JP2019070011A5 - - Google Patents

Download PDF

Info

Publication number
JP2019070011A5
JP2019070011A5 JP2019000681A JP2019000681A JP2019070011A5 JP 2019070011 A5 JP2019070011 A5 JP 2019070011A5 JP 2019000681 A JP2019000681 A JP 2019000681A JP 2019000681 A JP2019000681 A JP 2019000681A JP 2019070011 A5 JP2019070011 A5 JP 2019070011A5
Authority
JP
Japan
Prior art keywords
compstatin analog
long
acting compstatin
acting
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019000681A
Other languages
English (en)
Japanese (ja)
Other versions
JP6873167B2 (ja
JP2019070011A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2019070011A publication Critical patent/JP2019070011A/ja
Publication of JP2019070011A5 publication Critical patent/JP2019070011A5/ja
Priority to JP2021070898A priority Critical patent/JP7093871B2/ja
Application granted granted Critical
Publication of JP6873167B2 publication Critical patent/JP6873167B2/ja
Priority to JP2022098871A priority patent/JP7441271B2/ja
Priority to JP2024022058A priority patent/JP2024056923A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019000681A 2012-11-15 2019-01-07 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法 Active JP6873167B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021070898A JP7093871B2 (ja) 2012-11-15 2021-04-20 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法
JP2022098871A JP7441271B2 (ja) 2012-11-15 2022-06-20 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法
JP2024022058A JP2024056923A (ja) 2012-11-15 2024-02-16 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261727094P 2012-11-15 2012-11-15
US61/727,094 2012-11-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2015542850A Division JP2016505527A (ja) 2012-11-15 2013-11-15 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021070898A Division JP7093871B2 (ja) 2012-11-15 2021-04-20 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法

Publications (3)

Publication Number Publication Date
JP2019070011A JP2019070011A (ja) 2019-05-09
JP2019070011A5 true JP2019070011A5 (https=) 2019-10-10
JP6873167B2 JP6873167B2 (ja) 2021-05-19

Family

ID=50731833

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2015542850A Pending JP2016505527A (ja) 2012-11-15 2013-11-15 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法
JP2019000681A Active JP6873167B2 (ja) 2012-11-15 2019-01-07 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法
JP2021070898A Active JP7093871B2 (ja) 2012-11-15 2021-04-20 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法
JP2022098871A Active JP7441271B2 (ja) 2012-11-15 2022-06-20 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法
JP2024022058A Pending JP2024056923A (ja) 2012-11-15 2024-02-16 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2015542850A Pending JP2016505527A (ja) 2012-11-15 2013-11-15 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021070898A Active JP7093871B2 (ja) 2012-11-15 2021-04-20 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法
JP2022098871A Active JP7441271B2 (ja) 2012-11-15 2022-06-20 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法
JP2024022058A Pending JP2024056923A (ja) 2012-11-15 2024-02-16 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法

Country Status (25)

