JP7320951B2 - ペーパーベースのイムノアッセイにおいて使用するためのバイオマーカー濃縮及びシグナル増幅、ならびにｄｎａを抽出、濃縮、及び増幅するための単一プラットフォーム - Google Patents

ペーパーベースのイムノアッセイにおいて使用するためのバイオマーカー濃縮及びシグナル増幅、ならびにｄｎａを抽出、濃縮、及び増幅するための単一プラットフォーム Download PDF

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JP7320951B2
JP7320951B2 JP2018564267A JP2018564267A JP7320951B2 JP 7320951 B2 JP7320951 B2 JP 7320951B2 JP 2018564267 A JP2018564267 A JP 2018564267A JP 2018564267 A JP2018564267 A JP 2018564267A JP 7320951 B2 JP7320951 B2 JP 7320951B2
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ダニエル・タカシ・カメイ
ベンジャミン・ミン・ウ
ダニエル・ウィリアム・ブラッドバリー
シン・ティン・シェリーン・フリーダ・チュン
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University of California San Diego UCSD
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    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
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    • C12Q2531/00—Reactions of nucleic acids characterised by
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/625—Detection means characterised by use of a special device being a nucleic acid test strip device, e.g. dipsticks, strips, tapes, CD plates
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/631—Detection means characterised by use of a special device being a biochannel or pore

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2018564267A 2016-06-09 2017-06-07 ペーパーベースのイムノアッセイにおいて使用するためのバイオマーカー濃縮及びシグナル増幅、ならびにｄｎａを抽出、濃縮、及び増幅するための単一プラットフォーム Active JP7320951B2 (ja)

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US201662348038P 2016-06-09 2016-06-09
US62/348,038 2016-06-09
PCT/US2017/036418 WO2017214315A1 (en) 2016-06-09 2017-06-07 Biomarker concentration and signal amplification for use in paper-based immunoassays and a single platform for extracting, concentrating, and amplifying dna

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JP2019525136A JP2019525136A (ja) 2019-09-05
JP2019525136A5 JP2019525136A5 (enExample) 2020-07-27
JP7320951B2 true JP7320951B2 (ja) 2023-08-04

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US (1) US11828755B2 (enExample)
EP (2) EP3469365B1 (enExample)
JP (1) JP7320951B2 (enExample)
KR (1) KR102592388B1 (enExample)
CN (2) CN109477133B (enExample)
AU (2) AU2017277631B2 (enExample)
ES (1) ES2939842T3 (enExample)
PL (1) PL3469365T3 (enExample)
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102749064B1 (ko) 2014-03-07 2024-12-31 더 리전트 오브 더 유니버시티 오브 캘리포니아 분석물 추출, 농축 및 검출을 통합하기 위한 장치
AU2016318103B2 (en) 2015-09-04 2022-11-17 The Regents Of The University Of California Methods and devices for analyte collection, extraction, concentration, and detection for clinical applications
WO2017214315A1 (en) 2016-06-09 2017-12-14 The Regents Of The University Of California Biomarker concentration and signal amplification for use in paper-based immunoassays and a single platform for extracting, concentrating, and amplifying dna
WO2018039139A1 (en) 2016-08-22 2018-03-01 The Regents Of The University Of California Hydrogel platform for aqueous two-phase concentration of a target to enhance its detection
WO2018183211A1 (en) 2017-03-27 2018-10-04 The Regents Of The University Of California Semi-quantitative lateral-flow immunoassay for the detection of csf leaks
WO2018183454A1 (en) * 2017-03-28 2018-10-04 Chiu Yin To Method and device for accurate diagnosis of dental diseases
CN114839374A (zh) 2017-03-28 2022-08-02 相达生物科技国际有限公司 用于在液体活检中准确诊断疾病靶向生物标记的方法
WO2018222972A1 (en) 2017-06-01 2018-12-06 Yin To Chiu Phase separation behavior modifying agents for aqueous two-phase separation within porous material
US11609232B2 (en) 2017-09-01 2023-03-21 Phase Diagnostics, Inc. Method and device of using aqueous two-phase systems (ATPS) for enhancing diagnostics for sexually transmitted infections
ES2964100T3 (es) 2017-09-18 2024-04-04 Phase Scient International Ltd Método de utilización de un sistema acuoso bifásico para el aislamiento, purificación y/o concentración de fragmentos cortos de ácidos nucleicos
US12043826B2 (en) 2018-01-19 2024-07-23 Phase Scientific International, Ltd. Spontaneous nucleic acid purification and concentration in a single step
EP3740588A4 (en) 2018-01-19 2021-10-20 Phase Scientific International, Ltd. METHOD OF ISOLATION AND PURIFICATION OF NUCLEIC ACIDS USING A SOLID-LIQUID PHASE SYSTEM
CN108896506B (zh) * 2018-07-16 2020-10-27 济南大学 检测碱性磷酸酶活性以及碱性磷酸酶抑制剂浓度的方法
CN110205236A (zh) * 2019-06-12 2019-09-06 中国检验检疫科学研究院 一种基于rpa技术快速检测核酸的纸微流控芯片
BR112022018784A2 (pt) 2020-03-20 2023-01-31 Phase Scient International Ltd Composições e métodos para extração de ácido ribonucleico
CN111672544B (zh) * 2020-06-08 2022-03-01 江苏师范大学 一种基于水两相系统的纸基生化试剂存储方法
JPWO2022075313A1 (enExample) * 2020-10-06 2022-04-14
US12383906B2 (en) 2021-06-14 2025-08-12 University Of Washington Device and method for detection of pathogens
CN113528666B (zh) * 2021-07-16 2023-09-05 南京林业大学 一种多类型非编码rna检测方法及其在胃癌预警中的应用
CN113791214B (zh) * 2021-11-15 2022-02-22 南京黎明生物制品有限公司 一种沙眼衣原体抗原检测用增强液及其应用
WO2023147557A2 (en) * 2022-01-28 2023-08-03 The Johns Hopkins University Bio-engineered enzymes and uses thereof
US20230400459A1 (en) * 2022-06-09 2023-12-14 Hero Scientific Ltd. Gargle specimen sampling
CN115200954B (zh) * 2022-06-28 2025-05-06 珠海大略科技有限公司 一种降低唾液粘度的方法及其应用
NL2033124B1 (en) * 2022-09-23 2024-03-29 Rapidemic B V Methods and device for multiple-label nucleic acid amplification and detection
EP4612288A1 (en) 2022-11-02 2025-09-10 Phase Scientific International, Ltd. Methods for isolating target analytes from biological samples using atps and solid phase media

