CN105934240B - 杂交体、包含该杂交体的组合物、它们的制备方法及用途 - Google Patents
杂交体、包含该杂交体的组合物、它们的制备方法及用途 Download PDFInfo
- Publication number
- CN105934240B CN105934240B CN201580005079.XA CN201580005079A CN105934240B CN 105934240 B CN105934240 B CN 105934240B CN 201580005079 A CN201580005079 A CN 201580005079A CN 105934240 B CN105934240 B CN 105934240B
- Authority
- CN
- China
- Prior art keywords
- lipid
- peg
- hybrid
- cell
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
- A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Optics & Photonics (AREA)
- Cell Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110078273.8A CN112870163A (zh) | 2014-01-21 | 2015-01-20 | 杂交体、包含该杂交体的组合物、它们的制备方法及用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461929559P | 2014-01-21 | 2014-01-21 | |
| US61/929,559 | 2014-01-21 | ||
| PCT/IB2015/050436 WO2015110957A2 (en) | 2014-01-21 | 2015-01-20 | Hybridosomes, compositions comprising the same, processes for their production and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110078273.8A Division CN112870163A (zh) | 2014-01-21 | 2015-01-20 | 杂交体、包含该杂交体的组合物、它们的制备方法及用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105934240A CN105934240A (zh) | 2016-09-07 |
| CN105934240B true CN105934240B (zh) | 2021-02-09 |
Family
ID=52434912
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580005079.XA Active CN105934240B (zh) | 2014-01-21 | 2015-01-20 | 杂交体、包含该杂交体的组合物、它们的制备方法及用途 |
| CN202110078273.8A Pending CN112870163A (zh) | 2014-01-21 | 2015-01-20 | 杂交体、包含该杂交体的组合物、它们的制备方法及用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110078273.8A Pending CN112870163A (zh) | 2014-01-21 | 2015-01-20 | 杂交体、包含该杂交体的组合物、它们的制备方法及用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10561610B2 (https=) |
| EP (2) | EP3791863B1 (https=) |
| JP (3) | JP6598786B2 (https=) |
| KR (3) | KR102396026B1 (https=) |
| CN (2) | CN105934240B (https=) |
| AU (3) | AU2015208837B2 (https=) |
| CA (1) | CA2936514C (https=) |
| DK (1) | DK3096741T3 (https=) |
| EA (1) | EA037503B1 (https=) |
| ES (1) | ES2821758T3 (https=) |
| MX (2) | MX384911B (https=) |
| WO (1) | WO2015110957A2 (https=) |
| ZA (1) | ZA201604831B (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013070324A1 (en) | 2011-11-07 | 2013-05-16 | University Of Louisville Research Foundation, Inc. | Edible plant-derived microvesicle compositions for diagnosis and treatment of disease |
| US10272137B2 (en) | 2013-06-27 | 2019-04-30 | The Board Of Regents Of The University Of Texas System | Compositions and methods relating to myomaker-induced muscle cell fusion |
| KR102396026B1 (ko) | 2014-01-21 | 2022-05-09 | 안자리움 바이오사이언시스 아게 | 하이브리도좀, 이를 포함하는 조성물, 이의 제조 방법 및 이의 용도 |
| US20170035700A1 (en) | 2014-04-11 | 2017-02-09 | University Of Louisville Research Foundation, Inc. | Coated edible plant-derived microvesicle compositions and methods for using the same |
| WO2016123163A2 (en) | 2015-01-27 | 2016-08-04 | Kardiatonos, Inc. | Biomarkers of vascular disease |