Country Link
US (5) US10035822B2 (https=)
EP (3) EP3929206A1 (https=)
JP (5) JP2016505527A (https=)
CN (2) CN105051057B (https=)
AU (5) AU2013344462B2 (https=)
BR (1) BR112015011244B1 (https=)
CA (2) CA2891673C (https=)
CY (1) CY1124474T1 (https=)
DK (2) DK3660033T5 (https=)
ES (2) ES2879430T3 (https=)
FR (1) FR22C1025I2 (https=)
HR (1) HRP20211342T2 (https=)
HU (2) HUE055564T2 (https=)
IL (2) IL238852A0 (https=)
LT (2) LT3660033T (https=)
LU (1) LUC00265I2 (https=)
MX (2) MX366404B (https=)
NL (1) NL301178I2 (https=)
NO (1) NO2022017I1 (https=)
PL (2) PL2920201T3 (https=)
PT (2) PT2920201T (https=)
RS (1) RS62243B9 (https=)
SI (1) SI3660033T1 (https=)
SM (1) SMT202100514T1 (https=)
WO (1) WO2014078731A2 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
CN103687867B (zh) 2011-05-11 2017-02-08 阿佩利斯制药公司 细胞反应性的、长效的或靶向的坎普他汀类似物及其用途
ES2879430T3 (es) 2012-11-15 2021-11-22 Apellis Pharmaceuticals Inc Análogos de compstatina de acción prolongada y composiciones y métodos relacionados
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
WO2017035409A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
WO2017035405A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amino compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2017035401A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amide compounds for treatment of immune and inflammatory disorders
EP3359555B1 (en) * 2015-10-07 2023-12-20 Apellis Pharmaceuticals, Inc. Dosing regimens
RU2019113301A (ru) * 2016-10-17 2020-11-17 Апеллис Фармасьютикалс, Инк. Комбинированная терапия для ингибирования с3
CN110603252A (zh) 2017-03-01 2019-12-20 艾其林医药公司 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物
WO2018160891A1 (en) 2017-03-01 2018-09-07 Achillion Pharmaceutical, Inc. Pharmaceutical compounds for treatment of medical disorders
JP2020516607A (ja) * 2017-04-07 2020-06-11 アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. 投与レジメンならびに関連組成物および方法
US20190038623A1 (en) 2017-08-02 2019-02-07 Achillion Pharmaceuticals, Inc. Therapeutic regimens for treatment of paroxysmal nocturnal hemoglobinuria
CN109701030A (zh) * 2017-10-26 2019-05-03 湖南华腾制药有限公司 聚乙二醇化小分子药物的制备方法
AU2018386304B2 (en) 2017-12-15 2023-12-07 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
EP3645550B1 (en) * 2018-04-06 2021-11-03 The Trustees Of The University Of Pennsylvania Compstatin analogs with increased solubility and improved pharmacokinetic properties
WO2020041301A1 (en) 2018-08-20 2020-02-27 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
US11814363B2 (en) 2018-09-06 2023-11-14 Achillion Pharmaceuticals, Inc. Morphic forms of danicopan
WO2020051532A2 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
BR112021005506A2 (pt) 2018-09-25 2021-06-15 Achillion Pharmaceuticals, Inc. formas mórficas de inibidores de fator complementar d
WO2020109343A1 (en) 2018-11-29 2020-06-04 F. Hoffmann-La Roche Ag Combination therapy for treatment of macular degeneration
KR20210104071A (ko) 2018-12-17 2021-08-24 아칠리온 파르마세우티칼스 인코포레이티드 보체 매개 장애의 치료를 위한 표적 투약
WO2020198062A1 (en) 2019-03-22 2020-10-01 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders
US11510939B1 (en) 2019-04-19 2022-11-29 Apellis Pharmaceuticals, Inc. RNAs for complement inhibition
CN110244053B (zh) * 2019-05-09 2022-03-11 北京大学第三医院(北京大学第三临床医学院) 用于诊断狼疮肾炎并肺动脉高压疾病的分子标志物及其用途
CA3143257A1 (en) * 2019-07-05 2021-01-14 Apellis Pharmaceuticals, Inc. Viral vector therapy
US20220280598A1 (en) * 2019-07-18 2022-09-08 Apellis Pharmaceuticals, Inc. Complement inhibitor dosing regimens
WO2021168320A1 (en) 2020-02-20 2021-08-26 Achillion Pharmaceuticals, Inc. Heteroaryl compounds for treatment of complement factor d mediated disorders
CN111235264B (zh) * 2020-02-20 2023-05-16 圣湘生物科技股份有限公司 检测人tpmt基因和nudt15基因多态性的组合物、试剂盒及方法
CN111265651A (zh) * 2020-02-29 2020-06-12 华中科技大学同济医学院附属同济医院 补体c3抑制剂cp40-kk在制备防治肺动脉高压病药物中的应用
EP4132547A4 (en) * 2020-04-06 2024-05-01 The Trustees of Indiana University ALKALINE RESPIRATORY EPITHELIUM THERAPY TO TREAT VIRAL RESPIRATORY INFECTION
WO2022066774A1 (en) 2020-09-23 2022-03-31 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders
CN118812653A (zh) * 2023-04-18 2024-10-22 成都奥达生物科技有限公司 一种长效坎普他汀化合物
WO2025176847A1 (en) 2024-02-21 2025-08-28 Ags Therapeutics Sas Ocular delivery of active agents via microalgae extracellular vesicles

