NO20075650L - Tri- eller tetrasubstituterte 3-aminopyrrolidinderivater - Google Patents
Tri- eller tetrasubstituterte 3-aminopyrrolidinderivaterInfo
- Publication number
- NO20075650L NO20075650L NO20075650A NO20075650A NO20075650L NO 20075650 L NO20075650 L NO 20075650L NO 20075650 A NO20075650 A NO 20075650A NO 20075650 A NO20075650 A NO 20075650A NO 20075650 L NO20075650 L NO 20075650L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen atom
- carbon atoms
- alkyl group
- group containing
- represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Det er tilveiebrakt et syntetisk, antibakterielt kinolon-middel og et terapeutisk middel mot en infeksjon, som har bredspektret og sterk antibakteriell virkning mot både gram-positive og gram-negative bakterier, og som er også er meget sikkert. Forbindelsen som er tilveiebrakt, er representert ved følgende formel (I): hvor R1 og R2 representerer et hydrogenatom eller lignende; R3 representerer en alkylgruppe som inneholder 1 til 6 karbonatomer, eller lignende; R4 og R5 representerer uavhengig av hverandre et hydrogenatom, en alkylgruppe som inneholder 1 til 6 karbonatomer, eller lignende, med det forbehold at R4 og R5 ikke samtidig representerer et hydrogenatom; eller substituentene R4 og R5 sammen representerer (a) en 3- til 6-leddet, cyklisk struktur som omfatter karbonatomet som er felles for R4 og R5, og danner en spirocyklisk struktur med pyrrolidinringen; R6 og R7 representerer uavhengig av hverandre et hydrogenatom, en alkylgruppe som inneholder 1 til 6 karbonatomer, eller lignende; R8 representerer en halogen-substituert alkylgruppe som inneholder 1 til 6 karbonatomer, eller lignende; X1 representerer et hydrogenatom eller et halogenatom; A representerer et nitrogenatom eller en gruppe som er representert ved formel (II):
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005146386 | 2005-05-19 | ||
JP2005344514 | 2005-11-29 | ||
JP2006080629 | 2006-03-23 | ||
PCT/JP2006/310069 WO2006123792A1 (ja) | 2005-05-19 | 2006-05-19 | トリ-、テトラ-置換-3-アミノピロリジン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20075650L true NO20075650L (no) | 2007-12-13 |
Family
ID=37431361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20075650A NO20075650L (no) | 2005-05-19 | 2007-11-06 | Tri- eller tetrasubstituterte 3-aminopyrrolidinderivater |
Country Status (16)
Country | Link |
---|---|
US (3) | US7563805B2 (no) |
EP (2) | EP1882689B1 (no) |
JP (2) | JP5087394B2 (no) |
KR (1) | KR101307717B1 (no) |
AR (1) | AR054272A1 (no) |
AU (1) | AU2006248354B2 (no) |
BR (1) | BRPI0610114A2 (no) |
CA (1) | CA2608468C (no) |
ES (1) | ES2422858T3 (no) |
HK (1) | HK1116774A1 (no) |
IL (1) | IL186815A (no) |
MY (1) | MY143605A (no) |
NO (1) | NO20075650L (no) |
NZ (1) | NZ562959A (no) |
TW (1) | TWI384987B (no) |
WO (1) | WO2006123792A1 (no) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1757598A4 (en) * | 2004-05-13 | 2010-07-21 | Daiichi Seiyaku Co | SUBSTITUTED PYRROLIDINE DERIVATIVE |