| US11073511B2 (en) * | 2016-02-01 | 2021-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Exosome-Total-Isolation-Chip (ExoTIC) device for isolation of exosome-based biomarkers |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| CN107362370B (zh) * | 2016-05-13 | 2022-07-26 | 国家纳米科学中心 | 一种基于金纳米簇联合NGF siRNA治疗胰腺癌的方法 |
| IL263079B2 (en) | 2016-05-18 | 2024-05-01 | Modernatx Inc | Polynucleotides encoding relaxin |
| CN106280533B (zh) * | 2016-08-17 | 2018-03-09 | 赣南师范大学 | 一种近红外荧光染料及其合成方法和用于寄生虫荧光标记 |
| EP3292861A1 (en) * | 2016-09-13 | 2018-03-14 | Centre National De La Recherche Scientifique (Cnrs) | An in vitro method for obtaining a biohybrid vector |
| CN110709065B (zh) * | 2017-04-19 | 2023-02-10 | Apa先进技术有限公司 | 融合脂质体、组合物、试剂盒及其治疗癌症的用途 |
| CN107084956B (zh) * | 2017-05-05 | 2021-03-23 | 曲阜师范大学 | 一种基于醇溶剂诱导银纳米簇荧光增强的尿液中碘离子检测方法 |
| CA3062426A1 (en) | 2017-05-08 | 2018-11-15 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| WO2019022671A1 (en) | 2017-07-28 | 2019-01-31 | National University Of Singapore | BIOMOLECULAR COMPOSITES COMPRISING MODIFIED CELLULAR PHANTOMS |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| WO2019051428A1 (en) * | 2017-09-11 | 2019-03-14 | The Regents Of The University Of California | CAS9 ANTIBODY MEDIA ADMINISTRATION TO MAMMALIAN CELLS |
| KR102008665B1 (ko) * | 2017-09-30 | 2019-08-08 | 주식회사 엑소코바이오 | 사포게닌과 엑소좀을 유효성분으로 포함하는 조성물 |
| WO2019066434A1 (ko) * | 2017-09-30 | 2019-04-04 | 주식회사 엑소코바이오 | 사포게닌과 엑소좀을 유효성분으로 포함하는 조성물 |
| EP3710065B1 (en) * | 2017-11-13 | 2024-08-21 | Politecnico Di Torino | Biomimetic non-immunogenic nanoassembly for the antitumor therapy |
| WO2019104242A1 (en) | 2017-11-22 | 2019-05-31 | University Of Louisville Research Foundation, Inc. | Edible plant-derived nanoparticles for regulation of gut microbiota |
| CN108287134B (zh) * | 2017-12-28 | 2020-11-24 | 南京邮电大学 | 单颗粒生物探针及其等离子体生物存储器的构建方法 |
| AU2019222560B2 (en) * | 2018-02-17 | 2025-07-03 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for membrane protein delivery |
| WO2019178317A1 (en) | 2018-03-14 | 2019-09-19 | Children's Medical Center Corporation | Platform for assessment of the transcytosis of extracellular vesicles across endothelial barriers and uses thereof |
| JP7551110B2 (ja) | 2018-04-06 | 2024-09-17 | ノース カロライナ ステート ユニバーシティ | 癌免疫療法のためのチェックポイント阻害剤の細胞集団を介した送達 |
| EP3773520A4 (en) | 2018-04-09 | 2021-12-22 | Orgenesis Inc. | BIOXOMES AND REDOXOMES PARTICLES, PROCESS AND COMPOSITION |
| WO2019210189A1 (en) * | 2018-04-26 | 2019-10-31 | University Of Louisville Research Foundation, Inc. | Edible plant exosome-like nanovectors for vaccination |
| CA3003032A1 (en) * | 2018-04-27 | 2019-10-27 | Nanostics Inc. | Methods of diagnosing disease using microflow cytometry |
| CN110437628B (zh) * | 2018-05-04 | 2021-05-04 | 中国石油化工股份有限公司 | 一种改性剂母液和道路沥青及其合成方法 |
| SG11202011015QA (en) * | 2018-05-15 | 2020-12-30 | Flagship Pioneering Innovations V Inc | Fusosome compositions and uses thereof |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US12109310B2 (en) | 2018-06-28 | 2024-10-08 | Hadi Valadi | Exosome extracellular vesicles and methods of use |
