JP2019523757A5 - - Google Patents
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- JP2019523757A5 JP2019523757A5 JP2018561060A JP2018561060A JP2019523757A5 JP 2019523757 A5 JP2019523757 A5 JP 2019523757A5 JP 2018561060 A JP2018561060 A JP 2018561060A JP 2018561060 A JP2018561060 A JP 2018561060A JP 2019523757 A5 JP2019523757 A5 JP 2019523757A5
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- 239000000203 mixture Substances 0.000 claims 13
- 150000002632 lipids Chemical group 0.000 claims 12
- 239000002105 nanoparticle Substances 0.000 claims 10
- 229940002612 prodrug Drugs 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 8
- 125000005647 linker group Chemical group 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- 229910052751 metal Inorganic materials 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000013256 coordination polymer Substances 0.000 claims 3
- 229920001795 coordination polymer Polymers 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 229940122361 Bisphosphonate Drugs 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 150000004663 bisphosphonates Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 239000011247 coating layer Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108010001062 polysaccharide-K Proteins 0.000 claims 2
- 229940034049 polysaccharide-k Drugs 0.000 claims 2
- OMSYGYSPFZQFFP-UHFFFAOYSA-J zinc pyrophosphate Chemical compound [Zn+2].[Zn+2].[O-]P([O-])(=O)OP([O-])([O-])=O OMSYGYSPFZQFFP-UHFFFAOYSA-J 0.000 claims 2
- DNTYYKAZXNGNBX-UHFFFAOYSA-N (1-hydroxy-2-phenyl-1-phosphonoethyl)phosphonic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CC=C1 DNTYYKAZXNGNBX-UHFFFAOYSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- YHHSONZFOIEMCP-UHFFFAOYSA-N 2-(trimethylazaniumyl)ethyl hydrogen phosphate Chemical class C[N+](C)(C)CCOP(O)([O-])=O YHHSONZFOIEMCP-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 239000000232 Lipid Bilayer Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 150000001841 cholesterols Chemical class 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 150000002888 oleic acid derivatives Chemical class 0.000 claims 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022032275A JP2022078190A (ja) | 2016-05-20 | 2022-03-03 | 治療薬を送達するためのナノスケール粒子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662339594P | 2016-05-20 | 2016-05-20 | |
| US62/339,594 | 2016-05-20 | ||
| PCT/US2017/033822 WO2017201528A1 (en) | 2016-05-20 | 2017-05-22 | Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022032275A Division JP2022078190A (ja) | 2016-05-20 | 2022-03-03 | 治療薬を送達するためのナノスケール粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523757A JP2019523757A (ja) | 2019-08-29 |
| JP2019523757A5 true JP2019523757A5 (enExample) | 2020-06-25 |
| JP7090034B2 JP7090034B2 (ja) | 2022-06-23 |
Family
ID=60326621
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561060A Active JP7090034B2 (ja) | 2016-05-20 | 2017-05-22 | 化学療法、標的療法、光線力学療法、免疫療法及びそれらの任意の組み合わせのためのナノ粒子 |
| JP2022032275A Pending JP2022078190A (ja) | 2016-05-20 | 2022-03-03 | 治療薬を送達するためのナノスケール粒子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022032275A Pending JP2022078190A (ja) | 2016-05-20 | 2022-03-03 | 治療薬を送達するためのナノスケール粒子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11246877B2 (enExample) |
| EP (1) | EP3439666A4 (enExample) |
