JP2019218349A5 - - Google Patents
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- JP2019218349A5 JP2019218349A5 JP2019113819A JP2019113819A JP2019218349A5 JP 2019218349 A5 JP2019218349 A5 JP 2019218349A5 JP 2019113819 A JP2019113819 A JP 2019113819A JP 2019113819 A JP2019113819 A JP 2019113819A JP 2019218349 A5 JP2019218349 A5 JP 2019218349A5
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- Prior art keywords
- vesicle
- hybridsome
- lnp
- peg
- lipid
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022045805A JP2022101548A (ja) | 2014-01-21 | 2022-03-22 | ハイブリドソーム、それを含む組成物、それらの製造方法、およびその使用 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461929559P | 2014-01-21 | 2014-01-21 | |
| US61/929,559 | 2014-01-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546998A Division JP6598786B2 (ja) | 2014-01-21 | 2015-01-20 | ハイブリドソーム、それを含む組成物、それらの製造方法、およびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022045805A Division JP2022101548A (ja) | 2014-01-21 | 2022-03-22 | ハイブリドソーム、それを含む組成物、それらの製造方法、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019218349A JP2019218349A (ja) | 2019-12-26 |
| JP2019218349A5 true JP2019218349A5 (https=) | 2020-04-02 |
| JP7046872B2 JP7046872B2 (ja) | 2022-04-04 |
Family
ID=52434912
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546998A Active JP6598786B2 (ja) | 2014-01-21 | 2015-01-20 | ハイブリドソーム、それを含む組成物、それらの製造方法、およびその使用 |
| JP2019113819A Active JP7046872B2 (ja) | 2014-01-21 | 2019-06-19 | ハイブリドソーム、それを含む組成物、それらの製造方法、およびその使用 |
| JP2022045805A Pending JP2022101548A (ja) | 2014-01-21 | 2022-03-22 | ハイブリドソーム、それを含む組成物、それらの製造方法、およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546998A Active JP6598786B2 (ja) | 2014-01-21 | 2015-01-20 | ハイブリドソーム、それを含む組成物、それらの製造方法、およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022045805A Pending JP2022101548A (ja) | 2014-01-21 | 2022-03-22 | ハイブリドソーム、それを含む組成物、それらの製造方法、およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10561610B2 (https=) |
| EP (2) | EP3096741B1 (https=) |
| JP (3) | JP6598786B2 (https=) |
| KR (3) | KR102541164B1 (https=) |
| CN (2) | CN105934240B (https=) |
| AU (3) | AU2015208837B2 (https=) |
| CA (1) | CA2936514C (https=) |
| DK (1) | DK3096741T3 (https=) |
| EA (1) | EA037503B1 (https=) |
| ES (1) | ES2821758T3 (https=) |
| MX (2) | MX384911B (https=) |
| WO (1) | WO2015110957A2 (https=) |
| ZA (1) | ZA201604831B (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013070324A1 (en) | 2011-11-07 | 2013-05-16 | University Of Louisville Research Foundation, Inc. | Edible plant-derived microvesicle compositions for diagnosis and treatment of disease |
| US10272137B2 (en) | 2013-06-27 | 2019-04-30 | The Board Of Regents Of The University Of Texas System | Compositions and methods relating to myomaker-induced muscle cell fusion |
| EA037503B1 (ru) | 2014-01-21 | 2021-04-05 | Анджариум Байосайенсиз Аг | Способ получения гибридосомы, гибридосома, полученная при помощи способа, и способ доставки терапевтического или диагностического средства |
| US20170035700A1 (en) | 2014-04-11 | 2017-02-09 | University Of Louisville Research Foundation, Inc. | Coated edible plant-derived microvesicle compositions and methods for using the same |
| WO2016123163A2 (en) | 2015-01-27 | 2016-08-04 | Kardiatonos, Inc. | Biomarkers of vascular disease |
