JP2019500355A - 汎インテグリンアンタゴニストとしてのメタ−アザ環式アミノ安息香酸誘導体 - Google Patents

汎インテグリンアンタゴニストとしてのメタ−アザ環式アミノ安息香酸誘導体 Download PDF

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JP2019500355A
JP2019500355A JP2018530561A JP2018530561A JP2019500355A JP 2019500355 A JP2019500355 A JP 2019500355A JP 2018530561 A JP2018530561 A JP 2018530561A JP 2018530561 A JP2018530561 A JP 2018530561A JP 2019500355 A JP2019500355 A JP 2019500355A
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disease
amino
disorder
compound according
hydroxy
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JP2019500355A5 (enExample
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ピーター ジー． ルミンスキ，
ピーター ジー． ルミンスキ，
デイビッド ダブリュー． グリッグス，
デイビッド ダブリュー． グリッグス，
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セントルイス ユニバーシティ
セントルイス ユニバーシティ
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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JP2018530561A 2015-12-30 2016-12-30 汎インテグリンアンタゴニストとしてのメタ−アザ環式アミノ安息香酸誘導体 Pending JP2019500355A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562273246P 2015-12-30 2015-12-30
US62/273,246 2015-12-30
PCT/US2016/069511 WO2017117538A1 (en) 2015-12-30 2016-12-30 Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists

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JP2019500355A true JP2019500355A (ja) 2019-01-10
JP2019500355A5 JP2019500355A5 (enExample) 2020-01-30

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US (3) US10035778B2 (enExample)
EP (2) EP3294716B1 (enExample)
JP (1) JP2019500355A (enExample)
KR (1) KR20180107121A (enExample)
CN (1) CN108779077A (enExample)
AU (1) AU2016381336A1 (enExample)
BR (1) BR112018012981A2 (enExample)
CA (1) CA3008023A1 (enExample)
CO (1) CO2018007278A2 (enExample)
ES (1) ES2806276T3 (enExample)
HK (1) HK1244806A1 (enExample)
IL (1) IL259951A (enExample)
PH (1) PH12018501362A1 (enExample)
RU (1) RU2729518C2 (enExample)
SG (1) SG11201805387RA (enExample)
WO (1) WO2017117538A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021230325A1 (ja) * 2020-05-14 2021-11-18 宇部興産株式会社 １，４，５，６－テトラヒドロピリミジン－２－アミン誘導体
WO2023085396A1 (ja) * 2021-11-12 2023-05-19 Ｕｂｅ株式会社 アルポート症候群を治療または予防するための医薬組成物
WO2024262620A1 (ja) 2023-06-22 2024-12-26 株式会社抗体医学研究所 インテグリン阻害低分子化合物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016381336A1 (en) * 2015-12-30 2018-06-28 Saint Louis University Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
US11046685B2 (en) 2017-02-28 2021-06-29 Morphic Therapeutic, Inc. Inhibitors of (α-v)(β-6) integrin
SG11201907820SA (en) 2017-02-28 2019-09-27 Morphic Therapeutic Inc Inhibitors of (alpha-v)(beta-6) integrin
WO2019099560A1 (en) * 2017-11-14 2019-05-23 The Schepens Eye Research Institute, Inc. Runx1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition
EP3843727A4 (en) 2018-08-29 2022-08-17 Morphic Therapeutic, Inc. INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN
CA3109534A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibiting .alpha.v .beta.6 integrin
UY38352A (es) 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibidores de integrina alfavbeta6
EP4034236A1 (en) 2019-09-26 2022-08-03 Abionyx Pharma SA Compounds useful for treating liver diseases
TW202135811A (zh) * 2019-12-20 2021-10-01 瑞士商諾華公司 使用整聯蛋白抑制劑組合治療肝臟疾病
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11510814A (ja) * 1995-08-30 1999-09-21 ジー．ディー．サール アンド カンパニー インテグリンアンタゴニストとしてのメタ−グアニジン、尿素、チオ尿素またはアザ環状アミノ安息香酸誘導体
US6013651A (en) * 1995-08-30 2000-01-11 G. D. Searle & Co. Meta-azacyclic amino benzoic acid compounds and derivatives thereof
JP2006514050A (ja) * 2002-12-20 2006-04-27 ファルマシア・コーポレーション インテグリン受容体アンタゴニスト誘導体としてのβ−アミノ酸化合物のＲ異性体
US20140051715A1 (en) * 2012-07-18 2014-02-20 Saint Louis University 3,5 Phenyl-Substituted Beta Amino Acid Derivatives as Integrin Antagonists
JP2015524412A (ja) * 2012-07-18 2015-08-24 セントルイス ユニバーシティ インテグリンアンタゴニストとしてのβアミノ酸誘導体