Family Cites Families (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2295746A1 (fr) 1974-12-23 1976-07-23 Francaise Coop Pharma Nouveaux derives du tryptophane a activite nerveuse centrale renforcee
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
IT1179866B (it) 1984-12-12 1987-09-16 Rotta Research Lab Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono
US4576750A (en) 1985-04-22 1986-03-18 Merck & Co., Inc. Tryptophan derivative
US5157110A (en) 1988-08-20 1992-10-20 The Government Of The United States Of America Synthetic, anti-complement protein
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
IL95942A0 (en) 1989-10-13 1991-07-18 Syntex Inc Collagen-containing ophthalmic formulation
US6395888B1 (en) 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
US6582959B2 (en) 1991-03-29 2003-06-24 Genentech, Inc. Antibodies to vascular endothelial cell growth factor
EP1413587A2 (en) 1991-05-03 2004-04-28 Washington University Modified complement system regulator
US5492135A (en) 1992-09-09 1996-02-20 Devore; Dale P. Collagen modulators for use in photoablation excimer laser keratectomy
US5482135A (en) 1993-06-29 1996-01-09 Deere & Company Combined hydraulic reservoir and vehicle axle
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
WO1995003807A1 (en) 1993-07-27 1995-02-09 The University Of Sydney Treatment of age-related macular degeneration
US5470952A (en) 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5776970A (en) 1994-04-28 1998-07-07 Yeda Research And Development Co. Ltd. Tryptophan derivatives as protein tyrosine kinase blockers and their use in the treatment of neoplastic diseases
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
JPH08280800A (ja) 1995-04-12 1996-10-29 Nissho Corp 2液注射用プレフィルドシリンジ
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US6346398B1 (en) 1995-10-26 2002-02-12 Ribozyme Pharmaceuticals, Inc. Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor
WO1997033603A1 (en) 1996-03-13 1997-09-18 Trustees Of The University Of Pennsylvania Novel peptides which inhibit complement activation
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US5843778A (en) 1996-06-14 1998-12-01 The Johns Hopkins University School Of Medicine Use of chimeric vaccinia virus complement control proteins to inhibit complement
JPH1087700A (ja) 1996-06-17 1998-04-07 Smithkline Beecham Corp C3a受容体およびC3aを用いる治療およびスクリーニング方法
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US6051698A (en) 1997-06-06 2000-04-18 Janjic; Nebojsa Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
JP2002503223A (ja) 1997-04-11 2002-01-29 アドバンスト・メディシン・インコーポレイテッド 複数の活性分子を供与する分子
WO1998047002A2 (en) 1997-04-11 1998-10-22 Advanced Medicine, Inc. Polyvalent presenter combinatorial libraries and their uses
AUPO755097A0 (en) 1997-06-25 1997-07-17 University Of Queensland, The Receptor agonist and antagonist
US6169057B1 (en) 1997-09-04 2001-01-02 The Regents Of The University Of California Use of tryptophan and analogs as plant growth regulators
WO1999013899A1 (en) 1997-09-17 1999-03-25 Trustees Of The University Of Pennsylvania Peptides and peptidomimetics for inhibiting complement activation
US8088386B2 (en) 1998-03-20 2012-01-03 Genentech, Inc. Treatment of complement-associated disorders
JPH11197234A (ja) 1998-01-09 1999-07-27 Koken Co Ltd 眼科用コラーゲンゲル成形物
US7112327B2 (en) 1998-02-20 2006-09-26 Tanox, Inc. Inhibition of complement activation
WO1999044625A1 (en) 1998-03-03 1999-09-10 John Hopkins University Smallpox inhibitor of complement enzymes (spice) protein and methods of inhibiting complement activation
EP1067950B1 (en) 1998-04-10 2008-05-14 Mayo Foundation For Medical Education And Research Neo-tryptophan
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US7084106B1 (en) 1999-01-19 2006-08-01 University Of Louisville Research Foundation, Inc. Application of a viral complement inhibitory protein in the treatment and diagnosis of Alzheimer's Disease
JP2002536386A (ja) 1999-02-12 2002-10-29 コラジェネシス インク. 細胞または治療薬の送達のためのコラーゲンベースの注射システム
US20020102581A1 (en) 1999-02-19 2002-08-01 Hageman Gregory S. Diagnostics and therapeutics for ocular disorders
US7108982B1 (en) 1999-02-19 2006-09-19 University Of Iowa Research Foundation Diagnostics and the therapeutics for macular degeneration
WO2000071147A1 (en) 1999-05-25 2000-11-30 King Faisal Specialist Hospital And Research Centre Novel therapeutic use of viral inflammation modulatory protein in blocking xenograft rejection
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
