JP2021502120A5 - - Google Patents
Info
- Publication number
- JP2021502120A5 JP2021502120A5 JP2020544151A JP2020544151A JP2021502120A5 JP 2021502120 A5 JP2021502120 A5 JP 2021502120A5 JP 2020544151 A JP2020544151 A JP 2020544151A JP 2020544151 A JP2020544151 A JP 2020544151A JP 2021502120 A5 JP2021502120 A5 JP 2021502120A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- strand
- acid according
- nucleotides
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17201449.0 | 2017-11-13 | ||
| EP17201449.0A EP3483270A1 (en) | 2017-11-13 | 2017-11-13 | Products and compositions |
| EP18179175.7A EP3483271A3 (en) | 2017-11-13 | 2018-06-21 | Products and compositions |
| EP18179175.7 | 2018-06-21 | ||
| GB201815915 | 2018-09-28 | ||
| GB1815915.2 | 2018-09-28 | ||
| PCT/EP2018/081106 WO2019092283A1 (en) | 2017-11-13 | 2018-11-13 | Nucleic acids for inhibiting expression of lpa in a cell |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021502120A JP2021502120A (ja) | 2021-01-28 |
| JP2021502120A5 true JP2021502120A5 (https=) | 2022-08-25 |
| JP7245254B2 JP7245254B2 (ja) | 2023-03-23 |
Family
ID=66439085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544151A Active JP7245254B2 (ja) | 2017-11-13 | 2018-11-13 | 細胞におけるｌｐａの発現を抑制するための核酸 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US11319537B2 (https=) |
| EP (2) | EP3710586B1 (https=) |
| JP (1) | JP7245254B2 (https=) |
| KR (1) | KR102553382B1 (https=) |
| CN (2) | CN111465694A (https=) |
| AU (1) | AU2018363840B2 (https=) |
| BR (1) | BR112020009152A2 (https=) |
| CA (1) | CA3081905C (https=) |
| DK (1) | DK3710586T3 (https=) |
| ES (1) | ES2938193T3 (https=) |
| FI (1) | FI3710586T3 (https=) |
| HR (1) | HRP20230127T1 (https=) |
| HU (1) | HUE061265T2 (https=) |
| IL (1) | IL274503B2 (https=) |
| LT (1) | LT3710586T (https=) |
| MX (1) | MX2020004897A (https=) |
| PL (1) | PL3710586T3 (https=) |
| RS (1) | RS63955B1 (https=) |
| SG (1) | SG11202003230UA (https=) |
| SI (1) | SI3710586T1 (https=) |
| WO (1) | WO2019092283A1 (https=) |
| ZA (1) | ZA202003371B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3009630C (en) | 2015-12-16 | 2023-08-01 | Amastan Technologies Llc | Spheroidal dehydrogenated metals and metal alloy particles |
| US10987735B2 (en) | 2015-12-16 | 2021-04-27 | 6K Inc. | Spheroidal titanium metallic powders with custom microstructures |
| DK3607069T3 (da) * | 2017-04-05 | 2022-11-21 | Silence Therapeutics Gmbh | Produkter og sammensætninger |
| HRP20230127T1 (hr) | 2017-11-13 | 2023-03-31 | Silence Therapeutics Gmbh | Nukleinske kiseline za inhibiranje ekspresije lpa u stanici |
| KR20200109311A (ko) | 2018-01-16 | 2020-09-22 | 다이서나 파마수이티컬, 인크. | Aldh2 발현을 억제하기 위한 조성물 및 방법 |
| CN112654444A (zh) | 2018-06-19 | 2021-04-13 | 6K有限公司 | 由原材料制造球化粉末的方法 |
| PH12021550801B1 (en) | 2018-11-13 | 2024-04-26 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of lpa in a cell |
| BR112021019793A2 (pt) * | 2019-04-04 | 2021-12-07 | Dicerna Pharmaceuticals Inc | Composições e métodos para inibir expressão de gene no sistema nervoso central |
| SG11202111576QA (en) | 2019-04-30 | 2021-11-29 | 6K Inc | Mechanically alloyed powder feedstock |
| CN114641462A (zh) | 2019-11-18 | 2022-06-17 | 6K有限公司 | 用于球形粉末的独特原料及制造方法 |
| MX2022007005A (es) * | 2019-12-09 | 2022-08-25 | Amgen Inc | Construcciones de iarn y metodos para inhibir la expresion de lpa. |
| CA3180426A1 (en) | 2020-06-25 | 2021-12-30 | Richard K. Holman | Microcomposite alloy structure |
