JP2019525136A5 - - Google Patents
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- JP2019525136A5 JP2019525136A5 JP2018564267A JP2018564267A JP2019525136A5 JP 2019525136 A5 JP2019525136 A5 JP 2019525136A5 JP 2018564267 A JP2018564267 A JP 2018564267A JP 2018564267 A JP2018564267 A JP 2018564267A JP 2019525136 A5 JP2019525136 A5 JP 2019525136A5
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- Japan
- Prior art keywords
- atps
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- phase solution
- probe
- nucleic acid
- Prior art date
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- 239000000523 sample Substances 0.000 claims 48
- 239000003153 chemical reaction reagent Substances 0.000 claims 25
- 108020004707 nucleic acids Proteins 0.000 claims 22
- 102000039446 nucleic acids Human genes 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 22
- 239000012491 analyte Substances 0.000 claims 18
- 230000003321 amplification Effects 0.000 claims 17
- 238000003199 nucleic acid amplification method Methods 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- 238000003556 assay Methods 0.000 claims 13
- 229920000642 polymer Polymers 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 244000005700 microbiome Species 0.000 claims 8
- 239000000090 biomarker Substances 0.000 claims 7
- 238000006243 chemical reaction Methods 0.000 claims 7
- 230000002708 enhancing effect Effects 0.000 claims 7
- 239000000693 micelle Substances 0.000 claims 7
- 239000008280 blood Substances 0.000 claims 6
- 210000004369 blood Anatomy 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 5
- 229940088598 enzyme Drugs 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 4
- 241000195493 Cryptophyta Species 0.000 claims 4
- 229920002307 Dextran Polymers 0.000 claims 4
- 241000233866 Fungi Species 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 238000011901 isothermal amplification Methods 0.000 claims 4
- -1 polyethylene Polymers 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 238000000638 solvent extraction Methods 0.000 claims 4
- 108090001090 Lectins Proteins 0.000 claims 3
- 102000004856 Lectins Human genes 0.000 claims 3
- 108060004795 Methyltransferase Proteins 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 239000002523 lectin Substances 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000004743 Polypropylene Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 238000006073 displacement reaction Methods 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 229920001451 polypropylene glycol Polymers 0.000 claims 2
- 235000000346 sugar Nutrition 0.000 claims 2
- 150000008163 sugars Chemical class 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 235000011330 Armoracia rusticana Nutrition 0.000 claims 1
- 240000003291 Armoracia rusticana Species 0.000 claims 1
- 229910052684 Cerium Inorganic materials 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- 108010015776 Glucose oxidase Proteins 0.000 claims 1
- 239000004366 Glucose oxidase Substances 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 238000007397 LAMP assay Methods 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 229930040373 Paraformaldehyde Natural products 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 102000018120 Recombinases Human genes 0.000 claims 1
- 108010091086 Recombinases Proteins 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- 230000002745 absorbent Effects 0.000 claims 1
- 229920001222 biopolymer Polymers 0.000 claims 1
- 239000013592 cell lysate Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- GWXLDORMOJMVQZ-UHFFFAOYSA-N cerium Chemical compound [Ce] GWXLDORMOJMVQZ-UHFFFAOYSA-N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 229940116332 glucose oxidase Drugs 0.000 claims 1
- 235000019420 glucose oxidase Nutrition 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 238000002032 lab-on-a-chip Methods 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920006324 polyoxymethylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 239000010453 quartz Substances 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662348038P | 2016-06-09 | 2016-06-09 | |