| JP (2) | JP7090034B2 (enExample) |
| CN (1) | CN109310702A (enExample) |
| WO (1) | WO2017201528A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6049712B2 (ja) | 2011-07-08 | 2016-12-21 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ | 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子 |
| EP3439666A4 (en) | 2016-05-20 | 2019-12-11 | The University of Chicago | NANOPARTICLES FOR CHEMOTHERAPY, TARGETED THERAPY, PHOTODYNAMIC THERAPY, IMMUNOTHERAPY AND ALL COMBINATIONS THEREOF |
| WO2018213631A1 (en) * | 2017-05-18 | 2018-11-22 | The Regents Of The University Of California | Nano-enabled immunotherapy in cancer |
| US11433143B2 (en) | 2017-05-18 | 2022-09-06 | The Regents Of The University Of California | Nano-enabled immunotherapy in cancer |
| CN111194232B (zh) | 2017-08-02 | 2023-01-31 | 芝加哥大学 | 纳米级金属有机层和金属有机纳米片 |
| WO2019109126A1 (en) * | 2017-12-06 | 2019-06-13 | Newsouth Innovations Pty Limited | Liposomal system for drug delivery |
| JP7474702B2 (ja) | 2018-03-28 | 2024-04-25 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | エキソソームから単離されたｄｎａにおけるエピジェネティック変化の同定法 |
| US20190314324A1 (en) | 2018-04-13 | 2019-10-17 | The University Of Chicago | Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy |
| CN112512507A (zh) * | 2018-04-19 | 2021-03-16 | 得克萨斯州大学系统董事会 | 使用外排体对肿瘤抑制因子的治疗性调节 |
| CN108619511B (zh) * | 2018-04-20 | 2020-12-15 | 山东大学 | 一种基于阿糖胞苷小分子前药的金属有机框架载药系统的制备方法和应用 |
| CN108840896A (zh) * | 2018-04-23 | 2018-11-20 | 上海大学 | 刺激响应型双亲大分子及其制备方法 |
| CN108774264A (zh) * | 2018-05-18 | 2018-11-09 | 东北林业大学 | 卵磷脂类似物、制备方法及用途 |
| CN108794532A (zh) * | 2018-05-18 | 2018-11-13 | 东北林业大学 | 脑磷脂类似物、制备方法及用途 |
| CN110872324B (zh) * | 2018-08-29 | 2021-09-14 | 中国科学院上海药物研究所 | 奥沙利铂偶联前药、其制备方法及用途 |
| IL282213B2 (en) | 2018-10-16 | 2025-07-01 | Silicycle Inc | A tunable process for the preparation and use of silica capsules/spheres |
| CN109336857A (zh) * | 2018-11-13 | 2019-02-15 | 南方医科大学 | 一种含取代联苯的黄酮及其应用 |
| US12358941B2 (en) | 2019-03-07 | 2025-07-15 | Virginia Commonwealth University | Lipidic analogs of anti-cancer stem cell agent |
| CN111840228A (zh) * | 2019-04-09 | 2020-10-30 | 中国科学院上海药物研究所 | 肿瘤免疫脂质体，其制备方法和用途 |
| WO2020217472A1 (ja) * | 2019-04-26 | 2020-10-29 | 株式会社Jimro | 治療抵抗性がんの予防又は治療用の医薬組成物 |
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| CN110201162B (zh) * | 2019-06-14 | 2021-09-07 | 中山大学附属第八医院（深圳福田） | 光治疗剂在打破肿瘤免疫抑制微环境中的应用 |
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| KR20230066582A (ko) * | 2020-09-10 | 2023-05-16 | 남미 테라퓨틱스, 인크. | 암의 치료에 유용한 pd-1 길항제 전구약물을 함유하는 제제화된 및/또는 공동-제제화된 리포솜 조성물 및 그의 방법 |
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| KR20240107310A (ko) * | 2022-12-29 | 2024-07-09 | 가톨릭대학교 산학협력단 | 면역관문 억제제의 항암 효과 증진용 약학적 조성물 |
| IT202300015396A1 (it) * | 2023-07-21 | 2025-01-21 | Torino Politecnico | Nanoparticelle rivestite e loro uso per il trasporto di agenti terapeutici e diagnostici |
| CN119431497B (zh) * | 2023-07-31 | 2025-10-21 | 北京大学 | 靶向pd-l1蛋白的光敏剂嵌合体及其制备方法和应用 |
| WO2025077898A1 (en) * | 2023-10-13 | 2025-04-17 | The Chinese University Of Hong Kong | A therapeutic nucleic acid-encased nanoworm for gene delivery and endosomal escape |
| CN117442601B (zh) * | 2023-10-31 | 2024-05-28 | 上海市东方医院（同济大学附属东方医院） | 一种磷酸酶抑制剂类似物BX-金属NPs及其制备方法和应用 |
| CN118576709B (zh) * | 2024-05-23 | 2025-10-17 | 大连理工大学 | 一种光敏性载体及其制备方法与应用 |
