|
BE637271A
(enExample)
|
1963-04-04 |
1900-01-01 |
|
|
|
US3558618A
(en)
|
1968-04-01 |
1971-01-26 |
Dow Chemical Co |
Novel 4h-pyrazino(1,2-a)pyrimidine-4-ones
|
|
GB1383409A
(en)
|
1972-09-09 |
1974-02-12 |
Pfizer Ltd |
Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
|
|
US4122274A
(en)
|
1977-05-25 |
1978-10-24 |
Bristol-Myers Company |
3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
|
|
JPS56150091A
(en)
|
1980-03-28 |
1981-11-20 |
Janssen Pharmaceutica Nv |
3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidine- 4-one derivative and its manufacture
|
|
US4342870A
(en)
|
1980-03-28 |
1982-08-03 |
Janssen Pharmaceutica N.V. |
Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
|
|
JPS5852307A
(ja)
|
1981-09-22 |
1983-03-28 |
Hitachi Chem Co Ltd |
水分散樹脂組成物
|
|
US5089633A
(en)
|
1987-04-28 |
1992-02-18 |
Georgia Tech Research Corporation |
Substituted isocoumarins
|
|
US5599816A
(en)
|
1990-05-02 |
1997-02-04 |
Abbott Laboratories |
Quinolizinone type compounds
|
|
WO1993023398A1
(en)
|
1992-05-13 |
1993-11-25 |
E.I. Du Pont De Nemours And Company |
Substituted pyrido[1,2-a]pyrimidinone derivatives as fungicides
|
|
DE69435005T2
(de)
|
1993-05-11 |
2008-04-17 |
The University Of North Carolina At Chapel Hill |
Antisense Oligonukleotide die anomales Splicing verhindern und deren Verwendung
|
|
IL122296A0
(en)
|
1995-06-06 |
1998-04-05 |
Abbott Lab |
Quinolizinone type compounds
|
|
US5916916A
(en)
|
1996-10-10 |
1999-06-29 |
Eli Lilly And Company |
1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
|
|
US5869500A
(en)
|
1996-12-13 |
1999-02-09 |
Hoffmann-La Roche Inc. |
Pyridone compounds useful in treating Alzheimer's disease
|
|
CA2269561C
(en)
|
1998-04-22 |
2007-06-05 |
Dainippon Ink And Chemicals, Inc. |
Naphthalene derivative and liquid crystal composition comprising the same
|
|
WO2000017197A1
(en)
|
1998-09-21 |
2000-03-30 |
Biochem Pharma Inc. |
Quinolizinones as integrin inhibitors
|
|
US6214986B1
(en)
|
1998-10-07 |
2001-04-10 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of bcl-x expression
|
|
US6172216B1
(en)
|
1998-10-07 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Antisense modulation of BCL-X expression
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
EP1652839A3
(en)
|
1999-10-28 |
2006-07-05 |
Daiichi Pharmaceutical Co., Ltd. |
Drug efflux pump inhibitor
|
|
CN1891693A
(zh)
|
2000-01-24 |
2007-01-10 |
基纳西亚股份有限公司 |
用于治疗的吗啉代基取代的化合物
|
|
WO2002038738A2
(en)
|
2000-11-09 |
2002-05-16 |
Cold Spring Harbor Laboratory |
Chimeric molecules to modulate gene expression
|
|
US6774134B2
(en)
|
2000-12-20 |
2004-08-10 |
Bristol-Myers Squibb Company |
Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
|
|
CA2432799C
(en)
|
2000-12-21 |
2008-08-19 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
CA2665516A1
(en)
|
2001-04-26 |
2002-11-07 |
Daiichi Pharmaceutical Co., Ltd. |
Drug efflux pump inhibitor
|
|
EP1474147B1
(en)
|
2001-12-07 |
2010-05-05 |
Vertex Pharmaceuticals Incorporated |
Pyrimidine-based compounds useful as gsk-3 inhibitors