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003250575A (ja) 2002-03-04 2003-09-09 Tohoku Techno Arch Co Ltd ネコ腎臓病診断マーカー
WO2005042579A1 (ja) 2003-10-31 2005-05-12 Fujirebio Inc. 抗ｓａｒｓウイルス抗体、該抗体を産生するハイブリドーマ及び該抗体を用いる免疫測定試薬
JP2011075366A (ja) 2009-09-30 2011-04-14 Fujifilm Corp クロマトグラフ測定装置
WO2015134938A1 (en) 2014-03-07 2015-09-11 The Regents Of The University Of California Devices for integrating analyte extraction, concentration and detection

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
CA2020029A1 (en) 1989-07-12 1991-01-13 Yatin B. Thakore Device and method for separation of plasma from blood and determination of blood analytes
US5141850A (en) 1990-02-07 1992-08-25 Hygeia Sciences, Inc. Porous strip form assay device method
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
US5710005A (en) 1996-10-29 1998-01-20 Biocode, Inc. Analyte detection with a gradient lateral flow device
US6979576B1 (en) 1997-07-25 2005-12-27 Shu-Ching Cheng Methods of use of one step immunochromatographic device for Streptococcus A antigen
US6194221B1 (en) 1996-11-19 2001-02-27 Wyntek Diagnostics, Inc. Hybrid one-step immunochromatographic device and method of use
US6924153B1 (en) 1997-03-06 2005-08-02 Quidel Corporation Quantitative lateral flow assays and devices
EP1064553A4 (en) 1998-03-16 2001-09-12 Quidel Corp DEVICE AND METHOD FOR IMMUNOASSAY
US6743605B1 (en) 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US7390675B2 (en) 1999-10-15 2008-06-24 Christopher Feistel Multi-functional and configurable assay
DK1340085T3 (da) 2000-10-17 2008-12-01 Besst Test Aps Assay til direkte detektion af en biologisk celle i en legemsvæskepröve
US6855561B2 (en) 2001-09-10 2005-02-15 Quidel Corporation Method for adding an apparent non-signal line to a lateral flow assay
US20030215358A1 (en) 2002-01-15 2003-11-20 Schulman Lloyd S. Liquid permeable composition in dry reagent devices
AU2003243559A1 (en) 2002-06-13 2003-12-31 Neuropro Technologies, Inc. Apparatus and methods for detecting cerebrospinal fluid
US7244394B2 (en) 2002-10-03 2007-07-17 Novartis Ag Methods and kits for assays of analytes of interest in tears
US7459314B2 (en) 2003-02-13 2008-12-02 Inverness Medical Switzerland Gmbh Lateral flow immunoassay controls
WO2004081528A2 (en) 2003-03-10 2004-09-23 Robinson Joseph R Assay device and method
US20040203079A1 (en) 2003-04-09 2004-10-14 Research Foundation Of The State University Of New York Methods and kits for detecting cerebrospinal fluid in a sample
US8003765B2 (en) 2003-04-09 2011-08-23 Stony Brook Anaesthesiology, University Faculty Practice Corporation Methods, antibodies and kits for detecting cerebrospinal fluid in a sample
US20070003992A1 (en) 2003-04-09 2007-01-04 Pentyala Srinivas N Methods and kits for detecting cerebrospinal fluid in a sample
WO2005075998A1 (en) 2004-01-29 2005-08-18 Dsm Ip Assets B.V. Improved lateral flow binding assay
US7435577B2 (en) 2004-02-03 2008-10-14 Polymer Technology Systems, Inc. Direct measurement of chlolesterol from low density lipoprotein with test strip
WO2005098439A2 (en) 2004-03-30 2005-10-20 Whatman, Inc. Lateral flow format, materials and mehtods
EP1609800B1 (de) 2004-06-25 2007-11-14 Kühni Ag Verfahren zur Extraktion von biologischem Material
US20060019406A1 (en) 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
US8445293B2 (en) 2005-02-09 2013-05-21 Rapid Pathogen Screening, Inc. Method to increase specificity and/or accuracy of lateral flow immunoassays
