JP2019500355A5 - - Google Patents
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- JP2019500355A5 JP2019500355A5 JP2018530561A JP2018530561A JP2019500355A5 JP 2019500355 A5 JP2019500355 A5 JP 2019500355A5 JP 2018530561 A JP2018530561 A JP 2018530561A JP 2018530561 A JP2018530561 A JP 2018530561A JP 2019500355 A5 JP2019500355 A5 JP 2019500355A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- item
- disease
- disorder
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562273246P | 2015-12-30 | 2015-12-30 | |
| US62/273,246 | 2015-12-30 | ||
| PCT/US2016/069511 WO2017117538A1 (en) | 2015-12-30 | 2016-12-30 | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019500355A JP2019500355A (ja) | 2019-01-10 |
| JP2019500355A5 true JP2019500355A5 (enExample) | 2020-01-30 |
Family
ID=57868367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530561A Pending JP2019500355A (ja) | 2015-12-30 | 2016-12-30 | 汎インテグリンアンタゴニストとしてのメタ−アザ環式アミノ安息香酸誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10035778B2 (enExample) |
| EP (2) | EP3294716B1 (enExample) |
| JP (1) | JP2019500355A (enExample) |
| KR (1) | KR20180107121A (enExample) |
| CN (1) | CN108779077A (enExample) |
| AU (1) | AU2016381336A1 (enExample) |
| BR (1) | BR112018012981A2 (enExample) |
| CA (1) | CA3008023A1 (enExample) |
| CO (1) | CO2018007278A2 (enExample) |
| ES (1) | ES2806276T3 (enExample) |
| HK (1) | HK1244806A1 (enExample) |
| IL (1) | IL259951A (enExample) |
| PH (1) | PH12018501362A1 (enExample) |
| RU (1) | RU2729518C2 (enExample) |
| SG (1) | SG11201805387RA (enExample) |
| WO (1) | WO2017117538A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016381336A1 (en) * | 2015-12-30 | 2018-06-28 | Saint Louis University | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
| US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| SG11201907820SA (en) | 2017-02-28 | 2019-09-27 | Morphic Therapeutic Inc | Inhibitors of (alpha-v)(beta-6) integrin |
| WO2019099560A1 (en) * | 2017-11-14 | 2019-05-23 | The Schepens Eye Research Institute, Inc. | Runx1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition |
| EP3843727A4 (en) | 2018-08-29 | 2022-08-17 | Morphic Therapeutic, Inc. | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN |
| CA3109534A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibiting .alpha.v .beta.6 integrin |
| UY38352A (es) | 2018-08-29 | 2020-03-31 | Morphic Therapeutic Inc | Inhibidores de integrina alfavbeta6 |
| EP4034236A1 (en) | 2019-09-26 | 2022-08-03 | Abionyx Pharma SA | Compounds useful for treating liver diseases |
| TW202135811A (zh) * | 2019-12-20 | 2021-10-01 | 瑞士商諾華公司 | 使用整聯蛋白抑制劑組合治療肝臟疾病 |
| BR112022023058A2 (pt) * | 2020-05-14 | 2022-12-20 | Ube Corp | Derivado de 1,4,5,6-tetrahidropirimidin-2-amina |
| WO2022189856A1 (en) | 2021-03-08 | 2022-09-15 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| EP4431098A4 (en) * | 2021-11-12 | 2025-10-08 | Ube Corp | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF ALPORT SYNDROME |
| EP4733297A1 (en) | 2023-06-22 | 2026-04-29 | Antibody Therapeutics, Inc. | Integrin-inhibiting small molecule compound |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602155A (en) | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
| US5639765A (en) | 1995-01-17 | 1997-06-17 | G. D. Searle & Co. | Guanidinoalkyl glycine β-amino acids useful for inhibiting bone loss |
| US5681820A (en) | 1995-05-16 | 1997-10-28 | G. D. Searle & Co. | Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis |
| CZ293323B6 (cs) * | 1995-08-30 | 2004-04-14 | G. D. Searle & Co. | Meta-guanidinové, močovinové, thiomočovinové nebo azacyklické deriváty aminobenzoové kyseliny jako antagonisty integrinů |
| US6100423A (en) | 1995-08-30 | 2000-08-08 | G. D. Searle & Co. | Amino benzenepropanoic acid compounds and derivatives thereof |
| US6013651A (en) * | 1995-08-30 | 2000-01-11 | G. D. Searle & Co. | Meta-azacyclic amino benzoic acid compounds and derivatives thereof |
| PT891325E (pt) | 1996-03-29 | 2002-07-31 | Searle & Co | Derivados do acido fenilpropanoico para-substituido como antagonistas de integrina |
| WO1997036862A1 (en) | 1996-03-29 | 1997-10-09 | G.D. Searle & Co. | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS |
| DK0894084T3 (da) | 1996-03-29 | 2002-10-14 | Searle & Co | Kanelsyrederivater og deres anvendelse som integrinantagonister |
| JP2000514809A (ja) | 1996-07-12 | 2000-11-07 | ジー．ディー．サール アンド カンパニー | キラルβ―アミノ酸の不斉合成 |
| US6372719B1 (en) | 1998-03-04 | 2002-04-16 | Jay Cunningham | ανβ3 integrin antagonists in combination with chemotherapeutic agents |
