JP2019172692A5 - - Google Patents
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- JP2019172692A5 JP2019172692A5 JP2019112474A JP2019112474A JP2019172692A5 JP 2019172692 A5 JP2019172692 A5 JP 2019172692A5 JP 2019112474 A JP2019112474 A JP 2019112474A JP 2019112474 A JP2019112474 A JP 2019112474A JP 2019172692 A5 JP2019172692 A5 JP 2019172692A5
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- Prior art keywords
- pharmaceutical composition
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- acid
- prevention
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- -1 phenolic acid ester Chemical class 0.000 claims 6
- 235000013399 edible fruits Nutrition 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 4
- 230000004087 circulation Effects 0.000 claims 3
- 208000010125 myocardial infarction Diseases 0.000 claims 3
- 150000007965 phenolic acids Chemical class 0.000 claims 3
- 208000005189 Embolism Diseases 0.000 claims 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000001435 Thromboembolism Diseases 0.000 claims 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 230000017531 blood circulation Effects 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 229930003935 flavonoid Natural products 0.000 claims 2
- 150000002215 flavonoids Chemical class 0.000 claims 2
- 235000017173 flavonoids Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims 1
- WQSDYZZEIBAPIN-VBQORRLJSA-N 1-caffeoyl-beta-D-glucose Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 WQSDYZZEIBAPIN-VBQORRLJSA-N 0.000 claims 1
- RQFCJASXJCIDSX-UHFFFAOYSA-N 14C-Guanosin-5'-monophosphat Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(COP(O)(O)=O)C(O)C1O RQFCJASXJCIDSX-UHFFFAOYSA-N 0.000 claims 1
- NGSWKAQJJWESNS-ZZXKWVIFSA-M 4-Hydroxycinnamate Natural products OC1=CC=C(\C=C\C([O-])=O)C=C1 NGSWKAQJJWESNS-ZZXKWVIFSA-M 0.000 claims 1
- OHEYCHKLBCPRLZ-VHCZEJTMSA-N 4-O-beta-D-glucosyl-trans-caffeic acid Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(\C=C\C(O)=O)C=C1O OHEYCHKLBCPRLZ-VHCZEJTMSA-N 0.000 claims 1
- DFYRUELUNQRZTB-UHFFFAOYSA-N Acetovanillone Natural products COC1=CC(C(C)=O)=CC=C1O DFYRUELUNQRZTB-UHFFFAOYSA-N 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims 1
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims 1
- QJTYCCFDQWFJHU-UHFFFAOYSA-N Quercetin-5-O-beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC2=C1C(=O)C(O)=C(C=1C=C(O)C(O)=CC=1)O2 QJTYCCFDQWFJHU-UHFFFAOYSA-N 0.000 claims 1
- 241000208292 Solanaceae Species 0.000 claims 1
- 240000003768 Solanum lycopersicum Species 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 206010047249 Venous thrombosis Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 claims 1
- 229950006790 adenosine phosphate Drugs 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000005189 cardiac health Effects 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001851 cinnamic acid derivatives Chemical group 0.000 claims 1
- NGSWKAQJJWESNS-UHFFFAOYSA-N cis-para-coumaric acid Natural products OC(=O)C=CC1=CC=C(O)C=C1 NGSWKAQJJWESNS-UHFFFAOYSA-N 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- RAYJUFCFJUVJBB-UHFFFAOYSA-N dihydrokaempferol Natural products OC1Oc2c(O)cc(O)cc2C(=O)C1c3ccc(O)cc3 RAYJUFCFJUVJBB-UHFFFAOYSA-N 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims 1