US20060246513A1 (en) 2005-05-02 2006-11-02 Bohannon Robert C Method and device to detect the presence of analytes in a sample
WO2006122450A1 (en) 2005-05-20 2006-11-23 Calypte Biomedical Corporation Oral fluid rapid immunochromatography test
US7794656B2 (en) 2006-01-23 2010-09-14 Quidel Corporation Device for handling and analysis of a biological sample
WO2007092302A2 (en) 2006-02-07 2007-08-16 Envirologix Inc. Test device for analyte detection
WO2007098184A2 (en) 2006-02-21 2007-08-30 Nanogen, Inc. Methods and compositions for analyte detection
US20090110601A1 (en) 2006-07-09 2009-04-30 Raphael Levi Molecularly imprinted polymers for detection in lateral flow devices
WO2008043040A2 (en) 2006-10-05 2008-04-10 Massachusetts Institute Of Technology Integrated microfluidic device for preconcentration and detection of multiple biomarkers
CN101578520B (zh) 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
EP2076775B1 (en) 2006-10-18 2015-08-19 President and Fellows of Harvard College Lateral flow and flow-through bioassay based on patterned porous media, methods of making same, and methods of using same
US20080138842A1 (en) 2006-12-11 2008-06-12 Hans Boehringer Indirect lateral flow sandwich assay
KR100902093B1 (ko) 2007-05-23 2009-06-09 인하대학교 산학협력단 미세채널 내에서 가시광선의 투과도 측정을 이용한 액체의Ｄｒｏｐｌｅｔ／Ｐｌｕｇ 및 미세입자 크기와 개수측정장치 및 측정방법
WO2009018348A1 (en) 2007-07-30 2009-02-05 Cornell Research Foundation, Inc. Microchannel detection device and use thereof
WO2009083975A2 (en) 2007-12-27 2009-07-09 Infigo Diagnostics Ltd. Small molecules and protein analysis devices based on molecular imprinted polymers
US8628729B2 (en) 2008-03-27 2014-01-14 President And Fellows Of Harvard College Three-dimensional microfluidic devices
WO2009137059A1 (en) * 2008-05-05 2009-11-12 Los Alamos National Security, Llc Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control
US20130196310A1 (en) 2008-05-20 2013-08-01 Rapid Pathogen Screening, Inc. Method and Device for Combined Detection of Viral and Bacterial Infections
WO2010027812A2 (en) 2008-08-25 2010-03-11 University Of Washington Microfluidic systems incorporating flow-through membranes
KR101761426B1 (ko) 2009-04-28 2017-07-25 덴카 세이켄 가부시키가이샤 간이 멤브레인 어세이 장치
CA2807645C (en) 2009-08-07 2021-09-07 Affinimark Technologies, Inc. Device and methods for the immunological identification of cerebrospinal fluid
US9244057B2 (en) 2010-03-18 2016-01-26 The Regents Of The University Of Michigan Multiphase microarrays and uses thereof
WO2011159537A2 (en) * 2010-06-15 2011-12-22 The Regents Of The University Of California Method and device for analyte detection
US20110312759A1 (en) 2010-06-17 2011-12-22 Geneasys Pty Ltd Genetic analysis loc with reagent reservoir
FR2963108B1 (fr) 2010-07-21 2017-06-23 Diagast Procede magnetique d'immunodiagnostic et kit pour la mise en evidence de complexe anticorps/antigene de groupe/phenotype sanguin
WO2012125781A2 (en) 2011-03-15 2012-09-20 Colorado State University Research Foundation Rapid detection of pathogens using paper devices
DE102011001743A1 (de) 2011-04-01 2012-10-04 Technische Universität Dortmund Verfahren zur Trennung/Reinigung von Biomolekühlen
US9493736B2 (en) * 2011-04-27 2016-11-15 Merck Patent Gmbh Method for lysing cells
US9939442B2 (en) 2011-09-08 2018-04-10 The Regents Of The University Of California Salivary biomarkers for gastric cancer detection
CN104040358A (zh) 2011-09-30 2014-09-10 加利福尼亚大学董事会 微流体装置和使用其测定流体样品的方法