|
|
GB0205281D0
(en)
|
2002-03-06 |
2002-04-17 |
Novartis Ag |
Organic compounds
|
|
ATE548354T1
(de)
|
2002-07-24 |
2012-03-15 |
Ptc Therapeutics Inc |
Ureido-substituierte benzoesäureverbindungen und ihre verwendung für die nonsense-suppression und behandlung von erkrankungen
|
|
DE60326894D1
(de)
|
2002-09-30 |
2009-05-07 |
Neurosearch As |
1,4-Diazabicycloalkanderivate, deren Herstellung und Verwendung
|
|
CN1326857C
(zh)
*
|
2002-09-30 |
2007-07-18 |
神经研究公司 |
新的1,4－二氮杂双环烷烃衍生物、其制备和应用
|
|
US20070078144A1
(en)
|
2003-01-29 |
2007-04-05 |
Stockwell Brent R |
Agents for treating neurodegenerative diseases
|
|
AU2004249730A1
(en)
|
2003-06-20 |
2004-12-29 |
Novartis Vaccines And Diagnostics, Inc. |
Pyridino(1,2-A)pyrimidin-4-one compounds as anticancer agents
|
|
GB0315494D0
(en)
|
2003-07-02 |
2003-08-06 |
Biofocus Plc |
Compounds which bind to the active site of protein kinase enzymes
|
|
CN1829709A
(zh)
|
2003-08-01 |
2006-09-06 |
健亚生物科技公司 |
对抗黄病毒的双环咪唑衍生物
|
|
US7160888B2
(en)
|
2003-08-22 |
2007-01-09 |
Warner Lambert Company Llc |
[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
|
|
US20050074801A1
(en)
|
2003-09-09 |
2005-04-07 |
Monia Brett P. |
Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
|
|
US20050245531A1
(en)
*
|
2003-12-22 |
2005-11-03 |
Abbott Laboratories |
Fused bicycloheterocycle substituted quinuclidine derivatives
|
|
US20050137203A1
(en)
|
2003-12-22 |
2005-06-23 |
Jianguo Ji |
3-quinuclidinyl amino-substituted biaryl derivatives
|
|
US7309699B2
(en)
|
2003-12-22 |
2007-12-18 |
Abbott Laboratories |
3-Quinuclidinyl amino-substituted biaryl derivatives
|
|
US7655657B2
(en)
*
|
2003-12-22 |
2010-02-02 |
Abbott Laboratories |
Fused bicycloheterocycle substituted quinuclidine derivatives
|
|
JP5384793B2
(ja)
|
2003-12-24 |
2014-01-08 |
バイオウタ サイエンティフィック マネジメント プロプライエタリー リミテッド |
呼吸器合胞体ウイルス感染の処置のための多環式薬剤
|
|
SE0400184D0
(sv)
|
2004-01-30 |
2004-01-30 |
Fyrkloevern Scandinavia Ab |
New therapeutical use
|
|
TW200536830A
(en)
|
2004-02-06 |
2005-11-16 |
Chugai Pharmaceutical Co Ltd |
1-(2H)-isoquinolone derivative
|
|
CN1964717A
(zh)
|
2004-04-08 |
2007-05-16 |
神经能质公司 |
经取代∴啉－4－基胺
|
|
WO2005105801A1
(en)
|
2004-05-04 |
2005-11-10 |
Warner-Lambert Company Llc |
Pyrrolyl substituted pyrido[2,3-d]pyrimidin-7-ones and derivatives thereof as therapeutic agents
|
|
EP1846397A1
(en)
|
2005-01-21 |
2007-10-24 |
Janssen Pharmaceutica N.V. |
Novel heterocyclic benzoy[c]chromene derivatives useful as modulators of the estrogen receptors
|
|
US7879992B2
(en)
|
2005-01-31 |
2011-02-01 |
Isis Pharmaceuticals, Inc. |
Modification of MyD88 splicing using modified oligonucleotides
|
|
JP2006219453A
(ja)
|
2005-02-14 |
2006-08-24 |
Tokyo Univ Of Pharmacy & Life Science |
キノリン環を母核とする金属識別型二波長性蛍光分子
|
|
US7563601B1
(en)
|
2005-06-01 |
2009-07-21 |
City Of Hope |
Artificial riboswitch for controlling pre-mRNA splicing
|
|
ES2375929T3
(es)
*
|
2005-07-04 |
2012-03-07 |
High Point Pharmaceuticals, Llc |
Antagonistas del receptor histamina h3.