- 235000001785 ferulic acid Nutrition 0.000 claims 1
- 229940114124 ferulic acid Drugs 0.000 claims 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 229940029575 guanosine Drugs 0.000 claims 1
- RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 claims 1
- 230000036541 health Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- GXMWXESSGGEWEM-UHFFFAOYSA-N isoquercitrin Natural products OCC(O)C1OC(OC2C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)C(O)C1O GXMWXESSGGEWEM-UHFFFAOYSA-N 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims 1
- 229960004999 lycopene Drugs 0.000 claims 1
- 235000012661 lycopene Nutrition 0.000 claims 1
- 239000001751 lycopene Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012466 permeate Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000003331 prothrombotic effect Effects 0.000 claims 1
- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 claims 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims 1
- SZDMSNWMQAMVTJ-UHFFFAOYSA-N quercetin-3-O-glucoside Natural products OC1OC(COC2=C(C(=O)c3cc(O)cc(O)c3O2)c4ccc(O)c(O)c4)C(O)C(O)C1O SZDMSNWMQAMVTJ-UHFFFAOYSA-N 0.000 claims 1
- FZKBNCDAGYDHTP-UHFFFAOYSA-N quercetin-3-O-glycoside Natural products OC1C(O)C(O)C(O)OC1COC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O FZKBNCDAGYDHTP-UHFFFAOYSA-N 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims 1
- 235000005493 rutin Nutrition 0.000 claims 1
- 229960004555 rutoside Drugs 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000002537 thrombolytic effect Effects 0.000 claims 1
- 201000005665 thrombophilia Diseases 0.000 claims 1
- NGSWKAQJJWESNS-ZZXKWVIFSA-N trans-4-coumaric acid Chemical class OC(=O)\C=C\C1=CC=C(O)C=C1 NGSWKAQJJWESNS-ZZXKWVIFSA-N 0.000 claims 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 1
- 229940045145 uridine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0819959.8 | 2008-10-31 | ||
| GBGB0819959.8A GB0819959D0 (en) | 2008-10-31 | 2008-10-31 | Fruit extracts |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017230562A Division JP6545237B2 (ja) | 2008-10-31 | 2017-11-30 | 果実エキス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019172692A JP2019172692A (ja) | 2019-10-10 |
| JP2019172692A5 true JP2019172692A5 (https=) | 2020-02-06 |
| JP7049291B2 JP7049291B2 (ja) | 2022-04-06 |
Family
ID=40138109
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533821A Pending JP2012506901A (ja) | 2008-10-31 | 2009-11-02 | 果実エキス |
| JP2014257917A Pending JP2015057440A (ja) | 2008-10-31 | 2014-12-19 | 果実エキス |
| JP2017230562A Active JP6545237B2 (ja) | 2008-10-31 | 2017-11-30 | 果実エキス |
| JP2019112474A Active JP7049291B2 (ja) | 2008-10-31 | 2019-06-18 | 果実エキス |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533821A Pending JP2012506901A (ja) | 2008-10-31 | 2009-11-02 | 果実エキス |
| JP2014257917A Pending JP2015057440A (ja) | 2008-10-31 | 2014-12-19 | 果実エキス |
| JP2017230562A Active JP6545237B2 (ja) | 2008-10-31 | 2017-11-30 | 果実エキス |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20110206794A1 (https=) |
| EP (4) | EP2349303B1 (https=) |
| JP (4) | JP2012506901A (https=) |
| KR (5) | KR20170010100A (https=) |
| CN (1) | CN102271697B (https=) |
| AU (2) | AU2009309496B2 (https=) |