| US12435336B2 (en) * | 2020-08-05 | 2025-10-07 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting LPA expression |
| AU2021349358A1 (en) | 2020-09-24 | 2023-02-09 | 6K Inc. | Systems, devices, and methods for starting plasma |
| WO2022079221A1 (en) | 2020-10-16 | 2022-04-21 | Sanofi | Rna compositions and methods for inhibiting lipoprotein(a) |
| CA3196653A1 (en) | 2020-10-30 | 2022-05-05 | Sunil Bhalchandra BADWE | Systems and methods for synthesis of spheroidized metal powders |
| AU2021373780A1 (en) * | 2020-11-05 | 2023-06-08 | Amgen Inc. | METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE WITH LPA-TARGETED RNAi CONSTRUCTS |
| US20250304966A1 (en) | 2020-12-23 | 2025-10-02 | Argonaute RNA Limited | Treatment of cardiovascular disease |
| AU2022206483A1 (en) | 2021-01-11 | 2023-08-31 | 6K Inc. | Methods and systems for reclamation of li-ion cathode materials using microwave plasma processing |
| WO2022212291A1 (en) | 2021-03-31 | 2022-10-06 | 6K Inc. | Systems and methods for additive manufacturing of metal nitride ceramics |
| WO2023041508A2 (en) | 2021-09-14 | 2023-03-23 | Argonaute RNA Limited | Treatment of cardiovascular disease |
| IL312811A (en) | 2021-11-16 | 2024-07-01 | Shanghai Argo Biopharmaceutical Co Ltd | Composition and method for inhibiting angiotensinogen (agt) protein expression |
| KR20240103029A (ko) * | 2021-11-18 | 2024-07-03 | 노파르티스 아게 | 샤르코 마리 투스 질환 치료용 pmp22 표적화 화합물 |
| AU2022396536A1 (en) | 2021-11-24 | 2024-06-06 | Adarx Pharmaceuticals, Inc. | Complement factor b-modulating compositions and methods of use thereof |
| TW202345865A (zh) * | 2022-01-24 | 2023-12-01 | 大陸商上海舶望製藥有限公司 | 抑制LPA(Apo(a))蛋白表達的組合物和方法 |
| CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
| EP4522742A2 (en) | 2022-05-13 | 2025-03-19 | Alnylam Pharmaceuticals, Inc. | Single-stranded loop oligonucleotides |
| WO2023229928A1 (en) | 2022-05-23 | 2023-11-30 | 6K Inc. | Microwave plasma apparatus and methods for processing materials using an interior liner |
| US12040162B2 (en) | 2022-06-09 | 2024-07-16 | 6K Inc. | Plasma apparatus and methods for processing feed material utilizing an upstream swirl module and composite gas flows |
| JP2025522880A (ja) | 2022-06-30 | 2025-07-17 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 環状ジスルフィド修飾リン酸ベースのオリゴヌクレオチドプロドラッグ |
| WO2024044498A1 (en) | 2022-08-25 | 2024-02-29 | 6K Inc. | Plasma apparatus and methods for processing feed material utilizing a powder ingress preventor (pip) |
| CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
| US12195338B2 (en) | 2022-12-15 | 2025-01-14 | 6K Inc. | Systems, methods, and device for pyrolysis of methane in a microwave plasma for hydrogen and structured carbon powder production |
| WO2024151937A1 (en) * | 2023-01-13 | 2024-07-18 | Eli Lilly And Company | Therapeutic oligonucleotide-containing pharmaceutical compositions and dosing regimens using the same |
| EP4709855A2 (en) | 2023-05-12 | 2026-03-18 | Alnylam Pharmaceuticals, Inc. | Single-stranded loop oligonucleotides |
| TW202509024A (zh) | 2023-05-19 | 2025-03-01 | 大陸商深圳信立泰藥業股份有限公司 | 一種磺醯胺類化合物及其製備方法和醫藥用途 |
| KR20260034652A (ko) | 2023-07-04 | 2026-03-13 | 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 | LP(a) 유전자 발현을 억제하기 위한 dsRNA 분자 및 그 용도 |
| WO2025082058A1 (zh) * | 2023-10-16 | 2025-04-24 | 润佳(上海)医药技术有限公司 | 一种抑制LPA基因表达的dsRNA及其用途 |
| TW202540420A (zh) * | 2023-11-15 | 2025-10-16 | 大陸商北京加科瑞康醫藥科技有限公司 | 用於抑制LPA的基因表現的siRNA，含其的組合物及其用途 |
| WO2025119212A1 (zh) * | 2023-12-05 | 2025-06-12 | 广东东阳光药业股份有限公司 | 一种新型的双链siRNA、其缀合物及其用途 |
