BR112022023058A2 - Derivado de 1,4,5,6-tetrahidropirimidin-2-amina - Google Patents

Derivado de 1,4,5,6-tetrahidropirimidin-2-amina

Info

Publication number
BR112022023058A2
BR112022023058A2 BR112022023058A BR112022023058A BR112022023058A2 BR 112022023058 A2 BR112022023058 A2 BR 112022023058A2 BR 112022023058 A BR112022023058 A BR 112022023058A BR 112022023058 A BR112022023058 A BR 112022023058A BR 112022023058 A2 BR112022023058 A2 BR 112022023058A2
Authority
BR
Brazil
Prior art keywords
group
hydrogen atom
tetrahydropyrimidin
amine derivative
atom
Prior art date
Application number
BR112022023058A
Other languages
English (en)
Inventor
Komori Ken-Ichi
Yamada Haruka
Shimizu Hayato
Aga Yasuhiro
Ogawa Ayumi
Hasegawa Toru
Matsushita Takashi
Tokunaga Yasunori
Original Assignee
Ube Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Corp filed Critical Ube Corp
Publication of BR112022023058A2 publication Critical patent/BR112022023058A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADO DE 1,4,5,6-TETRAHIDROPIRIMIDIN-2-AMINA. É fornecido um composto representado pelas seguintes fórmulas gerais (I) ou (II) ou um sal farmaceuticamente aceitável do mesmo, em que A é um grupo C6-C10 arila ou um grupo heteroarila, em que pelo menos um átomo de hidrogênio do grupo arila ou do grupo heteroarila é opcionalmente substituído com um substituinte selecionado a partir de um grupo predeterminado, R é um átomo de hidrogênio ou um grupo C1-C6 alquila, R1 é um átomo de hidrogênio ou um átomo de halogênio e Y é um átomo de hidrogênio, um átomo de flúor ou um grupo hidroxi.
BR112022023058A 2020-05-14 2021-05-13 Derivado de 1,4,5,6-tetrahidropirimidin-2-amina BR112022023058A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020085420 2020-05-14
PCT/JP2021/018252 WO2021230325A1 (ja) 2020-05-14 2021-05-13 １，４，５，６－テトラヒドロピリミジン－２－アミン誘導体

Publications (1)

Publication Number Publication Date
BR112022023058A2 true BR112022023058A2 (pt) 2022-12-20

Family

ID=78524455

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022023058A BR112022023058A2 (pt) 2020-05-14 2021-05-13 Derivado de 1,4,5,6-tetrahidropirimidin-2-amina

Country Status (10)

Country Link
US (1) US20230192661A1 (pt)
EP (1) EP4151632A4 (pt)
JP (1) JPWO2021230325A1 (pt)
KR (1) KR20230011967A (pt)
CN (1) CN115551846B (pt)
AU (1) AU2021270095A1 (pt)
BR (1) BR112022023058A2 (pt)
CA (1) CA3182964A1 (pt)
MX (1) MX2022014200A (pt)
WO (1) WO2021230325A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023085396A1 (ja) * 2021-11-12 2023-05-19 Ｕｂｅ株式会社 アルポート症候群を治療または予防するための医薬組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028223A (en) 1995-08-30 2000-02-22 G. D. Searle & Co. Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid compounds and derivatives thereof
US6372719B1 (en) 1998-03-04 2002-04-16 Jay Cunningham ανβ3 integrin antagonists in combination with chemotherapeutic agents
ZA994406B (en) 1998-03-04 2000-02-11 Searle & Co Meta-azacyclic amino benzoic acid and derivatives thereof.
BR9910119A (pt) * 1998-04-10 2001-10-09 Searle & Co Derivados heterocìclicos de glicil beta-alanina como antagonistas de vitronectina
BR0317487A (pt) 2002-12-20 2005-11-29 Pharmacia Corp O r-isÈmero de compostos de aminoácido beta como derivados de antagonistas de receptores de integrina
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
US9085606B2 (en) * 2012-07-18 2015-07-21 Saint Louis University Beta amino acid derivatives as integrin antagonists
ES2806276T3 (es) * 2015-12-30 2021-02-17 Univ Saint Louis Derivados de ácido aminobenzoico meta-azaciclicos como antagonistas pan-integrina

Also Published As

Publication number Publication date
JPWO2021230325A1 (pt) 2021-11-18
AU2021270095A1 (en) 2022-12-22
CN115551846B (zh) 2024-03-08
EP4151632A1 (en) 2023-03-22
KR20230011967A (ko) 2023-01-25
US20230192661A1 (en) 2023-06-22
MX2022014200A (es) 2022-12-07
WO2021230325A1 (ja) 2021-11-18
CN115551846A (zh) 2022-12-30
CA3182964A1 (en) 2021-11-18
EP4151632A4 (en) 2024-04-24

Similar Documents

Publication Publication Date Title
CY1108481T1 (el) Ενωσεις 2,3-διϋδρο-6-νιτροϊμιδαζο[2,1-β]οξαζολιου για τη θεραπεια φυματιωσης
CL2020003386A1 (es) Agente profiláctico o terapéutico para atrofia muscular espinal
EA201101089A1 (ru) Производные оксадиазола в качестве агонистов рецептора s1p1
DE602004022404D1 (de) 4-anilino-chinazolin-derivate als proliferationshemmende mittel
ES2188016T3 (es) Derivaqdo de benzamidoxima, productos intermedios y procedimiento para su obtencion y su empleo como fungicidas.
BR122019003178B1 (pt) método de controle de pestes
UA91470C2 (ru) Нематоцидная композиция, способ борьбы с нематодами и применение производной n-2-(пиридил) этилкарбоксамида в качестве нематоцида
BR112014029501A2 (pt) composto heterocíclico fundido
CY1117923T1 (el) Αζωτουχος ετεροκυκλικη ενωση και γεωργικο ή κηπουρικο μυκητοκτονο
BRPI0817973A2 (pt) derivados de nicotinamida, o respectivo preparo e a respectiva aplicação em terapêutica
DK0636622T3 (da) Isoxazolderivater samt deres anvendelse som herbicider
NO20053449L (no) 3-substituerte 4-pyrimidonderivater
TNSN07178A1 (fr) N-sulfonylaminobenzyl-2-phenoxy-acetamides substitues
CR10034A (es) Derivados de oxadiazol
NO20075650L (no) Tri- eller tetrasubstituterte 3-aminopyrrolidinderivater
BR112022023058A2 (pt) Derivado de 1,4,5,6-tetrahidropirimidin-2-amina
MX2021008252A (es) Compuesto de pirimidina o sal del mismo.
KR890006590A (ko) 4-아미노피리딘 유도체
BR112018069551A2 (pt) composto heterocíclico.
ATE169921T1 (de) Optisch aktive beta-aminoalkoxyborankomplexe
DE69617909T2 (de) 2-substituierte vitamin-d3-derivate
CY1105158T1 (el) Εκδοχα πυριδοϊνδολονης που φερει υποκαταστατη στο -3 μια ετepοκυκλικη ομαδα, η παρασκευη τους και η εφαρμογη τους στη θepαπευτικη
MX2022002362A (es) Derivado de 2-aminoquinazolinona.
BR112018008885A2 (pt) composto heterocíclico condensado
DK1163258T3 (da) Derivater af 22R-hydroxycholesta-8, 14-dien til inhiberingen af meiosis