|
|
WO2007047913A2
(en)
|
2005-10-20 |
2007-04-26 |
Isis Pharmaceuticals, Inc |
Compositions and methods for modulation of lmna expression
|
|
CA2629323A1
(en)
|
2005-11-10 |
2007-05-24 |
The University Of North Carolina At Chapel Hill |
Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease
|
|
WO2007089611A2
(en)
|
2006-01-26 |
2007-08-09 |
Isis Pharmaceuticals Inc. |
Compositions and their uses directed to huntingtin
|
|
AU2007211082B2
(en)
|
2006-01-27 |
2012-09-27 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of microRNAs
|
|
AR059339A1
(es)
|
2006-02-09 |
2008-03-26 |
Chugai Pharmaceutical Co Ltd |
Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
|
|
US8110681B2
(en)
|
2006-03-17 |
2012-02-07 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Compounds for the treatment of spinal muscular atrophy and other uses
|
|
WO2007130383A2
(en)
*
|
2006-04-28 |
2007-11-15 |
Northwestern University |
Compositions and treatments using pyridazine compounds and secretases
|
|
US20080247964A1
(en)
|
2006-05-08 |
2008-10-09 |
Yuelian Xu |
Substituted azaspiro derivatives
|
|
WO2007133756A2
(en)
|
2006-05-15 |
2007-11-22 |
Neurogen Corporation |
Crf1 receptor ligands comprising heteroaryl fused bicycles
|
|
WO2007135121A1
(en)
|
2006-05-23 |
2007-11-29 |
Neurosearch A/S |
Novel 8,10-diaza-bicyclo[4.3.1]decane derivatives and their medical use
|
|
WO2008011109A2
(en)
|
2006-07-20 |
2008-01-24 |
Amgen Inc. |
Substituted pyridone compounds and methods of use
|
|
WO2008013997A2
(en)
|
2006-07-27 |
2008-01-31 |
The Trustees Of Columbia University In The City Of New York |
Fluorescent substrates for monoamine transporters as optical false neurotransmitters
|
|
US20100029685A1
(en)
*
|
2006-10-25 |
2010-02-04 |
Neurosearch A/S |
Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
|
|
US8314119B2
(en)
*
|
2006-11-06 |
2012-11-20 |
Abbvie Inc. |
Azaadamantane derivatives and methods of use
|
|
KR20100049698A
(ko)
|
2006-12-22 |
2010-05-12 |
아벡사 리미티드 |
바이사이클 피리미디논 및 그 용도
|
|
WO2008083226A2
(en)
|
2006-12-28 |
2008-07-10 |
Navinta Llc |
Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
|
|
FR2914188B1
(fr)
|
2007-03-28 |
2012-06-22 |
Trophos |
Nouvelle composition a base d'oxime de cholest-4-en-3-one
|
|
EP2014656A3
(en)
|
2007-06-11 |
2011-08-24 |
High Point Pharmaceuticals, LLC |
New heteocyclic h3 antagonists
|
|
CN101878219B
(zh)
|
2007-09-27 |
2014-04-02 |
西班牙国家癌症研究中心 |
用于作为蛋白激酶抑制剂使用的咪唑并噻二唑类
|
|
WO2009042907A1
(en)
|
2007-09-27 |
2009-04-02 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
|
|
US8153813B2
(en)
|
2007-12-20 |
2012-04-10 |
Abbott Laboratories |
Benzothiazole and benzooxazole derivatives and methods of use
|
|
WO2009114874A2
(en)
|
2008-03-14 |
2009-09-17 |
Intellikine, Inc. |
Benzothiazole kinase inhibitors and methods of use
|
|
WO2009126635A1
(en)
|
2008-04-09 |
2009-10-15 |
Abbott Laboratories |
2-amino-benzothiazole derivates useful as inhibitors of rock kinases
|
|
US20090264433A1
(en)
|
2008-04-21 |
2009-10-22 |
Institute For Oneworld Health |
Compounds, Compositions and Methods Comprising Triazine Derivatives
|
|
US8633019B2
(en)
|
2008-05-27 |
2014-01-21 |
Ptc Therapeutics, Inc. |
