JP2019201661A5 - - Google Patents
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- Publication number
- JP2019201661A5 JP2019201661A5 JP2019141485A JP2019141485A JP2019201661A5 JP 2019201661 A5 JP2019201661 A5 JP 2019201661A5 JP 2019141485 A JP2019141485 A JP 2019141485A JP 2019141485 A JP2019141485 A JP 2019141485A JP 2019201661 A5 JP2019201661 A5 JP 2019201661A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- culture medium
- cells
- adamts13
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000001963 growth medium Substances 0.000 claims 12
- 102000043853 ADAMTS13 Human genes 0.000 claims 8
- 108091005670 ADAMTS13 Proteins 0.000 claims 8
- 239000006228 supernatant Substances 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 102000029750 ADAMTS Human genes 0.000 claims 6
- 108091022879 ADAMTS Proteins 0.000 claims 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 4
- 239000011701 zinc Substances 0.000 claims 4
- 229910052725 zinc Inorganic materials 0.000 claims 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 3
- 229910052791 calcium Inorganic materials 0.000 claims 3
- 239000011575 calcium Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims 2
- 101000798281 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 13 Proteins 0.000 claims 1
- 239000005700 Putrescine Substances 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 102000057210 human ADAMTS13 Human genes 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 239000012134 supernatant fraction Substances 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021079239A JP7083059B2 (ja) | 2009-07-31 | 2021-05-07 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23047709P | 2009-07-31 | 2009-07-31 | |
| US61/230,477 | 2009-07-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018011373A Division JP6567707B2 (ja) | 2009-07-31 | 2018-01-26 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021079239A Division JP7083059B2 (ja) | 2009-07-31 | 2021-05-07 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019201661A JP2019201661A (ja) | 2019-11-28 |
| JP2019201661A5 true JP2019201661A5 (cg-RX-API-DMAC7.html) | 2020-01-23 |
| JP6883071B2 JP6883071B2 (ja) | 2021-06-09 |
Family
ID=42668009
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523110A Active JP5451884B2 (ja) | 2009-07-31 | 2010-07-30 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
| JP2016093240A Active JP6511007B2 (ja) | 2009-07-31 | 2016-05-06 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
| JP2018011373A Active JP6567707B2 (ja) | 2009-07-31 | 2018-01-26 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
| JP2019141485A Active JP6883071B2 (ja) | 2009-07-31 | 2019-07-31 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
| JP2021079239A Active JP7083059B2 (ja) | 2009-07-31 | 2021-05-07 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523110A Active JP5451884B2 (ja) | 2009-07-31 | 2010-07-30 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
| JP2016093240A Active JP6511007B2 (ja) | 2009-07-31 | 2016-05-06 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
| JP2018011373A Active JP6567707B2 (ja) | 2009-07-31 | 2018-01-26 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021079239A Active JP7083059B2 (ja) | 2009-07-31 | 2021-05-07 | Ａｄａｍｔｓタンパク質発現のための細胞培養培地 |
Country Status (21)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101574056B1 (ko) * | 2009-07-31 | 2015-12-02 | 백스터 인터내셔널 인코포레이티드 | Ａｄａｍｔｓ 단백질 발현을 위한 세포 배양 배지 |
| SG10201809632XA (en) | 2010-07-08 | 2018-12-28 | Baxalta Inc | METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT vWF IN CELL CULTURE |
| LT2837680T (lt) | 2011-07-01 | 2020-07-10 | Amgen Inc. | Žinduolių ląstelių kultūra |
| CN104822826B (zh) | 2012-10-15 | 2019-04-30 | 百时美施贵宝公司 | 用于蛋白产生的哺乳动物细胞培养过程 |
