JP2019500355A5 - - Google Patents
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- JP2019500355A5 JP2019500355A5 JP2018530561A JP2018530561A JP2019500355A5 JP 2019500355 A5 JP2019500355 A5 JP 2019500355A5 JP 2018530561 A JP2018530561 A JP 2018530561A JP 2018530561 A JP2018530561 A JP 2018530561A JP 2019500355 A5 JP2019500355 A5 JP 2019500355A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- item
- disease
- disorder
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562273246P | 2015-12-30 | 2015-12-30 | |
| US62/273,246 | 2015-12-30 | ||
| PCT/US2016/069511 WO2017117538A1 (en) | 2015-12-30 | 2016-12-30 | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019500355A JP2019500355A (ja) | 2019-01-10 |
| JP2019500355A5 true JP2019500355A5 (enExample) | 2020-01-30 |
Family
ID=57868367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530561A Pending JP2019500355A (ja) | 2015-12-30 | 2016-12-30 | 汎インテグリンアンタゴニストとしてのメタ−アザ環式アミノ安息香酸誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10035778B2 (enExample) |
| EP (2) | EP3294716B1 (enExample) |
| JP (1) | JP2019500355A (enExample) |
| KR (1) | KR20180107121A (enExample) |
| CN (1) | CN108779077A (enExample) |
| AU (1) | AU2016381336A1 (enExample) |
| BR (1) | BR112018012981A2 (enExample) |
| CA (1) | CA3008023A1 (enExample) |
| CO (1) | CO2018007278A2 (enExample) |
| ES (1) | ES2806276T3 (enExample) |
| HK (1) | HK1244806A1 (enExample) |
| IL (1) | IL259951A (enExample) |
| PH (1) | PH12018501362A1 (enExample) |
| RU (1) | RU2729518C2 (enExample) |
| SG (1) | SG11201805387RA (enExample) |
| WO (1) | WO2017117538A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1244806A1 (zh) * | 2015-12-30 | 2018-08-17 | Saint Louis University | 作為過氧乙醯硝酸整聯蛋白拮抗劑的間氮雜環氨基苯甲酸衍生物 |
| BR112019017929A2 (pt) | 2017-02-28 | 2020-05-19 | Morphic Therapeutic Inc | inibidores de integrina (alfa-v)(beta-6) |
| EP4147698A1 (en) | 2017-02-28 | 2023-03-15 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| EP3710008A4 (en) * | 2017-11-14 | 2021-08-25 | The Schepens Eye Research Institute, Inc. | RUNX1 INHIBITION FOR THE TREATMENT OF PROLIFERATIVE VITREORETINOPATHY AND DISEASES ASSOCIATED WITH EPITHELIAL-MESENCHYMAL TRANSITION |
| ES3019404T3 (en) | 2018-08-29 | 2025-05-20 | Morphic Therapeutic Inc | Integrin inhibitors |
| WO2021059023A1 (en) | 2019-09-26 | 2021-04-01 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| KR20220119424A (ko) * | 2019-12-20 | 2022-08-29 | 노파르티스 아게 | 인테그린 억제제를 사용한 간 질환의 조합 치료 |
| EP4151632A4 (en) * | 2020-05-14 | 2024-04-24 | UBE Corporation | 1, 4, 5, 6-tetrahydropyrimidine-2-amine derivative |
| WO2022189856A1 (en) | 2021-03-08 | 2022-09-15 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| EP4431098A4 (en) * | 2021-11-12 | 2025-10-08 | Ube Corp | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF ALPORT SYNDROME |
| WO2024262620A1 (ja) * | 2023-06-22 | 2024-12-26 | 株式会社抗体医学研究所 | インテグリン阻害低分子化合物 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639765A (en) | 1995-01-17 | 1997-06-17 | G. D. Searle & Co. | Guanidinoalkyl glycine β-amino acids useful for inhibiting bone loss |
| US5602155A (en) | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
| US5681820A (en) | 1995-05-16 | 1997-10-28 | G. D. Searle & Co. | Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis |
| US6013651A (en) * | 1995-08-30 | 2000-01-11 | G. D. Searle & Co. | Meta-azacyclic amino benzoic acid compounds and derivatives thereof |
| US6100423A (en) | 1995-08-30 | 2000-08-08 | G. D. Searle & Co. | Amino benzenepropanoic acid compounds and derivatives thereof |
| AU702487B2 (en) * | 1995-08-30 | 1999-02-25 | G.D. Searle & Co. | Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists |
| ES2162676T3 (es) | 1996-03-29 | 2002-01-01 | Searle & Co | Derivados de fenileno sustituidos en meta y su uso como antagonistas o inhibidores de integrina alfav,beta3. |
| JP2000510098A (ja) | 1996-03-29 | 2000-08-08 | ジー．ディー．サール アンド カンパニー | 桂皮酸誘導体 |
| ES2172780T3 (es) | 1996-03-29 | 2002-10-01 | Searle & Co | Derivados de acido fenilpropanoico sustituidos en para como antagonistas de integrina. |
| PT912495E (pt) | 1996-07-12 | 2002-04-29 | Searle & Co | Sintese assimetrica de beta-aminoacidos quirais |
| US6372719B1 (en) | 1998-03-04 | 2002-04-16 | Jay Cunningham | ανβ3 integrin antagonists in combination with chemotherapeutic agents |
