CN108779077A - 作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物 - Google Patents

作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物 Download PDF

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Publication number
CN108779077A
CN108779077A CN201680081360.6A CN201680081360A CN108779077A CN 108779077 A CN108779077 A CN 108779077A CN 201680081360 A CN201680081360 A CN 201680081360A CN 108779077 A CN108779077 A CN 108779077A
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disease
compound
amino
disorder
hydroxy
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彼得·G·鲁明斯基
大卫·W·格里格斯
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St Louis University
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St Louis University
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  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
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  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680081360.6A 2015-12-30 2016-12-30 作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物 Pending CN108779077A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562273246P 2015-12-30 2015-12-30
US62/273,246 2015-12-30
PCT/US2016/069511 WO2017117538A1 (en) 2015-12-30 2016-12-30 Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists

Publications (1)

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CN108779077A true CN108779077A (zh) 2018-11-09

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CN201680081360.6A Pending CN108779077A (zh) 2015-12-30 2016-12-30 作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物

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US (3) US10035778B2 (enExample)
EP (2) EP3738953A1 (enExample)
JP (1) JP2019500355A (enExample)
KR (1) KR20180107121A (enExample)
CN (1) CN108779077A (enExample)
AU (1) AU2016381336A1 (enExample)
BR (1) BR112018012981A2 (enExample)
CA (1) CA3008023A1 (enExample)
CO (1) CO2018007278A2 (enExample)
ES (1) ES2806276T3 (enExample)
HK (1) HK1244806A1 (enExample)
IL (1) IL259951A (enExample)
PH (1) PH12018501362A1 (enExample)
RU (1) RU2729518C2 (enExample)
SG (1) SG11201805387RA (enExample)
WO (1) WO2017117538A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3008023A1 (en) * 2015-12-30 2017-07-06 Saint Louis University Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
EP3589285A4 (en) 2017-02-28 2020-08-12 Morphic Therapeutic, Inc. INHIBITORS OF INTEGRIN (ALPHA-V) (BETA-6)
MA47697A (fr) 2017-02-28 2020-01-08 Morphic Therapeutic Inc Inhibiteurs de l'(alpha-v)(bêta-6) intégrine
JP7416700B2 (ja) * 2017-11-14 2024-01-17 ザ スキーペンズ アイ リサーチ インスティチュート インコーポレイテッド 増殖性硝子体網膜症および上皮間葉転換と関連付けられる状態の治療のためのｒｕｎｘ１阻害の方法
EP3617206A1 (en) 2018-08-29 2020-03-04 Morphic Therapeutic, Inc. Integrin inhibitors
EP4034236A1 (en) 2019-09-26 2022-08-03 Abionyx Pharma SA Compounds useful for treating liver diseases
IL293894A (en) * 2019-12-20 2022-08-01 Novartis Ag Combination treatment of liver diseases using integrin inhibitors
BR112022023058A2 (pt) * 2020-05-14 2022-12-20 Ube Corp Derivado de 1,4,5,6-tetrahidropirimidin-2-amina
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
JPWO2023085396A1 (enExample) 2021-11-12 2023-05-19
WO2024262620A1 (ja) * 2023-06-22 2024-12-26 株式会社抗体医学研究所 インテグリン阻害低分子化合物

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US20050020505A1 (en) * 2002-12-20 2005-01-27 Thomas Rogers R-isomer of beta amino acid compounds as integrin receptor antagonists derivatives
CN1656090A (zh) * 2002-05-24 2005-08-17 伊兰制药公司 抑制由α4整合素调介的白血球粘附的杂环化合物
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US20140051715A1 (en) * 2012-07-18 2014-02-20 Saint Louis University 3,5 Phenyl-Substituted Beta Amino Acid Derivatives as Integrin Antagonists

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