GB9930659D0 (en) 1999-12-24 2000-02-16 Bio Discovery Ltd Inhibitors of complement activation
US20050020525A1 (en) 2002-02-20 2005-01-27 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US20050032733A1 (en) 2001-05-18 2005-02-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
US7011952B2 (en) 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
PT1309726E (pt) 2000-03-30 2010-03-08 Whitehead Biomedical Inst Mediadores de interferência por rna específicos de sequência de rna
AU2001261103B2 (en) 2000-04-29 2007-08-23 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
US6692759B1 (en) 2000-06-28 2004-02-17 The Regents Of The University Of California Methods for preparing and using implantable substance delivery devices
WO2002011793A1 (fr) 2000-08-08 2002-02-14 Medical Information Services, Inc. Seringue pour preparation de necessaire d'injection, valve coulissante intermediaire pour seringues et preparation de necessaire d'injection
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
AU2001296594A1 (en) 2000-10-10 2002-04-22 Tanox, Inc. Inhibition of complement c5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection
US20040259247A1 (en) 2000-12-01 2004-12-23 Thomas Tuschl Rna interference mediating small rna molecules
EP1372602B1 (en) 2001-01-09 2007-04-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US20030175950A1 (en) 2001-05-29 2003-09-18 Mcswiggen James A. RNA interference mediated inhibition of HIV gene expression using short interfering RNA
US20050054596A1 (en) 2001-11-30 2005-03-10 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
WO2003039404A2 (en) 2001-11-09 2003-05-15 Eyetech Pharmaceuticals Methods for treating ocular neovascular diseases
JP2005538033A (ja) 2001-12-04 2005-12-15 ナノスペクトラ バイオサイエンセズ,インク. 過剰なあるいは不適切な新脈管形成によって特徴付けられる病状の治療
ATE371680T1 (de) * 2002-01-16 2007-09-15 Biocompatibles Uk Ltd Polymerkonjugate
US7261876B2 (en) * 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
AUPS160602A0 (en) 2002-04-08 2002-05-16 University Of Queensland, The Therapeutic method
AU2003276131A1 (en) 2002-06-18 2003-12-31 Epigenesis Pharmaceuticals, Inc. A dry powder oligonucleotide formulation, preparation and its uses
ITMI20021527A1 (it) 2002-07-11 2004-01-12 Consiglio Nazionale Ricerche Anticorpi anti componente c5 del complemento e loro uso
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
JP3976635B2 (ja) 2002-08-05 2007-09-19 久光製薬株式会社 キット製剤用注射器、注射器型キット製剤用中間摺動弁、及び、注射器型キット製剤、並びにx線造影剤キット製剤
PT1549333E (pt) * 2002-09-20 2012-01-03 Univ Pennsylvania Análogos de compstatina com actividade melhorada
AU2003277910A1 (en) 2002-09-27 2004-04-19 Novartis Ag Ocular gene therapy
US7459169B2 (en) 2002-10-21 2008-12-02 Allvivo, Inc. Surface coating comprising bioactive compound
WO2004041160A2 (en) 2002-10-30 2004-05-21 University Of Kentucky Research Foundation Methods and animal model for analyzing age-related macular degeneration
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
EP1594541A4 (en) 2003-02-21 2007-03-28 Rikshospitalet Radiumhospitale METHOD AND COMPOSITIONS FOR TREATING MECONIUM ASPIRATION SYNDROME
AU2004216176B2 (en) 2003-02-21 2008-04-03 Genentech, Inc. Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury
US20050255144A1 (en) 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
US20070116672A1 (en) 2003-09-05 2007-05-24 Kotwal Girish J Treatment of rheumatic diseases
WO2005023866A2 (en) 2003-09-10 2005-03-17 Baxter International Inc. Peptides that inhibit complement activation
ES2432112T3 (es) 2004-02-10 2013-11-29 The Regents Of The University Of Colorado, A Body Corporate Inhibición del factor B, de la vía alternativa del complemento y métodos relacionados
PL3385384T3 (pl) 2004-02-12 2021-03-08 Archemix Llc Aptamerowe środki terapeutyczne użyteczne w leczeniu zaburzeń powiązanych z dopełniaczem
WO2005110374A1 (en) 2004-04-30 2005-11-24 Allergan, Inc. Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20070142339A1 (en) 2004-05-10 2007-06-21 Novacea, Inc. Prevention of arterial restenosis with active vitamin d compounds
US8840893B2 (en) 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
JP2008512350A (ja) 2004-07-01 2008-04-24 イェール ユニバーシティ 標的化され、そして高密度で薬物が負荷されるポリマー性物質
US8043609B2 (en) 2004-10-08 2011-10-25 Potentia Pharmaceuticals, Inc. Viral complement control proteins for eye disorders
WO2006042252A2 (en) 2004-10-08 2006-04-20 Potentia Pharmeceuticals, Inc. Viral complement control proteins for eye disorders
CN102618644A (zh) 2004-11-18 2012-08-01 耶鲁大学 治疗眼病的方法和组合物