| ZA991107B (en) | 1998-03-04 | 2000-02-14 | Searle & Co | Process for preparing 3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino] benzoic acid. |
| ZA994406B (en) | 1998-03-04 | 2000-02-11 | Searle & Co | Meta-azacyclic amino benzoic acid and derivatives thereof. |
| ZA991105B (en) | 1998-03-04 | 2000-02-11 | Searle & Co | Synthesis of chiral beta-amino acids. |
| US6172256B1 (en) | 1998-03-04 | 2001-01-09 | G.D. Searle & Co. | Chiral-β-amino acid compounds and derivatives thereof |
| JP2002511462A (ja) | 1998-04-10 | 2002-04-16 | ジー・ディー・サール・アンド・カンパニー | ビトロネクチンアンタゴニストとしてのヘテロ環式グリシルβ−アラニン誘導体 |
| JP2002533404A (ja) | 1998-12-23 | 2002-10-08 | ジー・ディー・サール・アンド・カンパニー | 新生物形成の治療における組合わせ療法としてインテグリン拮抗剤及び放射線治療を使用する方法 |
| JP2004511434A (ja) | 2000-06-15 | 2004-04-15 | ファルマシア・コーポレーション | インテグリン受容体アンタゴニストとしてのヘテロアリールアルカン酸 |
| KR20030043955A (ko) | 2000-09-08 | 2003-06-02 | 파마시아 이탈리아 에스.피.에이. | 화학적 예방제로서 엑스메스탄 |
| US20040082557A1 (en) | 2001-01-26 | 2004-04-29 | Wajszczuk Charles Paul | Methods for treating estrogen-dependent disorders |
| ATE337787T1 (de) | 2001-01-26 | 2006-09-15 | Pfizer Italia Srl | Exemestan zur behandlung von hormonabhängigen störungen |
| MXPA04003405A (es) | 2001-10-10 | 2004-06-18 | Pharmacia Italia Spa | Metodos para prevenir y tratar la perdida de hueso con compuestos esteroidales. |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| JP2006514050A (ja) * | 2002-12-20 | 2006-04-27 | ファルマシア・コーポレーション | インテグリン受容体アンタゴニスト誘導体としてのβ−アミノ酸化合物のＲ異性体 |
| ES2308227T3 (es) | 2003-10-01 | 2008-12-01 | Merck Patent Gmbh | Antagonistas de integrina alfavbeta3 y alfavbeta6 como agentes antifibroticos. |
| TWI433839B (zh) | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| EP2730282A1 (en) | 2007-11-08 | 2014-05-14 | The General Hospital Corporation | Methods and compositions for the treatment of proteinuric diseases |
| WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
| CA2741683C (en) | 2008-10-24 | 2016-03-22 | Wake Forest University | Platinum acridine anti-cancer compounds and methods thereof |
| DE102009000854A1 (de) | 2009-02-13 | 2010-08-19 | Ernst-Moritz-Arndt-Universität Greifswald | Osteopontin-Rezeptor-Liganden zur Behandlung des chronischen Nierenversagens |
| WO2010104933A1 (en) | 2009-03-11 | 2010-09-16 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| WO2012027322A1 (en) | 2010-08-26 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| US9090640B2 (en) | 2011-09-02 | 2015-07-28 | Ulrich Bierbach | Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof |
| US8716226B2 (en) * | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
| CN104640857B (zh) * | 2012-07-18 | 2017-07-04 | 圣路易斯大学 | 作为整合素拮抗剂的β氨基酸衍生物 |
| WO2016172710A2 (en) | 2015-04-24 | 2016-10-27 | Cornell University | Methods and reagents for determination and treatment of organotropic metastasis |
| HK1244806A1 (zh) * | 2015-12-30 | 2018-08-17 | Saint Louis University | 作為過氧乙醯硝酸整聯蛋白拮抗劑的間氮雜環氨基苯甲酸衍生物 |
-
2016
- 2016-12-30 HK HK18104335.6A patent/HK1244806A1/zh unknown
- 2016-12-30 KR KR1020187021837A patent/KR20180107121A/ko not_active Withdrawn
- 2016-12-30 CA CA3008023A patent/CA3008023A1/en not_active Abandoned
- 2016-12-30 BR BR112018012981-0A patent/BR112018012981A2/pt not_active Application Discontinuation
- 2016-12-30 CN CN201680081360.6A patent/CN108779077A/zh active Pending
- 2016-12-30 ES ES16829387T patent/ES2806276T3/es active Active
- 2016-12-30 SG SG11201805387RA patent/SG11201805387RA/en unknown
- 2016-12-30 EP EP16829387.6A patent/EP3294716B1/en active Active
- 2016-12-30 EP EP20169477.5A patent/EP3738953A1/en not_active Withdrawn
- 2016-12-30 AU AU2016381336A patent/AU2016381336A1/en not_active Abandoned
- 2016-12-30 RU RU2018120935A patent/RU2729518C2/ru active
- 2016-12-30 WO PCT/US2016/069511 patent/WO2017117538A1/en not_active Ceased
- 2016-12-30 JP JP2018530561A patent/JP2019500355A/ja active Pending
-
2017
- 2017-11-14 US US15/812,986 patent/US10035778B2/en active Active
-
2018
- 2018-06-11 IL IL259951A patent/IL259951A/en unknown
- 2018-06-25 PH PH12018501362A patent/PH12018501362A1/en unknown
- 2018-07-12 CO CONC2018/0007278A patent/CO2018007278A2/es unknown
- 2018-07-30 US US16/049,679 patent/US10577330B2/en active Active
-
2020
- 2020-03-02 US US16/806,963 patent/US20200199079A1/en not_active Abandoned
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