MX2016009529A - Hibridosomas, composiciones que comprenden los mismos, procesos para su produccion y usos de los mismos. - Google Patents
Hibridosomas, composiciones que comprenden los mismos, procesos para su produccion y usos de los mismos.Info
- Publication number
- MX2016009529A MX2016009529A MX2016009529A MX2016009529A MX2016009529A MX 2016009529 A MX2016009529 A MX 2016009529A MX 2016009529 A MX2016009529 A MX 2016009529A MX 2016009529 A MX2016009529 A MX 2016009529A MX 2016009529 A MX2016009529 A MX 2016009529A
- Authority
- MX
- Mexico
- Prior art keywords
- hybridosomes
- processes
- compositions
- production
- same
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
- A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
Abstract
La presente invención proporciona un vehículo biocompatible híbrido (hibridosoma) que comprende elementos estructurales y bioactivos que se originan de al menos un módulo de liberación biocompatible (MLB) y al menos un módulo de encapsulación de fármacos modificado por ingeniería (MEFI) que comprende al menos un resto fusogénico ajustable. La invención proporciona además composiciones farmacéuticas que comprenden dichos hibridosomas, procesos para su fabricación, así como usos farmacéuticos y métodos farmacéuticos basados en los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461929559P | 2014-01-21 | 2014-01-21 | |
PCT/IB2015/050436 WO2015110957A2 (en) | 2014-01-21 | 2015-01-20 | Hybridosomes, compositions comprising the same, processes for their production and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016009529A true MX2016009529A (es) | 2016-10-17 |
Family
ID=52434912
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016009529A MX2016009529A (es) | 2014-01-21 | 2015-01-20 | Hibridosomas, composiciones que comprenden los mismos, procesos para su produccion y usos de los mismos. |
MX2021000174A MX2021000174A (es) | 2014-01-21 | 2016-07-21 | Hibridosomas, composiciones que comprenden los mismos, procesos para su produccion y usos de los mismos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021000174A MX2021000174A (es) | 2014-01-21 | 2016-07-21 | Hibridosomas, composiciones que comprenden los mismos, procesos para su produccion y usos de los mismos. |
Country Status (13)
Country | Link |
---|---|
US (3) | US10561610B2 (es) |
EP (2) | EP3791863A1 (es) |
JP (3) | JP6598786B2 (es) |
KR (3) | KR102507475B1 (es) |
CN (2) | CN112870163A (es) |
AU (3) | AU2015208837B2 (es) |
CA (1) | CA2936514C (es) |
DK (1) | DK3096741T3 (es) |
EA (1) | EA037503B1 (es) |
ES (1) | ES2821758T3 (es) |
MX (2) | MX2016009529A (es) |
WO (1) | WO2015110957A2 (es) |
ZA (1) | ZA201604831B (es) |
Families Citing this family (54)
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WO2013070324A1 (en) | 2011-11-07 | 2013-05-16 | University Of Louisville Research Foundation, Inc. | Edible plant-derived microvesicle compositions for diagnosis and treatment of disease |
WO2014210448A1 (en) | 2013-06-27 | 2014-12-31 | The Board Of Regents Of The University Of Texas System | Compositions and methods relating to myomaker-induced muscle cell fusion |
CA2936514C (en) | 2014-01-21 | 2023-08-08 | Joel DE BEER | Hybridosomes, compositions comprising the same, processes for their production and uses thereof |
CA3012985A1 (en) | 2015-01-27 | 2016-08-04 | Kardiatonos, Inc. | Biomarkers of vascular disease |
US11073511B2 (en) * | 2016-02-01 | 2021-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Exosome-Total-Isolation-Chip (ExoTIC) device for isolation of exosome-based biomarkers |
EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
CN107362370B (zh) * | 2016-05-13 | 2022-07-26 | 国家纳米科学中心 | 一种基于金纳米簇联合NGF siRNA治疗胰腺癌的方法 |
WO2017201340A2 (en) * | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding relaxin |
CN106280533B (zh) * | 2016-08-17 | 2018-03-09 | 赣南师范大学 | 一种近红外荧光染料及其合成方法和用于寄生虫荧光标记 |
EP3292861A1 (en) * | 2016-09-13 | 2018-03-14 | Centre National De La Recherche Scientifique (Cnrs) | An in vitro method for obtaining a biohybrid vector |
BR112019022016A2 (pt) * | 2017-04-19 | 2020-05-12 | Apa- Advanced Technologies Ltd. | Lipossomas fusogênicos, composições, kits e uso dos mesmos no tratamento do câncer |
CN107084956B (zh) * | 2017-05-05 | 2021-03-23 | 曲阜师范大学 | 一种基于醇溶剂诱导银纳米簇荧光增强的尿液中碘离子检测方法 |
JP7395355B2 (ja) * | 2017-05-08 | 2023-12-11 | フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド | 膜融合を促進するための組成物およびその使用 |
US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
EP3658125A4 (en) * | 2017-07-28 | 2021-04-28 | National University of Singapore | BIOMOLECULAR COMPOSITES INCLUDING MODIFIED CELL PHANTOMS |
WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
WO2019051428A1 (en) * | 2017-09-11 | 2019-03-14 | The Regents Of The University Of California | CAS9 ANTIBODY MEDIA ADMINISTRATION TO MAMMALIAN CELLS |
WO2019066434A1 (ko) * | 2017-09-30 | 2019-04-04 | 주식회사 엑소코바이오 | 사포게닌과 엑소좀을 유효성분으로 포함하는 조성물 |
KR102008665B1 (ko) * | 2017-09-30 | 2019-08-08 | 주식회사 엑소코바이오 | 사포게닌과 엑소좀을 유효성분으로 포함하는 조성물 |
CN108287134B (zh) * | 2017-12-28 | 2020-11-24 | 南京邮电大学 | 单颗粒生物探针及其等离子体生物存储器的构建方法 |
CA3091478A1 (en) * | 2018-02-17 | 2019-08-22 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for membrane protein delivery |
WO2019195819A1 (en) * | 2018-04-06 | 2019-10-10 | North Carolina State University | Cell assembly-mediated delivery of checkpoint inhibitors for cancer immunotherapy |
WO2019210189A1 (en) * | 2018-04-26 | 2019-10-31 | University Of Louisville Research Foundation, Inc. | Edible plant exosome-like nanovectors for vaccination |
CA3003032A1 (en) * | 2018-04-27 | 2019-10-27 | Nanostics Inc. | Methods of diagnosing disease using microflow cytometry |
CN110437628B (zh) * | 2018-05-04 | 2021-05-04 | 中国石油化工股份有限公司 | 一种改性剂母液和道路沥青及其合成方法 |
KR20210021473A (ko) * | 2018-05-15 | 2021-02-26 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 푸소솜 조성물 및 그의 용도 |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
EP3813798A1 (en) * | 2018-06-28 | 2021-05-05 | AstraZeneca AB | Exosome extracellular vesicles and methods of use |
PL3864163T3 (pl) | 2018-10-09 | 2024-05-20 | The University Of British Columbia | Kompozycje i układy zawierające pęcherzyki zdolne do transfekcji wolne od rozpuszczalników organicznych i detergentów oraz związane z nimi sposoby postępowania |
JP2022505714A (ja) * | 2018-10-24 | 2022-01-14 | エイピーエイ- アドバンスト・テクノロジーズ・リミテッド | 腫瘍細胞の選択的イメージングのための融合性リポソーム |
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CN109620969B (zh) * | 2019-01-30 | 2021-02-05 | 广东药科大学 | 一种针对耐药肿瘤细胞的靶向抗肿瘤药物体系及其构建方法 |
WO2021010586A1 (ko) * | 2019-07-15 | 2021-01-21 | (주)심플스틱 | 항노화를 위한 피부 리프팅용 화장료 조성물 및 이를 이용한 피부미용 방법 |
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CN111007170B (zh) * | 2019-12-13 | 2021-06-29 | 中国农业科学院农产品加工研究所 | 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途 |
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Publication number | Priority date | Publication date | Assignee | Title |
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