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602155A (en) 1995-01-17 1997-02-11 G. D. Searle & Co. Platelet aggregation inhibitors
US5639765A (en) 1995-01-17 1997-06-17 G. D. Searle & Co. Guanidinoalkyl glycine β-amino acids useful for inhibiting bone loss
US5681820A (en) 1995-05-16 1997-10-28 G. D. Searle & Co. Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis
US6100423A (en) 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
PT891325E (pt) 1996-03-29 2002-07-31 Searle & Co Derivados do acido fenilpropanoico para-substituido como antagonistas de integrina
WO1997036862A1 (en) 1996-03-29 1997-10-09 G.D. Searle & Co. META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS
DK0894084T3 (da) 1996-03-29 2002-10-14 Searle & Co Kanelsyrederivater og deres anvendelse som integrinantagonister
JP2000514809A (ja) 1996-07-12 2000-11-07 ジー．ディー．サール アンド カンパニー キラルβ―アミノ酸の不斉合成
US6372719B1 (en) 1998-03-04 2002-04-16 Jay Cunningham ανβ3 integrin antagonists in combination with chemotherapeutic agents
US6172256B1 (en) 1998-03-04 2001-01-09 G.D. Searle & Co. Chiral-β-amino acid compounds and derivatives thereof
ZA991107B (en) 1998-03-04 2000-02-14 Searle & Co Process for preparing 3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino] benzoic acid.
ZA991105B (en) 1998-03-04 2000-02-11 Searle & Co Synthesis of chiral beta-amino acids.
ZA994406B (en) 1998-03-04 2000-02-11 Searle & Co Meta-azacyclic amino benzoic acid and derivatives thereof.
KR20010042614A (ko) 1998-04-10 2001-05-25 윌리암스 로저 에이 비트로넥틴 길항제로서 복소환식 글리실 베타-알라닌 유도체
CN1398189A (zh) 1998-12-23 2003-02-19 G.D.西尔公司 用于治疗肿瘤形成的放疗与cox－2抑制剂的联合治疗
US6933304B2 (en) 2000-06-15 2005-08-23 Pharmacia Corporation Heteroarylalkanoic acids as integrin receptor antagonists
EP1317270A1 (en) 2000-09-08 2003-06-11 Pharmacia Italia S.p.A. Exemestane for the treatment of oestrogen-dependent cancers
CA2434611A1 (en) 2001-01-26 2002-09-19 Pharmacia Italia Spa Combined method for treating hormono-dependent disorders
US20040082557A1 (en) 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
EP1435967A2 (en) 2001-10-10 2004-07-14 Pharmacia Italia S.p.A. Methods for preventing and treating bone loss with steroid compounds
TWI281470B (en) * 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
JP4912881B2 (ja) 2003-10-01 2012-04-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗線維症薬としてのαｖβ３及びαｖβ６インテグリンアンタゴニスト
TWI433839B (zh) 2006-08-11 2014-04-11 Neomed Inst 新穎的苯并咪唑衍生物290
US9345739B2 (en) 2007-11-08 2016-05-24 The General Hospital Corporation Methods and compositions for the treatment of proteinuric diseases
WO2010010184A1 (en) 2008-07-25 2010-01-28 Galapagos Nv [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors
EP2358203A4 (en) 2008-10-24 2012-06-06 Univ Wake Forest PLATINACRIDIN COMPOUNDS AGAINST CANCER AND METHOD THEREFOR
DE102009000854A1 (de) 2009-02-13 2010-08-19 Ernst-Moritz-Arndt-Universität Greifswald Osteopontin-Rezeptor-Liganden zur Behandlung des chronischen Nierenversagens
WO2010104933A1 (en) 2009-03-11 2010-09-16 Merck Sharp & Dohme Corp. Inhibitors of akt activity
AR077975A1 (es) 2009-08-28 2011-10-05 Irm Llc Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
EP2609092B1 (en) 2010-08-26 2015-04-01 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
WO2013033430A1 (en) 2011-09-02 2013-03-07 Wake Forest School Of Medicine Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof
WO2016172710A2 (en) 2015-04-24 2016-10-27 Cornell University Methods and reagents for determination and treatment of organotropic metastasis
AU2016381336A1 (en) * 2015-12-30 2018-06-28 Saint Louis University Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11510814A (ja) * 1995-08-30 1999-09-21 ジー．ディー．サール アンド カンパニー インテグリンアンタゴニストとしてのメタ−グアニジン、尿素、チオ尿素またはアザ環状アミノ安息香酸誘導体
US6013651A (en) * 1995-08-30 2000-01-11 G. D. Searle & Co. Meta-azacyclic amino benzoic acid compounds and derivatives thereof
JP2006514050A (ja) * 2002-12-20 2006-04-27 ファルマシア・コーポレーション インテグリン受容体アンタゴニスト誘導体としてのβ−アミノ酸化合物のＲ異性体
US20140051715A1 (en) * 2012-07-18 2014-02-20 Saint Louis University 3,5 Phenyl-Substituted Beta Amino Acid Derivatives as Integrin Antagonists
JP2015524412A (ja) * 2012-07-18 2015-08-24 セントルイス ユニバーシティ インテグリンアンタゴニストとしてのβアミノ酸誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOORG. MED. CHEM., vol. １５, JPN6020047310, 2007, pages 3783 - 3800, ISSN: 0004403445 *

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WO2021230325A1 (ja) * 2020-05-14 2021-11-18 宇部興産株式会社 １，４，５，６－テトラヒドロピリミジン－２－アミン誘導体
JPWO2021230325A1 (enExample) * 2020-05-14 2021-11-18
CN115551846A (zh) * 2020-05-14 2022-12-30 Ｕｂｅ株式会社 1,4,5,6-四氢嘧啶-2-胺衍生物
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WO2024262620A1 (ja) 2023-06-22 2024-12-26 株式会社抗体医学研究所 インテグリン阻害低分子化合物

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