DK2788478T3 (en) 2011-12-09 2017-10-09 Pasteur Institut Multiplex IMMUNSCREENINGSASSAY
WO2013105090A1 (en) 2012-01-11 2013-07-18 Aptateck Bio Ltd. A versatile lateral flow strip device
JP5917201B2 (ja) 2012-03-02 2016-05-11 田中貴金属工業株式会社 イムノクロマトグラフィー用試験ストリップ
US20140004539A1 (en) 2012-06-15 2014-01-02 The Regents Of The University Of Michigan Systems and methods for multiplex solution assays
US9310300B2 (en) 2012-08-03 2016-04-12 Ingeneron Incorporated Compact portable apparatus for optical assay
US20160282343A1 (en) 2012-08-15 2016-09-29 Immunolab LLC Quantitative lateral flow assay strips for quantitative analysis of an analyte, kits containing such strips and methods of manufacture and use of same
US20150017656A1 (en) 2012-11-15 2015-01-15 Daniel Wang Rapid Lateral Flow Assay Method for Detecting Low Quantity Liquid or Dry Samples
US20150198592A1 (en) 2012-11-15 2015-07-16 Daniel Wang Rapid Lateral Flow Assay Method for Low Quantity Liquid or Dry Samples
US20150329900A1 (en) * 2012-12-18 2015-11-19 Qiagen Gmbh Nucleic Acid Amplification Method
CN103808926B (zh) 2014-01-14 2016-08-17 中国科学院生物物理研究所 纳米模拟酶免疫层析检测方法
US20160313307A1 (en) 2015-04-23 2016-10-27 Ted Titmus Diagnostic test strip for oral samples and method of use therefore
AU2016318103B2 (en) 2015-09-04 2022-11-17 The Regents Of The University Of California Methods and devices for analyte collection, extraction, concentration, and detection for clinical applications
US20170323441A1 (en) 2016-05-09 2017-11-09 University Of Washington Filter-free devices and systems for measuring fluorescence of a microfluidic assay and associated methods of use
WO2017214315A1 (en) 2016-06-09 2017-12-14 The Regents Of The University Of California Biomarker concentration and signal amplification for use in paper-based immunoassays and a single platform for extracting, concentrating, and amplifying dna
US11761958B2 (en) 2016-07-12 2023-09-19 Purdue Research Foundation Devices, systems, and methods for the detection of a target analyte using magnetic focus lateral flow immunoassay techniques
WO2018039139A1 (en) 2016-08-22 2018-03-01 The Regents Of The University Of California Hydrogel platform for aqueous two-phase concentration of a target to enhance its detection
WO2018183211A1 (en) 2017-03-27 2018-10-04 The Regents Of The University Of California Semi-quantitative lateral-flow immunoassay for the detection of csf leaks
EP3635400A4 (en) 2017-05-31 2021-02-24 The Regents of The University of California SINGLE-LEVEL, ATPS-EXTENDED LFA DIAGNOSTIC DESIGN

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003250575A (ja) 2002-03-04 2003-09-09 Tohoku Techno Arch Co Ltd ネコ腎臓病診断マーカー
WO2005042579A1 (ja) 2003-10-31 2005-05-12 Fujirebio Inc. 抗ｓａｒｓウイルス抗体、該抗体を産生するハイブリドーマ及び該抗体を用いる免疫測定試薬
JP2011075366A (ja) 2009-09-30 2011-04-14 Fujifilm Corp クロマトグラフ測定装置
WO2015134938A1 (en) 2014-03-07 2015-09-11 The Regents Of The University Of California Devices for integrating analyte extraction, concentration and detection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
R. Y. T. Chiu et al，Biomarker Concentration and Detection Directly on Paper，18th International Conference on Miniaturized Systems for Chemistry and Life Sciences，2014年10月26日，1572-1574
Ricky Y. T. Chiu et at，An Aqueous Two-Phase System for the Concentration and Extraction of Proteins from the Interface for Detection Using the Lateral-Flow Immunoassay，PLoS One，2015年11月10日，10(11)，e0142654

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