CN109715173A - 供基于nk细胞的疗法使用的hdac抑制剂 - Google Patents

供基于nk细胞的疗法使用的hdac抑制剂 Download PDF

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Publication number
CN109715173A
CN109715173A CN201780056873.6A CN201780056873A CN109715173A CN 109715173 A CN109715173 A CN 109715173A CN 201780056873 A CN201780056873 A CN 201780056873A CN 109715173 A CN109715173 A CN 109715173A
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cell
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CN201780056873.6A
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Chinese (zh)
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詹姆斯·N·伍迪
帕特里克·苏恩-施翁
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Veracrata Therapeutic Co
Conkwest Inc
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Veracrata Therapeutic Co
Conkwest Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
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CN201780056873.6A 2016-07-15 2017-07-14 供基于nk细胞的疗法使用的hdac抑制剂 Pending CN109715173A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662362959P 2016-07-15 2016-07-15
US62/362,959 2016-07-15
PCT/US2017/042222 WO2018013975A1 (en) 2016-07-15 2017-07-14 Hdac inhibitors for use with nk cell based therapies

Publications (1)

Publication Number Publication Date
CN109715173A true CN109715173A (zh) 2019-05-03

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CN201780056873.6A Pending CN109715173A (zh) 2016-07-15 2017-07-14 供基于nk细胞的疗法使用的hdac抑制剂
CN201780056835.0A Pending CN109803661A (zh) 2016-07-15 2017-07-14 用于免疫疗法的组蛋白脱乙酰酶抑制剂

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CN201780056835.0A Pending CN109803661A (zh) 2016-07-15 2017-07-14 用于免疫疗法的组蛋白脱乙酰酶抑制剂

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US (5) US20190216818A1 (https=)
EP (4) EP4596053A3 (https=)
JP (3) JP7158104B2 (https=)
CN (2) CN109715173A (https=)
GB (2) GB2567093A (https=)
WO (2) WO2018013962A1 (https=)

Cited By (3)

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WO2021169345A1 (zh) * 2020-02-24 2021-09-02 军事科学院军事医学研究院环境医学与作业医学研究所 一种提高外周血单个核细胞线粒体功能的方法和应用
CN113502265A (zh) * 2021-05-25 2021-10-15 昭泰英基生物医药（香港）有限公司 将t细胞重编程为类nk细胞的诱导剂及其应用
WO2024254774A1 (zh) * 2023-06-14 2024-12-19 香港北恒生物科技有限公司 免疫细胞联合疗法

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GB2567093A (en) 2016-07-15 2019-04-03 Viracta Therapeutics Inc Histone deacetylase inhibitors for use in immunotherapy
WO2018106862A1 (en) 2016-12-07 2018-06-14 Agenus Inc. Anti-ctla-4 antibodies and methods of use thereof
WO2019140296A1 (en) * 2018-01-12 2019-07-18 Viracta Therapeutics, Inc. Epigenetic modifiers for use in cellular immunotherapy
US11311603B2 (en) 2018-06-19 2022-04-26 Nantcell, Inc. HIV treatment compositions and methods
CN109306341B (zh) * 2018-09-12 2022-01-28 华东师范大学 Hdac11基因干扰的嵌合抗原受体t细胞及其应用
KR20240162586A (ko) 2018-10-31 2024-11-15 난트퀘스트, 인크. Pd-l1 키메라 항원 수용체-발현 nk 세포에 의한 pd-l1-양성 악성종양의 제거
CA3142142A1 (en) 2019-05-31 2020-12-03 Viracta Subsidiary, Inc. Methods of treating virally associated cancers with histone deacetylase inhibitors
CN112439070A (zh) * 2019-08-28 2021-03-05 深圳微芯生物科技股份有限公司 一种西达本胺药物组合物及其应用
CN114829375A (zh) * 2019-10-07 2022-07-29 维拉克塔附属公司 具有降低的副作用的hdac治疗的剂量
KR102789613B1 (ko) 2019-11-26 2025-04-01 난트퀘스트, 인크. 일차 nk car 구축물 및 방법
WO2021113694A1 (en) 2019-12-05 2021-06-10 Viracta Therapeutics, Inc. Hdac inhibitor solid state forms
KR20230097098A (ko) 2020-10-28 2023-06-30 비락타 서브시디어리 인크. Hdac 억제제 고체 상태 형태
WO2023003972A1 (en) * 2021-07-21 2023-01-26 Viracta Subsidiary, Inc. Cancer treatment combinations
CN119923405A (zh) * 2022-06-23 2025-05-02 艾克西米恩生物技术股份有限公司 与疱疹病毒感染相关的医学病症的治疗或预防

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CN105647946A (zh) * 2016-03-18 2016-06-08 苏州康元生物科技有限公司 一种基于FcγRⅢa的嵌合基因及其用途
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