| BR (1) | BRPI0920446B1 (https=) |
| CA (1) | CA2742213A1 (https=) |
| DK (1) | DK2349303T3 (https=) |
| ES (2) | ES2829974T3 (https=) |
| GB (1) | GB0819959D0 (https=) |
| HU (1) | HUE033986T2 (https=) |
| IL (1) | IL212579B (https=) |
| MX (1) | MX2011004531A (https=) |
| NZ (1) | NZ592227A (https=) |
| PH (2) | PH12015500810B1 (https=) |
| PL (4) | PL4218783T3 (https=) |
| PT (1) | PT2349303T (https=) |
| WO (1) | WO2010049707A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0819959D0 (en) | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Fruit extracts |
| GB0819958D0 (en) * | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Therapeutic compositions |
| CA2857368C (en) * | 2011-12-16 | 2015-09-08 | Centre De Recherche Industrielle Du Quebec | Method for extracting anthocyanin derivatives from a plant source |
| CN107397830A (zh) | 2012-04-23 | 2017-11-28 | 奥斯陆大学 | 番茄提取物用作抗高血压剂的用途以及制造水溶性无糖番茄提取物的方法 |
| CN102796746B (zh) * | 2012-08-07 | 2014-02-19 | 山东农业大学 | 一种调节茄科类黄酮和咖啡酰奎尼酸合成的基因片段及其应用 |
| GB201223365D0 (en) * | 2012-12-24 | 2013-02-06 | Provexis Natural Products Ltd | Compositions |
| EP2948005B1 (en) * | 2013-01-22 | 2020-07-15 | Lycored Ltd. | Compositions comprising heat-treated clear tomato concentrate |
| CN103293252B (zh) * | 2013-05-09 | 2015-02-04 | 杭州师范大学 | 一种中药的膜富集方法 |
| US9241677B2 (en) | 2013-07-02 | 2016-01-26 | MobHealth Corporation | Device and methods for assessing, diagnosing, and/or monitoring heart health |
| WO2015046183A1 (ja) | 2013-09-24 | 2015-04-02 | 味の素株式会社 | 糖アミノ酸およびその用途 |
| JP6392043B2 (ja) * | 2014-09-11 | 2018-09-19 | キッコーマン株式会社 | トマト含有飲食品の呈味改善方法 |
| JP7104032B2 (ja) | 2016-11-02 | 2022-07-20 | プロヴェクシス ナチュラル プロダクツ リミテッド | 大気汚染の悪影響に対する水溶性トマト抽出物の保護 |
| CN107843665A (zh) * | 2017-11-01 | 2018-03-27 | 汤臣倍健股份有限公司 | 一种腺苷含量的测定方法及其应用 |
| CN111529711A (zh) * | 2020-05-06 | 2020-08-14 | 湖南科诺康美生命科技有限公司 | 一种抗血小板聚集的芦荟提取物及其在prp制备中的应用 |
| GB202208323D0 (en) | 2022-06-07 | 2022-07-20 | Provexis Natural Products Ltd | Compostions |
| CN115611728A (zh) * | 2022-09-06 | 2023-01-17 | 浙江工业大学 | 一种结合态酚酸释放的超声波方法 |
| CN115645337B (zh) * | 2022-12-23 | 2023-06-02 | 汤臣倍健股份有限公司 | 植物提取物组合物及其应用 |
| KR102906986B1 (ko) * | 2023-02-09 | 2026-01-02 | 서원대학교 산학협력단 | 성인병 예방 및 음용성이 우수한 산딸기 고농축 음료의 제조 방법 |
| CN116803404B (zh) * | 2023-08-24 | 2023-12-15 | 汤臣倍健股份有限公司 | 水溶性番茄浓缩物在制备减少脱发、育发的产品中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6467173A (en) * | 1987-09-04 | 1989-03-13 | Sanei Kagaku Kogyo Kk | Preparation of vegetable or fruit juices |
| JP2722670B2 (ja) | 1989-05-30 | 1998-03-04 | ライオン株式会社 | 高血圧症予防用飲食品及びその製造方法 |
| US5502038A (en) * | 1993-06-21 | 1996-03-26 | Medical Research Foundation Of Oregon | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption |
| DE19720767A1 (de) | 1997-05-07 | 1998-11-12 | Protekum Umweltinstitut Gmbh O | Pharmazeutisches Produkt, insbesondere zur Therapie und Prophylaxe von Herz-Kreislauf-Erkrankungen |
| GB9808796D0 (en) * | 1998-04-24 | 1998-06-24 | Rowett Research Services Limit | Antithrombotic agents |
| DE69907342T2 (de) * | 1998-09-02 | 2004-03-25 | Unilever N.V. | Mit beta-cyclocitral angereicherte Tomatenprodukte |
| AU5965399A (en) | 1998-10-12 | 2000-05-01 | Andreas Bockelmann | Pharmaceutically active composition |
