JP2019523757A5 - - Google Patents
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- JP2019523757A5 JP2019523757A5 JP2018561060A JP2018561060A JP2019523757A5 JP 2019523757 A5 JP2019523757 A5 JP 2019523757A5 JP 2018561060 A JP2018561060 A JP 2018561060A JP 2018561060 A JP2018561060 A JP 2018561060A JP 2019523757 A5 JP2019523757 A5 JP 2019523757A5
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- 239000000203 mixture Substances 0.000 claims 13
- 150000002632 lipids Chemical group 0.000 claims 12
- 239000002105 nanoparticle Substances 0.000 claims 10
- 229940002612 prodrug Drugs 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 8
- 125000005647 linker group Chemical group 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- 229910052751 metal Inorganic materials 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000013256 coordination polymer Substances 0.000 claims 3
- 229920001795 coordination polymer Polymers 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 229940122361 Bisphosphonate Drugs 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 150000004663 bisphosphonates Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 239000011247 coating layer Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108010001062 polysaccharide-K Proteins 0.000 claims 2
- 229940034049 polysaccharide-k Drugs 0.000 claims 2
- OMSYGYSPFZQFFP-UHFFFAOYSA-J zinc pyrophosphate Chemical compound [Zn+2].[Zn+2].[O-]P([O-])(=O)OP([O-])([O-])=O OMSYGYSPFZQFFP-UHFFFAOYSA-J 0.000 claims 2
- DNTYYKAZXNGNBX-UHFFFAOYSA-N (1-hydroxy-2-phenyl-1-phosphonoethyl)phosphonic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CC=C1 DNTYYKAZXNGNBX-UHFFFAOYSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- YHHSONZFOIEMCP-UHFFFAOYSA-N 2-(trimethylazaniumyl)ethyl hydrogen phosphate Chemical class C[N+](C)(C)CCOP(O)([O-])=O YHHSONZFOIEMCP-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 239000000232 Lipid Bilayer Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 150000001841 cholesterols Chemical class 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 150000002888 oleic acid derivatives Chemical class 0.000 claims 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022032275A JP2022078190A (ja) | 2016-05-20 | 2022-03-03 | 治療薬を送達するためのナノスケール粒子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662339594P | 2016-05-20 | 2016-05-20 | |
| US62/339,594 | 2016-05-20 | ||
| PCT/US2017/033822 WO2017201528A1 (en) | 2016-05-20 | 2017-05-22 | Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022032275A Division JP2022078190A (ja) | 2016-05-20 | 2022-03-03 | 治療薬を送達するためのナノスケール粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523757A JP2019523757A (ja) | 2019-08-29 |
| JP2019523757A5 true JP2019523757A5 (enExample) | 2020-06-25 |
| JP7090034B2 JP7090034B2 (ja) | 2022-06-23 |
Family
ID=60326621
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561060A Active JP7090034B2 (ja) | 2016-05-20 | 2017-05-22 | 化学療法、標的療法、光線力学療法、免疫療法及びそれらの任意の組み合わせのためのナノ粒子 |
| JP2022032275A Pending JP2022078190A (ja) | 2016-05-20 | 2022-03-03 | 治療薬を送達するためのナノスケール粒子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022032275A Pending JP2022078190A (ja) | 2016-05-20 | 2022-03-03 | 治療薬を送達するためのナノスケール粒子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11246877B2 (enExample) |
| EP (1) | EP3439666A4 (enExample) |
| JP (2) | JP7090034B2 (enExample) |
| CN (1) | CN109310702A (enExample) |
| WO (1) | WO2017201528A1 (enExample) |
Families Citing this family (59)
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| WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| US11246877B2 (en) | 2016-05-20 | 2022-02-15 | The University Of Chicago | Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof |
| EP3624810A4 (en) * | 2017-05-18 | 2021-02-17 | The Regents of The University of California | NANO-ACTIVATED IMMUNOTHERAPY FOR CANCER DISEASES |
| US11433143B2 (en) | 2017-05-18 | 2022-09-06 | The Regents Of The University Of California | Nano-enabled immunotherapy in cancer |
| WO2019028250A1 (en) | 2017-08-02 | 2019-02-07 | The University Of Chicago | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
| CA3084833A1 (en) * | 2017-12-06 | 2019-06-13 | Newsouth Innovations Pty Limited | Liposomal system for drug delivery |
| AU2019242912B2 (en) | 2018-03-28 | 2025-07-17 | Board Of Regents, The University Of Texas System | Identification of epigenetic alterations in DNA isolated from exosomes |
| SI3773544T1 (sl) | 2018-04-10 | 2026-01-30 | Cellectar Biosciences, Inc. | Fosfolipid-flavaglin konjugati ter postopki njihove uporabe za ciljno zdravljenje raka |
| US20190314324A1 (en) | 2018-04-13 | 2019-10-17 | The University Of Chicago | Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy |
| AU2019255765B2 (en) * | 2018-04-19 | 2025-02-06 | Board Of Regents, The University Of Texas System | Therapeutic modulation of tumor suppressors using exosomes |
| CN108619511B (zh) * | 2018-04-20 | 2020-12-15 | 山东大学 | 一种基于阿糖胞苷小分子前药的金属有机框架载药系统的制备方法和应用 |
| CN108840896A (zh) * | 2018-04-23 | 2018-11-20 | 上海大学 | 刺激响应型双亲大分子及其制备方法 |
| CN108774264A (zh) * | 2018-05-18 | 2018-11-09 | 东北林业大学 | 卵磷脂类似物、制备方法及用途 |
| CN108794532A (zh) * | 2018-05-18 | 2018-11-13 | 东北林业大学 | 脑磷脂类似物、制备方法及用途 |
| JP2021531266A (ja) | 2018-07-12 | 2021-11-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 免疫応答を調節可能な金属含有製剤のための組成物および方法 |
| CN110872324B (zh) * | 2018-08-29 | 2021-09-14 | 中国科学院上海药物研究所 | 奥沙利铂偶联前药、其制备方法及用途 |
| JP7486505B2 (ja) | 2018-10-16 | 2024-05-17 | ファーマ イン シリカ ラボラトリーズ インコーポレイティド | シリカカプセル／スフェアの調製のためのチューニング可能な方法及びそれらの使用 |
| CN109336857A (zh) * | 2018-11-13 | 2019-02-15 | 南方医科大学 | 一种含取代联苯的黄酮及其应用 |
| EP3934642B1 (en) * | 2019-03-07 | 2025-11-19 | Virginia Commonwealth University | Lipidic analogs of anti-cancer stem cell agent |
| CN111840228A (zh) * | 2019-04-09 | 2020-10-30 | 中国科学院上海药物研究所 | 肿瘤免疫脂质体，其制备方法和用途 |
| WO2020217472A1 (ja) * | 2019-04-26 | 2020-10-29 | 株式会社Jimro | 治療抵抗性がんの予防又は治療用の医薬組成物 |
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| WO2024144339A1 (ko) * | 2022-12-29 | 2024-07-04 | 가톨릭대학교 산학협력단 | 면역관문 억제제의 항암 효과 증진용 약학적 조성물 |
| IT202300015396A1 (it) * | 2023-07-21 | 2025-01-21 | Torino Politecnico | Nanoparticelle rivestite e loro uso per il trasporto di agenti terapeutici e diagnostici |
| CN119431497B (zh) * | 2023-07-31 | 2025-10-21 | 北京大学 | 靶向pd-l1蛋白的光敏剂嵌合体及其制备方法和应用 |
| WO2025077898A1 (en) * | 2023-10-13 | 2025-04-17 | The Chinese University Of Hong Kong | A therapeutic nucleic acid-encased nanoworm for gene delivery and endosomal escape |
| CN117442601B (zh) * | 2023-10-31 | 2024-05-28 | 上海市东方医院（同济大学附属东方医院） | 一种磷酸酶抑制剂类似物BX-金属NPs及其制备方法和应用 |
| CN118576709B (zh) * | 2024-05-23 | 2025-10-17 | 大连理工大学 | 一种光敏性载体及其制备方法与应用 |
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-
2017
- 2017-05-22 US US16/302,185 patent/US11246877B2/en active Active
- 2017-05-22 WO PCT/US2017/033822 patent/WO2017201528A1/en not_active Ceased
- 2017-05-22 JP JP2018561060A patent/JP7090034B2/ja active Active
- 2017-05-22 EP EP17800330.7A patent/EP3439666A4/en active Pending
- 2017-05-22 CN CN201780031000.XA patent/CN109310702A/zh active Pending
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2022
- 2022-03-03 JP JP2022032275A patent/JP2022078190A/ja active Pending
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