Methods for treating spinal muscular atrophy
|
|
EP2315588B1
(en)
|
2008-06-20 |
2012-12-19 |
Rottapharm S.p.A. |
6-1h-imidazo-quinazoline and quinolines derivatives, new mao inhibitors and imidazoline receptor ligands
|
|
EP2138493A1
(en)
|
2008-06-26 |
2009-12-30 |
Sanofi-Aventis |
Substituted pyrimidone derivatives
|
|
PL2212324T3
(pl)
|
2008-07-02 |
2014-11-28 |
Avexa Ltd |
Związki posiadające właściwości przeciwwirusowe
|
|
US8986935B2
(en)
|
2008-08-13 |
2015-03-24 |
Ptc Therapeutics, Inc. |
Methods for treating spinal muscular atrophy
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
US8283360B2
(en)
|
2008-12-19 |
2012-10-09 |
Merck Sharp & Dohme Corp. |
Bicyclic heterocyclic derivatives and methods of use thereof
|
|
BRPI1008020A2
(pt)
*
|
2009-02-11 |
2016-03-15 |
Sunovion Pharmaceuticals Inc |
antagonistas e agonistas inversos h3 da histamina e métodos de uso dos mesmos
|
|
FR2945289A1
(fr)
|
2009-05-11 |
2010-11-12 |
Sanofi Aventis |
Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique
|
|
KR20120044978A
(ko)
*
|
2009-06-19 |
2012-05-08 |
아보트 러보러터리즈 |
디아자호모아다만탄 유도체 및 이들의 사용 방법
|
|
EP3626823A1
(en)
|
2009-09-11 |
2020-03-25 |
Ionis Pharmaceuticals, Inc. |
Modulation of huntingtin expression
|
|
WO2011050245A1
(en)
|
2009-10-23 |
2011-04-28 |
Yangbo Feng |
Bicyclic heteroaryls as kinase inhibitors
|
|
WO2011057204A2
(en)
|
2009-11-06 |
2011-05-12 |
The Johns Hopkins University |
Lrrk2-mediated neuronal toxicity
|
|
US8754220B2
(en)
|
2009-11-20 |
2014-06-17 |
Merck Sharp & Dohme Corp. |
Quinolizidinone carboxamide M1 receptor positive allosteric modulators
|
|
CA2786329A1
(en)
|
2010-01-13 |
2011-07-21 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Anti - infective pyrido (1,2-a) pyrimidines
|
|
US20130059902A1
(en)
|
2010-02-08 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Methods and compositions useful in treatment of diseases or conditions related to repeat expansion
|
|
AU2011213562B2
(en)
|
2010-02-08 |
2016-07-07 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
EP2534262B1
(en)
|
2010-02-08 |
2016-12-14 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
WO2011149856A1
(en)
|
2010-05-24 |
2011-12-01 |
Presidio Pharmaceuticals, Inc. |
Inhibitors of hcv ns5a
|
|
WO2012009367A1
(en)
*
|
2010-07-12 |
2012-01-19 |
Advanced Energy Industries, Inc. |
Power inverter systems with high-accuracy reference signal generation and associated methods of control
|
|
DK3031920T3
(da)
|
2010-07-19 |
2019-10-14 |
Ionis Pharmaceuticals Inc |
Modulation af dystrofi myotonica-protein kinase (dmpk) ekspression
|
|
WO2012075393A2
(en)
*
|
2010-12-02 |
2012-06-07 |
President And Fellows Of Harvard College |
Activators of proteasomal degradation and uses thereof
|
|
WO2012104823A2
(en)
|
2011-02-04 |
2012-08-09 |
Novartis Ag |
Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
|
|
EP3067421B1
(en)
|
2011-02-08 |
2018-10-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
US8703763B2
(en)
|
2011-03-02 |
2014-04-22 |
Hoffmann-La Roche Inc. |
Bridged piperidine derivatives
|
|
WO2013019938A1
(en)
|
2011-08-02 |
2013-02-07 |
The Brigham And Women's Hospital, Inc. |
Pyridazine derivatives as eaat2 activators