| CN120114415B (zh) * | 2025-05-15 | 2025-08-29 | 浙江大学 | 一种具有腹腔靶向性的氯膦酸盐脂质纳米颗粒及其应用 |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61351A (en) | 1980-10-27 | 1983-12-30 | Yeda Res & Dev | Organometallic polymers,their preparation and compositions of co-ordination compounds containing them |
| US5147806A (en) | 1988-04-29 | 1992-09-15 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescence measurements |
| US5213788A (en) | 1988-09-29 | 1993-05-25 | Ranney David F | Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement |
| CA2086527A1 (en) | 1990-07-26 | 1992-01-27 | Samuel J. Tremont | Polymeric drug delivery system |
| US6013638A (en) | 1991-10-02 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5871710A (en) | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
| US5591730A (en) | 1993-10-12 | 1997-01-07 | The Regents Of The University Of California | Inhibition of urinary calculi growth |
| US5641623A (en) | 1995-01-04 | 1997-06-24 | Martin; Mark T. | Electrochemiluminescence assay |
| US20010003647A1 (en) | 1995-06-07 | 2001-06-14 | Ji Sun | Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same |
| US6022737A (en) | 1995-11-02 | 2000-02-08 | Amgen Inc. | Formulations for non-viral in vivo transfection in the lungs |
| US5648508A (en) | 1995-11-22 | 1997-07-15 | Nalco Chemical Company | Crystalline metal-organic microporous materials |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| ATE236188T1 (de) | 1997-01-24 | 2003-04-15 | Conpharma As | Gemcitabin-derivate |
| US6180082B1 (en) | 1997-11-24 | 2001-01-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method to enhance tissue accumulation of radiolabeled compounds |
| US6984400B2 (en) | 1998-07-14 | 2006-01-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of treating restenosis using bisphosphonate nanoparticles |
| US6818227B1 (en) | 1999-02-08 | 2004-11-16 | Alza Corporation | Liposome composition and method for administration of a radiosensitizer |
| EP1161226B1 (en) * | 1999-02-18 | 2004-05-26 | SuperGen, Inc. | Phosphocholine linked prodrug derivatives |
| US20020064520A1 (en) * | 1999-08-19 | 2002-05-30 | Yanina Rozenberg | Targeted artificial gene delivery |
| US6602932B2 (en) | 1999-12-15 | 2003-08-05 | North Carolina State University | Nanoparticle composites and nanocapsules for guest encapsulation and methods for synthesizing same |
| CA2405360A1 (en) | 2000-04-07 | 2001-10-18 | The Board Of Regents Of The University Of Texas System | Unique compositions of zwitterionic phospholipids and bisphosphonates and use of the compositions as bisphosphate delivery systems with reduced gi toxicity |
| US6548264B1 (en) | 2000-05-17 | 2003-04-15 | University Of Florida | Coated nanoparticles |
| US6565873B1 (en) | 2000-10-25 | 2003-05-20 | Salvona Llc | Biodegradable bioadhesive controlled release system of nano-particles for oral care products |
| US20020127224A1 (en) | 2001-03-02 | 2002-09-12 | James Chen | Use of photoluminescent nanoparticles for photodynamic therapy |
| ES2269761T3 (es) | 2001-04-30 | 2007-04-01 | The Regents Of The University Of Michigan | Estructuras organometalicas isorreticulares, procedimiento para su formacion, y diseño sistematico del calibre de poros y funcionalidad de los mismos, con aplicacion para el almacenamiento de gases. |
