JP2021529173A5 - - Google Patents

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Publication number
JP2021529173A5
JP2021529173A5 JP2020570909A JP2020570909A JP2021529173A5 JP 2021529173 A5 JP2021529173 A5 JP 2021529173A5 JP 2020570909 A JP2020570909 A JP 2020570909A JP 2020570909 A JP2020570909 A JP 2020570909A JP 2021529173 A5 JP2021529173 A5 JP 2021529173A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
composition according
cancer
nucleotide sequence
rig
Prior art date
Application number
JP2020570909A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2019246450A5 (https=
JP2021529173A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/038323 external-priority patent/WO2019246450A1/en
Publication of JP2021529173A publication Critical patent/JP2021529173A/ja
Publication of JPWO2019246450A5 publication Critical patent/JPWO2019246450A5/ja
Publication of JP2021529173A5 publication Critical patent/JP2021529173A5/ja
Pending legal-status Critical Current

Links

JP2020570909A 2018-06-20 2019-06-20 Rig−iアゴニストおよびそれを使用した処置 Pending JP2021529173A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862687606P 2018-06-20 2018-06-20
US62/687,606 2018-06-20
US201862743369P 2018-10-09 2018-10-09
US62/743,369 2018-10-09
US201962815870P 2019-03-08 2019-03-08
US62/815,870 2019-03-08
PCT/US2019/038323 WO2019246450A1 (en) 2018-06-20 2019-06-20 Rig-i agonists and treatments using same

Publications (3)

Publication Number Publication Date
JP2021529173A JP2021529173A (ja) 2021-10-28
JPWO2019246450A5 JPWO2019246450A5 (https=) 2022-06-10
JP2021529173A5 true JP2021529173A5 (https=) 2022-06-10

Family

ID=68982664

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020570909A Pending JP2021529173A (ja) 2018-06-20 2019-06-20 Rig−iアゴニストおよびそれを使用した処置

Country Status (6)

Country Link
US (3) US12472198B2 (https=)
EP (1) EP3810151B1 (https=)
JP (1) JP2021529173A (https=)
CN (1) CN112672748A (https=)
CA (1) CA3110102A1 (https=)
WO (1) WO2019246450A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180133327A1 (en) 2015-03-16 2018-05-17 Amal Therapeutics Sa Cell Penetrating Peptides and Complexes Comprising the Same
DK3429618T5 (da) 2016-03-16 2024-09-16 Amal Therapeutics Sa Kombination af en immuncheckpoint-modulator og et kompleks som omfatter et cellepenetrerende peptid, en last og en tlr-peptidagonist til anvendelse i medicin
DK3515476T3 (da) 2016-09-21 2024-09-02 Amal Therapeutics Sa Fusion der omfatter et cellepenetrerende peptid, en multiepitop og en trl-peptidagnost til behandlingen af cancer
WO2019204743A1 (en) * 2018-04-19 2019-10-24 Checkmate Pharmaceuticals, Inc. Synthetic rig-i-like receptor agonists
JP2022512651A (ja) * 2018-10-09 2022-02-07 イエール ユニバーシティ Rig-iアゴニストおよびそれを使用する方法
US20220395487A1 (en) * 2019-11-04 2022-12-15 Yale University Rig-i innate immune receptor antagonists and methods of using same
EP4228681A1 (en) * 2020-10-14 2023-08-23 Boehringer Ingelheim International GmbH Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist
US11786545B2 (en) * 2020-12-09 2023-10-17 Yale University Compositions and methods for treating SARS-CoV-2 infection
JP2024527322A (ja) 2021-07-02 2024-07-24 イエール ユニバーシティ がんを治療するための組成物および方法
WO2023034864A1 (en) 2021-08-31 2023-03-09 Yale University Compositions and methods for treating cancers
WO2023168352A1 (en) 2022-03-03 2023-09-07 Yale University Humanized 3e10 antibodies, variants, and antigen binding fragments thereof
CN114814231B (zh) * 2022-03-08 2024-08-27 上海交通大学医学院附属瑞金医院 维甲酸诱导基因i在癌症治疗中的应用
WO2025040743A1 (en) 2023-08-22 2025-02-27 Univerza V Ljubljani Conjugated tlr7 and rig-i agonists
WO2026039779A1 (en) 2024-08-15 2026-02-19 Yale University Humanized 3e10 antibodies and antigen binding fragments optimized for rad51 binding