EP2357254A1 (en) 2005-02-14 2011-08-17 University of Iowa Research Foundation Methods and reagents for treatment and diagnosis of age-related macular degeneration
US20060257359A1 (en) 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
AU2006223108A1 (en) 2005-03-11 2006-09-21 Potentia Pharmaceuticals, Inc. Compositions comprising modulators of G-protein-coupled receptor for treatment of macular degeneration
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
MX351152B (es) * 2005-10-08 2017-10-04 Potentia Pharmaceuticals Inc Compstatina y analogos de la misma para tratar trastornos oculares.
US20070134244A1 (en) 2005-10-14 2007-06-14 Alcon, Inc. Combination treatment for pathologic ocular angiogenesis
EP3299027A1 (en) 2005-11-04 2018-03-28 Genentech, Inc. Use of complement pathway inhibitors to treat ocular diseases
ES2390828T3 (es) 2005-11-28 2012-11-16 The Trustees Of The University Of Pennsylvania Análogos potentes de la compstatina
CN101346473A (zh) 2005-12-22 2009-01-14 爱尔康研究有限公司 用于在具有补体因子h的风险变体的患者中预防和治疗年龄相关性黄斑变性的c3-转化酶抑制剂
US20070196367A1 (en) 2006-02-22 2007-08-23 Valentin Dinu Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
KR101394768B1 (ko) 2006-03-30 2014-05-21 드라이스 파마슈티컬스 아이엔씨 캄토테신-세포 투과 펩티드 결합체 및 이를 포함하는 약학 조성물
PL2148691T3 (pl) 2007-02-05 2015-12-31 Apellis Pharmaceuticals Inc Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego
KR101508621B1 (ko) 2007-02-28 2015-04-07 세리나 쎄라퓨틱스, 인코포레이티드 활성화된 폴리옥사졸린 및 이를 포함하는 조성물
CN101795695B (zh) * 2007-07-19 2016-01-06 阿列克斯塞尔公司 作为抗癌剂的自组装的两亲性聚合物
WO2009015087A2 (en) * 2007-07-20 2009-01-29 Potentia Pharmaceuticals, Inc. Compositions and methods for treatment of trauma
US8088884B2 (en) 2007-09-27 2012-01-03 Serina Therapeutics, Inc. Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
AU2008308657A1 (en) 2007-10-02 2009-04-09 Potentia Pharmaceuticals, Inc. Sustained delivery of compstatin analogs from gels
US8110651B2 (en) 2008-01-11 2012-02-07 Serina Therapeutics, Inc. Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
JP2011510750A (ja) 2008-01-29 2011-04-07 クライマン、ギルバート・エイチ 薬物送達デバイス、キット及びそれらの方法
EP2278987A4 (en) 2008-03-28 2012-08-22 Apellis Ag MODULATION AND REPLY / IMPROVEMENT OF THE COMPLEMENTARY SYSTEM IN THE TREATMENT OF TRAUMATISM
JP5642673B2 (ja) 2008-07-10 2014-12-17 セリナ・セラピユーテイツクス・インコーポレーテツド 不活性末端基を有するポリオキサゾリン類、保護された開始基から調製されるポリオキサゾリン類及び関連化合物
PL2424557T3 (pl) 2009-05-01 2018-04-30 The Trustees Of The University Of Pennsylvania Zmodyfikowana kompstatyna z modyfikacjami szkieletu peptydowego i c-końca
US9291622B2 (en) 2009-05-21 2016-03-22 Apellis Pharmaceuticals, Inc. Complement assays and uses thereof
US20130041134A1 (en) * 2009-11-05 2013-02-14 Sangart ,Inc. Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material
EP2338520A1 (de) * 2009-12-21 2011-06-29 Ludwig Maximilians Universität Konjugat mit Zielfindungsligand und dessen Verwendung
US8625635B2 (en) 2010-04-26 2014-01-07 Cleversafe, Inc. Dispersed storage network frame protocol header
US9421240B2 (en) 2010-06-22 2016-08-23 Apellis Pharmaceuticals, Inc. Compstatin analogs for treatment of neuropathic pain
US20130324482A1 (en) 2010-07-09 2013-12-05 Apellis Pharmaceuticals, Inc. Compstatin analogs for treatment of rhinosinusitis and nasal polyposis
CA2813049A1 (en) 2010-09-23 2012-03-29 The Trustees Of The University Of Pennsylvania Modified compstatin with improved stability and binding properties
CN103687867B (zh) 2011-05-11 2017-02-08 阿佩利斯制药公司 细胞反应性的、长效的或靶向的坎普他汀类似物及其用途
CN103796667A (zh) 2011-06-22 2014-05-14 艾普莱斯制药公司 用补体抑制剂治疗慢性障碍的方法
CN110229216B (zh) 2011-09-07 2023-06-16 宾夕法尼亚州大学理事会 具有改善的药代动力学性质的坎普他汀类肽
WO2014028861A1 (en) 2012-08-17 2014-02-20 Apellis Pharmaceuticals, Inc. Detection of high risk drusen
ES2879430T3 (es) 2012-11-15 2021-11-22 Apellis Pharmaceuticals Inc Análogos de compstatina de acción prolongada y composiciones y métodos relacionados
WO2014078734A2 (en) 2012-11-15 2014-05-22 Apellis Pharmaceuticals, Inc. Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
US9512180B2 (en) 2012-12-19 2016-12-06 The Regents Of The University Of California Compstatin analogs
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
WO2015006915A1 (zh) 2013-07-16 2015-01-22 北京机械设备研究所 适用于高层和超高层建筑火灾扑救的消防车
US9806963B2 (en) 2013-10-18 2017-10-31 Cellco Partnership Feature activation on device
EP3359555B1 (en) * 2015-10-07 2023-12-20 Apellis Pharmaceuticals, Inc. Dosing regimens
JP2020516607A (ja) * 2017-04-07 2020-06-11 アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. 投与レジメンならびに関連組成物および方法