| CN112955174A (zh) | 2018-07-09 | 2021-06-11 | 旗舰先锋创新V股份有限公司 | 融合剂脂质体组合物和其用途 |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| HRP20240586T1 (hr) | 2018-10-09 | 2024-07-19 | The University Of British Columbia | Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima |
| CA3117914A1 (en) * | 2018-10-24 | 2020-04-30 | Apa- Advanced Technologies Ltd. | Fusogenic liposomes for selective imaging of tumor cells |
| EP3880832A1 (en) * | 2018-11-14 | 2021-09-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for hematopoietic stem cell delivery |
| CN113631718A (zh) * | 2018-11-14 | 2021-11-09 | 旗舰先锋创新V股份有限公司 | 用于特定隔室货物递送的组合物和方法 |
| CN109620969B (zh) * | 2019-01-30 | 2021-02-05 | 广东药科大学 | 一种针对耐药肿瘤细胞的靶向抗肿瘤药物体系及其构建方法 |
| WO2021010586A1 (ko) * | 2019-07-15 | 2021-01-21 | (주)심플스틱 | 항노화를 위한 피부 리프팅용 화장료 조성물 및 이를 이용한 피부미용 방법 |
| KR20220044816A (ko) * | 2019-08-12 | 2022-04-11 | 인티그레이티드 나노테라퓨틱스 아이엔씨. | 하전 물질 전달을 위한 지질, 이의 제형 및 그 제조 방법 |
| CN114980869B (zh) * | 2019-08-16 | 2024-08-27 | 儿童医学中心公司 | 外排体模拟物的大规模产生及其用途 |
| CN112415081A (zh) * | 2019-08-23 | 2021-02-26 | 四川大学 | 一种基于稳定同位素检测的无标记CRISPR-Cas9分析方法 |
| KR102297995B1 (ko) * | 2019-10-24 | 2021-09-02 | 포항공과대학교 산학협력단 | 개방 동공을 갖는 산화철 나노큐브, 이의 제조방법 및 이의 용도 |
| CN111007170B (zh) * | 2019-12-13 | 2021-06-29 | 中国农业科学院农产品加工研究所 | 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途 |
| CA3169669A1 (en) * | 2020-01-31 | 2021-08-05 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| EP3858332A1 (en) * | 2020-01-31 | 2021-08-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Bottom-up assembly of synthetic extracellular vesicles |
| CN115427021A (zh) * | 2020-02-25 | 2022-12-02 | 翻译生物公司 | 制备负载mrna的脂质纳米颗粒的改进方法 |
| US20230143984A1 (en) * | 2020-03-20 | 2023-05-11 | Heidelberg University | Colloidal carrier systems for transfer of agents to a desired site of action |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Dna分子の組成物、その作製方法、及びその使用方法 |
| CN112094809A (zh) * | 2020-10-19 | 2020-12-18 | 军事科学院军事医学研究院环境医学与作业医学研究所 | 一种从血清或血浆中提取外泌体的方法 |
| KR20240028975A (ko) | 2021-04-08 | 2024-03-05 | 사나 바이오테크놀로지, 인크. | Cd8-특이적 항체 구조체들 및 이의 조성물 |
| US20240218046A1 (en) | 2021-04-14 | 2024-07-04 | Anjarium Biosciences Ag | Fc-derived polypeptides |
| JP2024514157A (ja) | 2021-04-14 | 2024-03-28 | アンジャリウム バイオサイエンシズ エージー | 薬物送達のためのペプチド、ナノ小胞、及びその使用 |
| KR20230173150A (ko) | 2021-04-20 | 2023-12-26 | 테라파워, 엘엘씨 | Ac-225 생성용 티타니아 기반 발생기 |
| WO2022255851A1 (ko) * | 2021-06-04 | 2022-12-08 | 기초과학연구원 | 나노소포체 반응기 및 이의 제조방법 |
| AU2022315530A1 (en) | 2021-07-20 | 2024-01-18 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their preparation, and uses |
| JPWO2023027082A1 (https=) * | 2021-08-23 | 2023-03-02 | ||
| WO2023144127A1 (en) | 2022-01-31 | 2023-08-03 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon administration, and uses |
| WO2023244084A1 (ko) * | 2022-06-17 | 2023-12-21 | 주식회사 엠디뮨 | 양이온성 지질 및 핵산분자를 포함하는 세포유래 베지클 및 이의 제조방법 |
| WO2024088808A1 (en) | 2022-10-24 | 2024-05-02 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof |
| EP4665865A1 (en) | 2023-02-17 | 2025-12-24 | Anjarium Biosciences AG | Methods of making dna molecules and compositions and uses thereof |