| AU2003226082A1 (en) | 2002-03-25 | 2003-11-11 | The General Hospital Corporation | Methods of adjuvant photodynamic therapy to enhance radiation sensitization |
| CA2499977A1 (en) | 2002-09-28 | 2004-04-08 | Mcneil-Ppc, Inc. | Edible solid composition and dosage form |
| WO2004041203A2 (en) | 2002-11-04 | 2004-05-21 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| KR100401335B1 (en) | 2003-03-08 | 2003-10-10 | Mijitech Co Ltd | Metal nanoparticle surface-coated with silicon oxides and preparation thereof |
| US6878838B2 (en) | 2003-03-24 | 2005-04-12 | The University Of North Carolina At Chapel Hill | Chiral porous metal phosphonates for heterogeneous asymmetric catalysis |
| WO2004084871A1 (en) | 2003-03-26 | 2004-10-07 | Ltt Bio-Pharma Co., Ltd. | Intravenous nanoparticles for targenting drug delivery and sustained drug release |
| WO2004089345A1 (en) | 2003-04-03 | 2004-10-21 | Semafore Pharmaceuticals Inc. | Bone targeting of biodegradable drug-containing nanoparticles |
| KR101278432B1 (ko) | 2003-05-09 | 2013-07-04 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 결정들에서 우수한 수준의 표면적과 다공성의 성취를 위한 방법의 이행 |
| AU2004261243A1 (en) | 2003-07-31 | 2005-02-10 | 3M Innovative Properties Company | Bioactive compositions comprising triazines |
| US20050227929A1 (en) | 2003-11-13 | 2005-10-13 | Masferrer Jaime L | Combination therapy comprising a Cox-2 inhibitor and an antineoplastic agent |
| US20050147963A1 (en) | 2003-12-29 | 2005-07-07 | Intel Corporation | Composite organic-inorganic nanoparticles and methods for use thereof |
| JP4487032B2 (ja) | 2004-03-29 | 2010-06-23 | 独立行政法人放射線医学総合研究所 | ヒール効果補正フィルタ、ｘ線照射装置、ｘ線ｃｔ装置及びｘ線ｃｔ撮像方法 |
| US20070259966A1 (en) | 2004-04-22 | 2007-11-08 | Allos Therapeutics, Inc. | Coadministration of Radiation, Efaproxiral Sodium, and Supplemental Oxygen for the Treatment of Cancer |
| FR2869803B1 (fr) | 2004-05-10 | 2006-07-28 | Nanobiotix Sarl | Particules activables, preparation et utilisations |
| FR2874016B1 (fr) | 2004-06-30 | 2006-11-24 | Centre Nat Rech Scient Cnrse | Nanoparticules de derives de la gemcitabine |
| US7964571B2 (en) | 2004-12-09 | 2011-06-21 | Egen, Inc. | Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases |
| US20070218049A1 (en) | 2006-02-02 | 2007-09-20 | Wei Chen | Nanoparticle based photodynamic therapy and methods of making and using same |
| JP4992091B2 (ja) | 2005-02-17 | 2012-08-08 | ハダシット メディカル リサーチ サービシーズ アンド デベロップメント リミテッド | 子宮内膜症を治療するためのビスホスホネート |
| CN1305937C (zh) | 2005-02-25 | 2007-03-21 | 复旦大学 | 一种金属配位聚合物纳米结构材料的制备方法 |
| EP1865928A1 (en) | 2005-03-17 | 2007-12-19 | Elan Pharma International Limited | Nanoparticulate biphosphonate compositions |
| NO322682B1 (no) | 2005-03-18 | 2006-11-27 | Clavis Pharma Asa | Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer |
| PE20070360A1 (es) | 2005-09-01 | 2007-04-19 | Novartis Ag | Composiciones de liposomas |
| US20080095699A1 (en) | 2006-10-20 | 2008-04-24 | Shiying Zheng | Imaging contrast agents using nanoparticles |
| US7263170B2 (en) | 2005-09-30 | 2007-08-28 | Pellegrino Anthony J | Radiation therapy system featuring rotatable filter assembly |
| US20070088161A1 (en) | 2005-10-19 | 2007-04-19 | Stockel Richard F | Novel chelated bisphosphonates for use as pharmaceutical agents |
| US20090242856A1 (en) | 2006-02-09 | 2009-10-01 | Simon Fraser University | Birefringent metal-containing coordination polymers |