| WO2017136430A1 (en) | 2016-02-01 | 2017-08-10 | The Board Of Trustees Of The Leland Stanford Junior University | Exosome-total-isoloation-chip (exotic) device for isolation of exosome-based biomarkers |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| CN107362370B (zh) * | 2016-05-13 | 2022-07-26 | 国家纳米科学中心 | 一种基于金纳米簇联合NGF siRNA治疗胰腺癌的方法 |
| KR20230074598A (ko) * | 2016-05-18 | 2023-05-30 | 모더나티엑스, 인크. | 릴랙신을 인코딩하는 폴리뉴클레오타이드 |
| CN106280533B (zh) * | 2016-08-17 | 2018-03-09 | 赣南师范大学 | 一种近红外荧光染料及其合成方法和用于寄生虫荧光标记 |
| EP3292861A1 (en) * | 2016-09-13 | 2018-03-14 | Centre National De La Recherche Scientifique (Cnrs) | An in vitro method for obtaining a biohybrid vector |
| JP2020517750A (ja) * | 2017-04-19 | 2020-06-18 | エイピーエイ− アドバンスト・テクノロジーズ・リミテッドＡｐａ− Ａｄｖａｎｃｅｄ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｔｄ． | 癌処置のための融合性リポソーム、組成物、キットおよびその使用 |
| CN107084956B (zh) * | 2017-05-05 | 2021-03-23 | 曲阜师范大学 | 一种基于醇溶剂诱导银纳米簇荧光增强的尿液中碘离子检测方法 |
| AU2018266111B2 (en) * | 2017-05-08 | 2024-11-07 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| US12433843B2 (en) | 2017-07-28 | 2025-10-07 | National University Of Singapore | Biomolecular composites comprising modified cell ghosts |
| WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
| JP2020537498A (ja) * | 2017-09-11 | 2020-12-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 哺乳類細胞へのｃａｓ９の抗体媒介性送達 |
| WO2019066434A1 (ko) * | 2017-09-30 | 2019-04-04 | 주식회사 엑소코바이오 | 사포게닌과 엑소좀을 유효성분으로 포함하는 조성물 |
| KR102008665B1 (ko) * | 2017-09-30 | 2019-08-08 | 주식회사 엑소코바이오 | 사포게닌과 엑소좀을 유효성분으로 포함하는 조성물 |
| US20200330616A1 (en) * | 2017-11-13 | 2020-10-22 | POLITECNICO Dl TORINO | Biomimetic non-immunogenic nanoassembly for the antitumor therapy |
| US12036262B2 (en) | 2017-11-22 | 2024-07-16 | University Of Louisville Research Foundation, Inc. | Edible plant-derived nanoparticles for regulation of gut microbiota |
| CN108287134B (zh) * | 2017-12-28 | 2020-11-24 | 南京邮电大学 | 单颗粒生物探针及其等离子体生物存储器的构建方法 |
| CA3091478A1 (en) | 2018-02-17 | 2019-08-22 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for membrane protein delivery |
| US12241888B2 (en) | 2018-03-14 | 2025-03-04 | Children's Medical Center Corporation | Platform for assessment of the transcytosis of extracellular vesicles across endothelial barriers and uses thereof |
| JP7551110B2 (ja) | 2018-04-06 | 2024-09-17 | ノース カロライナ ステート ユニバーシティ | 癌免疫療法のためのチェックポイント阻害剤の細胞集団を介した送達 |
| AU2019251449A1 (en) | 2018-04-09 | 2020-11-12 | Orgenesis Inc. | Bioxomes particles, redoxomes, method and composition |
| WO2019210189A1 (en) * | 2018-04-26 | 2019-10-31 | University Of Louisville Research Foundation, Inc. | Edible plant exosome-like nanovectors for vaccination |
| CA3003032A1 (en) * | 2018-04-27 | 2019-10-27 | Nanostics Inc. | Methods of diagnosing disease using microflow cytometry |
| CN110437628B (zh) * | 2018-05-04 | 2021-05-04 | 中国石油化工股份有限公司 | 一种改性剂母液和道路沥青及其合成方法 |
| AU2019269593A1 (en) * | 2018-05-15 | 2020-11-26 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3813798A1 (en) * | 2018-06-28 | 2021-05-05 | AstraZeneca AB | Exosome extracellular vesicles and methods of use |
| EP3820509A1 (en) | 2018-07-09 | 2021-05-19 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
| CN113271926A (zh) | 2018-09-20 | 2021-08-17 | 摩登纳特斯有限公司 | 脂质纳米颗粒的制备及其施用方法 |