| US11944604B1 (en) | 2023-03-10 | 2024-04-02 | King Saud University | Nanoformulation of spriooxindole and methods for treating hepatocellular carcinoma |
| WO2024249782A2 (en) * | 2023-06-02 | 2024-12-05 | The Methodist Hospital | Biomimetic proteolipid nanovesicles for delivery of nucleic acids |
| WO2025008499A1 (en) | 2023-07-06 | 2025-01-09 | Anjarium Biosciences Ag | Methods and compositions for purifying particles and macromolecules |
| KR20250018222A (ko) * | 2023-07-26 | 2025-02-05 | 차의과학대학교 산학협력단 | 미토콘드리아가 캡슐화된 세포막 융합유도 리포좀을 포함하는 골관절염 치료를 위한 약학 조성물 |
| WO2025100747A1 (ko) * | 2023-11-09 | 2025-05-15 | 주식회사 엑토좀 | 줄기세포 유래 엑토-리포좀 융합 나노입자 및 그의 용도 |
| WO2025137252A1 (en) * | 2023-12-20 | 2025-06-26 | Cz Biohub Sf, Llc | High throughput method for screening lipid nanoparticle efficacy and cytotoxicity |
| WO2025176843A1 (en) | 2024-02-21 | 2025-08-28 | Ags Therapeutics Sas | Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof |
| WO2025196641A1 (ru) * | 2024-03-19 | 2025-09-25 | Биоплатформ Гмбх | Гибридные частицы, способ их получения и применение |
| KR20250150723A (ko) * | 2024-04-11 | 2025-10-21 | 주식회사 하이셀텍 | 하이브리드 엑소좀 및 이의 용도 |
| KR20250156281A (ko) * | 2024-04-25 | 2025-11-03 | 주식회사 보름바이오 | 고분자 나노입자와 세포막이 하이브리드화된 나노복합체 및 이의 의학적 용도 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552155A (en) * | 1992-12-04 | 1996-09-03 | The Liposome Company, Inc. | Fusogenic lipsomes and methods for making and using same |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| CN101641010A (zh) * | 2007-01-26 | 2010-02-03 | 路易斯维尔大学研究基金会公司 | 用作疫苗的外来体组分的修饰 |
| WO2010021865A1 (en) | 2008-08-18 | 2010-02-25 | Merck Sharp & Dohme Corp. | Novel lipid nanoparticles and novel components for delivery of nucleic acids |
| WO2010080724A1 (en) | 2009-01-12 | 2010-07-15 | Merck Sharp & Dohme Corp. | Novel lipid nanoparticles and novel components for delivery of nucleic acids |
| US20130053426A1 (en) * | 2009-04-17 | 2013-02-28 | Yiqi Seow | Composition For Delivery Of Genetic Material |
| KR100950713B1 (ko) | 2009-07-15 | 2010-03-31 | (주)블루앤 | 음이온 발생기를 구비한 엘이디 램프 |
| ES2579936T3 (es) | 2009-08-20 | 2016-08-17 | Sirna Therapeutics, Inc. | Nuevos lípidos catiónicos con diversos grupos de cabeza para el suministro oligonucleotídico |
| EP2485770A4 (en) | 2009-10-08 | 2013-04-10 | Merck Sharp & Dohme | Novel cationic lipids with short lipid chains for oligonucleotide delivery |
| CA3009891C (en) | 2009-12-23 | 2020-09-15 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| EP2525781A1 (en) | 2010-01-22 | 2012-11-28 | Schering Corporation | Novel cationic lipids for oligonucleotide delivery |
| WO2011097480A1 (en) * | 2010-02-05 | 2011-08-11 | University Of Louisville Research Foundation, Inc. | Exosomal compositions and methods for the treatment of disease |
| JP5149921B2 (ja) * | 2010-02-19 | 2013-02-20 | 学校法人君が淵学園 | 癌細胞増殖抑制性ハイブリッド型リポソーム製剤 |
| JP6027961B2 (ja) | 2010-04-07 | 2016-11-16 | シェン, ユエSHEN, Yue | 粘膜へ化合物を送るための媒体、それに関連する組成物、方法、及びシステム |
| US8802863B2 (en) | 2010-05-24 | 2014-08-12 | Sirna Therapeutics, Inc. | Amino alcohol cationic lipids for oligonucleotide delivery |