| US62/348,038 | 2016-06-09 | ||
| PCT/US2017/036418 WO2017214315A1 (en) | 2016-06-09 | 2017-06-07 | Biomarker concentration and signal amplification for use in paper-based immunoassays and a single platform for extracting, concentrating, and amplifying dna |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525136A JP2019525136A (ja) | 2019-09-05 |
| JP2019525136A5 true JP2019525136A5 (enExample) | 2020-07-27 |
| JP7320951B2 JP7320951B2 (ja) | 2023-08-04 |
Family
ID=60578148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564267A Active JP7320951B2 (ja) | 2016-06-09 | 2017-06-07 | ペーパーベースのイムノアッセイにおいて使用するためのバイオマーカー濃縮及びシグナル増幅、ならびにｄｎａを抽出、濃縮、及び増幅するための単一プラットフォーム |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11828755B2 (enExample) |
| EP (2) | EP3469365B1 (enExample) |
| JP (1) | JP7320951B2 (enExample) |
| KR (1) | KR102592388B1 (enExample) |
| CN (2) | CN109477133B (enExample) |
| AU (2) | AU2017277631B2 (enExample) |
| ES (1) | ES2939842T3 (enExample) |
| PL (1) | PL3469365T3 (enExample) |
| WO (1) | WO2017214315A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102749064B1 (ko) | 2014-03-07 | 2024-12-31 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 분석물 추출, 농축 및 검출을 통합하기 위한 장치 |
| AU2016318103B2 (en) | 2015-09-04 | 2022-11-17 | The Regents Of The University Of California | Methods and devices for analyte collection, extraction, concentration, and detection for clinical applications |
| WO2017214315A1 (en) | 2016-06-09 | 2017-12-14 | The Regents Of The University Of California | Biomarker concentration and signal amplification for use in paper-based immunoassays and a single platform for extracting, concentrating, and amplifying dna |
| WO2018039139A1 (en) | 2016-08-22 | 2018-03-01 | The Regents Of The University Of California | Hydrogel platform for aqueous two-phase concentration of a target to enhance its detection |
| WO2018183211A1 (en) | 2017-03-27 | 2018-10-04 | The Regents Of The University Of California | Semi-quantitative lateral-flow immunoassay for the detection of csf leaks |
| WO2018183454A1 (en) * | 2017-03-28 | 2018-10-04 | Chiu Yin To | Method and device for accurate diagnosis of dental diseases |
| CN114839374A (zh) | 2017-03-28 | 2022-08-02 | 相达生物科技国际有限公司 | 用于在液体活检中准确诊断疾病靶向生物标记的方法 |
| WO2018222972A1 (en) | 2017-06-01 | 2018-12-06 | Yin To Chiu | Phase separation behavior modifying agents for aqueous two-phase separation within porous material |
| US11609232B2 (en) | 2017-09-01 | 2023-03-21 | Phase Diagnostics, Inc. | Method and device of using aqueous two-phase systems (ATPS) for enhancing diagnostics for sexually transmitted infections |
| ES2964100T3 (es) | 2017-09-18 | 2024-04-04 | Phase Scient International Ltd | Método de utilización de un sistema acuoso bifásico para el aislamiento, purificación y/o concentración de fragmentos cortos de ácidos nucleicos |
| US12043826B2 (en) | 2018-01-19 | 2024-07-23 | Phase Scientific International, Ltd. | Spontaneous nucleic acid purification and concentration in a single step |
| EP3740588A4 (en) | 2018-01-19 | 2021-10-20 | Phase Scientific International, Ltd. | METHOD OF ISOLATION AND PURIFICATION OF NUCLEIC ACIDS USING A SOLID-LIQUID PHASE SYSTEM |
| CN108896506B (zh) * | 2018-07-16 | 2020-10-27 | 济南大学 | 检测碱性磷酸酶活性以及碱性磷酸酶抑制剂浓度的方法 |
| CN110205236A (zh) * | 2019-06-12 | 2019-09-06 | 中国检验检疫科学研究院 | 一种基于rpa技术快速检测核酸的纸微流控芯片 |
| BR112022018784A2 (pt) | 2020-03-20 | 2023-01-31 | Phase Scient International Ltd | Composições e métodos para extração de ácido ribonucleico |
| CN111672544B (zh) * | 2020-06-08 | 2022-03-01 | 江苏师范大学 | 一种基于水两相系统的纸基生化试剂存储方法 |
| JPWO2022075313A1 (enExample) * | 2020-10-06 | 2022-04-14 | ||
| US12383906B2 (en) | 2021-06-14 | 2025-08-12 | University Of Washington | Device and method for detection of pathogens |
| CN113528666B (zh) * | 2021-07-16 | 2023-09-05 | 南京林业大学 | 一种多类型非编码rna检测方法及其在胃癌预警中的应用 |
| CN113791214B (zh) * | 2021-11-15 | 2022-02-22 | 南京黎明生物制品有限公司 | 一种沙眼衣原体抗原检测用增强液及其应用 |