|
|
US8871756B2
(en)
|
2011-08-11 |
2014-10-28 |
Hoffmann-La Roche Inc. |
Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
|
|
WO2013022966A1
(en)
|
2011-08-11 |
2013-02-14 |
Isis Pharmaceuticals, Inc. |
Linkage modified gapped oligomeric compounds and uses thereof
|
|
US20130046093A1
(en)
|
2011-08-18 |
2013-02-21 |
Korea Institute Of Science And Technology |
Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
|
|
US9976138B2
(en)
|
2011-08-29 |
2018-05-22 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
WO2013059606A1
(en)
|
2011-10-21 |
2013-04-25 |
Tufts Medical Center, Inc. |
Compounds and methods for the treatment of muscular disease, and related screening methods
|
|
GB201119538D0
(en)
|
2011-11-10 |
2011-12-21 |
Viral Ltd |
Pharmaceutical compounds
|
|
MX2014006409A
(es)
*
|
2011-11-28 |
2014-07-30 |
Novartis Ag |
Novedosos derivados de trifluoro-metil-oxadiazol y su uso en el tratamiento de enfermedades.
|
|
CN104244944B
(zh)
|
2011-12-30 |
2018-06-08 |
Ptc医疗公司 |
用于治疗脊髓性肌萎缩症的化合物
|
|
JP6193888B2
(ja)
|
2012-01-26 |
2017-09-06 |
ピーティーシー セラピューティクス， インコーポレイテッド |
脊髄性筋萎縮症を治療するための化合物
|
|
PL2812004T3
(pl)
|
2012-02-10 |
2019-01-31 |
Ptc Therapeutics, Inc. |
Związki do leczenia rdzeniowego zaniku mięśni
|
|
CN104302181B
(zh)
|
2012-03-01 |
2017-09-15 |
Ptc医疗公司 |
用于治疗脊髓性肌萎缩的化合物
|
|
EA028382B1
(ru)
|
2012-03-23 |
2017-11-30 |
ПиТиСи ТЕРАПЬЮТИКС, ИНК. |
Соединения для лечения спинальной мышечной атрофии
|
|
SMT201800608T1
(it)
|
2012-04-24 |
2019-01-11 |
Vertex Pharma |
Inibitori di dna-pk
|
|
US8980934B2
(en)
*
|
2012-06-22 |
2015-03-17 |
University Health Network |
Kinase inhibitors and method of treating cancer with same
|
|
EP2872493B1
(en)
|
2012-07-13 |
2018-11-14 |
Indiana University Research and Technology Corporation |
5,6,7-trimethoxy 4-phenyl quinolin-2-one derivatives for treatment of spinal muscular atrophy
|
|
US8729263B2
(en)
*
|
2012-08-13 |
2014-05-20 |
Novartis Ag |
1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
|
|
EP2906256B1
(en)
|
2012-10-12 |
2018-08-22 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
EP2906255B1
(en)
|
2012-10-12 |
2023-02-22 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
|
US9227976B2
(en)
|
2012-10-25 |
2016-01-05 |
Usher Iii Initiative, Inc. |
Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
|
|
US9040712B2
(en)
|
2013-01-23 |
2015-05-26 |
Novartis Ag |
Thiadiazole analogs thereof and methods for treating SMN-deficiency-related-conditions
|
|
CA2899924A1
(en)
|
2013-02-04 |
2014-08-07 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
WO2014135244A1
(en)
|
2013-03-05 |
2014-09-12 |
Merck Patent Gmbh |
Triazolo[4,5-d]pyrimidine derivatives for the treatment of diseases such as cancer
|
|
JP2016518421A
(ja)
|
2013-05-14 |
2016-06-23 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
呼吸器合胞体ウイルス感染症の処置および予防のためのアザ−オキソ−インドール
|
|
EP3013345B1
(en)
|
2013-06-25 |
2017-11-22 |
F. Hoffmann-La Roche AG |
Compounds for treating spinal muscular atrophy
|
|
MX2020011652A
(es)
|
2013-07-31 |
2022-09-27 |
Novartis Ag |
Derivados de piridazina 1,4-disustituida, y su uso para el tratamiento de afecciones relacionadas con la deficiencia de smn.