| US20100189222A1 (en) | 2006-02-16 | 2010-07-29 | Steller Micro Devices | Panoramic irradiation system using flat panel x-ray sources |
| KR100943923B1 (ko) | 2006-03-17 | 2010-02-24 | 홍순해 | 킬레이팅 유기 고분자와 생물학적 금속으로 이루어진 나노입자, 그리고 ｅｐｒ 효과를 이용한 새로운 광범위 무독성항암제 및 그 제조 방법 |
| US20090317335A1 (en) | 2006-04-20 | 2009-12-24 | Wenbin Lin | Hybrid Nanomaterials as Multimodal Imaging Contrast Agents |
| WO2008016172A1 (fr) | 2006-08-04 | 2008-02-07 | Kurume University | Inhibiteur de métastase |
| US7985868B1 (en) | 2006-11-01 | 2011-07-26 | Sandia Corporation | Hybrid metal organic scintillator materials system and particle detector |
| US20080124281A1 (en) | 2006-11-29 | 2008-05-29 | Board Of Regents, The University Of Texas System | Nanotubular probes as ultrasensitive mr contrast agent |
| JPWO2008102632A1 (ja) | 2007-02-21 | 2010-05-27 | コニカミノルタエムジー株式会社 | Ｘ線バンドパスフィルタ、ｘ線照射システム及びｘ線撮影システム |
| WO2008124639A2 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Poly (amino acid) targeting moieties |
| US8486452B2 (en) | 2007-07-20 | 2013-07-16 | Mylan Pharmaceuticals Inc. | Stabilized tolterodine tartrate formulations |
| US8691748B2 (en) | 2007-09-25 | 2014-04-08 | The Regents Of The University Of California | Edible and biocompatible metal-organic frameworks |
| FR2921838A1 (fr) | 2007-10-05 | 2009-04-10 | Guerbet Sa | Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice gem-bisphosphonate couplee a des ligands de biodistribution hydrophile |
| WO2009139939A2 (en) | 2008-02-22 | 2009-11-19 | The University Of North Carolina At Chapel Hill | Hybrid nanoparticles as anti-cancer therapeutic agents and dual therapeutic/imaging contrast agents |
| WO2009114476A1 (en) | 2008-03-12 | 2009-09-17 | Intradigm Corporation | Compositions comprising survivin sirna and methods of use thereof |
| GB0807862D0 (en) | 2008-04-29 | 2008-06-04 | Uni I Oslo | Compounds |
| WO2010096464A1 (en) | 2009-02-18 | 2010-08-26 | Boyes Stephen G | Gold/lanthanide nanoparticle conjugates and uses thereof |
| US20100221329A1 (en) | 2008-12-03 | 2010-09-02 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase c agonists and methods of use |
| US9302003B2 (en) | 2009-04-24 | 2016-04-05 | Socpra—Sciences Santé´Et Humaines | Compositions comprising a radiosensitizer and an anti-cancer agent and methods of uses thereof |
| SG176103A1 (en) | 2009-05-25 | 2011-12-29 | Merck Patent Gmbh | Continuous administration of cilengitide in cancer treatments |
| WO2010140986A1 (en) | 2009-06-05 | 2010-12-09 | Nanyang Technological University | Targetted drug delivery to the bone |
| GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
| WO2011049743A1 (en) | 2009-10-06 | 2011-04-28 | Stellarray, Inc. | Self contained irradiation system using flat panel x-ray sources |
| EP2488206B1 (en) | 2009-10-16 | 2018-03-21 | University Health Network (UHN) | Porphyrin nanovesicles |
| AU2010322516A1 (en) | 2009-11-20 | 2012-05-17 | Clavis Pharma Asa | Parenteral formulations of gemcitabine derivatives |
| GB201013307D0 (en) | 2010-08-09 | 2010-09-22 | Univ St Andrews | Anti-microbial metal organic framework |
| IT1401882B1 (it) | 2010-10-01 | 2013-08-28 | Rosa De | Nanoparticelle autoassemblanti per il rilascio di bifosfonati nel trattamento di tumori. |
| WO2012138419A1 (en) | 2011-04-04 | 2012-10-11 | Georgia Tech Research Corporation | Mof nanocrystals |