| CN113166783B (zh) | 2018-10-09 | 2024-10-11 | 不列颠哥伦比亚大学 | 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法 |
| WO2020084623A2 (en) * | 2018-10-24 | 2020-04-30 | Apa- Advanced Technologies Ltd. | Fusogenic liposomes for selective imaging of tumor cells |
| US12496274B2 (en) | 2018-11-14 | 2025-12-16 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
| EP3880832A1 (en) * | 2018-11-14 | 2021-09-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for hematopoietic stem cell delivery |
| CN109620969B (zh) * | 2019-01-30 | 2021-02-05 | 广东药科大学 | 一种针对耐药肿瘤细胞的靶向抗肿瘤药物体系及其构建方法 |
| WO2021010586A1 (ko) * | 2019-07-15 | 2021-01-21 | (주)심플스틱 | 항노화를 위한 피부 리프팅용 화장료 조성물 및 이를 이용한 피부미용 방법 |
| KR20220044816A (ko) * | 2019-08-12 | 2022-04-11 | 인티그레이티드 나노테라퓨틱스 아이엔씨. | 하전 물질 전달을 위한 지질, 이의 제형 및 그 제조 방법 |
| WO2021034582A1 (en) * | 2019-08-16 | 2021-02-25 | Children's Medical Center Corporation | Large scale production of exosome mimetics and uses thereof |
| CN112415081A (zh) * | 2019-08-23 | 2021-02-26 | 四川大学 | 一种基于稳定同位素检测的无标记CRISPR-Cas9分析方法 |
| KR102297995B1 (ko) * | 2019-10-24 | 2021-09-02 | 포항공과대학교 산학협력단 | 개방 동공을 갖는 산화철 나노큐브, 이의 제조방법 및 이의 용도 |
| CN111007170B (zh) * | 2019-12-13 | 2021-06-29 | 中国农业科学院农产品加工研究所 | 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途 |
| US20230285297A1 (en) * | 2020-01-31 | 2023-09-14 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| EP3858332A1 (en) | 2020-01-31 | 2021-08-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Bottom-up assembly of synthetic extracellular vesicles |
| JP7744354B2 (ja) * | 2020-02-25 | 2025-09-25 | トランスレイト バイオ， インコーポレイテッド | Ｍｒｎａ担持脂質ナノ粒子を調製する改善された方法 |
| US20230143984A1 (en) * | 2020-03-20 | 2023-05-11 | Heidelberg University | Colloidal carrier systems for transfer of agents to a desired site of action |
| CN116234917A (zh) | 2020-07-27 | 2023-06-06 | 安杰瑞姆生物科学公司 | Dna分子组合物及其制备方法和使用方法 |
| CN112094809A (zh) * | 2020-10-19 | 2020-12-18 | 军事科学院军事医学研究院环境医学与作业医学研究所 | 一种从血清或血浆中提取外泌体的方法 |
| IL307544A (en) | 2021-04-08 | 2023-12-01 | Sana Biotechnology Inc | Cd8-specific antibody constructs and compositions thereof |
| US20240218046A1 (en) | 2021-04-14 | 2024-07-04 | Anjarium Biosciences Ag | Fc-derived polypeptides |
| CA3214655A1 (en) | 2021-04-14 | 2022-10-20 | Joel DE BEER | Peptides, nanovesicles, and uses thereof for drug delivery |
| JP2024515104A (ja) | 2021-04-20 | 2024-04-04 | テラパワー， エルエルシー | Ａｃ－２２５生成のためのチタニアに基づくジェネレータ |
| JP2024522149A (ja) * | 2021-06-04 | 2024-06-11 | インスティテュート フォー ベーシック サイエンス | ナノベシクルリアクター及びその製造方法 |
| CA3226019A1 (en) | 2021-07-20 | 2023-01-26 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their preparation, and uses |
| JPWO2023027082A1 (https=) * | 2021-08-23 | 2023-03-02 | ||
| WO2023144127A1 (en) | 2022-01-31 | 2023-08-03 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon administration, and uses |
| WO2023244084A1 (ko) * | 2022-06-17 | 2023-12-21 | 주식회사 엠디뮨 | 양이온성 지질 및 핵산분자를 포함하는 세포유래 베지클 및 이의 제조방법 |
| CN121038801A (zh) | 2022-10-24 | 2025-11-28 | Ags治疗简易股份公司 | 来自微藻的细胞外囊泡、它们在鼻内施用时的生物分布及其用途 |
| EP4665865A1 (en) | 2023-02-17 | 2025-12-24 | Anjarium Biosciences AG | Methods of making dna molecules and compositions and uses thereof |
| US11944604B1 (en) | 2023-03-10 | 2024-04-02 | King Saud University | Nanoformulation of spriooxindole and methods for treating hepatocellular carcinoma |