|
|
CN105392790B
(zh)
|
2013-08-19 |
2019-04-19 |
豪夫迈·罗氏有限公司 |
4H-吡啶并[1,2-a]嘧啶-4-酮化合物制备用于预防或治疗癌症的药物的用途
|
|
WO2015095446A1
(en)
|
2013-12-19 |
2015-06-25 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount of rna transcripts
|
|
WO2015095449A1
(en)
|
2013-12-19 |
2015-06-25 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount rna transcripts
|
|
EP3082820B1
(en)
|
2013-12-19 |
2022-07-20 |
PTC Therapeutics, Inc. |
Methods for modulating the amount of rna transcripts
|
|
KR20230152178A
(ko)
|
2014-01-16 |
2023-11-02 |
웨이브 라이프 사이언시스 리미티드 |
키랄 디자인
|
|
ES2699354T3
(es)
|
2014-01-17 |
2019-02-08 |
Novartis Ag |
Derivados de 1-(triazin-3-il/piridazin-3-il)-piper(-azin)idina y composiciones de las mismas para inhibir la actividad de SHP2
|
|
AR099134A1
(es)
|
2014-01-24 |
2016-06-29 |
Hoffmann La Roche |
Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
|
|
HK1226064A1
(zh)
|
2014-03-14 |
2017-09-22 |
拉夸里亚创药株式会社 |
作为trpm8拮抗剂的氮杂螺衍生物
|
|
ES2949660T3
(es)
|
2014-05-15 |
2023-10-02 |
Hoffmann La Roche |
Procedimiento para la preparación de compuestos útiles para tratar la atrofia muscular espinal
|
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
|
EP3157875A2
(en)
|
2014-06-17 |
2017-04-26 |
Novozymes A/S |
Biological phosphorus removal from wastewater
|
|
RU2725979C2
(ru)
|
2014-06-25 |
2020-07-08 |
Ф. Хоффманн-Ля Рош Аг |
ИМИДАЗО[1,2-а]ПИРАЗИН-1-ИЛ-БЕНЗАМИДЫ ДЛЯ ЛЕЧЕНИЯ СПИНАЛЬНОЙ МЫШЕЧНОЙ АТРОФИИ
|
|
EP3237618B1
(en)
|
2014-12-24 |
2019-05-22 |
uniQure IP B.V. |
Rnai induced huntingtin gene suppression
|
|
ES2928714T3
(es)
|
2015-01-16 |
2022-11-22 |
Massachusetts Gen Hospital |
Compuestos para mejorar el empalme del ARNm
|
|
CN107428729B
(zh)
|
2015-02-09 |
2021-07-16 |
豪夫迈·罗氏有限公司 |
用于治疗癌症的化合物
|
|
GB201502567D0
(en)
|
2015-02-16 |
2015-04-01 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
GB201506933D0
(en)
|
2015-04-23 |
2015-06-10 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
JP6749343B2
(ja)
|
2015-05-20 |
2020-09-02 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
脊髄性筋萎縮症を処置するための化合物
|
|
US10668171B2
(en)
|
2015-05-30 |
2020-06-02 |
Ptc Therapeutics, Inc. |
Methods for modulating RNA splicing
|
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
WO2017023987A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
|
|
WO2017059251A1
(en)
|
2015-10-02 |
2017-04-06 |
Incyte Corporation |
Heterocyclic compounds useful as pim kinase inhibitors
|
|
KR102162062B1
(ko)
|
2015-11-12 |
2020-10-07 |
에프. 호프만-라 로슈 아게 |
척수성 근위축증의 치료용 조성물
|
|
EP3374362A1
(en)
|
2015-11-12 |
2018-09-19 |
H. Hoffnabb-La Roche Ag |
Compounds for treating amyotrophic lateral sclerosis
|
|
EP3386978B1
(en)
|