| NO2694640T3 (enExample) | 2011-04-15 | 2018-03-17 | ||
| US20120301537A1 (en) | 2011-05-23 | 2012-11-29 | Delta-Fly Pharma, Inc. | LIPOSOME CONTAINING shRNA MOLECULE TARGETING A THYMIDYLATE SYNTHASE AND USE THEREOF |
| JP6076968B2 (ja) | 2011-06-06 | 2017-02-08 | ユニバーシティ・ヘルス・ネットワーク | ポルフィリン−リン脂質コンジュゲートを合成する方法 |
| EP2721032A4 (en) | 2011-06-16 | 2014-11-05 | Univ South Florida | POLYHEDRIC CAGE WITH METAL OPORPHYRENE EQUIPMENT, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THEIR USE |
| JP6049712B2 (ja) | 2011-07-08 | 2016-12-21 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ | 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子 |
| WO2013012628A2 (en) | 2011-07-15 | 2013-01-24 | The University Of Georgia Research Foundation, Inc. | Immune-stimulating photoactive hybrid nanoparticles |
| CN102432654A (zh) | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| WO2013068965A2 (en) | 2011-11-11 | 2013-05-16 | Koninklijke Philips Electronics N.V. | Lighting apparatus and manufacturing method for manufacturing the lighting apparatus |
| MX362089B (es) | 2011-12-16 | 2019-01-07 | Nanobiotix | Nanopartículas que comprenden materiales metálicos y óxido de hafnio, preparación y usos de los mismos. |
| WO2013188763A1 (en) | 2012-06-15 | 2013-12-19 | The Brigham And Women's Hospital, Inc. | Compositions for treating cancer and methods for making the same |
| WO2014107873A1 (zh) | 2013-01-11 | 2014-07-17 | 苏州丁孚靶点生物技术有限公司 | 用于肿瘤治疗的试剂、其用途及方法 |
| US10350275B2 (en) | 2013-09-21 | 2019-07-16 | Advantagene, Inc. | Methods of cytotoxic gene therapy to treat tumors |
| WO2015069926A1 (en) * | 2013-11-06 | 2015-05-14 | The University Of Chicago | Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers |
| US10647733B2 (en) | 2014-03-28 | 2020-05-12 | The University Of Chicago | Metal-organic frameworks containing nitrogen-donor ligands for efficient catalytic organic transformations |
| WO2015149068A1 (en) | 2014-03-28 | 2015-10-01 | The University Of Chicago | Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis |
| US10806694B2 (en) | 2014-10-14 | 2020-10-20 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
| EP3206987B2 (en) | 2014-10-14 | 2024-07-24 | The University of Chicago | Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof |
| US20180214563A1 (en) * | 2015-07-31 | 2018-08-02 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Immunostimulatory nanocarrier |
| US10953393B2 (en) | 2015-10-12 | 2021-03-23 | The University Of Chicago | Stabilization of active metal catalysts at metal-organic framework nodes for highly efficient organic transformations |
| CN105457038A (zh) | 2015-11-09 | 2016-04-06 | 东南大学 | 一种速释型药物磷脂化合物及其药物组合物 |
| EP3439666A4 (en) | 2016-05-20 | 2019-12-11 | The University of Chicago | NANOPARTICLES FOR CHEMOTHERAPY, TARGETED THERAPY, PHOTODYNAMIC THERAPY, IMMUNOTHERAPY AND ALL COMBINATIONS THEREOF |
-
2017
- 2017-05-22 EP EP17800330.7A patent/EP3439666A4/en active Pending
- 2017-05-22 CN CN201780031000.XA patent/CN109310702A/zh active Pending
- 2017-05-22 US US16/302,185 patent/US11246877B2/en active Active
- 2017-05-22 JP JP2018561060A patent/JP7090034B2/ja active Active
- 2017-05-22 WO PCT/US2017/033822 patent/WO2017201528A1/en not_active Ceased
-
2022
- 2022-03-03 JP JP2022032275A patent/JP2022078190A/ja active Pending
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