| CA2798739A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| DK2575767T3 (en) | 2010-06-04 | 2017-03-13 | Sirna Therapeutics Inc | HOWEVER UNKNOWN LOW MOLECULAR CATIONIC LIPIDS TO PROCESS OIGONUCLEOTIDES |
| JP5635690B2 (ja) * | 2010-07-01 | 2014-12-03 | ポステック アカデミー‐インダストリー ファウンデーション | 細菌由来マイクロベシクルを用いた癌治療及び癌診断方法 |
| KR101130137B1 (ko) | 2010-07-02 | 2012-03-28 | 연세대학교 산학협력단 | 발광다이오드 모듈 |
| WO2012024621A2 (en) | 2010-08-20 | 2012-02-23 | Selecta Biosciences, Inc. | Synthetic nanocarrier vaccines comprising peptides obtained or derived from human influenza a virus hemagglutinin |
| CA2809858C (en) | 2010-09-20 | 2019-11-12 | Sirna Therapeutics, Inc. | Novel low molecular weight cationic lipids for oligonucleotide delivery |
| CA2811430A1 (en) | 2010-09-30 | 2012-04-05 | Merck Sharp & Dohme Corp. | Low molecular weight cationic lipids for oligonucleotide delivery |
| EP3485913A1 (en) | 2010-10-21 | 2019-05-22 | Sirna Therapeutics, Inc. | Low molecular weight cationic lipids for oligonucleotide delivery |
| WO2012061259A2 (en) | 2010-11-05 | 2012-05-10 | Merck Sharp & Dohme Corp. | Novel low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery |
| WO2012099805A2 (en) | 2011-01-19 | 2012-07-26 | Ocean Nanotech, Llc | Nanoparticle based immunological stimulation |
| WO2013048734A1 (en) | 2011-09-28 | 2013-04-04 | Tufts Medical Center, Inc. | Treatment and prevention of cardiovascular disease with cell derived lipid vesicles, microvesicles and exosomes |
| WO2013086373A1 (en) * | 2011-12-07 | 2013-06-13 | Alnylam Pharmaceuticals, Inc. | Lipids for the delivery of active agents |
| JP2013128452A (ja) | 2011-12-21 | 2013-07-04 | Toshiba Corp | 定量分析装置、定量分析方法、脂質膜小胞、及び試薬 |
| WO2014089239A1 (en) | 2012-12-07 | 2014-06-12 | Alnylam Pharmaceuticals, Inc. | Improved nucleic acid lipid particle formulations |
| JP2016507543A (ja) | 2013-02-07 | 2016-03-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 小胞を含む医薬組成物 |
| KR102396026B1 (ko) | 2014-01-21 | 2022-05-09 | 안자리움 바이오사이언시스 아게 | 하이브리도좀, 이를 포함하는 조성물, 이의 제조 방법 및 이의 용도 |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Dna分子の組成物、その作製方法、及びその使用方法 |
| US20240218046A1 (en) | 2021-04-14 | 2024-07-04 | Anjarium Biosciences Ag | Fc-derived polypeptides |
| JP2024514157A (ja) | 2021-04-14 | 2024-03-28 | アンジャリウム バイオサイエンシズ エージー | 薬物送達のためのペプチド、ナノ小胞、及びその使用 |
| JP2024517427A (ja) | 2021-04-20 | 2024-04-22 | アンジャリウム バイオサイエンシズ エージー | アミロ-α-1,6-グルコシダーゼ、4-α-グルカノトランスフェラーゼをコードするDNA分子の組成物、その作製の方法、及びその使用の方法 |
| JP2025504404A (ja) | 2022-01-14 | 2025-02-12 | アンジャリウム バイオサイエンシズ エージー | Viii因子をコードするdna分子の組成物、それを作製する方法、及びその使用方法 |
-
2015
- 2015-01-20 KR KR1020167020767A patent/KR102396026B1/ko active Active
- 2015-01-20 EP EP20190918.1A patent/EP3791863B1/en active Active
- 2015-01-20 DK DK15701846.6T patent/DK3096741T3/da active
- 2015-01-20 CN CN201580005079.XA patent/CN105934240B/zh active Active
- 2015-01-20 EA EA201691448A patent/EA037503B1/ru unknown
- 2015-01-20 US US15/112,180 patent/US10561610B2/en active Active
- 2015-01-20 CA CA2936514A patent/CA2936514C/en active Active