TW200640899A (en) * | 2005-01-21 | 2006-12-01 | Daiichi Seiyaku Co | Fluoroalkylpyrrolidine derivative |
US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
WO2006123767A1 (ja) * | 2005-05-20 | 2006-11-23 | Daiichi Sankyo Company, Limited | 不斉四置換炭素原子含有化合物の製法 |
TW200744598A (en) * | 2005-09-28 | 2007-12-16 | Daiichi Seiyaku Co | Process for the production of freeze-dried preparations containing quinolones |
WO2007037303A1 (ja) * | 2005-09-28 | 2007-04-05 | Daiichi Sankyo Company, Limited | テトラ置換-5-アザスピロ[2.4]へプタン誘導体の製法およびその光学活性中間体 |
US7977346B2 (en) | 2006-01-17 | 2011-07-12 | Guoqing Paul Chen | Spiro compounds and methods of use |
TWI386401B (zh) * | 2006-03-27 | 2013-02-21 | Daiichi Seiyaku Co | 醫藥用水合物 |
CA2674369C (en) * | 2007-01-05 | 2012-04-03 | Daiichi Sankyo Company, Limited | Fused substituted aminopyrrolidine derivative |
JP5174365B2 (ja) * | 2007-03-23 | 2013-04-03 | 第一三共株式会社 | キノロン含有凍結乾燥製剤の製造方法 |
CA2700227A1 (en) | 2007-09-21 | 2009-04-02 | Epiphany Biosciences, Inc. | Valomaciclovir polymorphs |
WO2010124005A1 (en) * | 2009-04-21 | 2010-10-28 | Purdue Research Foundation | Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor |
EP2709455A4 (en) * | 2011-05-18 | 2014-11-05 | Enanta Pharm Inc | PROCESSES FOR THE PREPARATION OF 5-AZASPIRO [2.4] HEPTANE-6-CARBOXYLIC ACID AND ITS DERIVATIVES |
JP6235492B2 (ja) | 2013-01-25 | 2017-11-22 | 株式会社アイエイアイ | アクチュエータ |
WO2019025250A1 (en) | 2017-08-04 | 2019-02-07 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5872589A (ja) | 1981-10-28 | 1983-04-30 | Dai Ichi Seiyaku Co Ltd | ピリド〔1,2,3−de〕〔1,4〕ベンゾオキサジン誘導体 |
US4822801A (en) | 1984-07-20 | 1989-04-18 | Warner-Lambert Company | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents |
IE58742B1 (en) | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
JPS61137885A (ja) | 1984-12-08 | 1986-06-25 | Dainippon Pharmaceut Co Ltd | 1,8−ナフチリジン誘導体、そのエステルおよびその塩 |
JPS61152682A (ja) | 1984-12-27 | 1986-07-11 | Dainippon Pharmaceut Co Ltd | ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
JPS61282382A (ja) | 1985-06-06 | 1986-12-12 | Dainippon Pharmaceut Co Ltd | フエニル置換1,8−ナフチリジン誘導体、そのエステルおよびその塩 |
JPH0635457B2 (ja) * | 1985-06-28 | 1994-05-11 | 杏林製薬株式会社 | ピリドンカルボン酸誘導体およびその製造方法 |
US4735949A (en) | 1986-02-18 | 1988-04-05 | Warner-Lambert Company | Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents |
JPS63198664A (ja) * | 1986-03-31 | 1988-08-17 | Sankyo Co Ltd | キノロンカルボン酸誘導体 |
EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
JPS63152318A (ja) | 1986-08-07 | 1988-06-24 | Dainippon Pharmaceut Co Ltd | 抗マイコプラズマ剤 |
EP0259804B1 (de) | 1986-09-12 | 1993-11-18 | F. Hoffmann-La Roche Ag | Pyrido [3,2,1-ij]-1,3,4-benzoxadiazinderivate, Verfahren zu deren Herstellung, entsprechende pharmazeutische Präparate und im Verfahren verwendbare Zwischenprodukte |
ZW16387A1 (en) * | 1986-09-12 | 1988-05-25 | Hoffmann La Roche | Tricyclic compounds |