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
FR2722506B1 (fr) 1994-07-13 1996-08-14 Rhone Poulenc Rorer Sa Composition contenant des acides nucleiques, preparation et utilisations
ES2192672T3 (es) 1996-11-18 2003-10-16 Takeshi Imanishi Nuevos analogos de nucleotidos.
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6143877A (en) 1997-04-30 2000-11-07 Epoch Pharmaceuticals, Inc. Oligonucleotides including pyrazolo[3,4-D]pyrimidine bases, bound in double stranded nucleic acids
AU9063398A (en) 1997-09-12 1999-04-05 Exiqon A/S Oligonucleotide analogues
US6127121A (en) 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
JP4768132B2 (ja) 1999-03-24 2011-09-07 エクシコン エ/エス [2.2.1]ビシクロヌクレオシドの改良された製法
EP1178999B1 (en) 1999-05-04 2007-03-14 Santaris Pharma A/S L-ribo-lna analogues
US6287778B1 (en) 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
US6660845B1 (en) 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
US20090247613A1 (en) 2002-02-20 2009-10-01 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF B-CELL CLL/LYMPHOMA-2 (BCL2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US8017737B2 (en) 2002-11-19 2011-09-13 Hasan Kulaksiz Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor
US20070270360A1 (en) 2003-04-15 2007-11-22 Sirna Therapeutics, Inc. Rna Interference Mediated Inhibition of Severe Acute Respiratory Syndrome (Sars) Gene Expression Using Short Interfering Nucleic Acid
CA2538169A1 (en) 2003-09-09 2005-03-17 Albert Einstein College Of Medicine Of Yeshiva University Transition state analog inhibitors of ricin a-chain
US20080293053A1 (en) 2006-12-28 2008-11-27 The Regents Of The University Of Michigan shRNA Materials and Methods of Using Same for Inhibition of DKK-1
US20090123501A1 (en) 2007-05-17 2009-05-14 Baylor College Of Medicine Inhibition of the sh2-domain containing protein tyr-phosphatase, shp-1, to enhance vaccines
JP2011518116A (ja) 2008-02-21 2011-06-23 ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション トール様受容体3拮抗薬としての超小型rna
WO2009126933A2 (en) 2008-04-11 2009-10-15 Alnylam Pharmaceuticals, Inc. Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
EP2297323A1 (en) 2008-05-21 2011-03-23 Hartmann, Gunther 5' triphosphate oligonucleotide with blunt end and uses thereof
EP2318528A1 (en) 2008-07-24 2011-05-11 Rxi Pharmaceuticals Corporation Rnai constructs and uses therof
US8283460B2 (en) 2008-10-15 2012-10-09 Somagenics, Inc. Short hairpin RNAs for inhibition of gene expression
WO2010111891A1 (zh) 2009-04-03 2010-10-07 北京大学 修饰的寡聚核酸分子及其制备方法和应用
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
JP2015502365A (ja) 2011-12-12 2015-01-22 オンコイミューニン,インコーポレイティド オリゴヌクレオチドのイン−ビボ送達
US10947543B2 (en) * 2013-03-13 2021-03-16 Yale University Interferon production using short RNA duplexes
RS59500B1 (sr) * 2013-05-18 2019-12-31 Aduro Biotech Inc Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“
US10392444B2 (en) 2014-08-08 2019-08-27 Oncoquest, Inc. Tumor antigen specific antibodies and TLR3 stimulation to enhance the performance of checkpoint interference therapy of cancer
CA3089875A1 (en) * 2016-02-15 2017-08-24 Trizell Ltd. Improved interferon therapy
WO2017173427A1 (en) 2016-04-01 2017-10-05 Vycellix Inc Novel rna construct and methods of use thereof for enhancing the therapeutic effects of cytotoxic cells and stem cells
MX2019001920A (es) * 2016-08-19 2019-07-01 Curevac Ag Arn la terapia contra el cancer.
US11382966B2 (en) * 2017-03-24 2022-07-12 Rigontec Gmbh Method for designing RIG-I ligands
US10710272B2 (en) 2017-12-14 2020-07-14 United Technologies Corporation Hybrid material airflow impression molds
US10736957B2 (en) 2017-12-19 2020-08-11 President And Fellows Of Harvard College Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences
EP3727146A4 (en) 2017-12-19 2021-10-06 Blaze Bioscience, Inc. TUMOR HOMING AND CELL-PENETANT PEPTIDE IMMUNO-ONCOLOGY AGENT COMPLEX AND METHOD OF USE
TW201930591A (zh) * 2018-01-08 2019-08-01 瑞士商諾華公司 用於與嵌合抗原受體療法併用之免疫增強rna
US11499157B2 (en) * 2018-01-17 2022-11-15 Nanyang Technological University Immunomodulatory small hairpin RNA molecules
WO2019204743A1 (en) 2018-04-19 2019-10-24 Checkmate Pharmaceuticals, Inc. Synthetic rig-i-like receptor agonists

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