| WO2024249782A2 (en) * | 2023-06-02 | 2024-12-05 | The Methodist Hospital | Biomimetic proteolipid nanovesicles for delivery of nucleic acids |
| EP4719632A1 (en) | 2023-07-06 | 2026-04-08 | National Resilience, LLC | Methods and compositions for purifying particles and macromolecules |
| KR20250018222A (ko) * | 2023-07-26 | 2025-02-05 | 차의과학대학교 산학협력단 | 미토콘드리아가 캡슐화된 세포막 융합유도 리포좀을 포함하는 골관절염 치료를 위한 약학 조성물 |
| WO2025100747A1 (ko) * | 2023-11-09 | 2025-05-15 | 주식회사 엑토좀 | 줄기세포 유래 엑토-리포좀 융합 나노입자 및 그의 용도 |
| WO2025137252A1 (en) * | 2023-12-20 | 2025-06-26 | Cz Biohub Sf, Llc | High throughput method for screening lipid nanoparticle efficacy and cytotoxicity |
| WO2025176847A1 (en) | 2024-02-21 | 2025-08-28 | Ags Therapeutics Sas | Ocular delivery of active agents via microalgae extracellular vesicles |
| WO2025196641A1 (ru) * | 2024-03-19 | 2025-09-25 | Биоплатформ Гмбх | Гибридные частицы, способ их получения и применение |
| KR20250150723A (ko) * | 2024-04-11 | 2025-10-21 | 주식회사 하이셀텍 | 하이브리드 엑소좀 및 이의 용도 |
| KR20250156281A (ko) * | 2024-04-25 | 2025-11-03 | 주식회사 보름바이오 | 고분자 나노입자와 세포막이 하이브리드화된 나노복합체 및 이의 의학적 용도 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552155A (en) * | 1992-12-04 | 1996-09-03 | The Liposome Company, Inc. | Fusogenic lipsomes and methods for making and using same |
| US7901708B2 (en) | 2002-06-28 | 2011-03-08 | Protiva Biotherapeutics, Inc. | Liposomal apparatus and manufacturing methods |
| US8455188B2 (en) * | 2007-01-26 | 2013-06-04 | University Of Louisville Research Foundation, Inc. | Modification of exosomal components for use as a vaccine |
| US20110224447A1 (en) | 2008-08-18 | 2011-09-15 | Bowman Keith A | Novel Lipid Nanoparticles and Novel Components for Delivery of Nucleic Acids |
| WO2010080724A1 (en) | 2009-01-12 | 2010-07-15 | Merck Sharp & Dohme Corp. | Novel lipid nanoparticles and novel components for delivery of nucleic acids |
| EP3569254B1 (en) | 2009-04-17 | 2022-07-20 | Oxford University Innovation Limited | Composition for delivery of genetic material |
| KR100950713B1 (ko) | 2009-07-15 | 2010-03-31 | (주)블루앤 | 음이온 발생기를 구비한 엘이디 램프 |
| EP2467357B1 (en) | 2009-08-20 | 2016-03-30 | Sirna Therapeutics, Inc. | Novel cationic lipids with various head groups for oligonucleotide delivery |
| US20120253032A1 (en) | 2009-10-08 | 2012-10-04 | Merck Sharp & Dohme Corporation | Novel cationic lipids with short lipid chains for oligonucleotide delivery |
| WO2011076807A2 (en) | 2009-12-23 | 2011-06-30 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| US20130116419A1 (en) | 2010-01-22 | 2013-05-09 | Daniel Zewge | Post-synthetic chemical modification of rna at the 2'-position of the ribose ring via "click" chemistry |
| WO2011097480A1 (en) * | 2010-02-05 | 2011-08-11 | University Of Louisville Research Foundation, Inc. | Exosomal compositions and methods for the treatment of disease |
| JP5149921B2 (ja) * | 2010-02-19 | 2013-02-20 | 学校法人君が淵学園 | 癌細胞増殖抑制性ハイブリッド型リポソーム製剤 |
| WO2011127302A2 (en) | 2010-04-07 | 2011-10-13 | Yue Shen | Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems |
| US8802863B2 (en) | 2010-05-24 | 2014-08-12 | Sirna Therapeutics, Inc. | Amino alcohol cationic lipids for oligonucleotide delivery |