| EP2970916B1 (en) | 2013-03-13 | 2021-04-14 | Merck Sharp & Dohme Corp. | Adapted lepidopteran insect cells for the production of recombinant proteins |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| CA2926517C (en) * | 2013-10-14 | 2021-03-23 | Ares Trading S.A. | New medium for high performance mammalian fed-batch cultures |
| US11384378B2 (en) | 2014-06-04 | 2022-07-12 | Amgen Inc. | Methods for harvesting mammalian cell cultures |
| KR101867134B1 (ko) * | 2015-03-23 | 2018-06-12 | 한양대학교 산학협력단 | 포유류 세포를 이용하여 목적 물질을 고효율로 생산하기 위한 세포 배양 배지, 이를 이용한 세포 배양 방법 및 목적 물질의 생산 방법 |
| PT3298138T (pt) * | 2015-05-22 | 2022-11-02 | Dupont Nutrition Biosci Aps | Acetolactato descarboxilase |
| TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| BR112019002194A2 (pt) | 2016-08-04 | 2019-05-21 | Baxalta GmbH | uso de adamts13 para tratar, melhorar e/ou prevenir a crise vaso-oclusiva na doença falciforme, lesão pulmonar aguda e/ou síndrome da insuficiência respiratória aguda |
| FI3535388T3 (fi) * | 2016-11-04 | 2023-06-14 | Takeda Pharmaceuticals Co | Adeno-assosioituneen viruksen puhdistusmenetelmiä |
| KR102782655B1 (ko) * | 2017-07-06 | 2025-03-14 | 리제너론 파마슈티칼스 인코포레이티드 | 당단백질을 만들기 위한 세포 배양 과정 |
| MX2020009605A (es) * | 2018-03-16 | 2021-01-08 | Genzyme Corp | Metodos para mejorar la viabilidad celular en un biorreactor de produccion. |
| US20210189358A1 (en) * | 2018-06-18 | 2021-06-24 | Synthetic Biologics, Inc. | Methods of making alkaline phosphatase agents |
| US20220339266A1 (en) | 2019-10-04 | 2022-10-27 | The Children's Medical Center Corporation | Adamts13 treatment to enhance graft survival |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| SG11202110968VA (en) | 2019-12-06 | 2021-10-28 | Regeneron Pharma | Anti-vegf protein compositions and methods for producing the same |
| CN115836126A (zh) | 2020-04-02 | 2023-03-21 | 武田药品工业株式会社 | Adamts13变体、组合物及其用途 |
| CA3182893A1 (en) | 2020-05-08 | 2021-11-11 | Regeneron Pharmaceuticals, Inc. | Vegf traps and mini-traps and methods for treating ocular disorders and cancer |
| US20230201319A1 (en) | 2020-05-22 | 2023-06-29 | Takeda Pharmaceutical Company Limited | Adamts13 compositions and methods for treating and diagnosing complications of coronavirus disease |
| WO2021246557A1 (ko) * | 2020-06-05 | 2021-12-09 | 주식회사 프로앱텍 | 특정한 갯수의 알부민이 연결된 요산산화효소-알부민 복합체 및 이의 제조 방법 |
| CN111808822B (zh) * | 2020-07-02 | 2024-01-12 | 北京百普赛斯生物科技股份有限公司 | 细胞培养用补料液及提高重组hek293细胞蛋白表达量的方法 |
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| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5250421A (en) | 1986-01-03 | 1993-10-05 | Genetics Institute, Inc. | Method for producing factor VIII:C-type proteins |
| CZ280901B6 (cs) | 1988-10-06 | 1996-05-15 | Hideaki Yamada | Způsob kultivace bakterií |
| JPH0753104B2 (ja) * | 1989-02-28 | 1995-06-07 | 秀明 山田 | 細菌の培養法 |
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| CA2415990C (en) | 1994-11-10 | 2009-07-07 | Immuno Aktiengesellschaft | Method for producing biologicals in protein-free culture |
| EP0811056B1 (en) | 1995-02-23 | 2000-05-31 | Quest International B.V. | Peptides for tissue and cell culture media |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| EP2221361A3 (en) | 1996-08-30 | 2011-02-09 | Life Technologies Corporation | Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium |
| IT1285158B1 (it) * | 1996-09-17 | 1998-06-03 | Angeletti P Ist Richerche Bio | Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il |
| DK0929507T3 (da) | 1996-10-07 | 2003-03-24 | Solutia Inc | Fremgangsmåde til hydroxylering af benzen |
| ATE399855T1 (de) | 1996-10-10 | 2008-07-15 | Invitrogen Corp | Tierzellkulturmedium mit pflanzlichen nährstoffen |
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| AT407255B (de) | 1997-06-20 | 2001-02-26 | Immuno Ag | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
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| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
