JP2019500355A - 汎インテグリンアンタゴニストとしてのメタ−アザ環式アミノ安息香酸誘導体 - Google Patents

汎インテグリンアンタゴニストとしてのメタ−アザ環式アミノ安息香酸誘導体 Download PDF

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JP2019500355A
JP2019500355A JP2018530561A JP2018530561A JP2019500355A JP 2019500355 A JP2019500355 A JP 2019500355A JP 2018530561 A JP2018530561 A JP 2018530561A JP 2018530561 A JP2018530561 A JP 2018530561A JP 2019500355 A JP2019500355 A JP 2019500355A
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disease
amino
disorder
compound according
hydroxy
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JP2019500355A5 (enExample
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ピーター ジー． ルミンスキ，
ピーター ジー． ルミンスキ，
デイビッド ダブリュー． グリッグス，
デイビッド ダブリュー． グリッグス，
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セントルイス ユニバーシティ
セントルイス ユニバーシティ
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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JP2018530561A 2015-12-30 2016-12-30 汎インテグリンアンタゴニストとしてのメタ−アザ環式アミノ安息香酸誘導体 Pending JP2019500355A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562273246P 2015-12-30 2015-12-30
US62/273,246 2015-12-30
PCT/US2016/069511 WO2017117538A1 (en) 2015-12-30 2016-12-30 Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists

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JP2019500355A true JP2019500355A (ja) 2019-01-10
JP2019500355A5 JP2019500355A5 (enExample) 2020-01-30

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US (3) US10035778B2 (enExample)
EP (2) EP3738953A1 (enExample)
JP (1) JP2019500355A (enExample)
KR (1) KR20180107121A (enExample)
CN (1) CN108779077A (enExample)
AU (1) AU2016381336A1 (enExample)
BR (1) BR112018012981A2 (enExample)
CA (1) CA3008023A1 (enExample)
CO (1) CO2018007278A2 (enExample)
ES (1) ES2806276T3 (enExample)
HK (1) HK1244806A1 (enExample)
IL (1) IL259951A (enExample)
PH (1) PH12018501362A1 (enExample)
RU (1) RU2729518C2 (enExample)
SG (1) SG11201805387RA (enExample)
WO (1) WO2017117538A1 (enExample)

Cited By (3)

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WO2021230325A1 (ja) * 2020-05-14 2021-11-18 宇部興産株式会社 １，４，５，６－テトラヒドロピリミジン－２－アミン誘導体
WO2023085396A1 (ja) * 2021-11-12 2023-05-19 Ｕｂｅ株式会社 アルポート症候群を治療または予防するための医薬組成物
WO2024262620A1 (ja) 2023-06-22 2024-12-26 株式会社抗体医学研究所 インテグリン阻害低分子化合物

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HK1244806A1 (zh) * 2015-12-30 2018-08-17 Saint Louis University 作為過氧乙醯硝酸整聯蛋白拮抗劑的間氮雜環氨基苯甲酸衍生物
US11046685B2 (en) 2017-02-28 2021-06-29 Morphic Therapeutic, Inc. Inhibitors of (α-v)(β-6) integrin
EP4159727B1 (en) 2017-02-28 2026-04-08 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
CA3082643A1 (en) * 2017-11-14 2019-05-23 The Schepens Eye Research Institute, Inc. Runx1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition
WO2020047208A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
AU2019327475B2 (en) 2018-08-29 2025-06-05 Morphic Therapeutic, Inc. INHIBITING αV β6 INTEGRIN
PT3844162T (pt) 2018-08-29 2025-03-28 Morphic Therapeutic Inc Inibidores da integrina alfa v beta6
EP4034236A1 (en) 2019-09-26 2022-08-03 Abionyx Pharma SA Compounds useful for treating liver diseases
EP4076454A1 (en) * 2019-12-20 2022-10-26 Novartis AG Combination treatment of liver diseases using integrin inhibitors
WO2021216378A1 (en) 2020-04-23 2021-10-28 The Schepens Eye Research Institute, Inc. Methods and materials for treatment of fibrosis
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases

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JPH11510814A (ja) * 1995-08-30 1999-09-21 ジー．ディー．サール アンド カンパニー インテグリンアンタゴニストとしてのメタ−グアニジン、尿素、チオ尿素またはアザ環状アミノ安息香酸誘導体
US6013651A (en) * 1995-08-30 2000-01-11 G. D. Searle & Co. Meta-azacyclic amino benzoic acid compounds and derivatives thereof
JP2006514050A (ja) * 2002-12-20 2006-04-27 ファルマシア・コーポレーション インテグリン受容体アンタゴニスト誘導体としてのβ−アミノ酸化合物のＲ異性体
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JP2015524412A (ja) * 2012-07-18 2015-08-24 セントルイス ユニバーシティ インテグリンアンタゴニストとしてのβアミノ酸誘導体

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