| AU2011258165B2 (en) | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| US8748667B2 (en) | 2010-06-04 | 2014-06-10 | Sirna Therapeutics, Inc. | Low molecular weight cationic lipids for oligonucleotide delivery |
| CN103079592B (zh) | 2010-07-01 | 2015-10-21 | 浦项工科大学校产学协力团 | 使用来自细胞的微泡治疗和诊断癌症的方法 |
| KR101130137B1 (ko) | 2010-07-02 | 2012-03-28 | 연세대학교 산학협력단 | 발광다이오드 모듈 |
| US20120058153A1 (en) | 2010-08-20 | 2012-03-08 | Selecta Biosciences, Inc. | Synthetic nanocarrier vaccines comprising proteins obtained or derived from human influenza a virus hemagglutinin |
| ES2888231T3 (es) | 2010-09-20 | 2022-01-03 | Sirna Therapeutics Inc | Lípidos catiónicos de bajo peso molecular para el suministro de oligonucleótidos |
| EP2621480B1 (en) | 2010-09-30 | 2018-08-15 | Sirna Therapeutics, Inc. | Low molecular weight cationic lipids for oligonucleotide delivery |
| JP2013545727A (ja) | 2010-10-21 | 2013-12-26 | メルク・シャープ・アンド・ドーム・コーポレーション | オリゴヌクレオチド送達用の新規低分子量カチオン性脂質 |
| EP2635265B1 (en) | 2010-11-05 | 2018-04-04 | Sirna Therapeutics, Inc. | Novel low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery |
| WO2012099805A2 (en) | 2011-01-19 | 2012-07-26 | Ocean Nanotech, Llc | Nanoparticle based immunological stimulation |
| WO2013048734A1 (en) * | 2011-09-28 | 2013-04-04 | Tufts Medical Center, Inc. | Treatment and prevention of cardiovascular disease with cell derived lipid vesicles, microvesicles and exosomes |
| US20140308304A1 (en) * | 2011-12-07 | 2014-10-16 | Alnylam Pharmaceuticals, Inc. | Lipids for the delivery of active agents |
| JP2013128452A (ja) * | 2011-12-21 | 2013-07-04 | Toshiba Corp | 定量分析装置、定量分析方法、脂質膜小胞、及び試薬 |
| US9687448B2 (en) | 2012-12-07 | 2017-06-27 | Alnylam Pharmaceuticals, Inc. | Nucleic acid lipid particle formulations |
| JP2016507543A (ja) | 2013-02-07 | 2016-03-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 小胞を含む医薬組成物 |
| EA037503B1 (ru) | 2014-01-21 | 2021-04-05 | Анджариум Байосайенсиз Аг | Способ получения гибридосомы, гибридосома, полученная при помощи способа, и способ доставки терапевтического или диагностического средства |
| CN116234917A (zh) | 2020-07-27 | 2023-06-06 | 安杰瑞姆生物科学公司 | Dna分子组合物及其制备方法和使用方法 |
| CA3214655A1 (en) | 2021-04-14 | 2022-10-20 | Joel DE BEER | Peptides, nanovesicles, and uses thereof for drug delivery |
| US20240218046A1 (en) | 2021-04-14 | 2024-07-04 | Anjarium Biosciences Ag | Fc-derived polypeptides |
| AU2022260111A1 (en) | 2021-04-20 | 2023-11-30 | Anjarium Biosciences Ag | Compositions of dna molecules encoding amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase, methods of making thereof, and methods of use thereof |
| JP2025504404A (ja) | 2022-01-14 | 2025-02-12 | アンジャリウム バイオサイエンシズ エージー | Ｖｉｉｉ因子をコードするｄｎａ分子の組成物、それを作製する方法、及びその使用方法 |
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2015
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- 2015-01-20 CN CN201580005079.XA patent/CN105934240B/zh active Active
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- 2015-01-20 CN CN202110078273.8A patent/CN112870163A/zh active Pending
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- 2015-01-20 WO PCT/IB2015/050436 patent/WO2015110957A2/en not_active Ceased
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2016
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