| WO2023147557A2 (en) * | 2022-01-28 | 2023-08-03 | The Johns Hopkins University | Bio-engineered enzymes and uses thereof |
| US20230400459A1 (en) * | 2022-06-09 | 2023-12-14 | Hero Scientific Ltd. | Gargle specimen sampling |
| CN115200954B (zh) * | 2022-06-28 | 2025-05-06 | 珠海大略科技有限公司 | 一种降低唾液粘度的方法及其应用 |
| NL2033124B1 (en) * | 2022-09-23 | 2024-03-29 | Rapidemic B V | Methods and device for multiple-label nucleic acid amplification and detection |
| EP4612288A1 (en) | 2022-11-02 | 2025-09-10 | Phase Scientific International, Ltd. | Methods for isolating target analytes from biological samples using atps and solid phase media |
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| US9310300B2 (en) | 2012-08-03 | 2016-04-12 | Ingeneron Incorporated | Compact portable apparatus for optical assay |
| US20160282343A1 (en) | 2012-08-15 | 2016-09-29 | Immunolab LLC | Quantitative lateral flow assay strips for quantitative analysis of an analyte, kits containing such strips and methods of manufacture and use of same |
| US20150017656A1 (en) | 2012-11-15 | 2015-01-15 | Daniel Wang | Rapid Lateral Flow Assay Method for Detecting Low Quantity Liquid or Dry Samples |
| US20150198592A1 (en) | 2012-11-15 | 2015-07-16 | Daniel Wang | Rapid Lateral Flow Assay Method for Low Quantity Liquid or Dry Samples |
| US20150329900A1 (en) * | 2012-12-18 | 2015-11-19 | Qiagen Gmbh | Nucleic Acid Amplification Method |
| CN103808926B (zh) | 2014-01-14 | 2016-08-17 | 中国科学院生物物理研究所 | 纳米模拟酶免疫层析检测方法 |
| KR102749064B1 (ko) * | 2014-03-07 | 2024-12-31 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 분석물 추출, 농축 및 검출을 통합하기 위한 장치 |
| US20160313307A1 (en) | 2015-04-23 | 2016-10-27 | Ted Titmus | Diagnostic test strip for oral samples and method of use therefore |
| AU2016318103B2 (en) | 2015-09-04 | 2022-11-17 | The Regents Of The University Of California | Methods and devices for analyte collection, extraction, concentration, and detection for clinical applications |
| US20170323441A1 (en) | 2016-05-09 | 2017-11-09 | University Of Washington | Filter-free devices and systems for measuring fluorescence of a microfluidic assay and associated methods of use |
| WO2017214315A1 (en) | 2016-06-09 | 2017-12-14 | The Regents Of The University Of California | Biomarker concentration and signal amplification for use in paper-based immunoassays and a single platform for extracting, concentrating, and amplifying dna |
| US11761958B2 (en) | 2016-07-12 | 2023-09-19 | Purdue Research Foundation | Devices, systems, and methods for the detection of a target analyte using magnetic focus lateral flow immunoassay techniques |
| WO2018039139A1 (en) | 2016-08-22 | 2018-03-01 | The Regents Of The University Of California | Hydrogel platform for aqueous two-phase concentration of a target to enhance its detection |
| WO2018183211A1 (en) | 2017-03-27 | 2018-10-04 | The Regents Of The University Of California | Semi-quantitative lateral-flow immunoassay for the detection of csf leaks |
| EP3635400A4 (en) | 2017-05-31 | 2021-02-24 | The Regents of The University of California | SINGLE-LEVEL, ATPS-EXTENDED LFA DIAGNOSTIC DESIGN |
-
2017
- 2017-06-07 WO PCT/US2017/036418 patent/WO2017214315A1/en not_active Ceased
- 2017-06-07 EP EP17810966.6A patent/EP3469365B1/en active Active
- 2017-06-07 KR KR1020197000413A patent/KR102592388B1/ko active Active
- 2017-06-07 PL PL17810966.6T patent/PL3469365T3/pl unknown
- 2017-06-07 EP EP22211678.2A patent/EP4202439B1/en active Active
- 2017-06-07 JP JP2018564267A patent/JP7320951B2/ja active Active
- 2017-06-07 CN CN201780046652.0A patent/CN109477133B/zh active Active
- 2017-06-07 AU AU2017277631A patent/AU2017277631B2/en active Active
- 2017-06-07 ES ES17810966T patent/ES2939842T3/es active Active
- 2017-06-07 US US16/307,125 patent/US11828755B2/en active Active
- 2017-06-07 CN CN202310306917.3A patent/CN116083539A/zh active Pending
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2023
- 2023-12-11 AU AU2023282181A patent/AU2023282181A1/en active Pending
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