Similar Documents

Publication Publication Date Title
JP2019070011A5 (https=)
IL274503B1 (en) Nucleic acids for inhibiting expression of lpa in a cell
DE69813291T2 (de) Herstellung stellen-spezifischer polyethylenglycol-grf konjugate
DE69130333T2 (de) Harze für die Feststoff-Peptidsynthese
JP2005538035A5 (https=)
JP2023123491A5 (https=)
JP2021502120A5 (https=)
CN103242536B (zh) 聚肽-聚乳酸-聚乙二醇双接枝共聚物的制备方法
CA2525399A1 (en) Novel spacer moiety for poly(ethylene glycol)-modified peptide-based co mpounds
US20060204472A1 (en) Multifunctional dendrimers and hyperbranched polymers as drug and gene delivery systems
JP2004513981A5 (https=)
TR200001956A2 (tr) Eritropoietin türevleri.
JP2005519041A5 (https=)
CN108472385A (zh) 与钉合或拼接肽缀合的生物活性化合物
JP2018515101A5 (https=)
JP2012521201A5 (https=)
JP2011521902A5 (https=)
CN101538316B (zh) 一种固相法制备Eptifibatide的方法
RU2016130448A (ru) Пептидные дендримеры, содержащие фибриноген-связывающие пептиды
US20230000999A1 (en) Compositions and methods for nucleic acid delivery
JP2019501867A5 (https=)
WO2006091894A4 (en) New polymeric materials and methods
WO2013117083A1 (zh) 一种依非巴特的制备方法
JP2007504169A5 (https=)
JP2020520917A5 (https=)