| CN1352941A (zh) | 2000-11-11 | 2002-06-12 | 吉建军 | 亚油酸胶囊 |
| WO2002090386A2 (en) * | 2001-05-04 | 2002-11-14 | Ato B.V. | Regulatory protein involved in pectin modification |
| DE10300049A1 (de) | 2003-01-03 | 2004-07-15 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Faktor VIIa inhibieren |
| ITMI20020632A1 (it) * | 2002-03-27 | 2003-09-29 | Indena Spa | Processo per la preparazione di estratti di pomodoro ad elevato contenuto di licopene |
| KR20050073611A (ko) | 2002-11-06 | 2005-07-14 | 카오카부시키가이샤 | 혈액 유동성 개선제 |
| BRPI0408814A (pt) * | 2003-03-27 | 2006-04-04 | Unigen Inc | composição farmacêutica, e, alimento para o cuidado da saúde |
| JP4571783B2 (ja) | 2003-04-14 | 2010-10-27 | 林原 健 | 抗微生物剤 |
| US20040223962A1 (en) * | 2003-05-07 | 2004-11-11 | Riordan Neil H. | Method and composition for preventing or reducing edema, deep vein thrombosis and/or pulmonary embolism |
| EP1481669A1 (en) | 2003-05-30 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | Use of polyhydroxy phenols and polyphenols for modulating p-selectin activity |
| EP1508325B1 (fr) * | 2003-08-21 | 2009-03-11 | Nestec S.A. | Concentré naturel de Lycopène et procédé d'obtention |
| CN1234387C (zh) * | 2004-01-12 | 2006-01-04 | 李迺灿 | 一种具有清肺功能的组合物及其制备方法 |
| FR2871378B1 (fr) | 2004-06-15 | 2007-03-30 | Seppic Sa | Nouveau medicament a base de flavanois et de leurs derives et son utilisation pour obtenir un medicament destine a la prevention de la restenose et de la maladie atheromateuse chez les patients coronariens |
| EP1640001A1 (en) | 2004-09-24 | 2006-03-29 | New Pharma Investments Holding | Composition against cardiovascular diseases |
| CN100488535C (zh) | 2004-12-09 | 2009-05-20 | 郭富凤 | 一种番茄红素混合物 |
| US7419960B2 (en) * | 2005-01-07 | 2008-09-02 | Hong Kong Baptist University | Hemiterpene glycosides with anti-platelet aggregation activities from Ilex pubescens |
| GB0502985D0 (en) * | 2005-02-14 | 2005-03-16 | Provexis Ltd | Therapeutic uses of tomato extracts |
| WO2006094120A2 (en) | 2005-03-02 | 2006-09-08 | The Regents Of The University Of California | Treatment for embolic stroke |
| JP4260158B2 (ja) * | 2005-07-07 | 2009-04-30 | 長谷川香料株式会社 | トマトジュース濃縮物の製造方法およびトマト風味組成物 |
| AT503521A1 (de) | 2006-05-05 | 2007-11-15 | Omnica Gmbh | Verwendung eines extraktes von kiwi-frucht |
| GB0610790D0 (en) | 2006-06-02 | 2006-07-12 | Provexis Natural Products Ltd | Therapeutic uses of tomato extracts |
| US20080009449A1 (en) * | 2006-07-07 | 2008-01-10 | Kailash Prasad | Lignan complex derived from flax seed used for treatment of hypercholesterolemic atherosclerosis |
| WO2008080162A2 (en) | 2006-12-22 | 2008-07-03 | The Johns Hopkins University | Anti-cholesterolemic compounds and methods of use |
| WO2008131047A2 (en) | 2007-04-16 | 2008-10-30 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism |
| GB0819958D0 (en) | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Therapeutic compositions |
| GB0819959D0 (en) | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Fruit extracts |
| CN107397830A (zh) * | 2012-04-23 | 2017-11-28 | 奥斯陆大学 | 番茄提取物用作抗高血压剂的用途以及制造水溶性无糖番茄提取物的方法 |
| GB201223365D0 (en) * | 2012-12-24 | 2013-02-06 | Provexis Natural Products Ltd | Compositions |
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