2015-12-10 |
2021-01-27 |
H. Hoffnabb-La Roche Ag |
Bridged piperidine derivatives
|
|
CN113750101A
(zh)
|
2015-12-10 |
2021-12-07 |
Ptc医疗公司 |
用于治疗亨廷顿病的方法
|
|
US10526345B2
(en)
|
2016-04-08 |
2020-01-07 |
Mankind Pharma Ltd. |
Compounds as GPR119 agonists
|
|
AR108325A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
|
MA45270A
(fr)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
WO2017210134A1
(en)
|
2016-05-31 |
2017-12-07 |
Board Of Regents, University Of Texas System |
Heterocyclic inhibitors of ptpn11
|
|
US20190264267A1
(en)
|
2016-07-25 |
2019-08-29 |
Wave Life Sciences Ltd. |
Phasing
|
|
TWI848901B
(zh)
|
2016-10-24 |
2024-07-21 |
美商傳達治療有限公司 |
Shp2磷酸酶抑制劑及其使用方法
|
|
US11857599B2
(en)
|
2017-04-03 |
2024-01-02 |
Acceleron Pharma Inc. |
Compositions and methods for treating spinal muscular atrophy
|
|
EP3630770B1
(en)
|
2017-05-26 |
2024-08-28 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
|
|
US11407753B2
(en)
|
2017-06-05 |
2022-08-09 |
Ptc Therapeutics, Inc. |
Compounds for treating Huntington's disease
|
|
EP3645121B8
(en)
|
2017-06-28 |
2025-06-18 |
PTC Therapeutics, Inc. |
Methods for treating huntington's disease
|
|
CA3067591A1
(en)
|
2017-06-28 |
2019-01-03 |
Ptc Therapeutics, Inc. |
Methods for treating huntington's disease
|
|
SG10202002990XA
(en)
|
2017-08-04 |
2020-05-28 |
Skyhawk Therapeutics Inc |
Methods and compositions for modulating splicing
|
|
WO2019165073A1
(en)
|
2018-02-21 |
2019-08-29 |
Relay Therapeutics, Inc. |
Shp2 phosphatase inhibitors and methods of use thereof
|
|
US20220315586A1
(en)
|
2018-03-21 |
2022-10-06 |
Relay Therapeutics, Inc. |
Shp2 phosphatase inhibitors and methods of use thereof
|
|
WO2019183364A1
(en)
|
2018-03-21 |
2019-09-26 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof
|
|
KR20210005559A
(ko)
|
2018-03-27 |
2021-01-14 |
피티씨 테라퓨틱스, 인크. |
헌팅턴병 치료 화합물
|
|
LT3814357T
(lt)
|
2018-06-27 |
2024-06-25 |
Ptc Therapeutics, Inc. |
Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui
|
|
US11685746B2
(en)
|
2018-06-27 |
2023-06-27 |
Ptc Therapeutics, Inc. |
Heteroaryl compounds for treating Huntington's disease
|
|
WO2020005877A1
(en)
|
2018-06-27 |
2020-01-02 |
Ptc Therapeutics, Inc. |
Heteroaryl compounds for treating huntington's disease
|
|
WO2020231977A1
(en)
|
2019-05-13 |
2020-11-19 |
Ptc Therapeutics, Inc. |
Compounds for treating huntington's disease
|
|
WO2021007378A1
(en)
|
2019-07-11 |
2021-01-14 |
Ptc Therapeutics, Inc. |
Compounds for use in treating huntington's disease
|
|
US20240216369A1
(en)
|
2019-11-01 |
2024-07-04 |
Novartis Ag |
The use of a splicing modulator for a treatment slowing progression of huntington's disease
|