NO20075650L - Tri- eller tetrasubstituterte 3-aminopyrrolidinderivater - Google Patents

Tri- eller tetrasubstituterte 3-aminopyrrolidinderivater

Info

Publication number
NO20075650L
NO20075650L NO20075650A NO20075650A NO20075650L NO 20075650 L NO20075650 L NO 20075650L NO 20075650 A NO20075650 A NO 20075650A NO 20075650 A NO20075650 A NO 20075650A NO 20075650 L NO20075650 L NO 20075650L
Authority
NO
Norway
Prior art keywords
hydrogen atom
carbon atoms
alkyl group
group containing
represent
Prior art date
Application number
NO20075650A
Other languages
English (en)
Inventor
Hisashi Takahashi
Rie Miyauchi
Makoto Takemura
Hiroaki Inagaki
Satoshi Komoriya
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37431361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20075650(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of NO20075650L publication Critical patent/NO20075650L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Det er tilveiebrakt et syntetisk, antibakterielt kinolon-middel og et terapeutisk middel mot en infeksjon, som har bredspektret og sterk antibakteriell virkning mot både gram-positive og gram-negative bakterier, og som er også er meget sikkert. Forbindelsen som er tilveiebrakt, er representert ved følgende formel (I): hvor R1 og R2 representerer et hydrogenatom eller lignende; R3 representerer en alkylgruppe som inneholder 1 til 6 karbonatomer, eller lignende; R4 og R5 representerer uavhengig av hverandre et hydrogenatom, en alkylgruppe som inneholder 1 til 6 karbonatomer, eller lignende, med det forbehold at R4 og R5 ikke samtidig representerer et hydrogenatom; eller substituentene R4 og R5 sammen representerer (a) en 3- til 6-leddet, cyklisk struktur som omfatter karbonatomet som er felles for R4 og R5, og danner en spirocyklisk struktur med pyrrolidinringen; R6 og R7 representerer uavhengig av hverandre et hydrogenatom, en alkylgruppe som inneholder 1 til 6 karbonatomer, eller lignende; R8 representerer en halogen-substituert alkylgruppe som inneholder 1 til 6 karbonatomer, eller lignende; X1 representerer et hydrogenatom eller et halogenatom; A representerer et nitrogenatom eller en gruppe som er representert ved formel (II):
NO20075650A 2005-05-19 2007-11-06 Tri- eller tetrasubstituterte 3-aminopyrrolidinderivater NO20075650L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005146386 2005-05-19
JP2005344514 2005-11-29
JP2006080629 2006-03-23
PCT/JP2006/310069 WO2006123792A1 (ja) 2005-05-19 2006-05-19 トリ－、テトラ－置換－３－アミノピロリジン誘導体

Publications (1)

Publication Number Publication Date
NO20075650L true NO20075650L (no) 2007-12-13

Family

ID=37431361

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075650A NO20075650L (no) 2005-05-19 2007-11-06 Tri- eller tetrasubstituterte 3-aminopyrrolidinderivater

Country Status (16)

Country Link
US (3) US7563805B2 (no)
EP (2) EP1882689B1 (no)
JP (2) JP5087394B2 (no)
KR (1) KR101307717B1 (no)
AR (1) AR054272A1 (no)
AU (1) AU2006248354B2 (no)
BR (1) BRPI0610114A2 (no)
CA (1) CA2608468C (no)
ES (1) ES2422858T3 (no)
HK (1) HK1116774A1 (no)
IL (1) IL186815A (no)
MY (1) MY143605A (no)
NO (1) NO20075650L (no)
NZ (1) NZ562959A (no)
TW (1) TWI384987B (no)
WO (1) WO2006123792A1 (no)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
EP1757598A4 (en) * 2004-05-13 2010-07-21 Daiichi Seiyaku Co SUBSTITUTED PYRROLIDINE DERIVATIVE
TW200640899A (en) * 2005-01-21 2006-12-01 Daiichi Seiyaku Co Fluoroalkylpyrrolidine derivative
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
EP1882685A4 (en) 2005-05-20 2010-10-27 Daiichi Sankyo Co Ltd METHOD FOR PRODUCING AN ASYMMETRIC TETRASUBSTITUTED CARBON CONTAINING COMPOUND
US7842818B2 (en) * 2005-09-28 2010-11-30 Daiichi Sankyo Company, Limited Process for preparation of tetrasubstituted 5-azaspiro[2.4]- heptane derivatives and optically active intermediates thereof
JPWO2007037330A1 (ja) * 2005-09-28 2009-04-09 第一三共株式会社 キノロン含有凍結乾燥製剤の製造方法
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
TWI386401B (zh) * 2006-03-27 2013-02-21 Daiichi Seiyaku Co 醫藥用水合物
ES2428344T3 (es) * 2007-01-05 2013-11-07 Daiichi Sankyo Company, Limited Derivado de aminopirrolidina sustituido fusionado
JP5174365B2 (ja) * 2007-03-23 2013-04-03 第一三共株式会社 キノロン含有凍結乾燥製剤の製造方法
JP2010540440A (ja) 2007-09-21 2010-12-24 エピファニー バイオサイエンシズ， インク． バロマシクロビル多形体
EP2421862B1 (en) 2009-04-21 2014-06-11 Purdue Research Foundation Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor
JP5669984B2 (ja) * 2011-05-18 2015-02-18 エナンタ ファーマシューティカルズ インコーポレイテッド ５−アザスピロ［２．４］ヘプタン−６−カルボン酸およびその誘導体の製造方法
KR20150112940A (ko) 2013-01-25 2015-10-07 가부시기가이샤 아이 에이 아이 액추에이터
WO2019025250A1 (en) 2017-08-04 2019-02-07 Basf Se SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

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Also Published As

Publication number Publication date
NZ562959A (en) 2010-07-30
EP1882689A4 (en) 2010-01-06
TW200716131A (en) 2007-05-01
EP1882689B1 (en) 2013-07-10
JP2012193195A (ja) 2012-10-11
US8211910B2 (en) 2012-07-03
HK1116774A1 (en) 2009-01-02
AU2006248354B2 (en) 2011-11-03
ES2422858T3 (es) 2013-09-16
KR101307717B1 (ko) 2013-09-11
US8476429B2 (en) 2013-07-02
JPWO2006123792A1 (ja) 2008-12-25
US7563805B2 (en) 2009-07-21
EP2463274A1 (en) 2012-06-13
US20060264428A1 (en) 2006-11-23
EP1882689A1 (en) 2008-01-30
IL186815A0 (en) 2008-02-09
CA2608468C (en) 2013-02-26
JP5087394B2 (ja) 2012-12-05
TWI384987B (zh) 2013-02-11
US20090253726A1 (en) 2009-10-08
AR054272A1 (es) 2007-06-13
CA2608468A1 (en) 2006-11-23
IL186815A (en) 2013-09-30
WO2006123792A1 (ja) 2006-11-23
KR20080020603A (ko) 2008-03-05
AU2006248354A1 (en) 2006-11-23
BRPI0610114A2 (pt) 2010-06-01
MY143605A (en) 2011-06-15
JP5475841B2 (ja) 2014-04-16
US20120232288A1 (en) 2012-09-13

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