NZ222047A (en) | 1986-10-08 | 1991-01-29 | Bristol Myers Co | Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents |
JPS63130594A (ja) | 1986-11-21 | 1988-06-02 | Tokyo Tanabe Co Ltd | ベンゾ〔ij〕キノリジン−2−カルボン酸化合物及びその製造法 |
JPS63188626A (ja) | 1987-01-30 | 1988-08-04 | Dainippon Pharmaceut Co Ltd | ピリドンカルボン酸の可溶化方法 |
MY105136A (en) | 1988-04-27 | 1994-08-30 | Daiichi Seiyaku Co | Optically active pyridonecarboxylic acid derivatives. |
JP2807277B2 (ja) | 1988-08-31 | 1998-10-08 | 第一製薬株式会社 | スピロ化合物 |
US5286723A (en) | 1988-08-31 | 1994-02-15 | Daiichi Seiyaku Co., Ltd. | Spiro compound |
CA1336090C (en) | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
US5324735A (en) * | 1989-07-21 | 1994-06-28 | Ss Pharmaceutical Co., Ltd. | Quinoline carboxylic acid derivatives |
JP2991381B2 (ja) | 1990-07-16 | 1999-12-20 | 大日本製薬株式会社 | 新規キノリンカルボン酸誘導体、そのエステルおよびその塩 |
KR920004385A (ko) | 1990-08-09 | 1992-03-27 | 와꾸나가 기스께 | 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제 |
JPH0559052A (ja) * | 1990-08-09 | 1993-03-09 | Wakunaga Pharmaceut Co Ltd | 新規三環性化合物又はその塩及びこれを含有する抗菌剤 |
WO1992021659A1 (en) * | 1991-05-28 | 1992-12-10 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivative |
DE4123918A1 (de) | 1991-07-19 | 1993-01-21 | Bayer Ag | 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren |
US5468742A (en) | 1991-07-19 | 1995-11-21 | Bayer Aktiengesellschaft | 8-vinyl- and 9-ethinyl-quinolone-carboxylic acids |
EP0596126A4 (en) | 1991-12-27 | 1994-06-08 | Wakunaga Seiyaku Kk | Novel quinolone derivative or salt thereof and antibacterial containing the same. |
JPH05279364A (ja) | 1992-02-07 | 1993-10-26 | Wakunaga Pharmaceut Co Ltd | 新規三環性化合物又はその塩及びこれを含有する抗菌剤 |
WO1993025545A1 (en) * | 1992-06-09 | 1993-12-23 | Korea Research Institute Of Chemical Technology | Novel quinoline derivatives and processes for preparing the same |
JPH06228138A (ja) | 1993-02-03 | 1994-08-16 | Fujisawa Pharmaceut Co Ltd | ピリドシンノリン化合物またはその塩及びこれを含有する抗菌剤 |
TW273551B (no) | 1993-05-24 | 1996-04-01 | Wakiei Seiyaku Kk | |
JPH0725873A (ja) | 1993-07-09 | 1995-01-27 | Wakunaga Pharmaceut Co Ltd | キノロン誘導体又はその塩並びに該化合物を含有する抗菌剤 |
SK281341B6 (sk) * | 1994-06-14 | 2001-02-12 | Dainippon Pharmaceutical Co., Ltd. | Deriváty pyridónkarboxylovej kyseliny alebo jej farmaceuticky prijateľných solí, spôsob ich prípravy a farmakologické prostriedky ich obsahujúce |
US5910498A (en) | 1994-10-20 | 1999-06-08 | Wakunaga Seiyaku Kabushiki Kaisha | Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient |
KR100499366B1 (ko) | 1995-01-30 | 2005-09-08 | 와쿠나가 세이야쿠 가부시키 가이샤 | 신규피리돈카르복실산유도체또는그염및그물질을유효성분으로하는항균제 |
JP4323574B2 (ja) | 1995-12-13 | 2009-09-02 | 大日本住友製薬株式会社 | 抗腫瘍剤 |
DE69811367T2 (de) | 1997-06-24 | 2003-11-27 | Daiichi Pharmaceutical Co., Ltd. | Cis-substituierte fluoromethylpyrrolidin-derivate |
WO2001072738A1 (fr) | 2000-03-31 | 2001-10-04 | Daiichi Pharmaceutical Co., Ltd. | Derive d'acide quinolone-carboxylique |