- 2015-01-20 AU AU2015208837A patent/AU2015208837B2/en active Active
- 2015-01-20 MX MX2016009529A patent/MX384911B/es unknown
- 2015-01-20 ES ES15701846T patent/ES2821758T3/es active Active
- 2015-01-20 KR KR1020227015021A patent/KR102507475B1/ko active Active
- 2015-01-20 WO PCT/IB2015/050436 patent/WO2015110957A2/en not_active Ceased
- 2015-01-20 CN CN202110078273.8A patent/CN112870163A/zh active Pending
- 2015-01-20 EP EP15701846.6A patent/EP3096741B1/en active Active
- 2015-01-20 KR KR1020237007470A patent/KR102541164B1/ko active Active
- 2015-01-20 JP JP2016546998A patent/JP6598786B2/ja active Active
-
2016
- 2016-07-13 ZA ZA2016/04831A patent/ZA201604831B/en unknown
- 2016-07-21 MX MX2021000174A patent/MX2021000174A/es unknown
-
2019
- 2019-06-19 JP JP2019113819A patent/JP7046872B2/ja active Active
-
2020
- 2020-01-02 US US16/732,567 patent/US11484500B2/en active Active
- 2020-09-07 AU AU2020227129A patent/AU2020227129B2/en active Active
-
2022
- 2022-03-22 JP JP2022045805A patent/JP2022101548A/ja active Pending
- 2022-08-19 AU AU2022218603A patent/AU2022218603B2/en active Active
- 2022-09-12 US US17/942,617 patent/US11944706B2/en active Active
Non-Patent Citations (1)
| Title |
|---|
| Role of Cholesterol, DOTAP, and DPPC in Prostasome/Spermatozoa Interaction and Fusion;Carlo A. Palmerini et al;《J. Membrane Biol.》;20061231;第211卷;参见第187页图1和第189页讨论部分 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105934240B (zh) | 杂交体、包含该杂交体的组合物、它们的制备方法及用途 | |
| Lila et al. | Liposomal delivery systems: design optimization and current applications | |
| Soltani et al. | Synthetic and biological vesicular nano-carriers designed for gene delivery | |
| JP5835741B2 (ja) | 抗原または薬物送達複合体 | |
| CN106619515A (zh) | 脂质体组合物及其用途 | |
| JP2000516630A (ja) | 全身への送達を増加させる新規のリポソーム複合体 | |
| US20250177301A1 (en) | Triplex nanoparticles | |
| Moitra et al. | Cancer stem cell-targeted gene delivery mediated by aptamer-decorated ph-sensitive Nanoliposomes | |
| Xie et al. | Hepatic carcinoma selective nucleic acid nanovector assembled by endogenous molecules based on modular strategy | |
| Ou et al. | Nano-biohybrid systems for the targeted delivery of chemotherapeutics | |
| BR112016016802B1 (pt) | Processo para fabricar um carreador biocompatível híbrido (hibridossoma) | |
| WO2025003463A9 (en) | Polyproline-based block copolymers | |
| JP2014114267A (ja) | 脂質膜構造体に対して肝臓血管内皮細胞への移行能を付与および/または増強するペプチド、肝臓血管内皮細胞への移行能を有するまたは肝臓血管内皮細胞への移行能が増強された脂質膜構造体、ならびに脂質膜構造体に対して肝臓血管内皮細胞への移行能を付与および/または増強する剤 | |
| Cleal | Exploring the use of Quantum dots as quantitative model delivery agents for small molecules, peptides and proteins |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: Swiss Shi Lilun Patentee after: DE BEER, Joel Address before: Swiss hole Patentee before: DE BEER, Joel |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20251216 Address after: U.S.A. Patentee after: The State Recovery Limited Liability Company Country or region after: U.S.A. Address before: Swiss Shi Lilun Patentee before: DE BEER, Joel Country or region before: Switzerland |