| WO2026008063A1 (en) * | 2024-07-05 | 2026-01-08 | Geneditbio Limited | Methods and compositions for lpa gene editing and therapy using crispr system |
| WO2026046153A1 (zh) * | 2024-08-26 | 2026-03-05 | 倍臻生物技术（苏州）有限公司 | 修饰的双链核糖核酸及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
| US7227014B2 (en) | 2001-08-07 | 2007-06-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein (a) expression |
| US7259150B2 (en) * | 2001-08-07 | 2007-08-21 | Isis Pharmaceuticals, Inc. | Modulation of apolipoprotein (a) expression |
| US20060160759A1 (en) * | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
| WO2009151644A2 (en) * | 2008-06-13 | 2009-12-17 | Yale University | Small molecule inhibitors of autotaxin methods of use |
| KR101567576B1 (ko) * | 2012-05-22 | 2015-11-10 | 올릭스 주식회사 | 세포 내 관통능을 가지고 ｒｎａ 간섭을 유도하는 핵산 분자 및 그 용도 |
| WO2016149020A1 (en) * | 2015-03-17 | 2016-09-22 | Arrowhead Research Corporation | Rna interference agents |
| JOP20160211B1 (ar) * | 2015-10-01 | 2021-08-17 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| EP3228326A1 (en) | 2016-04-05 | 2017-10-11 | Silence Therapeutics GmbH | Nucleic acid linked to a trivalent glycoconjugate |
| DK3607069T3 (da) | 2017-04-05 | 2022-11-21 | Silence Therapeutics Gmbh | Produkter og sammensætninger |
| HRP20230127T1 (hr) | 2017-11-13 | 2023-03-31 | Silence Therapeutics Gmbh | Nukleinske kiseline za inhibiranje ekspresije lpa u stanici |
| EP3735461A1 (en) | 2017-11-13 | 2020-11-11 | Silence Therapeutics GmbH | Nucleic acids for inhibiting expression of aldh2 in a cell |
| PH12021550801B1 (en) | 2018-11-13 | 2024-04-26 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of lpa in a cell |
-
2018
- 2018-11-13 HR HRP20230127TT patent/HRP20230127T1/hr unknown
- 2018-11-13 MX MX2020004897A patent/MX2020004897A/es unknown
- 2018-11-13 KR KR1020207016884A patent/KR102553382B1/ko active Active
- 2018-11-13 BR BR112020009152-9A patent/BR112020009152A2/pt not_active Application Discontinuation
- 2018-11-13 SG SG11202003230UA patent/SG11202003230UA/en unknown
- 2018-11-13 IL IL274503A patent/IL274503B2/en unknown
- 2018-11-13 AU AU2018363840A patent/AU2018363840B2/en active Active
- 2018-11-13 CN CN201880073189.3A patent/CN111465694A/zh active Pending
- 2018-11-13 CN CN202411317688.6A patent/CN119120476A/zh active Pending
- 2018-11-13 EP EP18803644.6A patent/EP3710586B1/en active Active
- 2018-11-13 ES ES18803644T patent/ES2938193T3/es active Active
- 2018-11-13 EP EP22208120.0A patent/EP4219716A3/en active Pending
- 2018-11-13 FI FIEP18803644.6T patent/FI3710586T3/fi active
- 2018-11-13 HU HUE18803644A patent/HUE061265T2/hu unknown
- 2018-11-13 RS RS20230097A patent/RS63955B1/sr unknown
- 2018-11-13 DK DK18803644.6T patent/DK3710586T3/da active
- 2018-11-13 PL PL18803644.6T patent/PL3710586T3/pl unknown
- 2018-11-13 LT LTEPPCT/EP2018/081106T patent/LT3710586T/lt unknown
- 2018-11-13 JP JP2020544151A patent/JP7245254B2/ja active Active
- 2018-11-13 US US16/763,458 patent/US11319537B2/en active Active
- 2018-11-13 SI SI201830845T patent/SI3710586T1/sl unknown
- 2018-11-13 WO PCT/EP2018/081106 patent/WO2019092283A1/en not_active Ceased
- 2018-11-13 CA CA3081905A patent/CA3081905C/en active Active
-
2020
- 2020-06-05 ZA ZA2020/03371A patent/ZA202003371B/en unknown
-
2022
- 2022-03-17 US US17/697,405 patent/US12054717B2/en active Active
-
2024
- 2024-06-17 US US18/745,632 patent/US20240327843A1/en active Pending
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