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| JP2007534675A (ja) * | 2004-04-16 | 2007-11-29 | ワイス | Ａｄａｍｔｓ−８タンパク質およびその使用 |
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| JP2007174948A (ja) * | 2005-12-27 | 2007-07-12 | Noritsu Koki Co Ltd | 酵素水製造装置 |
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| BRPI0622214A2 (pt) * | 2006-12-22 | 2012-01-03 | Springer Carrier Ltda | unidade de condicionamento de ar e mÉtodo de misturar ar em uma unidade de condicionamento de ar |
| US20090067805A1 (en) | 2007-09-10 | 2009-03-12 | Victor Company Of Japan, Limited | Recording and reproducing device |
| PT2574677T (pt) * | 2007-12-27 | 2017-10-19 | Baxalta Inc | Processos para cultura de células |
| KR101574056B1 (ko) * | 2009-07-31 | 2015-12-02 | 백스터 인터내셔널 인코포레이티드 | Ａｄａｍｔｓ 단백질 발현을 위한 세포 배양 배지 |
-
2010
- 2010-07-30 KR KR1020157009715A patent/KR101574056B1/ko active Active
- 2010-07-30 BR BR122021005965-9A patent/BR122021005965B1/pt active IP Right Grant
- 2010-07-30 EP EP10740810.6A patent/EP2459702B1/en active Active
- 2010-07-30 KR KR1020177035177A patent/KR101912552B1/ko active Active
- 2010-07-30 SI SI201031238A patent/SI2459702T1/sl unknown
- 2010-07-30 IN IN801DEN2012 patent/IN2012DN00801A/en unknown
- 2010-07-30 MX MX2012001261A patent/MX2012001261A/es active IP Right Grant
- 2010-07-30 NZ NZ597727A patent/NZ597727A/xx unknown
- 2010-07-30 US US12/847,999 patent/US8313926B2/en active Active
- 2010-07-30 KR KR1020177018298A patent/KR101808496B1/ko active Active
- 2010-07-30 BR BR112012002151-6A patent/BR112012002151B1/pt active IP Right Grant
- 2010-07-30 PT PT107408106T patent/PT2459702T/pt unknown
- 2010-07-30 WO PCT/US2010/044020 patent/WO2011014838A1/en not_active Ceased
- 2010-07-30 PL PL10740810.6T patent/PL2459702T3/pl unknown
- 2010-07-30 HR HRP20160783TT patent/HRP20160783T1/hr unknown
- 2010-07-30 CN CN201510186244.8A patent/CN104962539B/zh active Active
- 2010-07-30 EA EA201270224A patent/EA023193B1/ru not_active IP Right Cessation
- 2010-07-30 AU AU2010278751A patent/AU2010278751B2/en active Active
- 2010-07-30 ES ES10740810.6T patent/ES2583258T3/es active Active
- 2010-07-30 CA CA2769361A patent/CA2769361A1/en not_active Abandoned
- 2010-07-30 SG SG2012006839A patent/SG178194A1/en unknown
- 2010-07-30 HU HUE10740810A patent/HUE029110T2/en unknown
- 2010-07-30 KR KR1020127005425A patent/KR101573972B1/ko active Active
- 2010-07-30 CN CN201080042028.1A patent/CN102549145B/zh active Active
- 2010-07-30 JP JP2012523110A patent/JP5451884B2/ja active Active
- 2010-07-30 KR KR1020157033595A patent/KR101756354B1/ko active Active
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2012
- 2012-01-27 MX MX2013009470A patent/MX344970B/es unknown
- 2012-02-27 CO CO12033821A patent/CO6501191A2/es unknown
- 2012-09-19 US US13/622,939 patent/US8759026B2/en active Active
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2014
- 2014-05-13 US US14/276,819 patent/US9127265B2/en active Active
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2015
- 2015-07-23 US US14/807,745 patent/US9441216B2/en active Active
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2016
- 2016-05-06 JP JP2016093240A patent/JP6511007B2/ja active Active
- 2016-08-09 US US15/232,626 patent/US10072254B2/en active Active
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2018
- 2018-01-26 JP JP2018011373A patent/JP6567707B2/ja active Active
- 2018-09-08 US US16/125,688 patent/US10724024B2/en active Active
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2019
- 2019-07-31 JP JP2019141485A patent/JP6883071B2/ja active Active
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2020
- 2020-06-16 US US16/903,185 patent/US11254921B2/en active Active
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2021
- 2021-05-07 JP JP2021079239A patent/JP7083059B2/ja active Active
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