| US6172256B1 (en) | 1998-03-04 | 2001-01-09 | G.D. Searle & Co. | Chiral-β-amino acid compounds and derivatives thereof |
| ZA991107B (en) | 1998-03-04 | 2000-02-14 | Searle & Co | Process for preparing 3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino] benzoic acid. |
| ZA991105B (en) | 1998-03-04 | 2000-02-11 | Searle & Co | Synthesis of chiral beta-amino acids. |
| ZA994406B (en) | 1998-03-04 | 2000-02-11 | Searle & Co | Meta-azacyclic amino benzoic acid and derivatives thereof. |
| KR20010042614A (ko) | 1998-04-10 | 2001-05-25 | 윌리암스 로저 에이 | 비트로넥틴 길항제로서 복소환식 글리실 베타-알라닌 유도체 |
| CN1398189A (zh) | 1998-12-23 | 2003-02-19 | G.D.西尔公司 | 用于治疗肿瘤形成的放疗与cox－2抑制剂的联合治疗 |
| US6933304B2 (en) | 2000-06-15 | 2005-08-23 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
| EP1317270A1 (en) | 2000-09-08 | 2003-06-11 | Pharmacia Italia S.p.A. | Exemestane for the treatment of oestrogen-dependent cancers |
| CA2434611A1 (en) | 2001-01-26 | 2002-09-19 | Pharmacia Italia Spa | Combined method for treating hormono-dependent disorders |
| US20040082557A1 (en) | 2001-01-26 | 2004-04-29 | Wajszczuk Charles Paul | Methods for treating estrogen-dependent disorders |
| EP1435967A2 (en) | 2001-10-10 | 2004-07-14 | Pharmacia Italia S.p.A. | Methods for preventing and treating bone loss with steroid compounds |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| MXPA05006732A (es) * | 2002-12-20 | 2005-09-08 | Pharmacia Corp | El isomero r de compuesto de beta-aminoacido como derivados de antagonistas de receptor de la integrina. |
| JP4912881B2 (ja) | 2003-10-01 | 2012-04-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗線維症薬としてのαｖβ３及びαｖβ６インテグリンアンタゴニスト |
| TWI433839B (zh) | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| US9345739B2 (en) | 2007-11-08 | 2016-05-24 | The General Hospital Corporation | Methods and compositions for the treatment of proteinuric diseases |
| WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
| EP2358203A4 (en) | 2008-10-24 | 2012-06-06 | Univ Wake Forest | PLATINACRIDIN COMPOUNDS AGAINST CANCER AND METHOD THEREFOR |
| DE102009000854A1 (de) | 2009-02-13 | 2010-08-19 | Ernst-Moritz-Arndt-Universität Greifswald | Osteopontin-Rezeptor-Liganden zur Behandlung des chronischen Nierenversagens |
| WO2010104933A1 (en) | 2009-03-11 | 2010-09-16 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| EP2609092B1 (en) | 2010-08-26 | 2015-04-01 | Boehringer Ingelheim International GmbH | Oxadiazole inhibitors of leukotriene production |
| WO2013033430A1 (en) | 2011-09-02 | 2013-03-07 | Wake Forest School Of Medicine | Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof |
| US8716226B2 (en) * | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
| US9085606B2 (en) * | 2012-07-18 | 2015-07-21 | Saint Louis University | Beta amino acid derivatives as integrin antagonists |
| WO2016172710A2 (en) | 2015-04-24 | 2016-10-27 | Cornell University | Methods and reagents for determination and treatment of organotropic metastasis |
| AU2016381336A1 (en) * | 2015-12-30 | 2018-06-28 | Saint Louis University | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
-
2016
- 2016-12-30 AU AU2016381336A patent/AU2016381336A1/en not_active Abandoned
- 2016-12-30 SG SG11201805387RA patent/SG11201805387RA/en unknown
- 2016-12-30 HK HK18104335.6A patent/HK1244806A1/zh unknown
- 2016-12-30 CN CN201680081360.6A patent/CN108779077A/zh active Pending
- 2016-12-30 EP EP16829387.6A patent/EP3294716B1/en active Active
- 2016-12-30 CA CA3008023A patent/CA3008023A1/en not_active Abandoned
- 2016-12-30 KR KR1020187021837A patent/KR20180107121A/ko not_active Withdrawn
- 2016-12-30 BR BR112018012981-0A patent/BR112018012981A2/pt not_active Application Discontinuation
- 2016-12-30 WO PCT/US2016/069511 patent/WO2017117538A1/en not_active Ceased
- 2016-12-30 RU RU2018120935A patent/RU2729518C2/ru active
- 2016-12-30 EP EP20169477.5A patent/EP3738953A1/en not_active Withdrawn
- 2016-12-30 ES ES16829387T patent/ES2806276T3/es active Active
- 2016-12-30 JP JP2018530561A patent/JP2019500355A/ja active Pending
-
2017
- 2017-11-14 US US15/812,986 patent/US10035778B2/en active Active
-
2018
- 2018-06-11 IL IL259951A patent/IL259951A/en unknown
- 2018-06-25 PH PH12018501362A patent/PH12018501362A1/en unknown
- 2018-07-12 CO CONC2018/0007278A patent/CO2018007278A2/es unknown
- 2018-07-30 US US16/049,679 patent/US10577330B2/en active Active
-
2020
- 2020-03-02 US US16/806,963 patent/US20200199079A1/en not_active Abandoned
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