-04 2023-09-12 Nantomics Llc Method of treating a tumor in a patient based on an immune gene expression
CN111836636A (zh) 2018-01-12 2020-10-27 维拉克塔治疗公司 用于细胞免疫疗法的表观遗传修饰剂
EP4317972A3 (en) 2018-02-06 2024-03-13 The General Hospital Corporation Repeat rna as biomarkers of tumor immune response
WO2019195420A1 (en) * 2018-04-04 2019-10-10 Nant Holding IP, LLC Advanced avartar dendritic cells
US11823773B2 (en) * 2018-04-13 2023-11-21 Nant Holdings Ip, Llc Nant cancer vaccine strategies
WO2023003972A1 (en) 2021-07-21 2023-01-26 Viracta Subsidiary, Inc. Cancer treatment combinations

Similar Documents

Publication Publication Date Title
JP2019525957A5 (https=)
Messenheimer et al. Timing of PD-1 blockade is critical to effective combination immunotherapy with anti-OX40
US9663570B2 (en) Single domain antibodies directed against KRAS
JP2016525117A5 (https=)
FI3303396T3 (fi) Vasta-aineita ox40:ää vastaan ja niiden käyttöjä
JP2022515611A5 (https=)
JP2017534633A5 (https=)
RU2018135247A (ru) БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА К CD25 И Fc ГАММА-РЕЦЕПТОРУ ДЛЯ ЭЛИМИНАЦИИ ОПУХОЛЕСПЕЦИФИЧЕСКИХ КЛЕТОК
JP2016531907A5 (https=)
RU2016107426A (ru) Комбинирование агонистов cd27 и ингибирование иммунных контрольных точек для стимуляции иммунитета
JOP20190248A1 (ar) بروتينات ربط مولد ضد trem2 واستخداماته
JP2019511212A5 (https=)
HRP20192098T1 (hr) Antitijela na glukokortikoidom inducirani receptor faktora nekroze tumora (gitr) i njihove primjene
JP2018508483A5 (https=)
JP2017507936A5 (https=)
JP2019506428A5 (https=)
JP2012254092A5 (https=)
RU2018105963A (ru) Антитело против глипикана-3 и его применение
JP2017537892A5 (https=)
JP2018522887A5 (https=)
JP2018505674A5 (https=)
JP2018515474A5 (https=)
JP2017537972A5 (https=)
JP2015535691A5 (https=)
PE20241623A1 (es) Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y usos de los mismos