WO2005073238A1 (ja) | 2004-02-02 | 2005-08-11 | Daiichi Pharmaceutical Co., Ltd. | ピリドベンズオキサジン誘導体 |
EP1757598A4 (en) | 2004-05-13 | 2010-07-21 | Daiichi Seiyaku Co | SUBSTITUTED PYRROLIDINE DERIVATIVE |
US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
-
2006
- 2006-04-28 US US11/413,153 patent/US7563805B2/en not_active Expired - Fee Related
- 2006-05-05 MY MYPI20062086A patent/MY143605A/en unknown
- 2006-05-17 TW TW095117509A patent/TWI384987B/zh not_active IP Right Cessation
- 2006-05-18 AR AR20060102021A patent/AR054272A1/es unknown
- 2006-05-19 WO PCT/JP2006/310069 patent/WO2006123792A1/ja active Application Filing
- 2006-05-19 AU AU2006248354A patent/AU2006248354B2/en not_active Ceased
- 2006-05-19 JP JP2007516357A patent/JP5087394B2/ja not_active Expired - Fee Related
- 2006-05-19 KR KR1020077026606A patent/KR101307717B1/ko not_active IP Right Cessation
- 2006-05-19 EP EP06746676.3A patent/EP1882689B1/en active Active
- 2006-05-19 CA CA2608468A patent/CA2608468C/en not_active Expired - Fee Related
- 2006-05-19 EP EP12001575A patent/EP2463274A1/en not_active Withdrawn
- 2006-05-19 NZ NZ562959A patent/NZ562959A/en not_active IP Right Cessation
- 2006-05-19 ES ES06746676T patent/ES2422858T3/es active Active
- 2006-05-19 BR BRPI0610114-3A patent/BRPI0610114A2/pt not_active IP Right Cessation
-
2007
- 2007-10-21 IL IL186815A patent/IL186815A/en not_active IP Right Cessation
- 2007-11-06 NO NO20075650A patent/NO20075650L/no not_active Application Discontinuation
-
2008
- 2008-06-19 HK HK08106844.7A patent/HK1116774A1/xx not_active IP Right Cessation
-
2009
- 2009-04-13 US US12/422,726 patent/US8211910B2/en not_active Expired - Fee Related
-
2012
- 2012-04-25 US US13/455,486 patent/US8476429B2/en not_active Expired - Fee Related
- 2012-07-09 JP JP2012153741A patent/JP5475841B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AR054272A1 (es) | 2007-06-13 |
US8211910B2 (en) | 2012-07-03 |
AU2006248354A1 (en) | 2006-11-23 |
NZ562959A (en) | 2010-07-30 |
CA2608468A1 (en) | 2006-11-23 |
US20120232288A1 (en) | 2012-09-13 |
IL186815A0 (en) | 2008-02-09 |
KR101307717B1 (ko) | 2013-09-11 |
TW200716131A (en) | 2007-05-01 |
WO2006123792A1 (ja) | 2006-11-23 |
JP5475841B2 (ja) | 2014-04-16 |
TWI384987B (zh) | 2013-02-11 |
IL186815A (en) | 2013-09-30 |
BRPI0610114A2 (pt) | 2010-06-01 |
AU2006248354B2 (en) | 2011-11-03 |
EP2463274A1 (en) | 2012-06-13 |
EP1882689A4 (en) | 2010-01-06 |
JPWO2006123792A1 (ja) | 2008-12-25 |
JP2012193195A (ja) | 2012-10-11 |
US20060264428A1 (en) | 2006-11-23 |
EP1882689A1 (en) | 2008-01-30 |
HK1116774A1 (en) | 2009-01-02 |
US8476429B2 (en) | 2013-07-02 |
KR20080020603A (ko) | 2008-03-05 |
ES2422858T3 (es) | 2013-09-16 |
US20090253726A1 (en) | 2009-10-08 |
EP1882689B1 (en) | 2013-07-10 |
MY143605A (en) | 2011-06-15 |
CA2608468C (en) | 2013-02-26 |
JP5087394B2 (ja) | 2012-12-05 |
US7563805B2 (en) | 2009-07-21 |
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